Pedunculopontine arousal system physiology – implications for insomnia

Autores
Garcia Rill, Edgar; Luster, Brennon; Mahaffey, Susan; Bisagno, Veronica; Urbano Suarez, Francisco Jose
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activity during waking and REM sleep is controlled by two different intracellular pathways and channel types in PPN cells. We found three different PPN cell types that have one or both channels and may be active during waking only, REM sleep only, or both. These discoveries point to a specific mechanism and novel therapeutic avenues for insomnia.
Fil: Garcia Rill, Edgar. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Luster, Brennon. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Mahaffey, Susan. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Materia
Calcium channels
Gamma band activity
neuronal calcium sensor protein
N-type calcium channel
P/Q-type calcium channel
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13603
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pedunculopontine arousal system physiology – implications for insomniaGarcia Rill, EdgarLuster, BrennonMahaffey, SusanBisagno, VeronicaUrbano Suarez, Francisco JoseCalcium channelsGamma band activityneuronal calcium sensor proteinN-type calcium channelP/Q-type calcium channelhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activity during waking and REM sleep is controlled by two different intracellular pathways and channel types in PPN cells. We found three different PPN cell types that have one or both channels and may be active during waking only, REM sleep only, or both. These discoveries point to a specific mechanism and novel therapeutic avenues for insomnia.Fil: Garcia Rill, Edgar. University Of Arkansas For Medical Sciences; Estados UnidosFil: Luster, Brennon. University Of Arkansas For Medical Sciences; Estados UnidosFil: Mahaffey, Susan. University Of Arkansas For Medical Sciences; Estados UnidosFil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); ArgentinaFil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaElsevier Science2015-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13603Garcia Rill, Edgar; Luster, Brennon; Mahaffey, Susan; Bisagno, Veronica; Urbano Suarez, Francisco Jose; Pedunculopontine arousal system physiology – implications for insomnia; Elsevier Science; Sleep Science; 8; 2; 4-2015; 92-991984-0063enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S198400631500036Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.slsci.2015.06.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:05:37Zoai:ri.conicet.gov.ar:11336/13603instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:05:37.319CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pedunculopontine arousal system physiology – implications for insomnia
title Pedunculopontine arousal system physiology – implications for insomnia
spellingShingle Pedunculopontine arousal system physiology – implications for insomnia
Garcia Rill, Edgar
Calcium channels
Gamma band activity
neuronal calcium sensor protein
N-type calcium channel
P/Q-type calcium channel
title_short Pedunculopontine arousal system physiology – implications for insomnia
title_full Pedunculopontine arousal system physiology – implications for insomnia
title_fullStr Pedunculopontine arousal system physiology – implications for insomnia
title_full_unstemmed Pedunculopontine arousal system physiology – implications for insomnia
title_sort Pedunculopontine arousal system physiology – implications for insomnia
dc.creator.none.fl_str_mv Garcia Rill, Edgar
Luster, Brennon
Mahaffey, Susan
Bisagno, Veronica
Urbano Suarez, Francisco Jose
author Garcia Rill, Edgar
author_facet Garcia Rill, Edgar
Luster, Brennon
Mahaffey, Susan
Bisagno, Veronica
Urbano Suarez, Francisco Jose
author_role author
author2 Luster, Brennon
Mahaffey, Susan
Bisagno, Veronica
Urbano Suarez, Francisco Jose
author2_role author
author
author
author
dc.subject.none.fl_str_mv Calcium channels
Gamma band activity
neuronal calcium sensor protein
N-type calcium channel
P/Q-type calcium channel
topic Calcium channels
Gamma band activity
neuronal calcium sensor protein
N-type calcium channel
P/Q-type calcium channel
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activity during waking and REM sleep is controlled by two different intracellular pathways and channel types in PPN cells. We found three different PPN cell types that have one or both channels and may be active during waking only, REM sleep only, or both. These discoveries point to a specific mechanism and novel therapeutic avenues for insomnia.
Fil: Garcia Rill, Edgar. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Luster, Brennon. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Mahaffey, Susan. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
description We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activity during waking and REM sleep is controlled by two different intracellular pathways and channel types in PPN cells. We found three different PPN cell types that have one or both channels and may be active during waking only, REM sleep only, or both. These discoveries point to a specific mechanism and novel therapeutic avenues for insomnia.
publishDate 2015
dc.date.none.fl_str_mv 2015-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13603
Garcia Rill, Edgar; Luster, Brennon; Mahaffey, Susan; Bisagno, Veronica; Urbano Suarez, Francisco Jose; Pedunculopontine arousal system physiology – implications for insomnia; Elsevier Science; Sleep Science; 8; 2; 4-2015; 92-99
1984-0063
url http://hdl.handle.net/11336/13603
identifier_str_mv Garcia Rill, Edgar; Luster, Brennon; Mahaffey, Susan; Bisagno, Veronica; Urbano Suarez, Francisco Jose; Pedunculopontine arousal system physiology – implications for insomnia; Elsevier Science; Sleep Science; 8; 2; 4-2015; 92-99
1984-0063
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S198400631500036X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.slsci.2015.06.002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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