Conspicuous multidrug-resistant Mycobacterium tuberculosis cluster strains do not trespass country borders in Latin America and Spain

Autores
Ritacco, Gloria Viviana; Iglesias, Maria Jose; Ferrazoli, Lucilaine; Monteserin, Johana; Dalla Costa, Elis R.; Cebollada, Alberto; Morcillo, Nora Susana; Robledo, Jaime; de Waar, Jacobus H.; Araya, Pamela; Aristimiño, Liselotte; Diaz, Raúl; Gavin, Patricia; Imperiale, Belén Rocío; Simonsen, Vera; Zapata, Elsa M.; Jiménez, María S.; Rossetti, Maria L.; Martin, Carlos; Barrera, Lucía; Samper, Sofia
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Multidrug-resistant Mycobacterium tuberculosis strain diversity in Ibero-America was examined by comparing extant genotype collections in national or state tuberculosis networks. To this end, genotypes from over 1000 patients with multidrug-resistant tuberculosis diagnosed from 2004 through 2008 in Argentina, Brazil, Chile, Colombia, Venezuela and Spain were compared in a database constructed ad hoc. Most of the 116 clusters identified by IS6110 restriction fragment length polymorphism were small and restricted to individual countries. The three largest clusters, of 116, 49 and 25 patients, were found in Argentina and corresponded to previously documented locally-epidemic strains. Only 13 small clusters involved more than one country, altogether accounting for 41 patients, of whom 13 were, in turn, immigrants from Latin American countries different from those participating in the study (Peru, Ecuador and Bolivia). Most of these international clusters belonged either to the emerging RD(Rio) LAM lineage or to the Haarlem family of M. tuberculosis and four were further split by country when analyzed with spoligotyping and rifampin resistance-conferring mutations, suggesting that they did not represent ongoing transnational transmission events. The Beijing genotype accounted for 1.3% and 10.2% of patients with multidrug-resistant tuberculosis in Latin America and Spain, respectively, including one international cluster of two cases. In brief, Euro-American genotypes were widely predominant among multidrug-resistant M. tuberculosis strains in Ibero-America, reflecting closely their predominance in the general M. tuberculosis population in the region, and no evidence was found of acknowledged outbreak strains trespassing country borders.
Fil: Ritacco, Gloria Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina
Fil: Iglesias, Maria Jose. Universidad de Zaragoza; España
Fil: Ferrazoli, Lucilaine. Instituto Adolfo Lutz; Brasil
Fil: Monteserin, Johana. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dalla Costa, Elis R.. Centro de Desenvolvimento Científico e Tecnológico; Brasil
Fil: Cebollada, Alberto. Universidad de Zaragoza; España
Fil: Morcillo, Nora Susana. Provincia de Buenos Aires. Ministerio de Salud. Hospital ; Argentina
Fil: Robledo, Jaime. No especifíca;
Fil: de Waar, Jacobus H.. Instituto de Biomedicina; Venezuela
Fil: Araya, Pamela. Instituto de Salud Pública de Chile; Chile
Fil: Aristimiño, Liselotte. Universidad Centroccidental Lisandro Alvarado (ucla);
Fil: Diaz, Raúl. Instituto Pedro Khouri; Cuba
Fil: Gavin, Patricia. Universidad de Zaragoza; España
Fil: Imperiale, Belén Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Simonsen, Vera. Instituto Adolfo Lutz; Brasil
Fil: Zapata, Elsa M.. No especifíca;
Fil: Jiménez, María S.. Instituto de Salud Carlos III. Centro Nacional de Microbiología; España
Fil: Rossetti, Maria L.. No especifíca;
Fil: Martin, Carlos. Universidad de Zaragoza; España
Fil: Barrera, Lucía. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina
Fil: Samper, Sofia. Hospital Universitario Miguel Servet; España
Materia
MULTIDRUG-RESISTANT TUBERCULOSIS
GENOTYPE
LATIN AMERICA
SPAIN
RESTRICTION FRAGMENT LENGHT POLYMORPHISM
SPOLIGOTYPE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/245895
Acceder
id CONICETDig_6a0001adafd3dd447b71dff263f84246
oai_identifier_str oai:ri.conicet.gov.ar:11336/245895
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Conspicuous multidrug-resistant Mycobacterium tuberculosis cluster strains do not trespass country borders in Latin America and SpainRitacco, Gloria VivianaIglesias, Maria JoseFerrazoli, LucilaineMonteserin, JohanaDalla Costa, Elis R.Cebollada, AlbertoMorcillo, Nora SusanaRobledo, Jaimede Waar, Jacobus H.Araya, PamelaAristimiño, LiselotteDiaz, RaúlGavin, PatriciaImperiale, Belén RocíoSimonsen, VeraZapata, Elsa M.Jiménez, María S.Rossetti, Maria L.Martin, CarlosBarrera, LucíaSamper, SofiaMULTIDRUG-RESISTANT TUBERCULOSISGENOTYPELATIN AMERICASPAINRESTRICTION FRAGMENT LENGHT POLYMORPHISMSPOLIGOTYPEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Multidrug-resistant Mycobacterium tuberculosis strain diversity in Ibero-America was examined by comparing extant genotype collections in national or state tuberculosis networks. To this end, genotypes from over 1000 patients with multidrug-resistant tuberculosis diagnosed from 2004 through 2008 in