Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates
- Autores
- Salguero, Juan Agustín; Méndez, Santiago; Abate, Paula; Balaszczuk, Veronica
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Maternal alcohol consumption during pregnancy may cause neurocognitive and behavioral disorders that canpersist until adulthood. Epidemiological data has revealed an alarming increase in the frequency of alcoholintake in pregnant women. Nutritional variables may also have an impact on the behavioral alterations occasioned by alcohol during development. Moreover, omega-3, a polyunsaturated fatty acid necessary fornormal brain development, is deficient in ethanol-treated animals. Although studies have shown that omega-3supplementation after prenatal ethanol (EtOH) treatment improves some disorders, there are no reports aboutacute treatment with omega-3 in binge alcohol neurotoxic models during postnatal development. The goalof this study was to determine whether an administration of omega-3, after an acute ethanol dose in neonates, would be able to attenuate alcohol effects in offspring. Male/ female rats were administered ethanol(2.5 g/kg s.c. at 0 and 2 h) or saline on postnatal day (PND) 7, with a single dose of omega-3 (720 mg/kg),or omega-6, 15 min after the last alcohol injection. It has been found that EtOH-treated animals showedhyperlocomotion and anxiety-like behavior on PND 14. Administration of omega-3 after EtOH treatmentreduced hyperlocomotion and the anxiety-like behaviors on PND 14. On the other hand, animals treated withomega-6 did not reduce those EtOH effects. In conclusion, acute ethanol exposure induced neurobehavioral alterations that persisted in the offspring and omega 3 mitigates those effects but not omega 6. These dataare relevant considering that omega-3 treatment may have therapeutic effects through mitigating some ofethanol´s damaging consequences.
Fil: Salguero, Juan Agustín. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Méndez, Santiago. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Fil: Abate, Paula. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Fil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
IX International Meeting of the Latin American Society for Biomedical Research on Alcoholism (LASBRA): Determinants of Alcoholism: bridging the gap between epidemiological and basic research
Córdoba
Argentina
Latin American Society for Biomedical Research on Alcoholism - Materia
-
OMEGA-3
ETHANOL
PRENATAL EXPOSURE
INFANT RATS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/162692
Ver los metadatos del registro completo
id |
CONICETDig_574f9d6a39a53b4578325f625f9962cd |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/162692 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat NeonatesSalguero, Juan AgustínMéndez, SantiagoAbate, PaulaBalaszczuk, VeronicaOMEGA-3ETHANOLPRENATAL EXPOSUREINFANT RATShttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Maternal alcohol consumption during pregnancy may cause neurocognitive and behavioral disorders that canpersist until adulthood. Epidemiological data has revealed an alarming increase in the frequency of alcoholintake in pregnant women. Nutritional variables may also have an impact on the behavioral alterations occasioned by alcohol during development. Moreover, omega-3, a polyunsaturated fatty acid necessary fornormal brain development, is deficient in ethanol-treated animals. Although studies have shown that omega-3supplementation after prenatal ethanol (EtOH) treatment improves some disorders, there are no reports aboutacute treatment with omega-3 in binge alcohol neurotoxic models during postnatal development. The goalof this study was to determine whether an administration of omega-3, after an acute ethanol dose in neonates, would be able to attenuate alcohol effects in offspring. Male/ female rats were administered ethanol(2.5 g/kg s.c. at 0 and 2 h) or saline on postnatal day (PND) 7, with a single dose of omega-3 (720 mg/kg),or omega-6, 15 min after the last alcohol injection. It has been found that EtOH-treated animals showedhyperlocomotion and anxiety-like behavior on PND 14. Administration of omega-3 after EtOH treatmentreduced hyperlocomotion and the anxiety-like behaviors on PND 14. On the other hand, animals treated withomega-6 did not reduce those EtOH effects. In conclusion, acute ethanol exposure induced neurobehavioral alterations that persisted in the offspring and omega 3 mitigates those effects but not omega 6. These dataare relevant considering that omega-3 treatment may have therapeutic effects through mitigating some ofethanol´s damaging consequences.Fil: Salguero, Juan Agustín. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Méndez, Santiago. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaFil: Abate, Paula. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaFil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaIX International Meeting of the Latin American Society for Biomedical Research on Alcoholism (LASBRA): Determinants of Alcoholism: bridging the gap between epidemiological and basic researchCórdobaArgentinaLatin American Society for Biomedical Research on AlcoholismDougmar Publishing Group2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/162692Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates; IX International Meeting of the Latin American Society for Biomedical Research on Alcoholism (LASBRA): Determinants of Alcoholism: bridging the gap between epidemiological and basic research; Córdoba; Argentina; 2019; e63-e64CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.jfasrp.com/index.php/JFASRP/article/view/7info:eu-repo/semantics/altIdentifier/doi/10.22374/jfasrp.v2i1.7Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:44:21Zoai:ri.conicet.gov.ar:11336/162692instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:44:21.855CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates |
title |
Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates |
spellingShingle |
Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates Salguero, Juan Agustín OMEGA-3 ETHANOL PRENATAL EXPOSURE INFANT RATS |
title_short |
Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates |
