Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain
- Autores
- Eldholm, Vegard; Monteserin, Johana; Rieux, Adrien; Lopez, Beatriz; Sobkowiak, Benjamin; Ritacco, Gloria Viviana; Balloux, Francois
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a major public health issue. Here we reconstruct the timeline of the acquisition of antimicrobial resistance during a major ongoing outbreak of multidrug-resistant TB in Argentina. We estimate that the progenitor of the outbreak strain acquired resistance to isoniazid, streptomycin and rifampicin by around 1973, indicating continuous circulation of a multidrug-resistant TB strain for four decades. By around 1979 the strain had acquired additional resistance to three more drugs. Our results indicate that Mycobacterium tuberculosis (Mtb) with extensive resistance profiles circulated 15 years before the outbreak was detected, and about one decade before the earliest documented transmission of Mtb strains with such extensive resistance profiles globally.
Fil: Eldholm, Vegard. Norwegian Institute of Public Health; Noruega
Fil: Monteserin, Johana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rieux, Adrien. Colegio Universitario de Londres; Reino Unido
Fil: Lopez, Beatriz. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Sobkowiak, Benjamin. Colegio Universitario de Londres; Reino Unido
Fil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Balloux, Francois. Colegio Universitario de Londres; Reino Unido - Materia
-
MYCOBACTERIUM TUBERCULOSIS
MULTIDRUG-RESISTANT
ARGENTINA
WHOLE GENOME SEQUENCING - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/98453
Ver los metadatos del registro completo
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Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strainEldholm, VegardMonteserin, JohanaRieux, AdrienLopez, BeatrizSobkowiak, BenjaminRitacco, Gloria VivianaBalloux, FrancoisMYCOBACTERIUM TUBERCULOSISMULTIDRUG-RESISTANTARGENTINAWHOLE GENOME SEQUENCINGhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a major public health issue. Here we reconstruct the timeline of the acquisition of antimicrobial resistance during a major ongoing outbreak of multidrug-resistant TB in Argentina. We estimate that the progenitor of the outbreak strain acquired resistance to isoniazid, streptomycin and rifampicin by around 1973, indicating continuous circulation of a multidrug-resistant TB strain for four decades. By around 1979 the strain had acquired additional resistance to three more drugs. Our results indicate that Mycobacterium tuberculosis (Mtb) with extensive resistance profiles circulated 15 years before the outbreak was detected, and about one decade before the earliest documented transmission of Mtb strains with such extensive resistance profiles globally.Fil: Eldholm, Vegard. Norwegian Institute of Public Health; NoruegaFil: Monteserin, Johana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rieux, Adrien. Colegio Universitario de Londres; Reino UnidoFil: Lopez, Beatriz. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: Sobkowiak, Benjamin. Colegio Universitario de Londres; Reino UnidoFil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Balloux, Francois. Colegio Universitario de Londres; Reino UnidoNature Publishing Group2015-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/98453Eldholm, Vegard; Monteserin, Johana; Rieux, Adrien; Lopez, Beatriz; Sobkowiak, Benjamin; et al.; Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain; Nature Publishing Group; Nature Communications; 6; 5-2015; 1-92041-1723CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/ncomms8119info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/ncomms8119info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:51:11Zoai:ri.conicet.gov.ar:11336/98453instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:51:12.05CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain |
title |
Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain |
spellingShingle |
Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain Eldholm, Vegard MYCOBACTERIUM TUBERCULOSIS MULTIDRUG-RESISTANT ARGENTINA WHOLE GENOME SEQUENCING |
title_short |
Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain |
title_full |
Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain |
title_fullStr |
Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain |
title_full_unstemmed |
Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain |
title_sort |
Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain |
dc.creator.none.fl_str_mv |
Eldholm, Vegard Monteserin, Johana Rieux, Adrien Lopez, Beatriz Sobkowiak, Benjamin Ritacco, Gloria Viviana Balloux, Francois |
author |
Eldholm, Vegard |
author_facet |
Eldholm, Vegard Monteserin, Johana Rieux, Adrien Lopez, Beatriz Sobkowiak, Benjamin Ritacco, Gloria Viviana Balloux, Francois |
author_role |
author |
author2 |
Monteserin, Johana Rieux, Adrien Lopez, Beatriz Sobkowiak, Benjamin Ritacco, Gloria Viviana Balloux, Francois |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
MYCOBACTERIUM TUBERCULOSIS MULTIDRUG-RESISTANT ARGENTINA WHOLE GENOME SEQUENCING |
topic |
MYCOBACTERIUM TUBERCULOSIS MULTIDRUG-RESISTANT ARGENTINA WHOLE GENOME SEQUENCING |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a major public health issue. Here we reconstruct the timeline of the acquisition of antimicrobial resistance during a major ongoing outbreak of multidrug-resistant TB in Argentina. We estimate that the progenitor of the outbreak strain acquired resistance to isoniazid, streptomycin and rifampicin by around 1973, indicating continuous circulation of a multidrug-resistant TB strain for four decades. By around 1979 the strain had acquired additional resistance to three more drugs. Our results indicate that Mycobacterium tuberculosis (Mtb) with extensive resistance profiles circulated 15 years before the outbreak was detected, and about one decade before the earliest documented transmission of Mtb strains with such extensive resistance profiles globally. Fil: Eldholm, Vegard. Norwegian Institute of Public Health; Noruega Fil: Monteserin, Johana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Rieux, Adrien. Colegio Universitario de Londres; Reino Unido Fil: Lopez, Beatriz. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina Fil: Sobkowiak, Benjamin. Colegio Universitario de Londres; Reino Unido Fil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Balloux, Francois. Colegio Universitario de Londres; Reino Unido |
description |
The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a major public health issue. Here we reconstruct the timeline of the acquisition of antimicrobial resistance during a major ongoing outbreak of multidrug-resistant TB in Argentina. We estimate that the progenitor of the outbreak strain acquired resistance to isoniazid, streptomycin and rifampicin by around 1973, indicating continuous circulation of a multidrug-resistant TB strain for four decades. By around 1979 the strain had acquired additional resistance to three more drugs. Our results indicate that Mycobacterium tuberculosis (Mtb) with extensive resistance profiles circulated 15 years before the outbreak was detected, and about one decade before the earliest documented transmission of Mtb strains with such extensive resistance profiles globally. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/98453 Eldholm, Vegard; Monteserin, Johana; Rieux, Adrien; Lopez, Beatriz; Sobkowiak, Benjamin; et al.; Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain; Nature Publishing Group; Nature Communications; 6; 5-2015; 1-9 2041-1723 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/98453 |
identifier_str_mv |
Eldholm, Vegard; Monteserin, Johana; Rieux, Adrien; Lopez, Beatriz; Sobkowiak, Benjamin; et al.; Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain; Nature Publishing Group; Nature Communications; 6; 5-2015; 1-9 2041-1723 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1038/ncomms8119 info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/ncomms8119 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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