Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study

Autores
Buell Acosta, Julieth Daniela; Garces, Maria Fernanda; Parada Baños, Arturo José; Angel Muller, Edith; Paez, Maria Carolina; Eslava Schmalbach, Javier; Escobar Cordoba, Franklin; Caminos Cepeda, Sofia Alexandra; Lacunza, Ezequiel; Castaño, Justo P.; Nogueiras, Rubén; Dieguez, Carlos; Ruiz Parra, Ariel Iván; Caminos, Jorge Eduardo
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Fibroblast growth factor 21 (FGF-21) is an endocrine factor involved in glucose and lipid metabolism that exerts pleiotropic effects. The aim of this study was to investigate the serum FGF-21 profile in healthy and mild preeclamptic pregnant women at each trimester of pregnancy; (2) Methods: Serum FGF-21 levels were determined by ELISA in a nested case-control study within a longitudinal cohort study that included healthy (n = 54) and mild preeclamptic (n = 20) pregnant women, women at three months after delivery (n = 20) and eumenorrheic women during the menstrual cycle (n = 20); (3) Results: FGF-21 levels were significantly lower in the mid-luteal phase compared to the early follicular phase of the menstrual cycle in eumenorrheic women (p < 0.01). Maternal levels of FGF-21 were significantly lower in the first and second trimesters and peaked during the third trimester in healthy pregnant women (p < 0.01). Serum levels of FGF-21 in healthy pregnant were significantly lower in the first and second trimester of pregnancy compared with the follicular phase of the menstrual cycle and postpartum (p < 0.01). Serum FGF-21 levels were significantly higher in preeclamptic compared to healthy pregnant women during pregnancy (p < 0.01); (4) Conclusions: These results suggest that a peak of FGF-21 towards the end of pregnancy in healthy pregnancy and higher levels in preeclamptic women might play a critical role that contributes to protecting against the negatives effects of high concentrations of non-esterified fatty acids (NEFA) and hypertensive disorder. Furthermore, FGF-21 might play an important role in reproductive function in healthy eumenorrheic women during the menstrual cycle.
Fil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia; Colombia
Fil: Garces, Maria Fernanda. Universidad Nacional de Colombia; Colombia
Fil: Parada Baños, Arturo José. Universidad Nacional de Colombia; Colombia
Fil: Angel Muller, Edith. Universidad Nacional de Colombia; Colombia
Fil: Paez, Maria Carolina. Universidad Nacional de Colombia; Colombia
Fil: Eslava Schmalbach, Javier. Universidad Nacional de Colombia; Colombia
Fil: Escobar Cordoba, Franklin. Universidad Nacional de Colombia; Colombia
Fil: Caminos Cepeda, Sofia Alexandra. Universitat Pompeu Fabra; España
Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Castaño, Justo P.. Universidad Nacional de Colombia; Colombia
Fil: Nogueiras, Rubén. Instituto de Salud Carlos III; España
Fil: Dieguez, Carlos. Instituto de Salud Carlos III; España
Fil: Ruiz Parra, Ariel Iván. Universidad Nacional de Colombia; Colombia
Fil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia; Colombia
Materia
FGF-21
MENSTRUAL CYCLE
PREECLAMPSIA
PREGNANCY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/217285
Acceder
id CONICETDig_45669a70a85b04bf88f57d2eac2dfa00
oai_identifier_str oai:ri.conicet.gov.ar:11336/217285
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal StudyBuell Acosta, Julieth DanielaGarces, Maria FernandaParada Baños, Arturo JoséAngel Muller, EdithPaez, Maria CarolinaEslava Schmalbach, JavierEscobar Cordoba, FranklinCaminos Cepeda, Sofia AlexandraLacunza, EzequielCastaño, Justo P.Nogueiras, RubénDieguez, CarlosRuiz Parra, Ariel IvánCaminos, Jorge EduardoFGF-21MENSTRUAL CYCLEPREECLAMPSIAPREGNANCYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: Fibroblast growth factor 21 (FGF-21) is an endocrine factor involved in glucose and lipid metabolism that exerts pleiotropic effects. The aim of this study was to investigate the serum FGF-21 profile in healthy and mild preeclamptic pregnant women at each trimester of pregnancy; (2) Methods: Serum FGF-21 levels were determined by ELISA in a nested case-control study within a longitudinal cohort study that included healthy (n = 54) and mild preeclamptic (n = 20) pregnant women, women