The Critical Role of Intrinsic Membrane Oscillations

Autores
Lee, Sang-Hun; Urbano Suarez, Francisco Jose; Garcia Rill, Edgar
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Intrinsic, rhythmic subthreshold oscillations have been described in neurons of regions throughout the brain and have been found to influence the timing of action potentials induced by synaptic inputs. Some oscillations are sodium channel-dependent while others are calcium channel-dependent. These oscillations allow neurons to fire coherently at preferred frequencies and represent the main mechanism for maintaining high frequency network activity, especially in the cortex. Because cortical circuits are incapable of maintaining high frequency activity in the gamma range for prolonged periods, those processes dependent on continuous gamma band activity are subserved by subthreshold oscillations. As such, intrinsic oscillations, coupled with synaptic circuits, are essential to prolonged maintenance of such functions as sensory perception and "binding", problem solving, memory, waking, and rapid eye movement (REM) sleep.
Fil: Lee, Sang-Hun. Center For Translational Neuroscience; Estados Unidos
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Garcia Rill, Edgar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Materia
BOTTOM-UP GAMMA
N-TYPE CHANNEL
P/Q-TYPE CHANNEL
PARAFASCICULAR NUCLEUS
PEDUNCULOPONTINE NUCLEUS
SUBCOERULEUS NUCLEUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/89068
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The Critical Role of Intrinsic Membrane OscillationsLee, Sang-HunUrbano Suarez, Francisco JoseGarcia Rill, EdgarBOTTOM-UP GAMMAN-TYPE CHANNELP/Q-TYPE CHANNELPARAFASCICULAR NUCLEUSPEDUNCULOPONTINE NUCLEUSSUBCOERULEUS NUCLEUShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Intrinsic, rhythmic subthreshold oscillations have been described in neurons of regions throughout the brain and have been found to influence the timing of action potentials induced by synaptic inputs. Some oscillations are sodium channel-dependent while others are calcium channel-dependent. These oscillations allow neurons to fire coherently at preferred frequencies and represent the main mechanism for maintaining high frequency network activity, especially in the cortex. Because cortical circuits are incapable of maintaining high frequency activity in the gamma range for prolonged periods, those processes dependent on continuous gamma band activity are subserved by subthreshold oscillations. As such, intrinsic oscillations, coupled with synaptic circuits, are essential to prolonged maintenance of such functions as sensory perception and "binding", problem solving, memory, waking, and rapid eye movement (REM) sleep.Fil: Lee, Sang-Hun. Center For Translational Neuroscience; Estados UnidosFil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Garcia Rill, Edgar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaKarger2019-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/89068Lee, Sang-Hun; Urbano Suarez, Francisco Jose; Garcia Rill, Edgar; The Critical Role of Intrinsic Membrane Oscillations; Karger; Neurosignals; 26; 1; 4-2019; 66-761424-862X1424-8638CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/FullText/493900info:eu-repo/semantics/altIdentifier/doi/10.1159/000493900info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:45:02Zoai:ri.conicet.gov.ar:11336/89068instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:45:03.005CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Critical Role of Intrinsic Membrane Oscillations
title The Critical Role of Intrinsic Membrane Oscillations
spellingShingle The Critical Role of Intrinsic Membrane Oscillations
Lee, Sang-Hun
BOTTOM-UP GAMMA
N-TYPE CHANNEL
P/Q-TYPE CHANNEL
PARAFASCICULAR NUCLEUS
PEDUNCULOPONTINE NUCLEUS
SUBCOERULEUS NUCLEUS
title_short The Critical Role of Intrinsic Membrane Oscillations
title_full The Critical Role of Intrinsic Membrane Oscillations
title_fullStr The Critical Role of Intrinsic Membrane Oscillations
title_full_unstemmed The Critical Role of Intrinsic Membrane Oscillations
title_sort The Critical Role of Intrinsic Membrane Oscillations
dc.creator.none.fl_str_mv Lee, Sang-Hun
Urbano Suarez, Francisco Jose
Garcia Rill, Edgar
author Lee, Sang-Hun
author_facet Lee, Sang-Hun
Urbano Suarez, Francisco Jose
Garcia Rill, Edgar
author_role author
author2 Urbano Suarez, Francisco Jose
Garcia Rill, Edgar
author2_role author
author
dc.subject.none.fl_str_mv BOTTOM-UP GAMMA
N-TYPE CHANNEL
P/Q-TYPE CHANNEL
PARAFASCICULAR NUCLEUS
PEDUNCULOPONTINE NUCLEUS
SUBCOERULEUS NUCLEUS
topic BOTTOM-UP GAMMA
N-TYPE CHANNEL
P/Q-TYPE CHANNEL
PARAFASCICULAR NUCLEUS
PEDUNCULOPONTINE NUCLEUS
SUBCOERULEUS NUCLEUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Intrinsic, rhythmic subthreshold oscillations have been described in neurons of regions throughout the brain and have been found to influence the timing of action potentials induced by synaptic inputs. Some oscillations are sodium channel-dependent while others are calcium channel-dependent. These oscillations allow neurons to fire coherently at preferred frequencies and represent the main mechanism for maintaining high frequency network activity, especially in the cortex. Because cortical circuits are incapable of maintaining high frequency activity in the gamma range for prolonged periods, those processes dependent on continuous gamma band activity are subserved by subthreshold oscillations. As such, intrinsic oscillations, coupled with synaptic circuits, are essential to prolonged maintenance of such functions as sensory perception and "binding", problem solving, memory, waking, and rapid eye movement (REM) sleep.
Fil: Lee, Sang-Hun. Center For Translational Neuroscience; Estados Unidos
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Garcia Rill, Edgar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
description Intrinsic, rhythmic subthreshold oscillations have been described in neurons of regions throughout the brain and have been found to influence the timing of action potentials induced by synaptic inputs. Some oscillations are sodium channel-dependent while others are calcium channel-dependent. These oscillations allow neurons to fire coherently at preferred frequencies and represent the main mechanism for maintaining high frequency network activity, especially in the cortex. Because cortical circuits are incapable of maintaining high frequency activity in the gamma range for prolonged periods, those processes dependent on continuous gamma band activity are subserved by subthreshold oscillations. As such, intrinsic oscillations, coupled with synaptic circuits, are essential to prolonged maintenance of such functions as sensory perception and "binding", problem solving, memory, waking, and rapid eye movement (REM) sleep.
publishDate 2019
dc.date.none.fl_str_mv 2019-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/89068
Lee, Sang-Hun; Urbano Suarez, Francisco Jose; Garcia Rill, Edgar; The Critical Role of Intrinsic Membrane Oscillations; Karger; Neurosignals; 26; 1; 4-2019; 66-76
1424-862X
1424-8638
CONICET Digital
CONICET
url http://hdl.handle.net/11336/89068
identifier_str_mv Lee, Sang-Hun; Urbano Suarez, Francisco Jose; Garcia Rill, Edgar; The Critical Role of Intrinsic Membrane Oscillations; Karger; Neurosignals; 26; 1; 4-2019; 66-76
1424-862X
1424-8638
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/FullText/493900
info:eu-repo/semantics/altIdentifier/doi/10.1159/000493900
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614489123586048
score 13.070432

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