Maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant women
- Autores
- Garces, María Fernanda; Rodriguez Navarro, Haiver Antonio; Buell Acosta, Julieth Daniela; Burgos Cardenas, Alvaro Javier; Franco Vega, Roberto; Maldonado Acosta, Luis Miguel; Eslava Schmalbach, Javier; Parada Baños, Arturo José; Castro Pinzon, Andres; Sanchez, Elizabeth; Angel Muller, Edith; Lacunza, Ezequiel; Castaño, Justo P.; Dieguez, Carlos; Nogueiras, Rubén; Ruiz Parra, Ariel Ivan; Caminos, Jorge Eduardo
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Objective: Angiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues. However, the possible role of ANGPTL3 throughout gestation and its relationship with hormonal and biochemical variables are still unknown. The aim of this study was to determinate serum ANGPTL3 level in healthy non-pregnant women, during healthy and preeclamptic pregnancy and postpartum. Methods: Serum ANGPTL3 was analyzed by enzyme-linked immunosorbent assay (ELISA), in a prospective cohort of healthy pregnant women (n = 52) and women with mild preeclampsia (n = 21), and women at three months postpartum (n = 20) and healthy non-pregnant women (n = 20). The results obtained were correlated with biochemical, hormonal and anthropometric variables and insulin resistance indices. Results: Levels of ANGPTL3 were not different between the follicular and the luteal phases of the cycle in healthy non-pregnant women. There was a significant reduction in serum ANGPTL3 levels from the first to the third trimester in healthy pregnant women compared with healthy non-pregnant and postpartum women (p <0.01). ANGPTL3 levels do not differ significantly during the three trimesters of pregnancy neither in healthy women nor in preeclamptic women. The serum levels of ANGPTL3 in women who developed preeclampsia are not statistically different from those observed in healthy pregnant women in each trimester of pregnancy. A significant lineal positive correlation was observed between serum ANGPTL3 levels and triglyceride (P =0.0186, r =0.52), very low-density lipoprotein cholesterol (P =0.0224, r =0.50), and total cholesterol levels (P =0.0220, r =0.50) in healthy non-pregnant women (P 0.05). Besides, there were no significant correlations between serum ANGPTL3 and body mass index (BMI), high-density lipoprotein cholesterol, glucose, insulin, leptin, or HOMA-IR (P >0.05) Conclusions: We describe for the first time the profile of ANGPTL3 throughout pregnancy and postpartum as well as and discussed about explore their potential contribution interactions with lipoprotein metabolism throughout pregnancy and postpartum. Thus, low levels of ANGPTL3 during pregnancy might favor lipid uptake in oxidative tissues as the main maternal energy source, while may helping to preserve glucose for use by the fetus and placenta.
Fil: Garces, María Fernanda. Universidad Nacional de Colombia; Colombia
Fil: Rodriguez Navarro, Haiver Antonio. Universidad Nacional de Colombia; Colombia
Fil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia; Colombia
Fil: Burgos Cardenas, Alvaro Javier. Universidad Nacional de Colombia; Colombia
Fil: Franco Vega, Roberto. Universidad Nacional de Colombia; Colombia
Fil: Maldonado Acosta, Luis Miguel. Universidad Nacional de Colombia; Colombia
Fil: Eslava Schmalbach, Javier. Universidad Nacional de Colombia; Colombia
Fil: Parada Baños, Arturo José. Universidad Nacional de Colombia; Colombia
Fil: Castro Pinzon, Andres. Universidad Nacional de Colombia; Colombia
Fil: Sanchez, Elizabeth. Universidad Nacional de Colombia; Colombia
Fil: Angel Muller, Edith. Universidad Nacional de Colombia; Colombia
Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Castaño, Justo P.. Universidad de Córdoba; España
Fil: Dieguez, Carlos. Universidad de Santiago de Compostela; España
Fil: Nogueiras, Rubén. Universidad de Santiago de Compostela; España
Fil: Ruiz Parra, Ariel Ivan. Universidad Nacional de Colombia; Colombia
Fil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia; Colombia - Materia
-
ANGPTL
ANGPTL3
INSULIN RESISTANCE
PREECLAMPSIA
PREGNANCY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/152888
Ver los metadatos del registro completo
| id |
CONICETDig_603b23f5ce920a2bb1c0b78cc4451378 |
|---|---|
| oai_identifier_str |
oai:ri.conicet.gov.ar:11336/152888 |
| network_acronym_str |
CONICETDig |
| repository_id_str |
3498 |
| network_name_str |
CONICET Digital (CONICET) |
| spelling |
Maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant womenGarces, María FernandaRodriguez Navarro, Haiver AntonioBuell Acosta, Julieth DanielaBurgos Cardenas, Alvaro JavierFranco Vega, RobertoMaldonado Acosta, Luis MiguelEslava Schmalbach, JavierParada Baños, Arturo JoséCastro Pinzon, AndresSanchez, ElizabethAngel Muller, EdithLacunza, EzequielCastaño, Justo P.Dieguez, CarlosNogueiras, RubénRuiz Parra, Ariel IvanCaminos, Jorge EduardoANGPTLANGPTL3INSULIN RESISTANCEPREECLAMPSIAPREGNANCYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Objective: Angiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues. However, the possible role of ANGPTL3 throughout gestation and its relationship with hormonal and biochemical variables are still unknown. The aim of this study was to determinate serum ANGPTL3 level in healthy non-pregnant women, during healthy and preeclamptic pregnancy and postpartum. Methods: Serum ANGPTL3 was analyzed by enzyme-linked immunosorbent assay (ELISA), in a prospective cohort of healthy pregnant women (n = 52) and women with mild preeclampsia (n = 21), and women at three months postpartum (n = 20) and healthy non-pregnant women (n = 20). The results obtained were correlated with biochemical, hormonal and anthropometric variables and insulin resistance indices. Results: Levels of ANGPTL3 were not different between the follicular and the luteal phases of the cycle in healthy non-pregnant women. There was a significant reduction in serum ANGPTL3 levels from the first to the third trimester in healthy pregnant women compared with healthy non-pregnant and postpartum women (p <0.01). ANGPTL3 levels do not differ significantly during the three trimesters of pregnancy neither in healthy women nor in preeclamptic women. The serum levels of ANGPTL3 in women who developed preeclampsia are not statistically different from those observed in healthy pregnant women in each trimester of pregnancy. A significant lineal positive correlation was observed between serum ANGPTL3 levels and triglyceride (P =0.0186, r =0.52), very low-density lipoprotein cholesterol (P =0.0224, r =0.50), and total cholesterol levels (P =0.0220, r =0.50) in healthy non-pregnant women (P 0.05). Besides, there were no significant correlations between serum ANGPTL3 and body mass index (BMI), high-density lipoprotein cholesterol, glucose, insulin, leptin, or HOMA-IR (P >0.05) Conclusions: We describe for the first time the profile of ANGPTL3 throughout pregnancy and postpartum as well as and discussed about explore their potential contribution interactions with lipoprotein metabolism throughout pregnancy and postpartum. Thus, low levels of ANGPTL3 during pregnancy might favor lipid uptake in oxidative tissues as the main maternal energy source, while may helping to preserve glucose for use by the fetus and placenta.Fil: Garces, María Fernanda. Universidad Nacional de Colombia; ColombiaFil: Rodriguez Navarro, Haiver Antonio. Universidad Nacional de Colombia; ColombiaFil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia; ColombiaFil: Burgos Cardenas, Alvaro Javier. Universidad Nacional de Colombia; ColombiaFil: Franco Vega, Roberto. Universidad Nacional de Colombia; ColombiaFil: Maldonado Acosta, Luis Miguel. Universidad Nacional de Colombia; ColombiaFil: Eslava Schmalbach, Javier. Universidad Nacional de Colombia; ColombiaFil: Parada Baños, Arturo José. Universidad Nacional de Colombia; ColombiaFil: Castro Pinzon, Andres. Universidad Nacional de Colombia; ColombiaFil: Sanchez, Elizabeth. Universidad Nacional de Colombia; ColombiaFil: Angel Muller, Edith. Universidad Nacional de Colombia; ColombiaFil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Castaño, Justo P.. Universidad de Córdoba; EspañaFil: Dieguez, Carlos. Universidad de Santiago de Compostela; EspañaFil: Nogueiras, Rubén. Universidad de Santiago de Compostela; EspañaFil: Ruiz Parra, Ariel Ivan. Universidad Nacional de Colombia; ColombiaFil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia; ColombiaFrontiers Media S.A.2021-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/152888Garces, María Fernanda; Rodriguez Navarro, Haiver Antonio; Buell Acosta, Julieth Daniela; Burgos Cardenas, Alvaro Javier; Franco Vega, Roberto; et al.; Maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant women; Frontiers Media S.A.; Frontiers in Endocrinology; 12; 670357; 4-2021; 1-81664-2392CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fendo.2021.670357info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fendo.2021.670357/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:52:16Zoai:ri.conicet.gov.ar:11336/152888instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:52:16.578CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant women |
