Breathing alterations against hypoxia as a function of early ethanol exposure

Autores
Macchione, Ana Fabiola
Año de publicación
2023
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Maternal ethanol (EtOH) intake during pregnancy and lactation is a highly frequent “social” behavior in Argentine, exposing fetus or neonates to moderate EtOH intoxication through the amniotic fluid and placenta. Early EtOH exposure triggers a spectrum of neurobehavioral dysfunctions affecting, also, the breathing response. In an animal model equivalent to the 3rd trimester of the human gestation we explore the early ethanol exposure effects on the ventilatory responses in normoxic and hypoxic-air conditions. We also study central areas involved in breathing modulation as the solitary tract nucleus and the medullary raphe system. Our results show that a brief and early ethanol exposure alters both basal and hypoxia-induced breathing frequencies and apneas through modifications in the activation patterns of central areas of study. Actually, early ethanol exposure induces a basal breathing depression in normoxic conditions but, against a hypoxic challenge, ethanol triggers two consecutive altered events: first a lower hyperventilation rate during the hypoxic event itself and then, during the post-hypoxic period, ethanol elicit the emergency of an adaptive phenomenon, the ventilatory long-term facilitation. Alterations in the activation patterns in the NTS and raphe obscurus, and an increase in the 5HT levels in the medullary raphe nuclei (magnus, obscurus y pallidus) were observed as a function of different ways of early ethanol exposure. Funding by MINCyT-Cba; FONCyT and SECyT-UNC.
Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias
San Luis
Argentina
Sociedad Argentina de Investigación en Neurociencias
Universidad Nacional de San Luis
Materia
Ethanol
Hypoxia
Breeathing
Neonates
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/233230
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Breathing alterations against hypoxia as a function of early ethanol exposureMacchione, Ana FabiolaEthanolHypoxiaBreeathingNeonateshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Maternal ethanol (EtOH) intake during pregnancy and lactation is a highly frequent “social” behavior in Argentine, exposing fetus or neonates to moderate EtOH intoxication through the amniotic fluid and placenta. Early EtOH exposure triggers a spectrum of neurobehavioral dysfunctions affecting, also, the breathing response. In an animal model equivalent to the 3rd trimester of the human gestation we explore the early ethanol exposure effects on the ventilatory responses in normoxic and hypoxic-air conditions. We also study central areas involved in breathing modulation as the solitary tract nucleus and the medullary raphe system. Our results show that a brief and early ethanol exposure alters both basal and hypoxia-induced breathing frequencies and apneas through modifications in the activation patterns of central areas of study. Actually, early ethanol exposure induces a basal breathing depression in normoxic conditions but, against a hypoxic challenge, ethanol triggers two consecutive altered events: first a lower hyperventilation rate during the hypoxic event itself and then, during the post-hypoxic period, ethanol elicit the emergency of an adaptive phenomenon, the ventilatory long-term facilitation. Alterations in the activation patterns in the NTS and raphe obscurus, and an increase in the 5HT levels in the medullary raphe nuclei (magnus, obscurus y pallidus) were observed as a function of different ways of early ethanol exposure. Funding by MINCyT-Cba; FONCyT and SECyT-UNC.Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaXXXVIII Annual Meeting of the Sociedad Argentina de Investigación en NeurocienciasSan LuisArgentinaSociedad Argentina de Investigación en NeurocienciasUniversidad Nacional de San LuisSociedad Argentina de Investigación en Neurociencias2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/233230Breathing alterations against hypoxia as a function of early ethanol exposure; XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias; San Luis; Argentina; 2023; 60-60CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://csan2023.saneurociencias.org.ar/wp-content/uploads/2023/11/SANebook2023.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:47:11Zoai:ri.conicet.gov.ar:11336/233230instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:47:11.853CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Breathing alterations against hypoxia as a function of early ethanol exposure
title Breathing alterations against hypoxia as a function of early ethanol exposure
