Central serotonin and melanocortin pathways regulating energy homeostasis
- Autores
- Heisler, Lora K.; Cowley, Michael A.; Kishi, Toshiro; Tecott, Laurence H.; Fan, Wei; Low, Malcolm J.; Smart, James L.; Rubinstein, Marcelo; Tatro, Jeffrey B.; Zigman, Jeffrey M.; Cone, Roger D.; Elmquist, Joel K.
- Año de publicación
- 2003
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- It is now established that the hypothalamus is essential in coordinating endocrine, autonomic, and behavioral responses to changes in energy availability. However, the interaction of key peptides, neuropeptides, and neurotransmitters systems within the hypothalamus has yet to be delineated. Recently, we investigated the mechanisms through which central serotonergic (5-hydroxytryptamine, 5-HT) systems recruit leptin-responsive hypothalamic pathways, such as the melanocortin systems, to affect energy balance. Through a combination of functional neuroanatomy, feeding, and electrophysiology studies in rodents, we found that 5-HT drugs require functional melanocortin pathways to exert their effects on food intake. Specifically, we observed that anorectic 5-HT drugs activate pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (Arc). We provide evidence that the serotonin 2C receptor (5-HT2CR) is expressed on POMC neurons and contributes to this effect. Finally, we found that 5-HT drug-induced hypophagia is attenuated by pharmacological or genetic blockade of downstream melanocortin 3 and 4 receptors. We review candidate brain regions expressing melanocortin 3 and 4 receptors that play a role in energy balance. A model is presented in which activation of the melanocortin system is downstream of 5-HT and is necessary to produce the complete anorectic effect of 5-HT drugs. The data reviewed in this paper incorporate the central 5-HT system to the growing list of metabolic signals that converge on melanocortin neurons in the hypothalamus.
Fil: Heisler, Lora K.. Harvard Medical School; Estados Unidos
Fil: Cowley, Michael A.. Oregon Health and Science University; Estados Unidos
Fil: Kishi, Toshiro. Harvard Medical School; Estados Unidos
Fil: Tecott, Laurence H.. University of California; Estados Unidos
Fil: Fan, Wei. Oregon Health and Science University; Estados Unidos
Fil: Low, Malcolm J.. Oregon Health and Science University; Estados Unidos
Fil: Smart, James L.. Oregon Health and Science University; Estados Unidos
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Tatro, Jeffrey B.. Tufts University School of Medicine; Estados Unidos
Fil: Zigman, Jeffrey M.. Harvard Medical School; Estados Unidos
Fil: Cone, Roger D.. Oregon Health and Science University; Estados Unidos
Fil: Elmquist, Joel K.. Harvard Medical School; Estados Unidos - Materia
-
And Arcuate Nucleus
Body Weight
Food Intake
Hypothalamus
Melanocortin
Melanocortin 4 Receptor (Mc4-R)
Pro-Opiomelanocortin (Pomc)
Serotonin
Serotonin 2c Receptor (5-Ht2cr) - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/79832
Ver los metadatos del registro completo
id |
CONICETDig_2c5bb8c59d7a209777b4d7dfdff4f56e |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/79832 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Central serotonin and melanocortin pathways regulating energy homeostasisHeisler, Lora K.Cowley, Michael A.Kishi, ToshiroTecott, Laurence H.Fan, WeiLow, Malcolm J.Smart, James L.Rubinstein, MarceloTatro, Jeffrey B.Zigman, Jeffrey M.Cone, Roger D.Elmquist, Joel K.And Arcuate NucleusBody WeightFood IntakeHypothalamusMelanocortinMelanocortin 4 Receptor (Mc4-R)Pro-Opiomelanocortin (Pomc)SerotoninSerotonin 2c Receptor (5-Ht2cr)https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3It is now established that the hypothalamus is essential in coordinating endocrine, autonomic, and behavioral responses to changes in energy availability. However, the interaction of key peptides, neuropeptides, and neurotransmitters systems within the hypothalamus has yet to be delineated. Recently, we investigated the mechanisms through which central serotonergic (5-hydroxytryptamine, 5-HT) systems recruit leptin-responsive hypothalamic pathways, such as the melanocortin systems, to affect energy balance. Through a combination of functional neuroanatomy, feeding, and electrophysiology studies in rodents, we found that 5-HT drugs require functional melanocortin pathways to exert their effects on food intake. Specifically, we observed that anorectic 5-HT drugs activate pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (Arc). We provide evidence that the serotonin 2C receptor (5-HT2CR) is expressed on POMC neurons and contributes to this effect. Finally, we found that 5-HT drug-induced hypophagia is attenuated by pharmacological or genetic blockade of downstream melanocortin 3 and 4 receptors. We review candidate brain regions expressing melanocortin 3 and 4 receptors that play a role in energy balance. A model is presented in which activation of the melanocortin system is downstream of 5-HT and is necessary to produce the complete anorectic effect of 5-HT drugs. The data reviewed in this paper incorporate the central 5-HT system to the growing list of metabolic signals that converge on melanocortin neurons in the hypothalamus.Fil: Heisler, Lora K.. Harvard