| title |
Maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant women |
| spellingShingle |
Maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant women Garces, María Fernanda ANGPTL ANGPTL3 INSULIN RESISTANCE PREECLAMPSIA PREGNANCY |
| title_short |
Maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant women |
| title_full |
Maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant women |
| title_fullStr |
Maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant women |
| title_full_unstemmed |
Maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant women |
| title_sort |
Maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant women |
| dc.creator.none.fl_str_mv |
Garces, María Fernanda Rodriguez Navarro, Haiver Antonio Buell Acosta, Julieth Daniela Burgos Cardenas, Alvaro Javier Franco Vega, Roberto Maldonado Acosta, Luis Miguel Eslava Schmalbach, Javier Parada Baños, Arturo José Castro Pinzon, Andres Sanchez, Elizabeth Angel Muller, Edith Lacunza, Ezequiel Castaño, Justo P. Dieguez, Carlos Nogueiras, Rubén Ruiz Parra, Ariel Ivan Caminos, Jorge Eduardo |
| author |
Garces, María Fernanda |
| author_facet |
Garces, María Fernanda Rodriguez Navarro, Haiver Antonio Buell Acosta, Julieth Daniela Burgos Cardenas, Alvaro Javier Franco Vega, Roberto Maldonado Acosta, Luis Miguel Eslava Schmalbach, Javier Parada Baños, Arturo José Castro Pinzon, Andres Sanchez, Elizabeth Angel Muller, Edith Lacunza, Ezequiel Castaño, Justo P. Dieguez, Carlos Nogueiras, Rubén Ruiz Parra, Ariel Ivan Caminos, Jorge Eduardo |
| author_role |
author |
| author2 |
Rodriguez Navarro, Haiver Antonio Buell Acosta, Julieth Daniela Burgos Cardenas, Alvaro Javier Franco Vega, Roberto Maldonado Acosta, Luis Miguel Eslava Schmalbach, Javier Parada Baños, Arturo José Castro Pinzon, Andres Sanchez, Elizabeth Angel Muller, Edith Lacunza, Ezequiel Castaño, Justo P. Dieguez, Carlos Nogueiras, Rubén Ruiz Parra, Ariel Ivan Caminos, Jorge Eduardo |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
ANGPTL ANGPTL3 INSULIN RESISTANCE PREECLAMPSIA PREGNANCY |
| topic |
ANGPTL ANGPTL3 INSULIN RESISTANCE PREECLAMPSIA PREGNANCY |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
Objective: Angiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues. However, the possible role of ANGPTL3 throughout gestation and its relationship with hormonal and biochemical variables are still unknown. The aim of this study was to determinate serum ANGPTL3 level in healthy non-pregnant women, during healthy and preeclamptic pregnancy and postpartum. Methods: Serum ANGPTL3 was analyzed by enzyme-linked immunosorbent assay (ELISA), in a prospective cohort of healthy pregnant women (n = 52) and women with mild preeclampsia (n = 21), and women at three months postpartum (n = 20) and healthy non-pregnant women (n = 20). The results obtained were correlated with biochemical, hormonal and anthropometric variables and insulin resistance indices. Results: Levels of ANGPTL3 were not different between the follicular and the luteal phases of the cycle in healthy non-pregnant women. There was a significant reduction in serum ANGPTL3 levels from the first to the third trimester in healthy pregnant women compared with healthy non-pregnant and postpartum women (p <0.01). ANGPTL3 levels do not differ significantly during the three trimesters of pregnancy neither in healthy women nor in preeclamptic women. The serum levels of ANGPTL3 in women who developed preeclampsia are not statistically different from those observed in healthy pregnant women in each trimester of pregnancy. A significant lineal positive correlation was observed between serum ANGPTL3 levels and triglyceride (P =0.0186, r =0.52), very low-density lipoprotein cholesterol (P =0.0224, r =0.50), and total cholesterol levels (P =0.0220, r =0.50) in healthy non-pregnant women (P 0.05). Besides, there were no significant correlations between serum ANGPTL3 and body mass index (BMI), high-density lipoprotein cholesterol, glucose, insulin, leptin, or HOMA-IR (P >0.05) Conclusions: We describe for the first time the profile of ANGPTL3 throughout pregnancy and postpartum as well as and discussed about explore their potential contribution interactions with lipoprotein metabolism throughout pregnancy and postpartum. Thus, low levels of ANGPTL3 during pregnancy might favor lipid uptake in oxidative tissues as the main maternal energy source, while may helping to preserve glucose for use by the fetus and placenta. Fil: Garces, María Fernanda. Universidad Nacional de Colombia; Colombia Fil: Rodriguez