Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats
- Autores
- Cabrera, Valentin; Abate, Paula; Macchione, Ana Fabiola; Balaszczuk, Veronica
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- A report from the Panamerican Health Organization placed Argentina among Latin American countries with the highest per capita alcohol consumption. Alcohol consumption and the problems associated with it show patterns related to age, being adolescents the most exposed. Alcohol exposure may cause neurobiological and behavioral disorders. We can find that ethanol exposure may provoke an increase in anxiety-like behaviors in rodents. On the other hand, long chain polyunsaturated fatty acids ω-3 have proven to decrease alcohol induced anxiety-like behaviors in neonate rats. However, no literature was found about this effect in the adolescent stage.The aim of the present study is to analyze the neurobehavioral effects of a binge-like ethanol exposure and the possible amelioration of an ω-3 treatment in adolescent rats. We administered a dose of 2 g/kg or 0 g/kg of EtOH via i.g. at postnatal days (PDs) 28, 30 and 32. Fifteen min after administration, each animal received a dose of 1mg/kg or 0mg/kg of docosahexaenoic acid (DHA), a member of the ω-3 family via i.p. We are currently studying anxiety-like behavior at PD34 where subjects are being evaluated in an Elevated Plus Maze. Moreover, we assessed the expression of serotonin and GABA in the amygdala, a brain area associated with emotion processing by immunofluorescence technique. We hypothesize that ethanol exposure will produce anxiety-like behaviors and the treatment with DHA can decrease these ethanol induced anxiety.
Fil: Cabrera, Valentin. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Abate, Paula. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
SAN 2022 Meeting
Buenos Aires
Argentina
Sociedad Argentina de Investigación en Neurociencias - Materia
-
Ethanol
Omega 3
Anxiety
Adolescence - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/246115
Ver los metadatos del registro completo
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Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent ratsCabrera, ValentinAbate, PaulaMacchione, Ana FabiolaBalaszczuk, VeronicaEthanolOmega 3AnxietyAdolescencehttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5A report from the Panamerican Health Organization placed Argentina among Latin American countries with the highest per capita alcohol consumption. Alcohol consumption and the problems associated with it show patterns related to age, being adolescents the most exposed. Alcohol exposure may cause neurobiological and behavioral disorders. We can find that ethanol exposure may provoke an increase in anxiety-like behaviors in rodents. On the other hand, long chain polyunsaturated fatty acids ω-3 have proven to decrease alcohol induced anxiety-like behaviors in neonate rats. However, no literature was found about this effect in the adolescent stage.The aim of the present study is to analyze the neurobehavioral effects of a binge-like ethanol exposure and the possible amelioration of an ω-3 treatment in adolescent rats. We administered a dose of 2 g/kg or 0 g/kg of EtOH via i.g. at postnatal days (PDs) 28, 30 and 32. Fifteen min after administration, each animal received a dose of 1mg/kg or 0mg/kg of docosahexaenoic acid (DHA), a member of the ω-3 family via i.p. We are currently studying anxiety-like behavior at PD34 where subjects are being evaluated in an Elevated Plus Maze. Moreover, we assessed the expression of serotonin and GABA in the amygdala, a brain area associated with emotion processing by immunofluorescence technique. We hypothesize that ethanol exposure will produce anxiety-like behaviors and the treatment with DHA can decrease these ethanol induced anxiety.Fil: Cabrera, Valentin. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Abate, Paula. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaSAN 2022 MeetingBuenos AiresArgentinaSociedad Argentina de Investigación en NeurocienciasSociedad Argentina de Investigación en Neurociencias2022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/246115Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats; SAN 2022 Meeting; Buenos Aires; Argentina; 2022; 204-204CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://saneurociencias.org.ar/wp-content/uploads/2023/07/ebook2022-07072023-1.pdfinfo:eu-repo/semantics/altIdentifier/url/https://csan2022.saneurociencias.org.ar/index.htmlNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:55:23Zoai:ri.conicet.gov.ar:11336/246115instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:55:23.826CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats |
title |
Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats |
spellingShingle |
Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats Cabrera, Valentin Ethanol Omega 3 Anxiety Adolescence |
title_short |
Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats |
title_full |
Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats |
title_fullStr |
Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats |
title_full_unstemmed |
Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats |
title_sort |
Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats |
dc.creator.none.fl_str_mv |
Cabrera, Valentin Abate, Paula Macchione, Ana Fabiola Balaszczuk, Veronica |
author |
Cabrera, Valentin |
author_facet |
Cabrera, Valentin Abate, Paula Macchione, Ana Fabiola Balaszczuk, Veronica |
author_role |
author |
author2 |
Abate, Paula Macchione, Ana Fabiola Balaszczuk, Veronica |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Ethanol Omega 3 Anxiety Adolescence |
topic |
Ethanol Omega 3 Anxiety Adolescence |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/5.1 https://purl.org/becyt/ford/5 |
dc.description.none.fl_txt_mv |
A report from the Panamerican Health Organization placed Argentina among Latin American countries with the highest per capita alcohol consumption. Alcohol consumption and the problems associated with it show patterns related to age, being adolescents the most exposed. Alcohol exposure may cause neurobiological and behavioral disorders. We can find that ethanol exposure may provoke an increase in anxiety-like behaviors in rodents. On the other hand, long chain polyunsaturated fatty acids ω-3 have proven to decrease alcohol induced anxiety-like behaviors in neonate rats. However, no literature was found about this effect in the adolescent stage.The aim of the present study is to analyze the neurobehavioral effects of a binge-like ethanol exposure and the possible amelioration of an ω-3 treatment in adolescent rats. We administered a dose of 2 g/kg or 0 g/kg of EtOH via i.g. at postnatal days (PDs) 28, 30 and 32. Fifteen min after administration, each animal received a dose of 1mg/kg or 0mg/kg of docosahexaenoic acid (DHA), a member of the ω-3 family via i.p. We are currently studying anxiety-like behavior at PD34 where subjects are being evaluated in an Elevated Plus Maze. Moreover, we assessed the expression of serotonin and GABA in the amygdala, a brain area associated with emotion processing by immunofluorescence technique. We hypothesize that ethanol exposure will produce anxiety-like behaviors and the treatment with DHA can decrease these ethanol induced anxiety. Fil: Cabrera, Valentin. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina Fil: Abate, Paula. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina Fil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina SAN 2022 Meeting Buenos Aires Argentina Sociedad Argentina de Investigación en Neurociencias |
description |
A report from the Panamerican Health Organization placed Argentina among Latin American countries with the highest per capita alcohol consumption. Alcohol consumption and the problems associated with it show patterns related to age, being adolescents the most exposed. Alcohol exposure may cause neurobiological and behavioral disorders. We can find that ethanol exposure may provoke an increase in anxiety-like behaviors in rodents. On the other hand, long chain polyunsaturated fatty acids ω-3 have proven to decrease alcohol induced anxiety-like behaviors in neonate rats. However, no literature was found about this effect in the adolescent stage.The aim of the present study is to analyze the neurobehavioral effects of a binge-like ethanol exposure and the possible amelioration of an ω-3 treatment in adolescent rats. We administered a dose of 2 g/kg or 0 g/kg of EtOH via i.g. at postnatal days (PDs) 28, 30 and 32. Fifteen min after administration, each animal received a dose of 1mg/kg or 0mg/kg of docosahexaenoic acid (DHA), a member of the ω-3 family via i.p. We are currently studying anxiety-like behavior at PD34 where subjects are being evaluated in an Elevated Plus Maze. Moreover, we assessed the expression of serotonin and GABA in the amygdala, a brain area associated with emotion processing by immunofluorescence technique. We hypothesize that ethanol exposure will produce anxiety-like behaviors and the treatment with DHA can decrease these ethanol induced anxiety. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Congreso Book http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/246115 Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats; SAN 2022 Meeting; Buenos Aires; Argentina; 2022; 204-204 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/246115 |
identifier_str_mv |
Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats; SAN 2022 Meeting; Buenos Aires; Argentina; 2022; 204-204 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf application/pdf |
dc.coverage.none.fl_str_mv |
Nacional |
dc.publisher.none.fl_str_mv |
Sociedad Argentina de Investigación en Neurociencias |
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Sociedad Argentina de Investigación en Neurociencias |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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