Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain

Autores
Eldholm, Vegard; Monteserin, Johana; Rieux, Adrien; Lopez, Beatriz; Sobkowiak, Benjamin; Ritacco, Gloria Viviana; Balloux, Francois
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a major public health issue. Here we reconstruct the timeline of the acquisition of antimicrobial resistance during a major ongoing outbreak of multidrug-resistant TB in Argentina. We estimate that the progenitor of the outbreak strain acquired resistance to isoniazid, streptomycin and rifampicin by around 1973, indicating continuous circulation of a multidrug-resistant TB strain for four decades. By around 1979 the strain had acquired additional resistance to three more drugs. Our results indicate that Mycobacterium tuberculosis (Mtb) with extensive resistance profiles circulated 15 years before the outbreak was detected, and about one decade before the earliest documented transmission of Mtb strains with such extensive resistance profiles globally.
Fil: Eldholm, Vegard. Norwegian Institute of Public Health; Noruega
Fil: Monteserin, Johana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rieux, Adrien. Colegio Universitario de Londres; Reino Unido
Fil: Lopez, Beatriz. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Sobkowiak, Benjamin. Colegio Universitario de Londres; Reino Unido
Fil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Balloux, Francois. Colegio Universitario de Londres; Reino Unido
Materia
MYCOBACTERIUM TUBERCULOSIS
MULTIDRUG-RESISTANT
ARGENTINA
WHOLE GENOME SEQUENCING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/98453
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strainEldholm, VegardMonteserin, JohanaRieux, AdrienLopez, BeatrizSobkowiak, BenjaminRitacco, Gloria VivianaBalloux, FrancoisMYCOBACTERIUM TUBERCULOSISMULTIDRUG-RESISTANTARGENTINAWHOLE GENOME SEQUENCINGhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a major public health issue. Here we reconstruct the timeline of the acquisition of antimicrobial resistance during a major ongoing outbreak of multidrug-resistant TB in Argentina. We estimate that the progenitor of the outbreak strain acquired resistance to isoniazid, streptomycin and rifampicin by around 1973, indicating continuous circulation of a multidrug-resistant TB strain for four decades. By around 1979 the strain had acquired additional resistance to three more drugs. Our results indicate that Mycobacterium tuberculosis (Mtb) with extensive resistance profiles circulated 15 years before the outbreak was detected, and about one decade before the earliest documented transmission of Mtb strains with such extensive resistance profiles globally.Fil: Eldholm, Vegard. Norwegian Institute of Public Health; NoruegaFil: Monteserin, Johana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rieux, Adrien. Colegio Universitario de Londres; Reino UnidoFil: Lopez, Beatriz. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: Sobkowiak, Benjamin. Colegio Universitario de Londres; Reino UnidoFil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Balloux, Francois. Colegio Universitario de Londres; Reino UnidoNature Publishing Group2015-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/98453Eldholm, Vegard; Monteserin, Johana; Rieux, Adrien; Lopez, Beatriz; Sobkowiak, Benjamin; et al.; Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain; Nature Publishing Group; Nature Communications; 6; 5-2015; 1-92041-1723CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/ncomms8119info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/ncomms8119info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:20:32Zoai:ri.conicet.gov.ar:11336/98453instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:20:32.847CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain
title Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain
spellingShingle Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain
Eldholm, Vegard
MYCOBACTERIUM TUBERCULOSIS
MULTIDRUG-RESISTANT
ARGENTINA
WHOLE GENOME SEQUENCING
title_short Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain
title_full Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain
title_fullStr Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain
title_full_unstemmed Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain
title_sort Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain
dc.creator.none.fl_str_mv Eldholm, Vegard
Monteserin, Johana
Rieux, Adrien
Lopez, Beatriz
Sobkowiak, Benjamin
Ritacco, Gloria Viviana
Balloux, Francois
author Eldholm, Vegard
author_facet Eldholm, Vegard
Monteserin, Johana
Rieux, Adrien
Lopez, Beatriz
Sobkowiak, Benjamin
Ritacco, Gloria Viviana
Balloux, Francois
author_role author
author2 Monteserin, Johana
Rieux, Adrien
Lopez, Beatriz
Sobkowiak, Benjamin
Ritacco, Gloria Viviana
Balloux, Francois
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv MYCOBACTERIUM TUBERCULOSIS
MULTIDRUG-RESISTANT
ARGENTINA
WHOLE GENOME SEQUENCING
topic MYCOBACTERIUM TUBERCULOSIS
MULTIDRUG-RESISTANT
ARGENTINA
WHOLE GENOME SEQUENCING
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a major public health issue. Here we reconstruct the timeline of the acquisition of antimicrobial resistance during a major ongoing outbreak of multidrug-resistant TB in Argentina. We estimate that the progenitor of the outbreak strain acquired resistance to isoniazid, streptomycin and rifampicin by around 1973, indicating continuous circulation of a multidrug-resistant TB strain for four decades. By around 1979 the strain had acquired additional resistance to three more drugs. Our results indicate that Mycobacterium tuberculosis (Mtb) with extensive resistance profiles circulated 15 years before the outbreak was detected, and about one decade before the earliest documented transmission of Mtb strains with such extensive resistance profiles globally.
Fil: Eldholm, Vegard. Norwegian Institute of Public Health; Noruega
Fil: Monteserin, Johana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rieux, Adrien. Colegio Universitario de Londres; Reino Unido
Fil: Lopez, Beatriz. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Sobkowiak, Benjamin. Colegio Universitario de Londres; Reino Unido
Fil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Balloux, Francois. Colegio Universitario de Londres; Reino Unido
description The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a major public health issue. Here we reconstruct the timeline of the acquisition of antimicrobial resistance during a major ongoing outbreak of multidrug-resistant TB in Argentina. We estimate that the progenitor of the outbreak strain acquired resistance to isoniazid, streptomycin and rifampicin by around 1973, indicating continuous circulation of a multidrug-resistant TB strain for four decades. By around 1979 the strain had acquired additional resistance to three more drugs. Our results indicate that Mycobacterium tuberculosis (Mtb) with extensive resistance profiles circulated 15 years before the outbreak was detected, and about one decade before the earliest documented transmission of Mtb strains with such extensive resistance profiles globally.
publishDate 2015
dc.date.none.fl_str_mv 2015-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/98453
Eldholm, Vegard; Monteserin, Johana; Rieux, Adrien; Lopez, Beatriz; Sobkowiak, Benjamin; et al.; Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain; Nature Publishing Group; Nature Communications; 6; 5-2015; 1-9
2041-1723
CONICET Digital
CONICET
url http://hdl.handle.net/11336/98453
identifier_str_mv Eldholm, Vegard; Monteserin, Johana; Rieux, Adrien; Lopez, Beatriz; Sobkowiak, Benjamin; et al.; Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain; Nature Publishing Group; Nature Communications; 6; 5-2015; 1-9
2041-1723
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/ncomms8119
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/ncomms8119
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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