Early ethanol exposure elicits ventilatory alterations by a serotonergic phenotype in neonates of rats

Autores
Giacinto, Catalina Lucia; Palmeri, Tomás Mateo Jesús; Macchione, Ana Fabiola
Año de publicación
2023
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Alcohol consumption is highly frequent during pregnancy and lactation. Early ethanol exposure (EEE) affects the development, triggering different neurobehavioral dysfunctions and also affecting respiratory regulation. The serotonergic system modulates the respiratory frequency through efferents towards areas of the brainstem responsible for the generation of the respiratory rhythm.The mains goals of this study are to: i) analyze serotonin-5HT levels in areas of the medullary raphe according to acute or chronic EEE, or also the combination of both, and ii) correlates 5HT levels and plethysmographic recordings against an hypoxic challenge.The results indicate that breathing frequencies depress under any form of EEE. But, first acute ethanol intoxication elicits major breathing depression while the prior ethanol exposure induces ventilatory plasticity phenomena to recover and elevate them. Besides, any form of EEE is associated with an increase in 5HT levels in the medullary raphe nuclei analyzed. In turn, we find a significant association between 5HT levels in the raphe magnus and the ventilatory rates during hypoxia. Actually, higher respiratory frequencies are found in pups with lower 5HT levels in this nucleus. These results allow us to think about how the EEE with a moderate dose (2.0g/kg) induces a serotonergic phenotype that may be affecting the respiratory processes of metaplasticity observed in an hypoxic event.Financial support by FONCyT, CONICET and UNC.
Fil: Giacinto, Catalina Lucia. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Palmeri, Tomás Mateo Jesús. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias
San Luis
Argentina
Sociedad Argentina de Investigación en Neurociencias
Universidad Nacional de San Luis
Materia
Hypoxia
Ethanol
Serotonin
Breathing depression
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/233225
Acceder
id CONICETDig_453f88fcadbca431bec8c0e6f6d97207
oai_identifier_str oai:ri.conicet.gov.ar:11336/233225
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Early ethanol exposure elicits ventilatory alterations by a serotonergic phenotype in neonates of ratsGiacinto, Catalina LuciaPalmeri, Tomás Mateo JesúsMacchione, Ana FabiolaHypoxiaEthanolSerotoninBreathing depressionhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Alcohol consumption is highly frequent during pregnancy and lactation. Early ethanol exposure (EEE) affects the development, triggering different neurobehavioral dysfunctions and also affecting respiratory regulation. The serotonergic system modulates the respiratory frequency through efferents towards areas of the brainstem responsible for the generation of the respiratory rhythm.The mains goals of this study are to: i) analyze serotonin-5HT levels in areas of the medullary raphe according to acute or chronic EEE, or also the combination of both, and ii) correlates 5HT levels and plethysmographic recordings against an hypoxic challenge.The results indicate that breathing frequencies depress under any form of EEE. But, first acute ethanol intoxication elicits major breathing depression while the prior ethanol exposure induces ventilatory plasticity phenomena to recover and elevate them. Besides, any form of EEE is associated with an increase in 5HT levels in the medullary raphe nuclei analyzed. In turn, we find a significant association between 5HT levels in the raphe magnus and the ventilatory rates during hypoxia. Actually, higher respiratory frequencies are found in pups with lower 5HT levels in this nucleus. These results allow us to think about how the EEE with a moderate dose (2.0g/kg) induces a serotonergic phenotype that may be affecting the respiratory processes of metaplasticity observed in an hypoxic event.Financial support by FONCyT, CONICET and UNC.Fil: Giacinto, Catalina Lucia. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Palmeri, Tomás Mateo Jesús. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaXXXVIII Annual Meeting of the Sociedad Argentina de Investigación en NeurocienciasSan LuisArgentinaSociedad Argentina de Investigación en NeurocienciasUniversidad Nacional de San LuisSociedad Argentina de Investigación en Neurociencias2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/233225Early ethanol exposure elicits ventilatory alterations by a serotonergic phenotype in neonates of rats; XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias; San Luis; Argentina; 2023; 321-321CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://csan2023.saneurociencias.org.ar/wp-content/uploads/2023/11/SANebook2023.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:22Zoai:ri.conicet.gov.ar:11336/233225instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:23.004CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Early ethanol exposure elicits ventilatory alterations by a serotonergic phenotype in neonates of rats
title Early ethanol exposure elicits ventilatory alterations by a serotonergic phenotype in neonates of rats
