Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates

Autores
Salguero, Juan Agustín; Méndez, Santiago; Abate, Paula; Balaszczuk, Veronica
Año de publicación
2019
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Maternal alcohol consumption during pregnancy may cause neurocognitive and behavioral disorders that canpersist until adulthood. Epidemiological data has revealed an alarming increase in the frequency of alcoholintake in pregnant women. Nutritional variables may also have an impact on the behavioral alterations occasioned by alcohol during development. Moreover, omega-3, a polyunsaturated fatty acid necessary fornormal brain development, is deficient in ethanol-treated animals. Although studies have shown that omega-3supplementation after prenatal ethanol (EtOH) treatment improves some disorders, there are no reports aboutacute treatment with omega-3 in binge alcohol neurotoxic models during postnatal development. The goalof this study was to determine whether an administration of omega-3, after an acute ethanol dose in neonates, would be able to attenuate alcohol effects in offspring. Male/ female rats were administered ethanol(2.5 g/kg s.c. at 0 and 2 h) or saline on postnatal day (PND) 7, with a single dose of omega-3 (720 mg/kg),or omega-6, 15 min after the last alcohol injection. It has been found that EtOH-treated animals showedhyperlocomotion and anxiety-like behavior on PND 14. Administration of omega-3 after EtOH treatmentreduced hyperlocomotion and the anxiety-like behaviors on PND 14. On the other hand, animals treated withomega-6 did not reduce those EtOH effects. In conclusion, acute ethanol exposure induced neurobehavioral alterations that persisted in the offspring and omega 3 mitigates those effects but not omega 6. These dataare relevant considering that omega-3 treatment may have therapeutic effects through mitigating some ofethanol´s damaging consequences.
Fil: Salguero, Juan Agustín. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Méndez, Santiago. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Fil: Abate, Paula. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Fil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
IX International Meeting of the Latin American Society for Biomedical Research on Alcoholism (LASBRA): Determinants of Alcoholism: bridging the gap between epidemiological and basic research
Córdoba
Argentina
Latin American Society for Biomedical Research on Alcoholism
Materia
OMEGA-3
ETHANOL
PRENATAL EXPOSURE
INFANT RATS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/162692
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat NeonatesSalguero, Juan AgustínMéndez, SantiagoAbate, PaulaBalaszczuk, VeronicaOMEGA-3ETHANOLPRENATAL EXPOSUREINFANT RATShttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Maternal alcohol consumption during pregnancy may cause neurocognitive and behavioral disorders that canpersist until adulthood. Epidemiological data has revealed an alarming increase in the frequency of alcoholintake in pregnant women. Nutritional variables may also have an impact on the behavioral alterations occasioned by alcohol during development. Moreover, omega-3, a polyunsaturated fatty acid necessary fornormal brain development, is deficient in ethanol-treated animals. Although studies have shown that omega-3supplementation after prenatal ethanol (EtOH) treatment improves some disorders, there are no reports aboutacute treatment with omega-3 in binge alcohol neurotoxic models during postnatal development. The goalof this study was to determine whether an administration of omega-3, after an acute ethanol dose in neonates, would be able to attenuate alcohol effects in offspring. Male/ female rats were administered ethanol(2.5 g/kg s.c. at 0 and 2 h) or saline on postnatal day (PND) 7, with a single dose of omega-3 (720 mg/kg),or omega-6, 15 min after the last alcohol injection. It has been found that EtOH-treated animals showedhyperlocomotion and anxiety-like behavior on PND 14. Administration of omega-3 after EtOH treatmentreduced hyperlocomotion and the anxiety-like behaviors on PND 14. On the other hand, animals treated withomega-6 did not reduce those EtOH effects. In conclusion, acute ethanol exposure induced neurobehavioral alterations that persisted in the offspring and omega 3 mitigates those effects but not omega 6. These dataare relevant considering that omega-3 treatment may have therapeutic effects through mitigating some ofethanol´s damaging consequences.Fil: Salguero, Juan Agustín. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Méndez, Santiago. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaFil: Abate, Paula. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaFil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaIX International Meeting of the Latin American Society for Biomedical Research on Alcoholism (LASBRA): Determinants of Alcoholism: bridging the gap between epidemiological and basic researchCórdobaArgentinaLatin American Society for Biomedical Research on AlcoholismDougmar Publishing Group2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/162692Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates; IX International Meeting of the Latin American Society for Biomedical Research on Alcoholism (LASBRA): Determinants of Alcoholism: bridging the gap between epidemiological and basic research; Córdoba; Argentina; 2019; e63-e64CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.jfasrp.com/index.php/JFASRP/article/view/7info:eu-repo/semantics/altIdentifier/doi/10.22374/jfasrp.v2i1.7Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:37:50Zoai:ri.conicet.gov.ar:11336/162692instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:37:50.918CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates
title Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates
spellingShingle Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates
Salguero, Juan Agustín
OMEGA-3
ETHANOL
