The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial Hypertrophy

Autores
Cerrudo, Carolina Susana; Cavallero, Carmen Susana; Rodríguez Fermepin, Martin; Hertig, Cecilia Margarita; Fernandez, Belisario Enrique
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The interactions between pressure and volume overload that occur in hypertension lead to different patterns of cardiac hypertrophy and to increase in natriuretic peptides (NPs). The profiles of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) synthesis and secretion have been investigated in models of hypertension. However, the different evolution of these profiles during the acute and chronic periods of pressure overload-induced cardiac hypertrophy is still unknown. For this reason, we studied one-kidney, one clip model using Sprague-Dawley rats at weeks 2, 4, 6 and 12 and correlated the evolution of these profiles with cardiac hypertrophy and hypertension. We observed a positive correlation between blood pressure elevation and the degree of cardiac hypertrophy, with a time-dependent increase in both parameters from week 2. Levels of BNP expression showed an early increase after 2 weeks of treatment while ANP increased significantly after 6 weeks. Yet, the increase in ANP expression was gradual, allowing its correlation with hypertrophy and hypertension. The NP expression has a differential response in the early stages of the development of hypertrophy induced by the renovascular model, with an early increase in BNP expression. Once hypertrophy develops, BNP expression is no longer specific and the increase of both NPs depends on and correlates with the degree of cardiac hypertrophy.
Fil: Cerrudo, Carolina Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Cavallero, Carmen Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Rodríguez Fermepin, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Hertig, Cecilia Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Fernandez, Belisario Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Materia
Atrial Natriuretic peptide
Cardiomegaly
Renovascular Hypertension
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79691
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/79691
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network_name_str CONICET Digital (CONICET)
spelling The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial HypertrophyCerrudo, Carolina SusanaCavallero, Carmen SusanaRodríguez Fermepin, MartinHertig, Cecilia MargaritaFernandez, Belisario EnriqueAtrial Natriuretic peptideCardiomegalyRenovascular Hypertensionhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The interactions between pressure and volume overload that occur in hypertension lead to different patterns of cardiac hypertrophy and to increase in natriuretic peptides (NPs). The profiles of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) synthesis and secretion have been investigated in models of hypertension. However, the different evolution of these profiles during the acute and chronic periods of pressure overload-induced cardiac hypertrophy is still unknown. For this reason, we studied one-kidney, one clip model using Sprague-Dawley rats at weeks 2, 4, 6 and 12 and correlated the evolution of these profiles with cardiac hypertrophy and hypertension. We observed a positive correlation between blood pressure elevation and the degree of cardiac hypertrophy, with a time-dependent increase in both parameters from week 2. Levels of BNP expression showed an early increase after 2 weeks of treatment while ANP increased significantly after 6 weeks. Yet, the increase in ANP expression was gradual, allowing its correlation with hypertrophy and hypertension. The NP expression has a differential response in the early stages of the development of hypertrophy induced by the renovascular model, with an early increase in BNP expression. Once hypertrophy develops, BNP expression is no longer specific and the increase of both NPs depends on and correlates with the degree of cardiac hypertrophy.Fil: Cerrudo, Carolina Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Cavallero, Carmen Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Rodríguez Fermepin, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Hertig, Cecilia Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Fernandez, Belisario Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaSociedad Argentina de Cardiología2010-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79691Cerrudo, Carolina Susana; Cavallero, Carmen Susana; Rodríguez Fermepin, Martin; Hertig, Cecilia Margarita; Fernandez, Belisario Enrique; The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial Hypertrophy; Sociedad Argentina de Cardiología; Revista Argentina de cardiología; 78; 4; 8-2010; 339-3450034-7000CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sac.org.ar/wp-content/uploads/2014/04/2034.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:31Zoai:ri.conicet.gov.ar:11336/79691instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:32.023CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial Hypertrophy
title The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial Hypertrophy
spellingShingle The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial Hypertrophy
Cerrudo, Carolina Susana
Atrial Natriuretic peptide
Cardiomegaly
Renovascular Hypertension