spellingShingle Early ethanol exposure elicits ventilatory alterations by a serotonergic phenotype in neonates of rats
Giacinto, Catalina Lucia
Hypoxia
Ethanol
Serotonin
Breathing depression
title_short Early ethanol exposure elicits ventilatory alterations by a serotonergic phenotype in neonates of rats
title_full Early ethanol exposure elicits ventilatory alterations by a serotonergic phenotype in neonates of rats
title_fullStr Early ethanol exposure elicits ventilatory alterations by a serotonergic phenotype in neonates of rats
title_full_unstemmed Early ethanol exposure elicits ventilatory alterations by a serotonergic phenotype in neonates of rats
title_sort Early ethanol exposure elicits ventilatory alterations by a serotonergic phenotype in neonates of rats
dc.creator.none.fl_str_mv Giacinto, Catalina Lucia
Palmeri, Tomás Mateo Jesús
Macchione, Ana Fabiola
author Giacinto, Catalina Lucia
author_facet Giacinto, Catalina Lucia
Palmeri, Tomás Mateo Jesús
Macchione, Ana Fabiola
author_role author
author2 Palmeri, Tomás Mateo Jesús
Macchione, Ana Fabiola
author2_role author
author
dc.subject.none.fl_str_mv Hypoxia
Ethanol
Serotonin
Breathing depression
topic Hypoxia
Ethanol
Serotonin
Breathing depression
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Alcohol consumption is highly frequent during pregnancy and lactation. Early ethanol exposure (EEE) affects the development, triggering different neurobehavioral dysfunctions and also affecting respiratory regulation. The serotonergic system modulates the respiratory frequency through efferents towards areas of the brainstem responsible for the generation of the respiratory rhythm.The mains goals of this study are to: i) analyze serotonin-5HT levels in areas of the medullary raphe according to acute or chronic EEE, or also the combination of both, and ii) correlates 5HT levels and plethysmographic recordings against an hypoxic challenge.The results indicate that breathing frequencies depress under any form of EEE. But, first acute ethanol intoxication elicits major breathing depression while the prior ethanol exposure induces ventilatory plasticity phenomena to recover and elevate them. Besides, any form of EEE is associated with an increase in 5HT levels in the medullary raphe nuclei analyzed. In turn, we find a significant association between 5HT levels in the raphe magnus and the ventilatory rates during hypoxia. Actually, higher respiratory frequencies are found in pups with lower 5HT levels in this nucleus. These results allow us to think about how the EEE with a moderate dose (2.0g/kg) induces a serotonergic phenotype that may be affecting the respiratory processes of metaplasticity observed in an hypoxic event.Financial support by FONCyT, CONICET and UNC.
Fil: Giacinto, Catalina Lucia. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Palmeri, Tomás Mateo Jesús. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias
San Luis
Argentina
Sociedad Argentina de Investigación en Neurociencias
Universidad Nacional de San Luis
description Alcohol consumption is highly frequent during pregnancy and lactation. Early ethanol exposure (EEE) affects the development, triggering different neurobehavioral dysfunctions and also affecting respiratory regulation. The serotonergic system modulates the respiratory frequency through efferents towards areas of the brainstem responsible for the generation of the respiratory rhythm.The mains goals of this study are to: i) analyze serotonin-5HT levels in areas of the medullary raphe according to acute or chronic EEE, or also the combination of both, and ii) correlates 5HT levels and plethysmographic recordings against an hypoxic challenge.The results indicate that breathing frequencies depress under any form of EEE. But, first acute ethanol intoxication elicits major breathing depression while the prior ethanol exposure induces ventilatory plasticity phenomena to recover and elevate them. Besides, any form of EEE is associated with an increase in 5HT levels in the medullary raphe nuclei analyzed. In turn, we find a significant association between 5HT levels in the raphe magnus and the ventilatory rates during hypoxia. Actually, higher respiratory frequencies are found in pups with lower 5HT levels in this nucleus. These results allow us to think about how the EEE with a moderate dose (2.0g/kg) induces a serotonergic phenotype that may be affecting the respiratory processes of metaplasticity observed in an hypoxic event.Financial support by FONCyT, CONICET and UNC.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/233225
Early ethanol exposure elicits ventilatory alterations by a serotonergic phenotype in neonates of rats; XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias; San Luis; Argentina; 2023; 321-321
CONICET Digital
CONICET
url http://hdl.handle.net/11336/233225
identifier_str_mv Early ethanol exposure elicits ventilatory alterations by a serotonergic phenotype in neonates of rats; XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias; San Luis; Argentina; 2023; 321-321
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://csan2023.saneurociencias.org.ar/wp-content/uploads/2023/11/SANebook2023.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613449215115264
score 13.070432

Publicaciones similares