Human toxocariasis seroprevalence among patients with uveitis in Alborz Province, Iran

Autores
Zibaei, Mohammad; Alemi, Maryam; Cardillo, Natalia Marina; Derafshi, Hamid; Miahipour, Abolfazl; Bahadory, Saeed; Zarei, Mohammad
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction and objective. Toxocariasis, predominantly caused by Toxocara canis, is a common zoonotic parasitosis worldwide. Toxocara infection is a cause of vision impairment and blindness. The presented study investigates the frequency of antibodies against Toxocara among uveitis patients and the epidemiological factors associated with disease. Materials and method. Fifty-four patients with uveitis and 59 healthy subjects were studied. Anti-Toxocara antibodies status was determined in all serum samples using enzyme linked immunosorbent assay (ELISA), and seropositive samples analyzed by Western blot (WB) technique. Results. The frequency of Toxocara canis infection was found to be significantly higher in uveitis patients, compared to healthy controls by the use of ELISA test, being 14.8% and 1.7%, respectively. From 8 seropositive samples, 5 (62.5%) patients exhibited Toxocara immunoglobulin G (IgG) antibodies in response to Western blot, whereas in the control group, none were detected positive by Western blot. No significant difference was found between pet owners, nor between different places of residence. The seroprevalence to Toxocara among uveitis patients was significantly related to gender, age and medical diagnosis. The highest prevalence was found in patients with posterior uveitis (27.8%). Conclusion. Anti-Toxocara antibody titers are associated with the risk of vision impairment -uveitis. The risk factor associated with Toxocara exposure identified in this study warrants further investigation.
Fil: Zibaei, Mohammad. Alborz University of Medical Sciences; Irán
Fil: Alemi, Maryam. Alborz University of Medical Sciences; Irán
Fil: Cardillo, Natalia Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Unidad Ejecutora de Investigaciones en Producción Animal. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Unidad Ejecutora de Investigaciones en Producción Animal; Argentina
Fil: Derafshi, Hamid. Alborz University of Medical Sciences; Irán
Fil: Miahipour, Abolfazl. Alborz University of Medical Sciences; Irán
Fil: Bahadory, Saeed. Alborz University of Medical Sciences; Irán
Fil: Zarei, Mohammad. Tehran University of Medical Sciences; Irán
Materia
DIAGNOSIS
ELISA
TOXOCARA CANIS
TOXOCARIASIS
UVEITIS PATIENTS
WESTERN BLOT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/175494
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/175494
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Human toxocariasis seroprevalence among patients with uveitis in Alborz Province, IranZibaei, MohammadAlemi, MaryamCardillo, Natalia MarinaDerafshi, HamidMiahipour, AbolfazlBahadory, SaeedZarei, MohammadDIAGNOSISELISATOXOCARA CANISTOXOCARIASISUVEITIS PATIENTSWESTERN BLOThttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Introduction and objective. Toxocariasis, predominantly caused by Toxocara canis, is a common zoonotic parasitosis worldwide. Toxocara infection is a cause of vision impairment and blindness. The presented study investigates the frequency of antibodies against Toxocara among uveitis patients and the epidemiological factors associated with disease. Materials and method. Fifty-four patients with uveitis and 59 healthy subjects were studied. Anti-Toxocara antibodies status was determined in all serum samples using enzyme linked immunosorbent assay (ELISA), and seropositive samples analyzed by Western blot (WB) technique. Results. The frequency of Toxocara canis infection was found to be significantly higher in uveitis patients, compared to healthy controls by the use of ELISA test, being 14.8% and 1.7%, respectively. From 8 seropositive samples, 5 (62.5%) patients exhibited Toxocara immunoglobulin G (IgG) antibodies in response to Western blot, whereas in the control group, none were detected positive by Western blot. No significant difference was found between pet owners, nor between different places of residence. The seroprevalence to Toxocara among uveitis patients was significantly related to gender, age and medical diagnosis. The highest prevalence was found in patients with posterior uveitis (27.8%). Conclusion. Anti-Toxocara antibody titers are associated with the risk of vision impairment -uveitis. The risk factor associated with Toxocara exposure identified in this study warrants further investigation.Fil: Zibaei, Mohammad. Alborz University of Medical Sciences; IránFil: Alemi, Maryam. Alborz University of Medical Sciences; IránFil: Cardillo, Natalia Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Unidad Ejecutora de Investigaciones en Producción Animal. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Unidad Ejecutora de Investigaciones en Producción Animal; ArgentinaFil: Derafshi, Hamid. Alborz University of Medical Sciences; IránFil: Miahipour, Abolfazl. Alborz University of Medical Sciences; IránFil: Bahadory, Saeed. Alborz University of Medical Sciences; IránFil: Zarei, Mohammad. Tehran University of Medical Sciences; IránInst Agricultural Medicine2019-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/175494Zibaei, Mohammad; Alemi, Maryam; Cardillo, Natalia Marina; Derafshi, Hamid; Miahipour, Abolfazl; et al.; Human toxocariasis seroprevalence among patients with uveitis in Alborz Province, Iran; Inst Agricultural Medicine; Annals Of Agricultural And Environmental Medicine; 26; 1; 11-2019; 154-1581232-19661898-2263CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.26444/aaem/102293info:eu-repo/semantics/altIdentifier/url/https://www.aaem.pl/Human-toxocariasis-and-its-seroprevalence-among-patients-with-uveitis-in-Alborz-Province,102293,0,2.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:57Zoai:ri.conicet.gov.ar:11336/175494instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:58.189CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Human toxocariasis seroprevalence among patients with uveitis in Alborz Province, Iran
title Human toxocariasis seroprevalence among patients with uveitis in Alborz Province, Iran
spellingShingle Human toxocariasis seroprevalence among patients with uveitis in Alborz Province, Iran
Zibaei, Mohammad
DIAGNOSIS
ELISA
TOXOCARA CANIS
TOXOCARIASIS
UVEITIS PATIENTS
WESTERN BLOT
title_short Human toxocariasis seroprevalence among patients with uveitis in Alborz Province, Iran
title_full Human toxocariasis seroprevalence among patients with uveitis in Alborz Province, Iran
title_fullStr Human toxocariasis seroprevalence among patients with uveitis in Alborz Province, Iran
title_full_unstemmed Human toxocariasis seroprevalence among patients with uveitis in Alborz Province, Iran
title_sort Human toxocariasis seroprevalence among patients with uveitis in Alborz Province, Iran
dc.creator.none.fl_str_mv Zibaei, Mohammad
Alemi, Maryam
Cardillo, Natalia Marina
Derafshi, Hamid
Miahipour, Abolfazl
Bahadory, Saeed
Zarei, Mohammad
author Zibaei, Mohammad
author_facet Zibaei, Mohammad
Alemi, Maryam
Cardillo, Natalia Marina
Derafshi, Hamid
Miahipour, Abolfazl
Bahadory, Saeed
Zarei, Mohammad
author_role author
author2 Alemi, Maryam
Cardillo, Natalia Marina
Derafshi, Hamid
Miahipour, Abolfazl
Bahadory, Saeed
Zarei, Mohammad
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv DIAGNOSIS
ELISA
TOXOCARA CANIS
TOXOCARIASIS
UVEITIS PATIENTS
WESTERN BLOT
topic DIAGNOSIS
ELISA
TOXOCARA CANIS
TOXOCARIASIS
UVEITIS PATIENTS
WESTERN BLOT
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction and objective. Toxocariasis, predominantly caused by Toxocara canis, is a common zoonotic parasitosis worldwide. Toxocara infection is a cause of vision impairment and blindness. The presented study investigates the frequency of antibodies against Toxocara among uveitis patients and the epidemiological factors associated with disease. Materials and method. Fifty-four patients with uveitis and 59 healthy subjects were studied. Anti-Toxocara antibodies status was determined in all serum samples using enzyme linked immunosorbent assay (ELISA), and seropositive samples analyzed by Western blot (WB) technique. Results. The frequency of Toxocara canis infection was found to be significantly higher in uveitis patients, compared to healthy controls by the use of ELISA test, being 14.8% and 1.7%, respectively. From 8 seropositive samples, 5 (62.5%) patients exhibited Toxocara immunoglobulin G (IgG) antibodies in response to Western blot, whereas in the control group, none were detected positive by Western blot. No significant difference was found between pet owners, nor between different places of residence. The seroprevalence to Toxocara among uveitis patients was significantly related to gender, age and medical diagnosis. The highest prevalence was found in patients with posterior uveitis (27.8%). Conclusion. Anti-Toxocara antibody titers are associated with the risk of vision impairment -uveitis. The risk factor associated with Toxocara exposure identified in this study warrants further investigation.