title_short The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial Hypertrophy
title_full The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial Hypertrophy
title_fullStr The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial Hypertrophy
title_full_unstemmed The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial Hypertrophy
title_sort The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial Hypertrophy
dc.creator.none.fl_str_mv Cerrudo, Carolina Susana
Cavallero, Carmen Susana
Rodríguez Fermepin, Martin
Hertig, Cecilia Margarita
Fernandez, Belisario Enrique
author Cerrudo, Carolina Susana
author_facet Cerrudo, Carolina Susana
Cavallero, Carmen Susana
Rodríguez Fermepin, Martin
Hertig, Cecilia Margarita
Fernandez, Belisario Enrique
author_role author
author2 Cavallero, Carmen Susana
Rodríguez Fermepin, Martin
Hertig, Cecilia Margarita
Fernandez, Belisario Enrique
author2_role author
author
author
author
dc.subject.none.fl_str_mv Atrial Natriuretic peptide
Cardiomegaly
Renovascular Hypertension
topic Atrial Natriuretic peptide
Cardiomegaly
Renovascular Hypertension
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The interactions between pressure and volume overload that occur in hypertension lead to different patterns of cardiac hypertrophy and to increase in natriuretic peptides (NPs). The profiles of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) synthesis and secretion have been investigated in models of hypertension. However, the different evolution of these profiles during the acute and chronic periods of pressure overload-induced cardiac hypertrophy is still unknown. For this reason, we studied one-kidney, one clip model using Sprague-Dawley rats at weeks 2, 4, 6 and 12 and correlated the evolution of these profiles with cardiac hypertrophy and hypertension. We observed a positive correlation between blood pressure elevation and the degree of cardiac hypertrophy, with a time-dependent increase in both parameters from week 2. Levels of BNP expression showed an early increase after 2 weeks of treatment while ANP increased significantly after 6 weeks. Yet, the increase in ANP expression was gradual, allowing its correlation with hypertrophy and hypertension. The NP expression has a differential response in the early stages of the development of hypertrophy induced by the renovascular model, with an early increase in BNP expression. Once hypertrophy develops, BNP expression is no longer specific and the increase of both NPs depends on and correlates with the degree of cardiac hypertrophy.
Fil: Cerrudo, Carolina Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Cavallero, Carmen Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Rodríguez Fermepin, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Hertig, Cecilia Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Fernandez, Belisario Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
description The interactions between pressure and volume overload that occur in hypertension lead to different patterns of cardiac hypertrophy and to increase in natriuretic peptides (NPs). The profiles of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) synthesis and secretion have been investigated in models of hypertension. However, the different evolution of these profiles during the acute and chronic periods of pressure overload-induced cardiac hypertrophy is still unknown. For this reason, we studied one-kidney, one clip model using Sprague-Dawley rats at weeks 2, 4, 6 and 12 and correlated the evolution of these profiles with cardiac hypertrophy and hypertension. We observed a positive correlation between blood pressure elevation and the degree of cardiac hypertrophy, with a time-dependent increase in both parameters from week 2. Levels of BNP expression showed an early increase after 2 weeks of treatment while ANP increased significantly after 6 weeks. Yet, the increase in ANP expression was gradual, allowing its correlation with hypertrophy and hypertension. The NP expression has a differential response in the early stages of the development of hypertrophy induced by the renovascular model, with an early increase in BNP expression. Once hypertrophy develops, BNP expression is no longer specific and the increase of both NPs depends on and correlates with the degree of cardiac hypertrophy.
publishDate 2010
dc.date.none.fl_str_mv 2010-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79691
Cerrudo, Carolina Susana; Cavallero, Carmen Susana; Rodríguez Fermepin, Martin; Hertig, Cecilia Margarita; Fernandez, Belisario Enrique; The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial Hypertrophy; Sociedad Argentina de Cardiología; Revista Argentina de cardiología; 78; 4; 8-2010; 339-345
0034-7000
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79691
identifier_str_mv Cerrudo, Carolina Susana; Cavallero, Carmen Susana; Rodríguez Fermepin, Martin; Hertig, Cecilia Margarita; Fernandez, Belisario Enrique; The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial Hypertrophy; Sociedad Argentina de Cardiología; Revista Argentina de cardiología; 78; 4; 8-2010; 339-345
0034-7000
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sac.org.ar/wp-content/uploads/2014/04/2034.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Cardiología
publisher.none.fl_str_mv Sociedad Argentina de Cardiología
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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