Aspergillus terreusstrain improvement for enhanced lovastatin production
- Autores
- Babot, Jaime Daniel; Caro, Florencia Cecilia; Delgado, Osvaldo Daniel; Fariña, Julia Ines
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Cholesterol plays a vital role in body metabolism and membrane transport, and acts as precursor for the synthesis of several key biomolecules. Nevertheless, changes in cholesterol level lead to cardiovascular disorders, like atherosclerosis and hypercholesterolemia, which are currently the maincauses of death. This is why controlling cholesterol by inhibition of its biosynthesis is a promising approach. Cholesterol is synthetized from acetyl-CoA through a complex pathway, where the rate-limiting step is the conversion of HMG-CoA to mevalonate, catalyzed by HMG-CoA reductase.This key enzyme is selectively and competitively inhibited by lovastatin, a fungal secondary metaboliteused as a hypocholesterolemic which can therefore reduce the risk of cardiovascular diseases.
Fil: Babot, Jaime Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina
Fil: Caro, Florencia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina
Fil: Delgado, Osvaldo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Catamarca. Universidad Nacional de Catamarca. Centro de Investigaciones y Transferencia de Catamarca; Argentina. Universidad Nacional de Catamarca. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Fariña, Julia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina
XI Congreso Argentino de Microbiología General
Córdoba
Argentina
Sociedad Argentina de Microbiología General - Materia
-
LOVASTATIN
ENHANCED
PRODUCTION
Aspergillus terreus - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/188987
Ver los metadatos del registro completo
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Aspergillus terreusstrain improvement for enhanced lovastatin productionBabot, Jaime DanielCaro, Florencia CeciliaDelgado, Osvaldo DanielFariña, Julia InesLOVASTATINENHANCEDPRODUCTIONAspergillus terreushttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2Cholesterol plays a vital role in body metabolism and membrane transport, and acts as precursor for the synthesis of several key biomolecules. Nevertheless, changes in cholesterol level lead to cardiovascular disorders, like atherosclerosis and hypercholesterolemia, which are currently the maincauses of death. This is why controlling cholesterol by inhibition of its biosynthesis is a promising approach. Cholesterol is synthetized from acetyl-CoA through a complex pathway, where the rate-limiting step is the conversion of HMG-CoA to mevalonate, catalyzed by HMG-CoA reductase.This key enzyme is selectively and competitively inhibited by lovastatin, a fungal secondary metaboliteused as a hypocholesterolemic which can therefore reduce the risk of cardiovascular diseases.Fil: Babot, Jaime Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; ArgentinaFil: Caro, Florencia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; ArgentinaFil: Delgado, Osvaldo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Catamarca. Universidad Nacional de Catamarca. Centro de Investigaciones y Transferencia de Catamarca; Argentina. Universidad Nacional de Catamarca. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Fariña, Julia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; ArgentinaXI Congreso Argentino de Microbiología GeneralCórdobaArgentinaSociedad Argentina de Microbiología GeneralSociedad Argentina de Microbiología General2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/188987Aspergillus terreusstrain improvement for enhanced lovastatin production; XI Congreso Argentino de Microbiología General; Córdoba; Argentina; 2015; 1-3CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://samige.org.ar/wp-content/uploads/2022/10/Libro-SAMIGE-2015.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:44:50Zoai:ri.conicet.gov.ar:11336/188987instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:44:50.677CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Aspergillus terreusstrain improvement for enhanced lovastatin production |
title |
Aspergillus terreusstrain improvement for enhanced lovastatin production |
spellingShingle |
Aspergillus terreusstrain improvement for enhanced lovastatin production Babot, Jaime Daniel LOVASTATIN ENHANCED PRODUCTION Aspergillus terreus |
title_short |
Aspergillus terreusstrain improvement for enhanced lovastatin production |
title_full |
Aspergillus terreusstrain improvement for enhanced lovastatin production |
title_fullStr |
Aspergillus terreusstrain improvement for enhanced lovastatin production |
title_full_unstemmed |
Aspergillus terreusstrain improvement for enhanced lovastatin production |
title_sort |
Aspergillus terreusstrain improvement for enhanced lovastatin production |
dc.creator.none.fl_str_mv |
Babot, Jaime Daniel Caro, Florencia Cecilia Delgado, Osvaldo Daniel Fariña, Julia Ines |
author |
Babot, Jaime Daniel |
author_facet |
Babot, Jaime Daniel Caro, Florencia Cecilia Delgado, Osvaldo Daniel Fariña, Julia Ines |
author_role |
author |
author2 |
Caro, Florencia Cecilia Delgado, Osvaldo Daniel Fariña, Julia Ines |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
LOVASTATIN ENHANCED PRODUCTION Aspergillus terreus |
topic |
LOVASTATIN ENHANCED PRODUCTION Aspergillus terreus |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.9 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
Cholesterol plays a vital role in body metabolism and membrane transport, and acts as precursor for the synthesis of several key biomolecules. Nevertheless, changes in cholesterol level lead to cardiovascular disorders, like atherosclerosis and hypercholesterolemia, which are currently the maincauses of death. This is why controlling cholesterol by inhibition of its biosynthesis is a promising approach. Cholesterol is synthetized from acetyl-CoA through a complex pathway, where the rate-limiting step is the conversion of HMG-CoA to mevalonate, catalyzed by HMG-CoA reductase.This key enzyme is selectively and competitively inhibited by lovastatin, a fungal secondary metaboliteused as a hypocholesterolemic which can therefore reduce the risk of cardiovascular diseases. Fil: Babot, Jaime Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina Fil: Caro, Florencia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina Fil: Delgado, Osvaldo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Catamarca. Universidad Nacional de Catamarca. Centro de Investigaciones y Transferencia de Catamarca; Argentina. Universidad Nacional de Catamarca. Facultad de Ciencias Exactas y Naturales; Argentina Fil: Fariña, Julia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina XI Congreso Argentino de Microbiología General Córdoba Argentina Sociedad Argentina de Microbiología General |
description |
Cholesterol plays a vital role in body metabolism and membrane transport, and acts as precursor for the synthesis of several key biomolecules. Nevertheless, changes in cholesterol level lead to cardiovascular disorders, like atherosclerosis and hypercholesterolemia, which are currently the maincauses of death. This is why controlling cholesterol by inhibition of its biosynthesis is a promising approach. Cholesterol is synthetized from acetyl-CoA through a complex pathway, where the rate-limiting step is the conversion of HMG-CoA to mevalonate, catalyzed by HMG-CoA reductase.This key enzyme is selectively and competitively inhibited by lovastatin, a fungal secondary metaboliteused as a hypocholesterolemic which can therefore reduce the risk of cardiovascular diseases. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Congreso Book http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/188987 Aspergillus terreusstrain improvement for enhanced lovastatin production; XI Congreso Argentino de Microbiología General; Córdoba; Argentina; 2015; 1-3 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/188987 |
identifier_str_mv |
Aspergillus terreusstrain improvement for enhanced lovastatin production; XI Congreso Argentino de Microbiología General; Córdoba; Argentina; 2015; 1-3 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://samige.org.ar/wp-content/uploads/2022/10/Libro-SAMIGE-2015.pdf |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.coverage.none.fl_str_mv |
Nacional |
dc.publisher.none.fl_str_mv |
Sociedad Argentina de Microbiología General |
publisher.none.fl_str_mv |
Sociedad Argentina de Microbiología General |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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score |
13.070432 |