Sensitization to ethanol’s disruptive effects upon early breathing plasticity associated with hypoxia and hypercapnia

Autores
Anunziata, Florencia; Macchione, Ana Fabiola; Angulo Alcalde, Asier; Trujillo, María Verónica; Wille-bille, Aranza; Amigone, José Luis; Molina, Juan Carlos
Año de publicación
2019
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Ethanol (EtOH) consumption during pregnancy and lactation represents a risk factor related with the Sudden Infant Death Syndrome (SIDS). This phenomenon has promoted research linking prenatal EtOH effects on the respiratory system during early ontogeny. It should also be noted that prolonged episodes of neonatal respiratory depression represent a risk factor in terms of hypoxic-ischemic effects with negative consequences on brain development. In a first study during postnatal day (PD) 9 we analyzed the impact of different doses of EtOH (0.0, 0.75, 1.37 or 2.0 g/kg) upon the respiratory response and the potential psychomotor effects in pup rats pre-exposed or not to 2.0 g/kg of EtOH during PDs 3-7. At PD 9 animals were also subjected to sequential air conditions defined as initial normoxia, hypoxia and recovery normoxia. In a second study we analyzed the blood of animals only exposed to 0.0 or 2.0g/kg of EtOH during PDs 3-9 (not subjected to a hypoxic event). The aim was to examine if mere intoxication with a moderate dose of EtOH is capable of modifying blood metabolic patterns associated with hypoxia or hypercapnia. In the first study during PDs 3-7 EtOH exerted a depressant effect upon breathing frequencies. These animals also showed a progressive sensitization effect relative to the depressant effects of the drug and lesser levels of apneas. At PD 9 dose dependent respiratory depressions were observed when pups were challenged with a hypoxic event. Independently from prior experience with EtOH, drug treatment at PD 9 significantly disrupted respiratory frequencies particularly during the hypoxic and the recovery normoxia phases. Respiratory disorders triggered by these air conditions have been implicated in the pathophysiology of SIDS. These results show that breathing plasticity is disrupted during a critical stage where respiratory alterations may lead to hypoxiaassociated syndromes that endanger brain development. In terms of psychomotor activity, animals exposed to 2.0 g/kg of EtOH at PD 9 showed heightened duration and frequency of grooming. In the second study animals exposed at least one time to EtOH exhibited lower pH and higher CO2 than animals that were never exposed to EtOH. This results suggest metabolic acidosis probably due to EtOH-related hypercapnia during a vulnerable stage in development relative to SIDS.
Fil: Anunziata, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Macchione, Ana Fabiola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Angulo Alcalde, Asier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Trujillo, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Wille-bille, Aranza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Amigone, José Luis. Hospital Privado de Córdoba. Laboratorio de Bioquímica Clínica; Argentina
Fil: Molina, Juan Carlos. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
IX LASBRA International Meeting: Determinants of Alcoholism: bridging the gap between epidemiologic and basic research
Córdoba
Argentina
Latin American Society for Biomedical Research on Alcoholism
Materia
Ethanol
Hypoxia
Hypercapnia
Hyperventilation
Neonates
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/178052
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/178052
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sensitization to ethanol’s disruptive effects upon early breathing plasticity associated with hypoxia and hypercapniaAnunziata, FlorenciaMacchione, Ana FabiolaAngulo Alcalde, AsierTrujillo, María VerónicaWille-bille, AranzaAmigone, José LuisMolina, Juan CarlosEthanolHypoxiaHypercapniaHyperventilationNeonateshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Ethanol (EtOH) consumption during pregnancy and lactation represents a risk factor related with the Sudden Infant Death Syndrome (SIDS). This phenomenon has promoted research linking prenatal EtOH effects on the respiratory system during early ontogeny. It should also be noted that prolonged episodes of neonatal respiratory depression represent a risk factor in terms of hypoxic-ischemic effects with negative consequences on brain development. In a first study during postnatal day (PD) 9 we analyzed the impact of different doses of EtOH (0.0, 0.75, 1.37 or 2.0 g/kg) upon the respiratory response and the potential psychomotor effects in pup rats pre-exposed or not to 2.0 g/kg of EtOH during PDs 3-7. At PD 9 animals were also subjected to sequential air conditions defined as initial normoxia, hypoxia and recovery normoxia. In a second study we analyzed the blood of animals only exposed to 0.0 or 2.0g/kg of EtOH during PDs 3-9 (not subjected to a hypoxic event). The aim was to examine if mere intoxication with a moderate dose of EtOH is capable of modifying blood metabolic patterns associated with hypoxia or hypercapnia. In the first study during PDs 3-7 EtOH exerted a depressant effect upon breathing frequencies. These animals also showed a progressive sensitization effect relative to the depressant effects of the drug and lesser levels of apneas. At PD 9 dose dependent respiratory depressions were observed when pups were challenged with a hypoxic event. Independently from prior experience with EtOH, drug treatment at PD 9 significantly disrupted respiratory frequencies particularly during the hypoxic and the recovery normoxia phases. Respiratory disorders triggered by these air conditions have been implicated in the pathophysiology of SIDS. These results show that breathing plasticity is disrupted during a critical stage where respiratory alterations may lead to hypoxiaassociated syndromes that endanger brain development. In terms of psychomotor activity, animals exposed to 2.0 g/kg of EtOH at PD 9 showed heightened duration and frequency of grooming. In the second study animals exposed at least one time to EtOH exhibited lower pH and higher CO2 than animals that were never exposed to EtOH. This results suggest metabolic acidosis probably due to EtOH-related hypercapnia during a vulnerable stage in development relative to SIDS.Fil: Anunziata, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Macchione, Ana Fabiola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Angulo Alcalde, Asier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Trujillo, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Wille-bille, Aranza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Amigone, José Luis. Hospital Privado de Córdoba. Laboratorio de Bioquímica Clínica; ArgentinaFil: Molina, Juan Carlos. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaIX LASBRA International Meeting: Determinants of Alcoholism: bridging the gap between epidemiologic and basic researchCórdobaArgentinaLatin American Society for Biomedical Research on AlcoholismDougmar Press2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/178052Sensitization to ethanol’s disruptive effects upon early breathing plasticity associated with hypoxia and hypercapnia; IX LASBRA International Meeting: Determinants of Alcoholism: bridging the gap between epidemiologic and basic research; Córdoba; Argentina; 2019; 56-56CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://jfasrp.com/index.php/JFASRP/article/view/7Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:19:18Zoai:ri.conicet.gov.ar:11336/178052instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:19:19.243CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sensitization to ethanol’s disruptive effects upon early breathing plasticity associated with hypoxia and hypercapnia
title Sensitization to ethanol’s disruptive effects upon early breathing plasticity associated with hypoxia and hypercapnia
spellingShingle Sensitization to ethanol’s disruptive effects upon early breathing plasticity associated with hypoxia and hypercapnia
Anunziata, Florencia
Ethanol
Hypoxia
Hypercapnia
Hyperventilation
Neonates
title_short Sensitization to ethanol’s disruptive effects upon early breathing plasticity associated with hypoxia and hypercapnia
title_full Sensitization to ethanol’s disruptive effects upon early breathing plasticity associated with hypoxia and hypercapnia
title_fullStr Sensitization to ethanol’s disruptive effects upon early breathing plasticity associated with hypoxia and hypercapnia
title_full_unstemmed Sensitization to ethanol’s disruptive effects upon early breathing plasticity associated with hypoxia and hypercapnia
title_sort Sensitization to ethanol’s disruptive effects upon early breathing plasticity associated with hypoxia and hypercapnia
dc.creator.none.fl_str_mv Anunziata, Florencia
Macchione, Ana Fabiola
Angulo Alcalde, Asier
Trujillo, María Verónica
Wille-bille, Aranza
Amigone, José Luis
Molina, Juan Carlos
author Anunziata, Florencia
author_facet Anunziata, Florencia
Macchione, Ana Fabiola
Angulo Alcalde, Asier
Trujillo, María Verónica
Wille-bille, Aranza
Amigone, José Luis
Molina, Juan Carlos
author_role author
author2 Macchione, Ana Fabiola
Angulo Alcalde, Asier
Trujillo, María Verónica
Wille-bille, Aranza
Amigone, José Luis
Molina, Juan Carlos
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Ethanol
Hypoxia
Hypercapnia
Hyperventilation
Neonates
topic Ethanol
Hypoxia
Hypercapnia
Hyperventilation
Neonates
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Ethanol (EtOH) consumption during pregnancy and lactation represents a risk factor related with the Sudden Infant Death Syndrome (SIDS). This phenomenon has promoted research linking prenatal EtOH effects on the respiratory system during early ontogeny. It should also be noted that prolonged episodes of neonatal respiratory depression represent a risk factor in terms of hypoxic-ischemic effects with negative consequences on brain development. In a first study during postnatal day (PD) 9 we analyzed the impact of different doses of EtOH (0.0, 0.75, 1.37 or 2.0 g/kg) upon the respiratory response and the potential psychomotor effects in pup rats pre-exposed or not to 2.0 g/kg of EtOH during PDs 3-7. At PD 9 animals were also subjected to sequential air conditions defined as initial normoxia, hypoxia and recovery normoxia. In a second study we analyzed the blood of animals only exposed to 0.0 or 2.0g/kg of EtOH during PDs 3-9 (not subjected to a hypoxic event). The aim was to examine if mere intoxication with a moderate dose of EtOH is capable of modifying blood metabolic patterns associated with hypoxia or hypercapnia. In the first study during PDs 3-7 EtOH exerted a depressant effect upon breathing frequencies. These animals also showed a progressive sensitization effect relative to the depressant effects of the drug and lesser levels of apneas. At PD 9 dose dependent respiratory depressions were observed when pups were challenged with a hypoxic event. Independently from prior experience with EtOH, drug treatment at PD 9 significantly disrupted respiratory frequencies particularly during the hypoxic and the recovery normoxia phases. Respiratory disorders triggered by these air conditions have been implicated in the pathophysiology of SIDS. These results show that breathing plasticity is disrupted during a critical stage where respiratory alterations may lead to hypoxiaassociated syndromes that endanger brain development. In terms of psychomotor activity, animals exposed to 2.0 g/kg of EtOH at PD 9 showed heightened duration and frequency of grooming. In the second study animals exposed at least one time to EtOH exhibited lower pH and higher CO2 than animals that were never exposed to EtOH. This results suggest metabolic acidosis probably due to EtOH-related hypercapnia during a vulnerable stage in development relative to SIDS.
