From the magic bullet to nanotechnology: nanoantimicrobials as therapeutics to fight multidrug-resistant microorganisms

Autores
Paraje, María Gabriela
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A century ago, Paul Ehrlich, a Nobel laureate in 1907, definedthe concept of ‘‘magic bullet’’ to propose selectivedrug targeting, aiming to deliver drugs to the right place, atthe correct concentration, and for an appropriate duration,without harming the host organism. The global emergenceand spread of multidrug-resistant (MDR), extensively drugresistant(XDR), and pandrug-resistant (PDR) bacteria havebecome a critical global healthcare concern, which is currentlyconsidered one of the principal threats by different globalhealth organizations due to the limited efficacy of antimicrobial(ATM) agents1. MDR to first-line drugs increase healthcarecosts and generate the need for effective and safe alternativetreatments. However, the number of newly developedand approved ATM drugs has decreased over the past decades.The availability of few effective antimicrobials and the necessityto develop novel strategies and innovative antimicrobialsemphasize the need for novel approaches and different safeand effective alternatives2.
Fil: Paraje, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Materia
Nanotechnology
Nanoantimicrobials
Multidrug-resistant microorganisms
Nanomaterials
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/217646
Acceder
id CONICETDig_a86aa6d9ced16a9b19e389f6fa70364e
oai_identifier_str oai:ri.conicet.gov.ar:11336/217646
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling From the magic bullet to nanotechnology: nanoantimicrobials as therapeutics to fight multidrug-resistant microorganismsDesde la bala mágica a la nanotecnología: nanoantimicrobianos para combatir microorganismos multirresistentesParaje, María GabrielaNanotechnologyNanoantimicrobialsMultidrug-resistant microorganismsNanomaterialshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1A century ago, Paul Ehrlich, a Nobel laureate in 1907, definedthe concept of ‘‘magic bullet’’ to propose selectivedrug targeting, aiming to deliver drugs to the right place, atthe correct concentration, and for an appropriate duration,without harming the host organism. The global emergenceand spread of multidrug-resistant (MDR), extensively drugresistant(XDR), and pandrug-resistant (PDR) bacteria havebecome a critical global healthcare concern, which is currentlyconsidered one of the principal threats by different globalhealth organizations due to the limited efficacy of antimicrobial(ATM) agents1. MDR to first-line drugs increase healthcarecosts and generate the need for effective and safe alternativetreatments. However, the number of newly developedand approved ATM drugs has decreased over the past decades.The availability of few effective antimicrobials and the necessityto develop novel strategies and innovative antimicrobialsemphasize the need for novel approaches and different safeand effective alternatives2.Fil: Paraje, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaAsociación Argentina de Microbiología2023-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/217646Paraje, María Gabriela; From the magic bullet to nanotechnology: nanoantimicrobials as therapeutics to fight multidrug-resistant microorganisms; Asociación Argentina de Microbiología; Revista Argentina de Microbiología; 55; 3; 7-2023; 204-2050325-75411851-7617CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0325754123000639info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ram.2023.08.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T10:30:57Zoai:ri.conicet.gov.ar:11336/217646instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 10:30:57.755CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv From the magic bullet to nanotechnology: nanoantimicrobials as therapeutics to fight multidrug-resistant microorganisms
Desde la bala mágica a la nanotecnología: nanoantimicrobianos para combatir microorganismos multirresistentes
title From the magic bullet to nanotechnology: nanoantimicrobials as therapeutics to fight multidrug-resistant microorganisms
spellingShingle From the magic bullet to nanotechnology: nanoantimicrobials as therapeutics to fight multidrug-resistant microorganisms
Paraje, María Gabriela
Nanotechnology
Nanoantimicrobials
Multidrug-resistant microorganisms
Nanomaterials
title_short From the magic bullet to nanotechnology: nanoantimicrobials as therapeutics to fight multidrug-resistant microorganisms
title_full From the magic bullet to nanotechnology: nanoantimicrobials as therapeutics to fight multidrug-resistant microorganisms
title_fullStr From the magic bullet to nanotechnology: nanoantimicrobials as therapeutics to fight multidrug-resistant microorganisms
title_full_unstemmed From the magic bullet to nanotechnology: nanoantimicrobials as therapeutics to fight multidrug-resistant microorganisms
title_sort From the magic bullet to nanotechnology: nanoantimicrobials as therapeutics to fight multidrug-resistant microorganisms
dc.creator.none.fl_str_mv Paraje, María Gabriela
author Paraje, María Gabriela
author_facet Paraje, María Gabriela
author_role author
dc.subject.none.fl_str_mv Nanotechnology
Nanoantimicrobials
Multidrug-resistant microorganisms
Nanomaterials
topic Nanotechnology
Nanoantimicrobials
Multidrug-resistant microorganisms
Nanomaterials
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A century ago, Paul Ehrlich, a Nobel laureate in 1907, definedthe concept of ‘‘magic bullet’’ to propose selectivedrug targeting, aiming to deliver drugs to the right place, atthe correct concentration, and for an appropriate duration,without harming the host organism. The global emergenceand spread of multidrug-resistant (MDR), extensively drugresistant(XDR), and pandrug-resistant (PDR) bacteria havebecome a critical global healthcare concern, which is currentlyconsidered one of the principal threats by different globalhealth organizations due to the limited efficacy of antimicrobial(ATM) agents1. MDR to first-line drugs increase healthcarecosts and generate the need for effective and safe alternativetreatments. However, the number of newly developedand approved ATM drugs has decreased over the past decades.The availability of few effective antimicrobials and the necessityto develop novel strategies and innovative antimicrobialsemphasize the need for novel approaches and different safeand effective alternatives2.
Fil: Paraje, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
description A century ago, Paul Ehrlich, a Nobel laureate in 1907, definedthe concept of ‘‘magic bullet’’ to propose selectivedrug targeting, aiming to deliver drugs to the right place, atthe correct concentration, and for an appropriate duration,without harming the host organism. The global emergenceand spread of multidrug-resistant (MDR), extensively drugresistant(XDR), and pandrug-resistant (PDR) bacteria havebecome a critical global healthcare concern, which is currentlyconsidered one of the principal threats by different globalhealth organizations due to the limited efficacy of antimicrobial(ATM) agents1. MDR to first-line drugs increase healthcarecosts and generate the need for effective and safe alternativetreatments. However, the number of newly developedand approved ATM drugs has decreased over the past decades.The availability of few effective antimicrobials and the necessityto develop novel strategies and innovative antimicrobialsemphasize the need for novel approaches and different safeand effective alternatives2.
publishDate 2023
dc.date.none.fl_str_mv 2023-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/217646
Paraje, María Gabriela; From the magic bullet to nanotechnology: nanoantimicrobials as therapeutics to fight multidrug-resistant microorganisms; Asociación Argentina de Microbiología; Revista Argentina de Microbiología; 55; 3; 7-2023; 204-205
0325-7541
1851-7617
CONICET Digital
CONICET
url http://hdl.handle.net/11336/217646
identifier_str_mv Paraje, María Gabriela; From the magic bullet to nanotechnology: nanoantimicrobials as therapeutics to fight multidrug-resistant microorganisms; Asociación Argentina de Microbiología; Revista Argentina de Microbiología; 55; 3; 7-2023; 204-205
0325-7541
1851-7617
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0325754123000639
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ram.2023.08.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Asociación Argentina de Microbiología
publisher.none.fl_str_mv Asociación Argentina de Microbiología
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1847977982004559872
score 13.087074

Publicaciones similares