Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test

Autores
Garcés, Maria Fernanda; Buell Acosta, Julieth Daniela; Rodríguez Navarro, Haiver Antonio; Pulido Sánchez, Estefania; Rincon Ramírez, Juan José; Moreno Ordóñez, Diana Carolina; Franco Vega, Roberto; Roncancio Muñoz, Jhoan Sebastian; Burgos Cardenas, Alvaro Javier; Lacunza, Ezequiel; Castaño, Justo P.; Diéguez, Carlos; Nogueiras, Rubén; Sanchez, Elizabeth; Caminos, Jorge Eduardo
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case–control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m2) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m2) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3–area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3–AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride—glucose index. Moreover, ANGPTL3–AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.
Fil: Garcés, Maria Fernanda. Universidad Nacional de Colombia; Colombia
Fil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia; Colombia
Fil: Rodríguez Navarro, Haiver Antonio. Universidad Nacional de Colombia; Colombia
Fil: Pulido Sánchez, Estefania. Universidad Nacional de Colombia; Colombia
Fil: Rincon Ramírez, Juan José. Universidad Nacional de Colombia; Colombia
Fil: Moreno Ordóñez, Diana Carolina. Universidad Nacional de Colombia; Colombia
Fil: Franco Vega, Roberto. Universidad Nacional de Colombia; Colombia
Fil: Roncancio Muñoz, Jhoan Sebastian. Universidad Nacional de Colombia; Colombia
Fil: Burgos Cardenas, Alvaro Javier. Universidad Nacional de Colombia; Colombia
Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Castaño, Justo P.. Universidad de Córdoba; España
Fil: Diéguez, Carlos. Universidad de Santiago de Compostela; España
Fil: Nogueiras, Rubén. Universidad de Santiago de Compostela; España
Fil: Sanchez, Elizabeth. Universidad Nacional de Colombia; Colombia
Fil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia; Colombia
Materia
ANGPTL3
SERUM
OBESITY
DIABETES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/173552
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/173552
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance testGarcés, Maria FernandaBuell Acosta, Julieth DanielaRodríguez Navarro, Haiver AntonioPulido Sánchez, EstefaniaRincon Ramírez, Juan JoséMoreno Ordóñez, Diana CarolinaFranco Vega, RobertoRoncancio Muñoz, Jhoan SebastianBurgos Cardenas, Alvaro JavierLacunza, EzequielCastaño, Justo P.Diéguez, CarlosNogueiras, RubénSanchez, ElizabethCaminos, Jorge EduardoANGPTL3SERUMOBESITYDIABETEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case–control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m2) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m2) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3–area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3–AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride—glucose index. Moreover, ANGPTL3–AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.Fil: Garcés, Maria Fernanda. Universidad Nacional de Colombia; ColombiaFil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia; ColombiaFil: Rodríguez Navarro, Haiver Antonio. Universidad Nacional de Colombia; ColombiaFil: Pulido Sánchez, Estefania. Universidad Nacional de Colombia; ColombiaFil: Rincon Ramírez, Juan José. Universidad Nacional de Colombia; ColombiaFil: Moreno Ordóñez, Diana Carolina. Universidad Nacional de Colombia; ColombiaFil: Franco Vega, Roberto. Universidad Nacional de Colombia; ColombiaFil: Roncancio Muñoz, Jhoan Sebastian. Universidad Nacional de Colombia; ColombiaFil: Burgos Cardenas, Alvaro Javier. Universidad Nacional de Colombia; ColombiaFil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Castaño, Justo P.. Universidad de Córdoba; EspañaFil: Diéguez, Carlos. Universidad de Santiago de Compostela; EspañaFil: Nogueiras, Rubén. Universidad de Santiago de Compostela; EspañaFil: Sanchez, Elizabeth. Universidad Nacional de Colombia; ColombiaFil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia; ColombiaNature Publishing Group2020-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/173552Garcés, Maria Fernanda; Buell Acosta, Julieth Daniela; Rodríguez Navarro, Haiver Antonio; Pulido Sánchez, Estefania; Rincon Ramírez, Juan José; et al.; Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test; Nature Publishing Group; Scientific Reports; 10; 1; 12-2020; 1-92045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-77961-8info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-020-77961-8info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:28:06Zoai:ri.conicet.gov.ar:11336/173552instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:28:06.365CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
title Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
spellingShingle Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
Garcés, Maria Fernanda
ANGPTL3
SERUM
OBESITY
DIABETES
title_short Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
title_full Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
title_fullStr Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
title_full_unstemmed Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
title_sort Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
dc.creator.none.fl_str_mv Garcés, Maria Fernanda
Buell Acosta, Julieth Daniela
Rodríguez Navarro, Haiver Antonio
Pulido Sánchez, Estefania
Rincon Ramírez, Juan José
Moreno Ordóñez, Diana Carolina
Franco Vega, Roberto
Roncancio Muñoz, Jhoan Sebastian
Burgos Cardenas, Alvaro Javier
Lacunza, Ezequiel
Castaño, Justo P.