title_full |
Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates |
title_fullStr |
Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates |
title_full_unstemmed |
Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates |
title_sort |
Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates |
dc.creator.none.fl_str_mv |
Salguero, Juan Agustín Méndez, Santiago Abate, Paula Balaszczuk, Veronica |
author |
Salguero, Juan Agustín |
author_facet |
Salguero, Juan Agustín Méndez, Santiago Abate, Paula Balaszczuk, Veronica |
author_role |
author |
author2 |
Méndez, Santiago Abate, Paula Balaszczuk, Veronica |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
OMEGA-3 ETHANOL PRENATAL EXPOSURE INFANT RATS |
topic |
OMEGA-3 ETHANOL PRENATAL EXPOSURE INFANT RATS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/5.1 https://purl.org/becyt/ford/5 |
dc.description.none.fl_txt_mv |
Maternal alcohol consumption during pregnancy may cause neurocognitive and behavioral disorders that canpersist until adulthood. Epidemiological data has revealed an alarming increase in the frequency of alcoholintake in pregnant women. Nutritional variables may also have an impact on the behavioral alterations occasioned by alcohol during development. Moreover, omega-3, a polyunsaturated fatty acid necessary fornormal brain development, is deficient in ethanol-treated animals. Although studies have shown that omega-3supplementation after prenatal ethanol (EtOH) treatment improves some disorders, there are no reports aboutacute treatment with omega-3 in binge alcohol neurotoxic models during postnatal development. The goalof this study was to determine whether an administration of omega-3, after an acute ethanol dose in neonates, would be able to attenuate alcohol effects in offspring. Male/ female rats were administered ethanol(2.5 g/kg s.c. at 0 and 2 h) or saline on postnatal day (PND) 7, with a single dose of omega-3 (720 mg/kg),or omega-6, 15 min after the last alcohol injection. It has been found that EtOH-treated animals showedhyperlocomotion and anxiety-like behavior on PND 14. Administration of omega-3 after EtOH treatmentreduced hyperlocomotion and the anxiety-like behaviors on PND 14. On the other hand, animals treated withomega-6 did not reduce those EtOH effects. In conclusion, acute ethanol exposure induced neurobehavioral alterations that persisted in the offspring and omega 3 mitigates those effects but not omega 6. These dataare relevant considering that omega-3 treatment may have therapeutic effects through mitigating some ofethanol´s damaging consequences. Fil: Salguero, Juan Agustín. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina Fil: Méndez, Santiago. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina Fil: Abate, Paula. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina Fil: Balaszczuk, Veronica. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina IX International Meeting of the Latin American Society for Biomedical Research on Alcoholism (LASBRA): Determinants of Alcoholism: bridging the gap between epidemiological and basic research Córdoba Argentina Latin American Society for Biomedical Research on Alcoholism |
description |
Maternal alcohol consumption during pregnancy may cause neurocognitive and behavioral disorders that canpersist until adulthood. Epidemiological data has revealed an alarming increase in the frequency of alcoholintake in pregnant women. Nutritional variables may also have an impact on the behavioral alterations occasioned by alcohol during development. Moreover, omega-3, a polyunsaturated fatty acid necessary fornormal brain development, is deficient in ethanol-treated animals. Although studies have shown that omega-3supplementation after prenatal ethanol (EtOH) treatment improves some disorders, there are no reports aboutacute treatment with omega-3 in binge alcohol neurotoxic models during postnatal development. The goalof this study was to determine whether an administration of omega-3, after an acute ethanol dose in neonates, would be able to attenuate alcohol effects in offspring. Male/ female rats were administered ethanol(2.5 g/kg s.c. at 0 and 2 h) or saline on postnatal day (PND) 7, with a single dose of omega-3 (720 mg/kg),or omega-6, 15 min after the last alcohol injection. It has been found that EtOH-treated animals showedhyperlocomotion and anxiety-like behavior on PND 14. Administration of omega-3 after EtOH treatmentreduced hyperlocomotion and the anxiety-like behaviors on PND 14. On the other hand, animals treated withomega-6 did not reduce those EtOH effects. In conclusion, acute ethanol exposure induced neurobehavioral alterations that persisted in the offspring and omega 3 mitigates those effects but not omega 6. These dataare relevant considering that omega-3 treatment may have therapeutic effects through mitigating some ofethanol´s damaging consequences. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Reunión Journal http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/162692 Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates; IX International Meeting of the Latin American Society for Biomedical Research on Alcoholism (LASBRA): Determinants of Alcoholism: bridging the gap between epidemiological and basic research; Córdoba; Argentina; 2019; e63-e64 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/162692 |
identifier_str_mv |
Omega-3 but not Omega 6 mitigates Behavioral Impairments Induced by Binge Ethanol Exposure in Rat Neonates; IX International Meeting of the Latin American Society for Biomedical Research on Alcoholism (LASBRA): Determinants of Alcoholism: bridging the gap between epidemiological and basic research; Córdoba; Argentina; 2019; e63-e64 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.jfasrp.com/index.php/JFASRP/article/view/7 info:eu-repo/semantics/altIdentifier/doi/10.22374/jfasrp.v2i1.7 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.coverage.none.fl_str_mv |
Internacional |
dc.publisher.none.fl_str_mv |
Dougmar Publishing Group |
publisher.none.fl_str_mv |
Dougmar Publishing Group |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613396235812864 |
score |
13.070432 |