Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
- Autores
- Garcés, María Fernanda; Buell-Acosta, Julieth Daniela; Rodriguez-Navarro, Haiver Antonio; Pulido-Sánchez, Estefania; Rincon-Ramírez, Juan José; Moreno-Ordóñez, Diana Carolina; Franco-Vega, Roberto; Roncancio-Muñoz, Jhoan Sebastian; Burgos-Cardenas, Alvaro Javier; Lacunza, Ezequiel; Castaño, Justo P.; Dieguez, Carlos; Nogueiras, Rubén; Sanchez, Elizabeth; Caminos, Jorge E.
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case–control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m2) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m2) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3–area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3–AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride—glucose index. Moreover, ANGPTL3–AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.
Centro de Investigaciones Inmunológicas Básicas y Aplicadas - Materia
-
Ciencias Médicas
ANGPTL3 serum levels
Glucose tolerance - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/123483
Ver los metadatos del registro completo
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Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance testGarcés, María FernandaBuell-Acosta, Julieth DanielaRodriguez-Navarro, Haiver AntonioPulido-Sánchez, EstefaniaRincon-Ramírez, Juan JoséMoreno-Ordóñez, Diana CarolinaFranco-Vega, RobertoRoncancio-Muñoz, Jhoan SebastianBurgos-Cardenas, Alvaro JavierLacunza, EzequielCastaño, Justo P.Dieguez, CarlosNogueiras, RubénSanchez, ElizabethCaminos, Jorge E.Ciencias MédicasANGPTL3 serum levelsGlucose toleranceThis study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case–control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m<sup>2</sup>) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m<sup>2</sup>) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3–area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3–AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride—glucose index. Moreover, ANGPTL3–AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.Centro de Investigaciones Inmunológicas Básicas y Aplicadas2020-12-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/123483enginfo:eu-repo/semantics/altIdentifier/issn/2045-2322info:eu-repo/semantics/altIdentifier/pmid/33273510info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-77961-8info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-10T12:32:06Zoai:sedici.unlp.edu.ar:10915/123483Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-10 12:32:06.411SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test |
| title |
Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test |
| spellingShingle |
Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test Garcés, María Fernanda Ciencias Médicas ANGPTL3 serum levels Glucose tolerance |
| title_short |
Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test |
| title_full |
Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test |
| title_fullStr |
Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test |
| title_full_unstemmed |
Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test |
| title_sort |
Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test |
| dc.creator.none.fl_str_mv |
Garcés, María Fernanda Buell-Acosta, Julieth Daniela Rodriguez-Navarro, Haiver Antonio Pulido-Sánchez, Estefania Rincon-Ramírez, Juan José Moreno-Ordóñez, Diana Carolina Franco-Vega, Roberto Roncancio-Muñoz, Jhoan Sebastian Burgos-Cardenas, Alvaro Javier Lacunza, Ezequiel Castaño, Justo P. Dieguez, Carlos Nogueiras, Rubén Sanchez, Elizabeth Caminos, Jorge E. |
| author |
Garcés, María Fernanda |
| author_facet |
Garcés, María Fernanda Buell-Acosta, Julieth Daniela Rodriguez-Navarro, Haiver Antonio Pulido-Sánchez, Estefania Rincon-Ramírez, Juan José Moreno-Ordóñez, Diana Carolina Franco-Vega, Roberto Roncancio-Muñoz, Jhoan Sebastian Burgos-Cardenas, Alvaro Javier Lacunza, Ezequiel Castaño, Justo P. Dieguez, Carlos Nogueiras, Rubén Sanchez, Elizabeth Caminos, Jorge E. |
| author_role |
author |
| author2 |
Buell-Acosta, Julieth Daniela Rodriguez-Navarro, Haiver Antonio Pulido-Sánchez, Estefania Rincon-Ramírez, Juan José Moreno-Ordóñez, Diana Carolina Franco-Vega, Roberto Roncancio-Muñoz, Jhoan Sebastian Burgos-Cardenas, Alvaro Javier Lacunza, Ezequiel Castaño, Justo P. Dieguez, Carlos Nogueiras, Rubén Sanchez, Elizabeth Caminos, Jorge E. |
| author2_role |
author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Ciencias Médicas ANGPTL3 serum levels Glucose tolerance |
| topic |
Ciencias Médicas ANGPTL3 serum levels Glucose tolerance |
| dc.description.none.fl_txt_mv |
This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case–control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m<sup>2</sup>) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m<sup>2</sup>) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3–area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3–AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride—glucose index. Moreover, ANGPTL3–AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues. Centro de Investigaciones Inmunológicas Básicas y Aplicadas |
| description |
This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case–control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m<sup>2</sup>) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m<sup>2</sup>) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3–area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3–AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride—glucose index. Moreover, ANGPTL3–AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-12-03 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://sedici.unlp.edu.ar/handle/10915/123483 |
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eng |
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eng |
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info:eu-repo/semantics/altIdentifier/issn/2045-2322 info:eu-repo/semantics/altIdentifier/pmid/33273510 info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-77961-8 |
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info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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