Argentina, Brazil, Chile, Colombia, Venezuela and Spain were compared in a database constructed ad hoc. Most of the 116 clusters identified by IS6110 restriction fragment length polymorphism were small and restricted to individual countries. The three largest clusters, of 116, 49 and 25 patients, were found in Argentina and corresponded to previously documented locally-epidemic strains. Only 13 small clusters involved more than one country, altogether accounting for 41 patients, of whom 13 were, in turn, immigrants from Latin American countries different from those participating in the study (Peru, Ecuador and Bolivia). Most of these international clusters belonged either to the emerging RD(Rio) LAM lineage or to the Haarlem family of M. tuberculosis and four were further split by country when analyzed with spoligotyping and rifampin resistance-conferring mutations, suggesting that they did not represent ongoing transnational transmission events. The Beijing genotype accounted for 1.3% and 10.2% of patients with multidrug-resistant tuberculosis in Latin America and Spain, respectively, including one international cluster of two cases. In brief, Euro-American genotypes were widely predominant among multidrug-resistant M. tuberculosis strains in Ibero-America, reflecting closely their predominance in the general M. tuberculosis population in the region, and no evidence was found of acknowledged outbreak strains trespassing country borders.Fil: Ritacco, Gloria Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; ArgentinaFil: Iglesias, Maria Jose. Universidad de Zaragoza; EspañaFil: Ferrazoli, Lucilaine. Instituto Adolfo Lutz; BrasilFil: Monteserin, Johana. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Dalla Costa, Elis R.. Centro de Desenvolvimento Científico e Tecnológico; BrasilFil: Cebollada, Alberto. Universidad de Zaragoza; EspañaFil: Morcillo, Nora Susana. Provincia de Buenos Aires. Ministerio de Salud. Hospital ; ArgentinaFil: Robledo, Jaime. No especifíca;Fil: de Waar, Jacobus H.. Instituto de Biomedicina; VenezuelaFil: Araya, Pamela. Instituto de Salud Pública de Chile; ChileFil: Aristimiño, Liselotte. Universidad Centroccidental Lisandro Alvarado (ucla);Fil: Diaz, Raúl. Instituto Pedro Khouri; CubaFil: Gavin, Patricia. Universidad de Zaragoza; EspañaFil: Imperiale, Belén Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Simonsen, Vera. Instituto Adolfo Lutz; BrasilFil: Zapata, Elsa M.. No especifíca;Fil: Jiménez, María S.. Instituto de Salud Carlos III. Centro Nacional de Microbiología; EspañaFil: Rossetti, Maria L.. No especifíca;Fil: Martin, Carlos. Universidad de Zaragoza; EspañaFil: Barrera, Lucía. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; ArgentinaFil: Samper, Sofia. Hospital Universitario Miguel Servet; EspañaElsevier Science2012-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/245895Ritacco, Gloria Viviana; Iglesias, Maria Jose; Ferrazoli, Lucilaine; Monteserin, Johana; Dalla Costa, Elis R.; et al.; Conspicuous multidrug-resistant Mycobacterium tuberculosis cluster strains do not trespass country borders in Latin America and Spain; Elsevier Science; Infection, Genetics and Evolution; 12; 4; 6-2012; 711-7171567-1348CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S156713481100219Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2011.06.006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:45:12Zoai:ri.conicet.gov.ar:11336/245895instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:45:13.285CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Conspicuous multidrug-resistant Mycobacterium tuberculosis cluster strains do not trespass country borders in Latin America and Spain
title Conspicuous multidrug-resistant Mycobacterium tuberculosis cluster strains do not trespass country borders in Latin America and Spain
spellingShingle Conspicuous multidrug-resistant Mycobacterium tuberculosis cluster strains do not trespass country borders in Latin America and Spain
Ritacco, Gloria Viviana
MULTIDRUG-RESISTANT TUBERCULOSIS
GENOTYPE
LATIN AMERICA
SPAIN
RESTRICTION FRAGMENT LENGHT POLYMORPHISM
SPOLIGOTYPE
title_short Conspicuous multidrug-resistant Mycobacterium tuberculosis cluster strains do not trespass country borders in Latin America and Spain
title_full Conspicuous multidrug-resistant Mycobacterium tuberculosis cluster strains do not trespass country borders in Latin America and Spain
title_fullStr Conspicuous multidrug-resistant Mycobacterium tuberculosis cluster strains do not trespass country borders in Latin America and Spain
title_full_unstemmed Conspicuous multidrug-resistant Mycobacterium tuberculosis cluster strains do not trespass country borders in Latin America and Spain
title_sort Conspicuous multidrug-resistant Mycobacterium tuberculosis cluster strains do not trespass country borders in Latin America and Spain
dc.creator.none.fl_str_mv Ritacco, Gloria Viviana
Iglesias, Maria Jose
Ferrazoli, Lucilaine
Monteserin, Johana
Dalla Costa, Elis R.