Diéguez, Carlos
Nogueiras, Rubén
Sanchez, Elizabeth
Caminos, Jorge Eduardo
author Garcés, Maria Fernanda
author_facet Garcés, Maria Fernanda
Buell Acosta, Julieth Daniela
Rodríguez Navarro, Haiver Antonio
Pulido Sánchez, Estefania
Rincon Ramírez, Juan José
Moreno Ordóñez, Diana Carolina
Franco Vega, Roberto
Roncancio Muñoz, Jhoan Sebastian
Burgos Cardenas, Alvaro Javier
Lacunza, Ezequiel
Castaño, Justo P.
Diéguez, Carlos
Nogueiras, Rubén
Sanchez, Elizabeth
Caminos, Jorge Eduardo
author_role author
author2 Buell Acosta, Julieth Daniela
Rodríguez Navarro, Haiver Antonio
Pulido Sánchez, Estefania
Rincon Ramírez, Juan José
Moreno Ordóñez, Diana Carolina
Franco Vega, Roberto
Roncancio Muñoz, Jhoan Sebastian
Burgos Cardenas, Alvaro Javier
Lacunza, Ezequiel
Castaño, Justo P.
Diéguez, Carlos
Nogueiras, Rubén
Sanchez, Elizabeth
Caminos, Jorge Eduardo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANGPTL3
SERUM
OBESITY
DIABETES
topic ANGPTL3
SERUM
OBESITY
DIABETES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case–control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m2) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m2) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3–area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3–AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride—glucose index. Moreover, ANGPTL3–AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.
Fil: Garcés, Maria Fernanda. Universidad Nacional de Colombia; Colombia
Fil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia; Colombia
Fil: Rodríguez Navarro, Haiver Antonio. Universidad Nacional de Colombia; Colombia
Fil: Pulido Sánchez, Estefania. Universidad Nacional de Colombia; Colombia
Fil: Rincon Ramírez, Juan José. Universidad Nacional de Colombia; Colombia
Fil: Moreno Ordóñez, Diana Carolina. Universidad Nacional de Colombia; Colombia
Fil: Franco Vega, Roberto. Universidad Nacional de Colombia; Colombia
Fil: Roncancio Muñoz, Jhoan Sebastian. Universidad Nacional de Colombia; Colombia
Fil: Burgos Cardenas, Alvaro Javier. Universidad Nacional de Colombia; Colombia
Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Castaño, Justo P.. Universidad de Córdoba; España
Fil: Diéguez, Carlos. Universidad de Santiago de Compostela; España
Fil: Nogueiras, Rubén. Universidad de Santiago de Compostela; España
Fil: Sanchez, Elizabeth. Universidad Nacional de Colombia; Colombia
Fil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia; Colombia
description This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case–control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m2) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m2) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3–area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3–AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride—glucose index. Moreover, ANGPTL3–AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.
publishDate 2020
dc.date.none.fl_str_mv 2020-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/173552
Garcés, Maria Fernanda; Buell Acosta, Julieth Daniela; Rodríguez Navarro, Haiver Antonio; Pulido Sánchez, Estefania; Rincon Ramírez, Juan José; et al.; Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test; Nature Publishing Group; Scientific Reports; 10; 1; 12-2020; 1-9
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/173552
identifier_str_mv Garcés, Maria Fernanda; Buell Acosta, Julieth Daniela; Rodríguez Navarro, Haiver Antonio; Pulido Sánchez, Estefania; Rincon Ramírez, Juan José; et al.; Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test; Nature Publishing Group; Scientific Reports; 10; 1; 12-2020; 1-9
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-77961-8
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-020-77961-8
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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