at three months after delivery (n = 20) and eumenorrheic women during the menstrual cycle (n = 20); (3) Results: FGF-21 levels were significantly lower in the mid-luteal phase compared to the early follicular phase of the menstrual cycle in eumenorrheic women (p < 0.01). Maternal levels of FGF-21 were significantly lower in the first and second trimesters and peaked during the third trimester in healthy pregnant women (p < 0.01). Serum levels of FGF-21 in healthy pregnant were significantly lower in the first and second trimester of pregnancy compared with the follicular phase of the menstrual cycle and postpartum (p < 0.01). Serum FGF-21 levels were significantly higher in preeclamptic compared to healthy pregnant women during pregnancy (p < 0.01); (4) Conclusions: These results suggest that a peak of FGF-21 towards the end of pregnancy in healthy pregnancy and higher levels in preeclamptic women might play a critical role that contributes to protecting against the negatives effects of high concentrations of non-esterified fatty acids (NEFA) and hypertensive disorder. Furthermore, FGF-21 might play an important role in reproductive function in healthy eumenorrheic women during the menstrual cycle.Fil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia; ColombiaFil: Garces, Maria Fernanda. Universidad Nacional de Colombia; ColombiaFil: Parada Baños, Arturo José. Universidad Nacional de Colombia; ColombiaFil: Angel Muller, Edith. Universidad Nacional de Colombia; ColombiaFil: Paez, Maria Carolina. Universidad Nacional de Colombia; ColombiaFil: Eslava Schmalbach, Javier. Universidad Nacional de Colombia; ColombiaFil: Escobar Cordoba, Franklin. Universidad Nacional de Colombia; ColombiaFil: Caminos Cepeda, Sofia Alexandra. Universitat Pompeu Fabra; EspañaFil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Castaño, Justo P.. Universidad Nacional de Colombia; ColombiaFil: Nogueiras, Rubén. Instituto de Salud Carlos III; EspañaFil: Dieguez, Carlos. Instituto de Salud Carlos III; EspañaFil: Ruiz Parra, Ariel Iván. Universidad Nacional de Colombia; ColombiaFil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia; ColombiaMDPI2022-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/217285Buell Acosta, Julieth Daniela; Garces, Maria Fernanda; Parada Baños, Arturo José; Angel Muller, Edith; Paez, Maria Carolina; et al.; Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study; MDPI; Cells; 11; 14; 7-2022; 1-152073-44092073-4409CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/cells11142251info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:42Zoai:ri.conicet.gov.ar:11336/217285instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:43.212CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study
title Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study
spellingShingle Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study
Buell Acosta, Julieth Daniela
FGF-21
MENSTRUAL CYCLE
PREECLAMPSIA
PREGNANCY
title_short Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study
title_full Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study
title_fullStr Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study
title_full_unstemmed Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study
title_sort Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study
dc.creator.none.fl_str_mv Buell Acosta, Julieth Daniela
Garces, Maria Fernanda
Parada Baños, Arturo José
Angel Muller, Edith
Paez, Maria Carolina
Eslava Schmalbach, Javier
Escobar Cordoba, Franklin
Caminos Cepeda, Sofia Alexandra
Lacunza, Ezequiel
Castaño, Justo P.
Nogueiras, Rubén
Dieguez, Carlos
Ruiz Parra, Ariel Iván
Caminos, Jorge Eduardo
author Buell Acosta, Julieth Daniela
author_facet Buell Acosta, Julieth Daniela
Garces, Maria Fernanda
Parada Baños, Arturo José
Angel Muller, Edith
Paez, Maria Carolina
Eslava Schmalbach, Javier
Escobar Cordoba, Franklin
Caminos Cepeda, Sofia Alexandra
Lacunza, Ezequiel
Castaño, Justo P.
Nogueiras, Rubén
Dieguez, Carlos
Ruiz Parra, Ariel Iván
Caminos, Jorge Eduardo
author_role author
author2 Garces, Maria Fernanda
Parada Baños, Arturo José
Angel Muller, Edith
Paez, Maria Carolina
Eslava Schmalbach, Javier
Escobar Cordoba, Franklin
Caminos Cepeda, Sofia Alexandra
Lacunza, Ezequiel
Castaño, Justo P.