Cebollada, Alberto
Morcillo, Nora Susana
Robledo, Jaime
de Waar, Jacobus H.
Araya, Pamela
Aristimiño, Liselotte
Diaz, Raúl
Gavin, Patricia
Imperiale, Belén Rocío
Simonsen, Vera
Zapata, Elsa M.
Jiménez, María S.
Rossetti, Maria L.
Martin, Carlos
Barrera, Lucía
Samper, Sofia
author Ritacco, Gloria Viviana
author_facet Ritacco, Gloria Viviana
Iglesias, Maria Jose
Ferrazoli, Lucilaine
Monteserin, Johana
Dalla Costa, Elis R.
Cebollada, Alberto
Morcillo, Nora Susana
Robledo, Jaime
de Waar, Jacobus H.
Araya, Pamela
Aristimiño, Liselotte
Diaz, Raúl
Gavin, Patricia
Imperiale, Belén Rocío
Simonsen, Vera
Zapata, Elsa M.
Jiménez, María S.
Rossetti, Maria L.
Martin, Carlos
Barrera, Lucía
Samper, Sofia
author_role author
author2 Iglesias, Maria Jose
Ferrazoli, Lucilaine
Monteserin, Johana
Dalla Costa, Elis R.
Cebollada, Alberto
Morcillo, Nora Susana
Robledo, Jaime
de Waar, Jacobus H.
Araya, Pamela
Aristimiño, Liselotte
Diaz, Raúl
Gavin, Patricia
Imperiale, Belén Rocío
Simonsen, Vera
Zapata, Elsa M.
Jiménez, María S.
Rossetti, Maria L.
Martin, Carlos
Barrera, Lucía
Samper, Sofia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MULTIDRUG-RESISTANT TUBERCULOSIS
GENOTYPE
LATIN AMERICA
SPAIN
RESTRICTION FRAGMENT LENGHT POLYMORPHISM
SPOLIGOTYPE
topic MULTIDRUG-RESISTANT TUBERCULOSIS
GENOTYPE
LATIN AMERICA
SPAIN
RESTRICTION FRAGMENT LENGHT POLYMORPHISM
SPOLIGOTYPE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Multidrug-resistant Mycobacterium tuberculosis strain diversity in Ibero-America was examined by comparing extant genotype collections in national or state tuberculosis networks. To this end, genotypes from over 1000 patients with multidrug-resistant tuberculosis diagnosed from 2004 through 2008 in Argentina, Brazil, Chile, Colombia, Venezuela and Spain were compared in a database constructed ad hoc. Most of the 116 clusters identified by IS6110 restriction fragment length polymorphism were small and restricted to individual countries. The three largest clusters, of 116, 49 and 25 patients, were found in Argentina and corresponded to previously documented locally-epidemic strains. Only 13 small clusters involved more than one country, altogether accounting for 41 patients, of whom 13 were, in turn, immigrants from Latin American countries different from those participating in the study (Peru, Ecuador and Bolivia). Most of these international clusters belonged either to the emerging RD(Rio) LAM lineage or to the Haarlem family of M. tuberculosis and four were further split by country when analyzed with spoligotyping and rifampin resistance-conferring mutations, suggesting that they did not represent ongoing transnational transmission events. The Beijing genotype accounted for 1.3% and 10.2% of patients with multidrug-resistant tuberculosis in Latin America and Spain, respectively, including one international cluster of two cases. In brief, Euro-American genotypes were widely predominant among multidrug-resistant M. tuberculosis strains in Ibero-America, reflecting closely their predominance in the general M. tuberculosis population in the region, and no evidence was found of acknowledged outbreak strains trespassing country borders.
