Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats

Autores
Cabrera, Valentin; Abate, Paula; Macchione, Ana Fabiola; Balaszczuk, Veronica
Año de publicación
2022
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
A report from the Panamerican Health Organization placed Argentina among Latin American countries with the highest per capita alcohol consumption. Alcohol consumption and the problems associated with it show patterns related to age, being adolescents the most exposed. Alcohol exposure may cause neurobiological and behavioral disorders. We can find that ethanol exposure may provoke an increase in anxiety-like behaviors in rodents. On the other hand, long chain polyunsaturated fatty acids ω-3 have proven to decrease alcohol induced anxiety-like behaviors in neonate rats. However, no literature was found about this effect in the adolescent stage.The aim of the present study is to analyze the neurobehavioral effects of a binge-like ethanol exposure and the possible amelioration of an ω-3 treatment in adolescent rats. We administered a dose of 2 g/kg or 0 g/kg of EtOH via i.g. at postnatal days (PDs) 28, 30 and 32. Fifteen min after administration, each animal received a dose of 1mg/kg or 0mg/kg of docosahexaenoic acid (DHA), a member of the ω-3 family via i.p. We are currently studying anxiety-like behavior at PD34 where subjects are being evaluated in an Elevated Plus Maze. Moreover, we assessed the expression of serotonin and GABA in the amygdala, a brain area associated with emotion processing by immunofluorescence technique. We hypothesize that ethanol exposure will produce anxiety-like behaviors and the treatment with DHA can decrease these ethanol induced anxiety.
Fil: Cabrera, Valentin. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Abate, Paula. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
SAN 2022 Meeting
Buenos Aires
Argentina
Sociedad Argentina de Investigación en Neurociencias
Materia
Ethanol
Omega 3
Anxiety
Adolescence
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/246115
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/246115
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent ratsCabrera, ValentinAbate, PaulaMacchione, Ana FabiolaBalaszczuk, VeronicaEthanolOmega 3AnxietyAdolescencehttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5A report from the Panamerican Health Organization placed Argentina among Latin American countries with the highest per capita alcohol consumption. Alcohol consumption and the problems associated with it show patterns related to age, being adolescents the most exposed. Alcohol exposure may cause neurobiological and behavioral disorders. We can find that ethanol exposure may provoke an increase in anxiety-like behaviors in rodents. On the other hand, long chain polyunsaturated fatty acids ω-3 have proven to decrease alcohol induced anxiety-like behaviors in neonate rats. However, no literature was found about this effect in the adolescent stage.The aim of the present study is to analyze the neurobehavioral effects of a binge-like ethanol exposure and the possible amelioration of an ω-3 treatment in adolescent rats. We administered a dose of 2 g/kg or 0 g/kg of EtOH via i.g. at postnatal days (PDs) 28, 30 and 32. Fifteen min after administration, each animal received a dose of 1mg/kg or 0mg/kg of docosahexaenoic acid (DHA), a member of the ω-3 family via i.p. We are currently studying anxiety-like behavior at PD34 where subjects are being evaluated in an Elevated Plus Maze. Moreover, we assessed the expression of serotonin and GABA in the amygdala, a brain area associated with emotion processing by immunofluorescence technique. We hypothesize that ethanol exposure will produce anxiety-like behaviors and the treatment with DHA can decrease these ethanol induced anxiety.Fil: Cabrera, Valentin. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Abate, Paula. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaSAN 2022 MeetingBuenos AiresArgentinaSociedad Argentina de Investigación en NeurocienciasSociedad Argentina de Investigación en Neurociencias2022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/246115Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats; SAN 2022 Meeting; Buenos Aires; Argentina; 2022; 204-204CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://saneurociencias.org.ar/wp-content/uploads/2023/07/ebook2022-07072023-1.pdfinfo:eu-repo/semantics/altIdentifier/url/https://csan2022.saneurociencias.org.ar/index.htmlNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:50:19Zoai:ri.conicet.gov.ar:11336/246115instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:50:19.883CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats
title Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats
spellingShingle Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats
Cabrera, Valentin
Ethanol