Nogueiras, Rubén
Dieguez, Carlos
Ruiz Parra, Ariel Iván
Caminos, Jorge Eduardo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv FGF-21
MENSTRUAL CYCLE
PREECLAMPSIA
PREGNANCY
topic FGF-21
MENSTRUAL CYCLE
PREECLAMPSIA
PREGNANCY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Background: Fibroblast growth factor 21 (FGF-21) is an endocrine factor involved in glucose and lipid metabolism that exerts pleiotropic effects. The aim of this study was to investigate the serum FGF-21 profile in healthy and mild preeclamptic pregnant women at each trimester of pregnancy; (2) Methods: Serum FGF-21 levels were determined by ELISA in a nested case-control study within a longitudinal cohort study that included healthy (n = 54) and mild preeclamptic (n = 20) pregnant women, women at three months after delivery (n = 20) and eumenorrheic women during the menstrual cycle (n = 20); (3) Results: FGF-21 levels were significantly lower in the mid-luteal phase compared to the early follicular phase of the menstrual cycle in eumenorrheic women (p < 0.01). Maternal levels of FGF-21 were significantly lower in the first and second trimesters and peaked during the third trimester in healthy pregnant women (p < 0.01). Serum levels of FGF-21 in healthy pregnant were significantly lower in the first and second trimester of pregnancy compared with the follicular phase of the menstrual cycle and postpartum (p < 0.01). Serum FGF-21 levels were significantly higher in preeclamptic compared to healthy pregnant women during pregnancy (p < 0.01); (4) Conclusions: These results suggest that a peak of FGF-21 towards the end of pregnancy in healthy pregnancy and higher levels in preeclamptic women might play a critical role that contributes to protecting against the negatives effects of high concentrations of non-esterified fatty acids (NEFA) and hypertensive disorder. Furthermore, FGF-21 might play an important role in reproductive function in healthy eumenorrheic women during the menstrual cycle.
Fil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia; Colombia
Fil: Garces, Maria Fernanda. Universidad Nacional de Colombia; Colombia
Fil: Parada Baños, Arturo José. Universidad Nacional de Colombia; Colombia
Fil: Angel Muller, Edith. Universidad Nacional de Colombia; Colombia
Fil: Paez, Maria Carolina. Universidad Nacional de Colombia; Colombia
Fil: Eslava Schmalbach, Javier. Universidad Nacional de Colombia; Colombia
Fil: Escobar Cordoba, Franklin. Universidad Nacional de Colombia; Colombia
Fil: Caminos Cepeda, Sofia Alexandra. Universitat Pompeu Fabra; España
Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Castaño, Justo P.. Universidad Nacional de Colombia; Colombia
Fil: Nogueiras, Rubén. Instituto de Salud Carlos III; España
Fil: Dieguez, Carlos. Instituto de Salud Carlos III; España
Fil: Ruiz Parra, Ariel Iván. Universidad Nacional de Colombia; Colombia
Fil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia; Colombia
description Background: Fibroblast growth factor 21 (FGF-21) is an endocrine factor involved in glucose and lipid metabolism that exerts pleiotropic effects. The aim of this study was to investigate the serum FGF-21 profile in healthy and mild preeclamptic pregnant women at each trimester of pregnancy; (2) Methods: Serum FGF-21 levels were determined by ELISA in a nested case-control study within a longitudinal cohort study that included healthy (n = 54) and mild preeclamptic (n = 20) pregnant women, women at three months after delivery (n = 20) and eumenorrheic women during the menstrual cycle (n = 20); (3) Results: FGF-21 levels were significantly lower in the mid-luteal phase compared to the early follicular phase of the menstrual cycle in eumenorrheic women (p < 0.01). Maternal levels of FGF-21 were significantly lower in the first and second trimesters and peaked during the third trimester in healthy pregnant women (p < 0.01). Serum levels of FGF-21 in healthy pregnant were significantly lower in the first and second trimester of pregnancy compared with the follicular phase of the menstrual cycle and postpartum (p < 0.01). Serum FGF-21 levels were significantly higher in preeclamptic compared to healthy pregnant women during pregnancy (p < 0.01); (4) Conclusions: These results suggest that a peak of FGF-21 towards the end of pregnancy in healthy pregnancy and higher levels in preeclamptic women might play a critical role that contributes to protecting against the negatives effects of high concentrations of non-esterified fatty acids (NEFA) and hypertensive disorder. Furthermore, FGF-21 might play an important role in reproductive function in healthy eumenorrheic women during the menstrual cycle.
publishDate 2022
dc.date.none.fl_str_mv 2022-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/217285
Buell Acosta, Julieth Daniela; Garces, Maria Fernanda; Parada Baños, Arturo José; Angel Muller, Edith; Paez, Maria Carolina; et al.; Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study; MDPI; Cells; 11; 14; 7-2022; 1-15
2073-4409
2073-4409
CONICET Digital
CONICET
url http://hdl.handle.net/11336/217285
identifier_str_mv Buell Acosta, Julieth Daniela; Garces, Maria Fernanda; Parada Baños, Arturo José; Angel Muller, Edith; Paez, Maria Carolina; et al.; Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study; MDPI; Cells; 11; 14; 7-2022; 1-15
2073-4409
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/cells11142251
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269925011357696
score 13.13397

Publicaciones similares