Navarro, Haiver Antonio. Universidad Nacional de Colombia; Colombia Fil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia; Colombia Fil: Burgos Cardenas, Alvaro Javier. Universidad Nacional de Colombia; Colombia Fil: Franco Vega, Roberto. Universidad Nacional de Colombia; Colombia Fil: Maldonado Acosta, Luis Miguel. Universidad Nacional de Colombia; Colombia Fil: Eslava Schmalbach, Javier. Universidad Nacional de Colombia; Colombia Fil: Parada Baños, Arturo José. Universidad Nacional de Colombia; Colombia Fil: Castro Pinzon, Andres. Universidad Nacional de Colombia; Colombia Fil: Sanchez, Elizabeth. Universidad Nacional de Colombia; Colombia Fil: Angel Muller, Edith. Universidad Nacional de Colombia; Colombia Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Castaño, Justo P.. Universidad de Córdoba; España Fil: Dieguez, Carlos. Universidad de Santiago de Compostela; España Fil: Nogueiras, Rubén. Universidad de Santiago de Compostela; España Fil: Ruiz Parra, Ariel Ivan. Universidad Nacional de Colombia; Colombia Fil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia; Colombia |
| description |
Objective: Angiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues. However, the possible role of ANGPTL3 throughout gestation and its relationship with hormonal and biochemical variables are still unknown. The aim of this study was to determinate serum ANGPTL3 level in healthy non-pregnant women, during healthy and preeclamptic pregnancy and postpartum. Methods: Serum ANGPTL3 was analyzed by enzyme-linked immunosorbent assay (ELISA), in a prospective cohort of healthy pregnant women (n = 52) and women with mild preeclampsia (n = 21), and women at three months postpartum (n = 20) and healthy non-pregnant women (n = 20). The results obtained were correlated with biochemical, hormonal and anthropometric variables and insulin resistance indices. Results: Levels of ANGPTL3 were not different between the follicular and the luteal phases of the cycle in healthy non-pregnant women. There was a significant reduction in serum ANGPTL3 levels from the first to the third trimester in healthy pregnant women compared with healthy non-pregnant and postpartum women (p <0.01). ANGPTL3 levels do not differ significantly during the three trimesters of pregnancy neither in healthy women nor in preeclamptic women. The serum levels of ANGPTL3 in women who developed preeclampsia are not statistically different from those observed in healthy pregnant women in each trimester of pregnancy. A significant lineal positive correlation was observed between serum ANGPTL3 levels and triglyceride (P =0.0186, r =0.52), very low-density lipoprotein cholesterol (P =0.0224, r =0.50), and total cholesterol levels (P =0.0220, r =0.50) in healthy non-pregnant women (P 0.05). Besides, there were no significant correlations between serum ANGPTL3 and body mass index (BMI), high-density lipoprotein cholesterol, glucose, insulin, leptin, or HOMA-IR (P >0.05) Conclusions: We describe for the first time the profile of ANGPTL3 throughout pregnancy and postpartum as well as and discussed about explore their potential contribution interactions with lipoprotein metabolism throughout pregnancy and postpartum. Thus, low levels of ANGPTL3 during pregnancy might favor lipid uptake in oxidative tissues as the main maternal energy source, while may helping to preserve glucose for use by the fetus and placenta. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-04 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/152888 Garces, María Fernanda; Rodriguez Navarro, Haiver Antonio; Buell Acosta, Julieth Daniela; Burgos Cardenas, Alvaro Javier; Franco Vega, Roberto; et al.; Maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant women; Frontiers Media S.A.; Frontiers in Endocrinology; 12; 670357; 4-2021; 1-8 1664-2392 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/152888 |
| identifier_str_mv |
Garces, María Fernanda; Rodriguez Navarro, Haiver Antonio; Buell Acosta, Julieth Daniela; Burgos Cardenas, Alvaro Javier; Franco Vega, Roberto; et al.; Maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant women; Frontiers Media S.A.; Frontiers in Endocrinology; 12; 670357; 4-2021; 1-8 1664-2392 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.3389/fendo.2021.670357 info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fendo.2021.670357/full |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Frontiers Media S.A. |
| publisher.none.fl_str_mv |
Frontiers Media S.A. |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1846083050467753984 |
| score |
13.22299 |