Aspergillus terreusstrain improvement for enhanced lovastatin production

Autores
Babot, Jaime Daniel; Caro, Florencia Cecilia; Delgado, Osvaldo Daniel; Fariña, Julia Ines
Año de publicación
2015
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Cholesterol plays a vital role in body metabolism and membrane transport, and acts as precursor for the synthesis of several key biomolecules. Nevertheless, changes in cholesterol level lead to cardiovascular disorders, like atherosclerosis and hypercholesterolemia, which are currently the maincauses of death. This is why controlling cholesterol by inhibition of its biosynthesis is a promising approach. Cholesterol is synthetized from acetyl-CoA through a complex pathway, where the rate-limiting step is the conversion of HMG-CoA to mevalonate, catalyzed by HMG-CoA reductase.This key enzyme is selectively and competitively inhibited by lovastatin, a fungal secondary metaboliteused as a hypocholesterolemic which can therefore reduce the risk of cardiovascular diseases.
Fil: Babot, Jaime Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina
Fil: Caro, Florencia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina
Fil: Delgado, Osvaldo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Catamarca. Universidad Nacional de Catamarca. Centro de Investigaciones y Transferencia de Catamarca; Argentina. Universidad Nacional de Catamarca. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Fariña, Julia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina
XI Congreso Argentino de Microbiología General
Córdoba
Argentina
Sociedad Argentina de Microbiología General
Materia
LOVASTATIN
ENHANCED
PRODUCTION
Aspergillus terreus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/188987
Acceder
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spelling Aspergillus terreusstrain improvement for enhanced lovastatin productionBabot, Jaime DanielCaro, Florencia CeciliaDelgado, Osvaldo DanielFariña, Julia InesLOVASTATINENHANCEDPRODUCTIONAspergillus terreushttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2Cholesterol plays a vital role in body metabolism and membrane transport, and acts as precursor for the synthesis of several key biomolecules. Nevertheless, changes in cholesterol level lead to cardiovascular disorders, like atherosclerosis and hypercholesterolemia, which are currently the maincauses of death. This is why controlling cholesterol by inhibition of its biosynthesis is a promising approach. Cholesterol is synthetized from acetyl-CoA through a complex pathway, where the rate-limiting step is the conversion of HMG-CoA to mevalonate, catalyzed by HMG-CoA reductase.This key enzyme is selectively and competitively inhibited by lovastatin, a fungal secondary metaboliteused as a hypocholesterolemic which can therefore reduce the risk of cardiovascular diseases.Fil: Babot, Jaime Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; ArgentinaFil: Caro, Florencia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; ArgentinaFil: Delgado, Osvaldo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Catamarca. Universidad Nacional de Catamarca. Centro de Investigaciones y Transferencia de Catamarca; Argentina. Universidad Nacional de Catamarca. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Fariña, Julia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; ArgentinaXI Congreso Argentino de Microbiología GeneralCórdobaArgentinaSociedad Argentina de Microbiología GeneralSociedad Argentina de Microbiología General2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/188987Aspergillus terreusstrain improvement for enhanced lovastatin production; XI Congreso Argentino de Microbiología General; Córdoba; Argentina; 2015; 1-3CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://samige.org.ar/wp-content/uploads/2022/10/Libro-SAMIGE-2015.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:13:42Zoai:ri.conicet.gov.ar:11336/188987instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:13:43.283CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Aspergillus terreusstrain improvement for enhanced lovastatin production
title Aspergillus terreusstrain improvement for enhanced lovastatin production
spellingShingle Aspergillus terreusstrain improvement for enhanced lovastatin production
Babot, Jaime Daniel
LOVASTATIN
ENHANCED
PRODUCTION
Aspergillus terreus
title_short Aspergillus terreusstrain improvement for enhanced lovastatin production
title_full Aspergillus terreusstrain improvement for enhanced lovastatin production
title_fullStr Aspergillus terreusstrain improvement for enhanced lovastatin production
title_full_unstemmed Aspergillus terreusstrain improvement for enhanced lovastatin production
title_sort Aspergillus terreusstrain improvement for enhanced lovastatin production
dc.creator.none.fl_str_mv Babot, Jaime Daniel
Caro, Florencia Cecilia
Delgado, Osvaldo Daniel
Fariña, Julia Ines
author Babot, Jaime Daniel
author_facet Babot, Jaime Daniel
Caro, Florencia Cecilia
Delgado, Osvaldo Daniel
Fariña, Julia Ines
author_role author
author2 Caro, Florencia Cecilia
Delgado, Osvaldo Daniel
Fariña, Julia Ines
author2_role author
author
author
dc.subject.none.fl_str_mv LOVASTATIN
ENHANCED
PRODUCTION
Aspergillus terreus
topic LOVASTATIN
ENHANCED
PRODUCTION
Aspergillus terreus
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Cholesterol plays a vital role in body metabolism and membrane transport, and acts as precursor for the synthesis of several key biomolecules. Nevertheless, changes in cholesterol level lead to cardiovascular disorders, like atherosclerosis and hypercholesterolemia, which are currently the maincauses of death. This is why controlling cholesterol by inhibition of its biosynthesis is a promising approach. Cholesterol is synthetized from acetyl-CoA through a complex pathway, where the rate-limiting step is the conversion of HMG-CoA to mevalonate, catalyzed by HMG-CoA reductase.This key enzyme is selectively and competitively inhibited by lovastatin, a fungal secondary metaboliteused as a hypocholesterolemic which can therefore reduce the risk of cardiovascular diseases.
Fil: Babot, Jaime Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina
Fil: Caro, Florencia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina
Fil: Delgado, Osvaldo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Catamarca. Universidad Nacional de Catamarca. Centro de Investigaciones y Transferencia de Catamarca; Argentina. Universidad Nacional de Catamarca. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Fariña, Julia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina
XI Congreso Argentino de Microbiología General
Córdoba
Argentina
Sociedad Argentina de Microbiología General
description Cholesterol plays a vital role in body metabolism and membrane transport, and acts as precursor for the synthesis of several key biomolecules. Nevertheless, changes in cholesterol level lead to cardiovascular disorders, like atherosclerosis and hypercholesterolemia, which are currently the maincauses of death. This is why controlling cholesterol by inhibition of its biosynthesis is a promising approach. Cholesterol is synthetized from acetyl-CoA through a complex pathway, where the rate-limiting step is the conversion of HMG-CoA to mevalonate, catalyzed by HMG-CoA reductase.This key enzyme is selectively and competitively inhibited by lovastatin, a fungal secondary metaboliteused as a hypocholesterolemic which can therefore reduce the risk of cardiovascular diseases.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/188987
Aspergillus terreusstrain improvement for enhanced lovastatin production; XI Congreso Argentino de Microbiología General; Córdoba; Argentina; 2015; 1-3
CONICET Digital
CONICET
url http://hdl.handle.net/11336/188987
identifier_str_mv Aspergillus terreusstrain improvement for enhanced lovastatin production; XI Congreso Argentino de Microbiología General; Córdoba; Argentina; 2015; 1-3
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://samige.org.ar/wp-content/uploads/2022/10/Libro-SAMIGE-2015.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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application/pdf
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Sociedad Argentina de Microbiología General
publisher.none.fl_str_mv Sociedad Argentina de Microbiología General
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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