Omega 3
Anxiety
Adolescence
title_short Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats
title_full Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats
title_fullStr Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats
title_full_unstemmed Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats
title_sort Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats
dc.creator.none.fl_str_mv Cabrera, Valentin
Abate, Paula
Macchione, Ana Fabiola
Balaszczuk, Veronica
author Cabrera, Valentin
author_facet Cabrera, Valentin
Abate, Paula
Macchione, Ana Fabiola
Balaszczuk, Veronica
author_role author
author2 Abate, Paula
Macchione, Ana Fabiola
Balaszczuk, Veronica
author2_role author
author
author
dc.subject.none.fl_str_mv Ethanol
Omega 3
Anxiety
Adolescence
topic Ethanol
Omega 3
Anxiety
Adolescence
purl_subject.fl_str_mv https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv A report from the Panamerican Health Organization placed Argentina among Latin American countries with the highest per capita alcohol consumption. Alcohol consumption and the problems associated with it show patterns related to age, being adolescents the most exposed. Alcohol exposure may cause neurobiological and behavioral disorders. We can find that ethanol exposure may provoke an increase in anxiety-like behaviors in rodents. On the other hand, long chain polyunsaturated fatty acids ω-3 have proven to decrease alcohol induced anxiety-like behaviors in neonate rats. However, no literature was found about this effect in the adolescent stage.The aim of the present study is to analyze the neurobehavioral effects of a binge-like ethanol exposure and the possible amelioration of an ω-3 treatment in adolescent rats. We administered a dose of 2 g/kg or 0 g/kg of EtOH via i.g. at postnatal days (PDs) 28, 30 and 32. Fifteen min after administration, each animal received a dose of 1mg/kg or 0mg/kg of docosahexaenoic acid (DHA), a member of the ω-3 family via i.p. We are currently studying anxiety-like behavior at PD34 where subjects are being evaluated in an Elevated Plus Maze. Moreover, we assessed the expression of serotonin and GABA in the amygdala, a brain area associated with emotion processing by immunofluorescence technique. We hypothesize that ethanol exposure will produce anxiety-like behaviors and the treatment with DHA can decrease these ethanol induced anxiety.
Fil: Cabrera, Valentin. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Abate, Paula. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
SAN 2022 Meeting
Buenos Aires
Argentina
Sociedad Argentina de Investigación en Neurociencias
description A report from the Panamerican Health Organization placed Argentina among Latin American countries with the highest per capita alcohol consumption. Alcohol consumption and the problems associated with it show patterns related to age, being adolescents the most exposed. Alcohol exposure may cause neurobiological and behavioral disorders. We can find that ethanol exposure may provoke an increase in anxiety-like behaviors in rodents. On the other hand, long chain polyunsaturated fatty acids ω-3 have proven to decrease alcohol induced anxiety-like behaviors in neonate rats. However, no literature was found about this effect in the adolescent stage.The aim of the present study is to analyze the neurobehavioral effects of a binge-like ethanol exposure and the possible amelioration of an ω-3 treatment in adolescent rats. We administered a dose of 2 g/kg or 0 g/kg of EtOH via i.g. at postnatal days (PDs) 28, 30 and 32. Fifteen min after administration, each animal received a dose of 1mg/kg or 0mg/kg of docosahexaenoic acid (DHA), a member of the ω-3 family via i.p. We are currently studying anxiety-like behavior at PD34 where subjects are being evaluated in an Elevated Plus Maze. Moreover, we assessed the expression of serotonin and GABA in the amygdala, a brain area associated with emotion processing by immunofluorescence technique. We hypothesize that ethanol exposure will produce anxiety-like behaviors and the treatment with DHA can decrease these ethanol induced anxiety.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/246115
Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats; SAN 2022 Meeting; Buenos Aires; Argentina; 2022; 204-204
CONICET Digital
CONICET
url http://hdl.handle.net/11336/246115
identifier_str_mv Ethanol binge-like exposure and possible amelioration of Omega-3 Fatty Acid derived on anxiety-like behavior in adolescent rats; SAN 2022 Meeting; Buenos Aires; Argentina; 2022; 204-204
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://saneurociencias.org.ar/wp-content/uploads/2023/07/ebook2022-07072023-1.pdf
info:eu-repo/semantics/altIdentifier/url/https://csan2022.saneurociencias.org.ar/index.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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