PRENATAL EXPOSURE
INFANT RATS
title_short Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates
title_full Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates
title_fullStr Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates
title_full_unstemmed Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates
title_sort Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates
dc.creator.none.fl_str_mv Salguero, Juan Agustín
Méndez, Santiago
Abate, Paula
Balaszczuk, Veronica
author Salguero, Juan Agustín
author_facet Salguero, Juan Agustín
Méndez, Santiago
Abate, Paula
Balaszczuk, Veronica
author_role author
author2 Méndez, Santiago
Abate, Paula
Balaszczuk, Veronica
author2_role author
author
author
dc.subject.none.fl_str_mv OMEGA-3
ETHANOL
PRENATAL EXPOSURE
INFANT RATS
topic OMEGA-3
ETHANOL
PRENATAL EXPOSURE
INFANT RATS
purl_subject.fl_str_mv https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv Maternal alcohol consumption during pregnancy may cause neurocognitive and behavioral disorders that canpersist until adulthood. Epidemiological data has revealed an alarming increase in the frequency of alcoholintake in pregnant women. Nutritional variables may also have an impact on the behavioral alterations occasioned by alcohol during development. Moreover, omega-3, a polyunsaturated fatty acid necessary fornormal brain development, is deficient in ethanol-treated animals. Although studies have shown that omega-3supplementation after prenatal ethanol (EtOH) treatment improves some disorders, there are no reports aboutacute treatment with omega-3 in binge alcohol neurotoxic models during postnatal development. The goalof this study was to determine whether an administration of omega-3, after an acute ethanol dose in neonates, would be able to attenuate alcohol effects in offspring. Male/ female rats were administered ethanol(2.5 g/kg s.c. at 0 and 2 h) or saline on postnatal day (PND) 7, with a single dose of omega-3 (720 mg/kg),or omega-6, 15 min after the last alcohol injection. It has been found that EtOH-treated animals showedhyperlocomotion and anxiety-like behavior on PND 14. Administration of omega-3 after EtOH treatmentreduced hyperlocomotion and the anxiety-like behaviors on PND 14. On the other hand, animals treated withomega-6 did not reduce those EtOH effects. In conclusion, acute ethanol exposure induced neurobehavioral alterations that persisted in the offspring and omega 3 mitigates those effects but not omega 6. These dataare relevant considering that omega-3 treatment may have therapeutic effects through mitigating some ofethanol´s damaging consequences.
Fil: Salguero, Juan Agustín. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Méndez, Santiago. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Fil: Abate, Paula. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Fil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
IX International Meeting of the Latin American Society for Biomedical Research on Alcoholism (LASBRA): Determinants of Alcoholism: bridging the gap between epidemiological and basic research
Córdoba
Argentina
Latin American Society for Biomedical Research on Alcoholism
description Maternal alcohol consumption during pregnancy may cause neurocognitive and behavioral disorders that canpersist until adulthood. Epidemiological data has revealed an alarming increase in the frequency of alcoholintake in pregnant women. Nutritional variables may also have an impact on the behavioral alterations occasioned by alcohol during development. Moreover, omega-3, a polyunsaturated fatty acid necessary fornormal brain development, is deficient in ethanol-treated animals. Although studies have shown that omega-3supplementation after prenatal ethanol (EtOH) treatment improves some disorders, there are no reports aboutacute treatment with omega-3 in binge alcohol neurotoxic models during postnatal development. The goalof this study was to determine whether an administration of omega-3, after an acute ethanol dose in neonates, would be able to attenuate alcohol effects in offspring. Male/ female rats were administered ethanol(2.5 g/kg s.c. at 0 and 2 h) or saline on postnatal day (PND) 7, with a single dose of omega-3 (720 mg/kg),or omega-6, 15 min after the last alcohol injection. It has been found that EtOH-treated animals showedhyperlocomotion and anxiety-like behavior on PND 14. Administration of omega-3 after EtOH treatmentreduced hyperlocomotion and the anxiety-like behaviors on PND 14. On the other hand, animals treated withomega-6 did not reduce those EtOH effects. In conclusion, acute ethanol exposure induced neurobehavioral alterations that persisted in the offspring and omega 3 mitigates those effects but not omega 6. These dataare relevant considering that omega-3 treatment may have therapeutic effects through mitigating some ofethanol´s damaging consequences.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/162692
Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates; IX International Meeting of the Latin American Society for Biomedical Research on Alcoholism (LASBRA): Determinants of Alcoholism: bridging the gap between epidemiological and basic research; Córdoba; Argentina; 2019; e63-e64
CONICET Digital
CONICET
url http://hdl.handle.net/11336/162692
identifier_str_mv Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates; IX International Meeting of the Latin American Society for Biomedical Research on Alcoholism (LASBRA): Determinants of Alcoholism: bridging the gap between epidemiological and basic research; Córdoba; Argentina; 2019; e63-e64
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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application/pdf
application/pdf
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dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Dougmar Publishing Group
publisher.none.fl_str_mv Dougmar Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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