Fil: Anunziata, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Macchione, Ana Fabiola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Angulo Alcalde, Asier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Trujillo, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Wille-bille, Aranza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Amigone, José Luis. Hospital Privado de Córdoba. Laboratorio de Bioquímica Clínica; Argentina
Fil: Molina, Juan Carlos. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
IX LASBRA International Meeting: Determinants of Alcoholism: bridging the gap between epidemiologic and basic research
Córdoba
Argentina
Latin American Society for Biomedical Research on Alcoholism
description Ethanol (EtOH) consumption during pregnancy and lactation represents a risk factor related with the Sudden Infant Death Syndrome (SIDS). This phenomenon has promoted research linking prenatal EtOH effects on the respiratory system during early ontogeny. It should also be noted that prolonged episodes of neonatal respiratory depression represent a risk factor in terms of hypoxic-ischemic effects with negative consequences on brain development. In a first study during postnatal day (PD) 9 we analyzed the impact of different doses of EtOH (0.0, 0.75, 1.37 or 2.0 g/kg) upon the respiratory response and the potential psychomotor effects in pup rats pre-exposed or not to 2.0 g/kg of EtOH during PDs 3-7. At PD 9 animals were also subjected to sequential air conditions defined as initial normoxia, hypoxia and recovery normoxia. In a second study we analyzed the blood of animals only exposed to 0.0 or 2.0g/kg of EtOH during PDs 3-9 (not subjected to a hypoxic event). The aim was to examine if mere intoxication with a moderate dose of EtOH is capable of modifying blood metabolic patterns associated with hypoxia or hypercapnia. In the first study during PDs 3-7 EtOH exerted a depressant effect upon breathing frequencies. These animals also showed a progressive sensitization effect relative to the depressant effects of the drug and lesser levels of apneas. At PD 9 dose dependent respiratory depressions were observed when pups were challenged with a hypoxic event. Independently from prior experience with EtOH, drug treatment at PD 9 significantly disrupted respiratory frequencies particularly during the hypoxic and the recovery normoxia phases. Respiratory disorders triggered by these air conditions have been implicated in the pathophysiology of SIDS. These results show that breathing plasticity is disrupted during a critical stage where respiratory alterations may lead to hypoxiaassociated syndromes that endanger brain development. In terms of psychomotor activity, animals exposed to 2.0 g/kg of EtOH at PD 9 showed heightened duration and frequency of grooming. In the second study animals exposed at least one time to EtOH exhibited lower pH and higher CO2 than animals that were never exposed to EtOH. This results suggest metabolic acidosis probably due to EtOH-related hypercapnia during a vulnerable stage in development relative to SIDS.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/178052
Sensitization to ethanol’s disruptive effects upon early breathing plasticity associated with hypoxia and hypercapnia; IX LASBRA International Meeting: Determinants of Alcoholism: bridging the gap between epidemiologic and basic research; Córdoba; Argentina; 2019; 56-56
CONICET Digital
CONICET
url http://hdl.handle.net/11336/178052
identifier_str_mv Sensitization to ethanol’s disruptive effects upon early breathing plasticity associated with hypoxia and hypercapnia; IX LASBRA International Meeting: Determinants of Alcoholism: bridging the gap between epidemiologic and basic research; Córdoba; Argentina; 2019; 56-56
CONICET Digital
CONICET
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rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
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application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Dougmar Press
publisher.none.fl_str_mv Dougmar Press
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