Fil: Zibaei, Mohammad. Alborz University of Medical Sciences; Irán
Fil: Alemi, Maryam. Alborz University of Medical Sciences; Irán
Fil: Cardillo, Natalia Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Unidad Ejecutora de Investigaciones en Producción Animal. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Unidad Ejecutora de Investigaciones en Producción Animal; Argentina
Fil: Derafshi, Hamid. Alborz University of Medical Sciences; Irán
Fil: Miahipour, Abolfazl. Alborz University of Medical Sciences; Irán
Fil: Bahadory, Saeed. Alborz University of Medical Sciences; Irán
Fil: Zarei, Mohammad. Tehran University of Medical Sciences; Irán
description Introduction and objective. Toxocariasis, predominantly caused by Toxocara canis, is a common zoonotic parasitosis worldwide. Toxocara infection is a cause of vision impairment and blindness. The presented study investigates the frequency of antibodies against Toxocara among uveitis patients and the epidemiological factors associated with disease. Materials and method. Fifty-four patients with uveitis and 59 healthy subjects were studied. Anti-Toxocara antibodies status was determined in all serum samples using enzyme linked immunosorbent assay (ELISA), and seropositive samples analyzed by Western blot (WB) technique. Results. The frequency of Toxocara canis infection was found to be significantly higher in uveitis patients, compared to healthy controls by the use of ELISA test, being 14.8% and 1.7%, respectively. From 8 seropositive samples, 5 (62.5%) patients exhibited Toxocara immunoglobulin G (IgG) antibodies in response to Western blot, whereas in the control group, none were detected positive by Western blot. No significant difference was found between pet owners, nor between different places of residence. The seroprevalence to Toxocara among uveitis patients was significantly related to gender, age and medical diagnosis. The highest prevalence was found in patients with posterior uveitis (27.8%). Conclusion. Anti-Toxocara antibody titers are associated with the risk of vision impairment -uveitis. The risk factor associated with Toxocara exposure identified in this study warrants further investigation.
publishDate 2019
dc.date.none.fl_str_mv 2019-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/175494
Zibaei, Mohammad; Alemi, Maryam; Cardillo, Natalia Marina; Derafshi, Hamid; Miahipour, Abolfazl; et al.; Human toxocariasis seroprevalence among patients with uveitis in Alborz Province, Iran; Inst Agricultural Medicine; Annals Of Agricultural And Environmental Medicine; 26; 1; 11-2019; 154-158
1232-1966
1898-2263
CONICET Digital
CONICET
url http://hdl.handle.net/11336/175494
identifier_str_mv Zibaei, Mohammad; Alemi, Maryam; Cardillo, Natalia Marina; Derafshi, Hamid; Miahipour, Abolfazl; et al.; Human toxocariasis seroprevalence among patients with uveitis in Alborz Province, Iran; Inst Agricultural Medicine; Annals Of Agricultural And Environmental Medicine; 26; 1; 11-2019; 154-158
1232-1966
1898-2263
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.26444/aaem/102293
info:eu-repo/semantics/altIdentifier/url/https://www.aaem.pl/Human-toxocariasis-and-its-seroprevalence-among-patients-with-uveitis-in-Alborz-Province,102293,0,2.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Inst Agricultural Medicine
publisher.none.fl_str_mv Inst Agricultural Medicine
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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