Capillary electrophoresis of neurotransmitters with amperometric detection at melanin-type polymer-modified carbon electrodes

Autores
Chicharro, M.; Sánchez, A.; Zapardiel, A.; Rubianes, María Dolores; Rivas, Gustavo Adolfo
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This paper reports on the advantages of combining the separation capability of capillary electrophoresis using a novel home-made electrochemical cell adapted to commercially available capillary electrophoresis equipment with the permselective properties of melanin-type polymer-modified carbon electrodes as amperometric detectors. The excellent permselective properties of the melanic polymer have allowed a large improvement on the quantification of dopamine, epinephrine and norepinephrine. A linear response was obtained in the range 8-200 pg of dopamine with sensitivities between 3- and 5-times higher than those at the bare carbon electrodes and detection limits at submicromolar level (41 fmol in the volume injected). The effect of the carbon electrodes size, and capillary electrophoresis parameters on the analytical performance is also discussed. © 2004 Elsevier B.V. All rights reserved.
Fil: Chicharro, M.. Universidad Autónoma de Madrid; España
Fil: Sánchez, A.. Universidad Autónoma de Madrid; España
Fil: Zapardiel, A.. Universidad Nacional de Educacion a Distancia; España
Fil: Rubianes, María Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Materia
Capillary Electrophoresis
Carbon Electrodes
Melanin
Modified Electrodes
Neurotransmitters
Polymer
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/36617
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Capillary electrophoresis of neurotransmitters with amperometric detection at melanin-type polymer-modified carbon electrodesChicharro, M.Sánchez, A.Zapardiel, A.Rubianes, María DoloresRivas, Gustavo AdolfoCapillary ElectrophoresisCarbon ElectrodesMelaninModified ElectrodesNeurotransmittersPolymerhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1This paper reports on the advantages of combining the separation capability of capillary electrophoresis using a novel home-made electrochemical cell adapted to commercially available capillary electrophoresis equipment with the permselective properties of melanin-type polymer-modified carbon electrodes as amperometric detectors. The excellent permselective properties of the melanic polymer have allowed a large improvement on the quantification of dopamine, epinephrine and norepinephrine. A linear response was obtained in the range 8-200 pg of dopamine with sensitivities between 3- and 5-times higher than those at the bare carbon electrodes and detection limits at submicromolar level (41 fmol in the volume injected). The effect of the carbon electrodes size, and capillary electrophoresis parameters on the analytical performance is also discussed. © 2004 Elsevier B.V. All rights reserved.Fil: Chicharro, M.. Universidad Autónoma de Madrid; EspañaFil: Sánchez, A.. Universidad Autónoma de Madrid; EspañaFil: Zapardiel, A.. Universidad Nacional de Educacion a Distancia; EspañaFil: Rubianes, María Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaElsevier Science2004-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/36617Chicharro, M.; Sánchez, A.; Zapardiel, A.; Rubianes, María Dolores; Rivas, Gustavo Adolfo; Capillary electrophoresis of neurotransmitters with amperometric detection at melanin-type polymer-modified carbon electrodes; Elsevier Science; Analytica Chimica Acta; 523; 2; 10-2004; 185-1910003-2670CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.aca.2004.07.039info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0003267004008815info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:56Zoai:ri.conicet.gov.ar:11336/36617instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:57.333CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Capillary electrophoresis of neurotransmitters with amperometric detection at melanin-type polymer-modified carbon electrodes
title Capillary electrophoresis of neurotransmitters with amperometric detection at melanin-type polymer-modified carbon electrodes
spellingShingle Capillary electrophoresis of neurotransmitters with amperometric detection at melanin-type polymer-modified carbon electrodes
Chicharro, M.