Fil: Ritacco, Gloria Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina
Fil: Iglesias, Maria Jose. Universidad de Zaragoza; España
Fil: Ferrazoli, Lucilaine. Instituto Adolfo Lutz; Brasil
Fil: Monteserin, Johana. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dalla Costa, Elis R.. Centro de Desenvolvimento Científico e Tecnológico; Brasil
Fil: Cebollada, Alberto. Universidad de Zaragoza; España
Fil: Morcillo, Nora Susana. Provincia de Buenos Aires. Ministerio de Salud. Hospital ; Argentina
Fil: Robledo, Jaime. No especifíca;
Fil: de Waar, Jacobus H.. Instituto de Biomedicina; Venezuela
Fil: Araya, Pamela. Instituto de Salud Pública de Chile; Chile
Fil: Aristimiño, Liselotte. Universidad Centroccidental Lisandro Alvarado (ucla);
Fil: Diaz, Raúl. Instituto Pedro Khouri; Cuba
Fil: Gavin, Patricia. Universidad de Zaragoza; España
Fil: Imperiale, Belén Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Simonsen, Vera. Instituto Adolfo Lutz; Brasil
Fil: Zapata, Elsa M.. No especifíca;
Fil: Jiménez, María S.. Instituto de Salud Carlos III. Centro Nacional de Microbiología; España
Fil: Rossetti, Maria L.. No especifíca;
Fil: Martin, Carlos. Universidad de Zaragoza; España
Fil: Barrera, Lucía. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina
Fil: Samper, Sofia. Hospital Universitario Miguel Servet; España
description Multidrug-resistant Mycobacterium tuberculosis strain diversity in Ibero-America was examined by comparing extant genotype collections in national or state tuberculosis networks. To this end, genotypes from over 1000 patients with multidrug-resistant tuberculosis diagnosed from 2004 through 2008 in Argentina, Brazil, Chile, Colombia, Venezuela and Spain were compared in a database constructed ad hoc. Most of the 116 clusters identified by IS6110 restriction fragment length polymorphism were small and restricted to individual countries. The three largest clusters, of 116, 49 and 25 patients, were found in Argentina and corresponded to previously documented locally-epidemic strains. Only 13 small clusters involved more than one country, altogether accounting for 41 patients, of whom 13 were, in turn, immigrants from Latin American countries different from those participating in the study (Peru, Ecuador and Bolivia). Most of these international clusters belonged either to the emerging RD(Rio) LAM lineage or to the Haarlem family of M. tuberculosis and four were further split by country when analyzed with spoligotyping and rifampin resistance-conferring mutations, suggesting that they did not represent ongoing transnational transmission events. The Beijing genotype accounted for 1.3% and 10.2% of patients with multidrug-resistant tuberculosis in Latin America and Spain, respectively, including one international cluster of two cases. In brief, Euro-American genotypes were widely predominant among multidrug-resistant M. tuberculosis strains in Ibero-America, reflecting closely their predominance in the general M. tuberculosis population in the region, and no evidence was found of acknowledged outbreak strains trespassing country borders.
publishDate 2012
dc.date.none.fl_str_mv 2012-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/245895
Ritacco, Gloria Viviana; Iglesias, Maria Jose; Ferrazoli, Lucilaine; Monteserin, Johana; Dalla Costa, Elis R.; et al.; Conspicuous multidrug-resistant Mycobacterium tuberculosis cluster strains do not trespass country borders in Latin America and Spain; Elsevier Science; Infection, Genetics and Evolution; 12; 4; 6-2012; 711-717
1567-1348
CONICET Digital
CONICET
url http://hdl.handle.net/11336/245895
identifier_str_mv Ritacco, Gloria Viviana; Iglesias, Maria Jose; Ferrazoli, Lucilaine; Monteserin, Johana; Dalla Costa, Elis R.; et al.; Conspicuous multidrug-resistant Mycobacterium tuberculosis cluster strains do not trespass country borders in Latin America and Spain; Elsevier Science; Infection, Genetics and Evolution; 12; 4; 6-2012; 711-717
1567-1348
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S156713481100219X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2011.06.006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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