spellingShingle Breathing alterations against hypoxia as a function of early ethanol exposure
Macchione, Ana Fabiola
Ethanol
Hypoxia
Breeathing
Neonates
title_short Breathing alterations against hypoxia as a function of early ethanol exposure
title_full Breathing alterations against hypoxia as a function of early ethanol exposure
title_fullStr Breathing alterations against hypoxia as a function of early ethanol exposure
title_full_unstemmed Breathing alterations against hypoxia as a function of early ethanol exposure
title_sort Breathing alterations against hypoxia as a function of early ethanol exposure
dc.creator.none.fl_str_mv Macchione, Ana Fabiola
author Macchione, Ana Fabiola
author_facet Macchione, Ana Fabiola
author_role author
dc.subject.none.fl_str_mv Ethanol
Hypoxia
Breeathing
Neonates
topic Ethanol
Hypoxia
Breeathing
Neonates
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Maternal ethanol (EtOH) intake during pregnancy and lactation is a highly frequent “social” behavior in Argentine, exposing fetus or neonates to moderate EtOH intoxication through the amniotic fluid and placenta. Early EtOH exposure triggers a spectrum of neurobehavioral dysfunctions affecting, also, the breathing response. In an animal model equivalent to the 3rd trimester of the human gestation we explore the early ethanol exposure effects on the ventilatory responses in normoxic and hypoxic-air conditions. We also study central areas involved in breathing modulation as the solitary tract nucleus and the medullary raphe system. Our results show that a brief and early ethanol exposure alters both basal and hypoxia-induced breathing frequencies and apneas through modifications in the activation patterns of central areas of study. Actually, early ethanol exposure induces a basal breathing depression in normoxic conditions but, against a hypoxic challenge, ethanol triggers two consecutive altered events: first a lower hyperventilation rate during the hypoxic event itself and then, during the post-hypoxic period, ethanol elicit the emergency of an adaptive phenomenon, the ventilatory long-term facilitation. Alterations in the activation patterns in the NTS and raphe obscurus, and an increase in the 5HT levels in the medullary raphe nuclei (magnus, obscurus y pallidus) were observed as a function of different ways of early ethanol exposure. Funding by MINCyT-Cba; FONCyT and SECyT-UNC.
Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias
San Luis
Argentina
Sociedad Argentina de Investigación en Neurociencias
Universidad Nacional de San Luis
description Maternal ethanol (EtOH) intake during pregnancy and lactation is a highly frequent “social” behavior in Argentine, exposing fetus or neonates to moderate EtOH intoxication through the amniotic fluid and placenta. Early EtOH exposure triggers a spectrum of neurobehavioral dysfunctions affecting, also, the breathing response. In an animal model equivalent to the 3rd trimester of the human gestation we explore the early ethanol exposure effects on the ventilatory responses in normoxic and hypoxic-air conditions. We also study central areas involved in breathing modulation as the solitary tract nucleus and the medullary raphe system. Our results show that a brief and early ethanol exposure alters both basal and hypoxia-induced breathing frequencies and apneas through modifications in the activation patterns of central areas of study. Actually, early ethanol exposure induces a basal breathing depression in normoxic conditions but, against a hypoxic challenge, ethanol triggers two consecutive altered events: first a lower hyperventilation rate during the hypoxic event itself and then, during the post-hypoxic period, ethanol elicit the emergency of an adaptive phenomenon, the ventilatory long-term facilitation. Alterations in the activation patterns in the NTS and raphe obscurus, and an increase in the 5HT levels in the medullary raphe nuclei (magnus, obscurus y pallidus) were observed as a function of different ways of early ethanol exposure. Funding by MINCyT-Cba; FONCyT and SECyT-UNC.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/233230
Breathing alterations against hypoxia as a function of early ethanol exposure; XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias; San Luis; Argentina; 2023; 60-60
CONICET Digital
CONICET
url http://hdl.handle.net/11336/233230
identifier_str_mv Breathing alterations against hypoxia as a function of early ethanol exposure; XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias; San Luis; Argentina; 2023; 60-60
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://csan2023.saneurociencias.org.ar/wp-content/uploads/2023/11/SANebook2023.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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