Capillary Electrophoresis
Carbon Electrodes
Melanin
Modified Electrodes
Neurotransmitters
Polymer
title_short Capillary electrophoresis of neurotransmitters with amperometric detection at melanin-type polymer-modified carbon electrodes
title_full Capillary electrophoresis of neurotransmitters with amperometric detection at melanin-type polymer-modified carbon electrodes
title_fullStr Capillary electrophoresis of neurotransmitters with amperometric detection at melanin-type polymer-modified carbon electrodes
title_full_unstemmed Capillary electrophoresis of neurotransmitters with amperometric detection at melanin-type polymer-modified carbon electrodes
title_sort Capillary electrophoresis of neurotransmitters with amperometric detection at melanin-type polymer-modified carbon electrodes
dc.creator.none.fl_str_mv Chicharro, M.
Sánchez, A.
Zapardiel, A.
Rubianes, María Dolores
Rivas, Gustavo Adolfo
author Chicharro, M.
author_facet Chicharro, M.
Sánchez, A.
Zapardiel, A.
Rubianes, María Dolores
Rivas, Gustavo Adolfo
author_role author
author2 Sánchez, A.
Zapardiel, A.
Rubianes, María Dolores
Rivas, Gustavo Adolfo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Capillary Electrophoresis
Carbon Electrodes
Melanin
Modified Electrodes
Neurotransmitters
Polymer
topic Capillary Electrophoresis
Carbon Electrodes
Melanin
Modified Electrodes
Neurotransmitters
Polymer
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This paper reports on the advantages of combining the separation capability of capillary electrophoresis using a novel home-made electrochemical cell adapted to commercially available capillary electrophoresis equipment with the permselective properties of melanin-type polymer-modified carbon electrodes as amperometric detectors. The excellent permselective properties of the melanic polymer have allowed a large improvement on the quantification of dopamine, epinephrine and norepinephrine. A linear response was obtained in the range 8-200 pg of dopamine with sensitivities between 3- and 5-times higher than those at the bare carbon electrodes and detection limits at submicromolar level (41 fmol in the volume injected). The effect of the carbon electrodes size, and capillary electrophoresis parameters on the analytical performance is also discussed. © 2004 Elsevier B.V. All rights reserved.
Fil: Chicharro, M.. Universidad Autónoma de Madrid; España
Fil: Sánchez, A.. Universidad Autónoma de Madrid; España
Fil: Zapardiel, A.. Universidad Nacional de Educacion a Distancia; España
Fil: Rubianes, María Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
description This paper reports on the advantages of combining the separation capability of capillary electrophoresis using a novel home-made electrochemical cell adapted to commercially available capillary electrophoresis equipment with the permselective properties of melanin-type polymer-modified carbon electrodes as amperometric detectors. The excellent permselective properties of the melanic polymer have allowed a large improvement on the quantification of dopamine, epinephrine and norepinephrine. A linear response was obtained in the range 8-200 pg of dopamine with sensitivities between 3- and 5-times higher than those at the bare carbon electrodes and detection limits at submicromolar level (41 fmol in the volume injected). The effect of the carbon electrodes size, and capillary electrophoresis parameters on the analytical performance is also discussed. © 2004 Elsevier B.V. All rights reserved.
publishDate 2004
dc.date.none.fl_str_mv 2004-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/36617
Chicharro, M.; Sánchez, A.; Zapardiel, A.; Rubianes, María Dolores; Rivas, Gustavo Adolfo; Capillary electrophoresis of neurotransmitters with amperometric detection at melanin-type polymer-modified carbon electrodes; Elsevier Science; Analytica Chimica Acta; 523; 2; 10-2004; 185-191
0003-2670
CONICET Digital
CONICET
url http://hdl.handle.net/11336/36617
identifier_str_mv Chicharro, M.; Sánchez, A.; Zapardiel, A.; Rubianes, María Dolores; Rivas, Gustavo Adolfo; Capillary electrophoresis of neurotransmitters with amperometric detection at melanin-type polymer-modified carbon electrodes; Elsevier Science; Analytica Chimica Acta; 523; 2; 10-2004; 185-191
0003-2670
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.aca.2004.07.039
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0003267004008815
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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