Medical School; Estados UnidosFil: Cowley, Michael A.. Oregon Health and Science University; Estados UnidosFil: Kishi, Toshiro. Harvard Medical School; Estados UnidosFil: Tecott, Laurence H.. University of California; Estados UnidosFil: Fan, Wei. Oregon Health and Science University; Estados UnidosFil: Low, Malcolm J.. Oregon Health and Science University; Estados UnidosFil: Smart, James L.. Oregon Health and Science University; Estados UnidosFil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Tatro, Jeffrey B.. Tufts University School of Medicine; Estados UnidosFil: Zigman, Jeffrey M.. Harvard Medical School; Estados UnidosFil: Cone, Roger D.. Oregon Health and Science University; Estados UnidosFil: Elmquist, Joel K.. Harvard Medical School; Estados UnidosThe New York Academy of Sciences2003-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79832Heisler, Lora K.; Cowley, Michael A.; Kishi, Toshiro; Tecott, Laurence H.; Fan, Wei; et al.; Central serotonin and melanocortin pathways regulating energy homeostasis; The New York Academy of Sciences; Annals of the New York Academy of Sciences; 994; 6-2003; 169-1740077-8923CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/12851313info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1749-6632.2003.tb03177.xinfo:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.2003.tb03177.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:11Zoai:ri.conicet.gov.ar:11336/79832instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:11.813CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Central serotonin and melanocortin pathways regulating energy homeostasis |
title |
Central serotonin and melanocortin pathways regulating energy homeostasis |
spellingShingle |
Central serotonin and melanocortin pathways regulating energy homeostasis Heisler, Lora K. And Arcuate Nucleus Body Weight Food Intake Hypothalamus Melanocortin Melanocortin 4 Receptor (Mc4-R) Pro-Opiomelanocortin (Pomc) Serotonin Serotonin 2c Receptor (5-Ht2cr) |
title_short |
Central serotonin and melanocortin pathways regulating energy homeostasis |
title_full |
Central serotonin and melanocortin pathways regulating energy homeostasis |
title_fullStr |
Central serotonin and melanocortin pathways regulating energy homeostasis |
title_full_unstemmed |
Central serotonin and melanocortin pathways regulating energy homeostasis |
title_sort |
Central serotonin and melanocortin pathways regulating energy homeostasis |
dc.creator.none.fl_str_mv |
Heisler, Lora K. Cowley, Michael A. Kishi, Toshiro Tecott, Laurence H. Fan, Wei Low, Malcolm J. Smart, James L. Rubinstein, Marcelo Tatro, Jeffrey B. Zigman, Jeffrey M. Cone, Roger D. Elmquist, Joel K. |
author |
Heisler, Lora K. |
author_facet |
Heisler, Lora K. Cowley, Michael A. Kishi, Toshiro Tecott, Laurence H. Fan, Wei Low, Malcolm J. Smart, James L. Rubinstein, Marcelo Tatro, Jeffrey B. Zigman, Jeffrey M. Cone, Roger D. Elmquist, Joel K. |
author_role |
author |
author2 |
Cowley, Michael A. Kishi, Toshiro Tecott, Laurence H. Fan, Wei Low, Malcolm J. Smart, James L. Rubinstein, Marcelo Tatro, Jeffrey B. Zigman, Jeffrey M. Cone, Roger D. Elmquist, Joel K. |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
And Arcuate Nucleus Body Weight Food Intake Hypothalamus Melanocortin Melanocortin 4 Receptor (Mc4-R) Pro-Opiomelanocortin (Pomc) Serotonin Serotonin 2c Receptor (5-Ht2cr) |
topic |
And Arcuate Nucleus Body Weight Food Intake Hypothalamus Melanocortin Melanocortin 4 Receptor (Mc4-R) Pro-Opiomelanocortin (Pomc) Serotonin Serotonin 2c Receptor (5-Ht2cr) |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
It is now established that the hypothalamus is essential in coordinating endocrine, autonomic, and behavioral responses to changes in energy availability. However, the interaction of key peptides, neuropeptides, and neurotransmitters systems within the hypothalamus has yet to be delineated. Recently, we investigated the mechanisms through which central serotonergic (5-hydroxytryptamine, 5-HT) systems recruit leptin-responsive hypothalamic pathways, such as the melanocortin systems, to affect energy balance. Through a combination of functional neuroanatomy, feeding, and electrophysiology studies in rodents, we found that 5-HT drugs require functional melanocortin pathways to exert their effects on food intake. Specifically, we observed that anorectic 5-HT drugs activate pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (Arc). We provide evidence that the serotonin 2C receptor (5-HT2CR) is expressed on POMC neurons and contributes to this effect. Finally, we found that 5-HT drug-induced hypophagia is attenuated by pharmacological or genetic blockade of downstream melanocortin 3 and 4 receptors. We review candidate brain regions expressing melanocortin 3 and 4 receptors that play a role in energy balance. A model is presented in which activation of the melanocortin system is downstream of 5-HT and is necessary to produce the complete anorectic effect of 5-HT drugs. The data reviewed in this paper incorporate the central 5-HT system to the growing list of metabolic signals that converge on melanocortin neurons in the hypothalamus. Fil: Heisler, Lora K.. Harvard Medical School; Estados Unidos Fil: Cowley, Michael A.. Oregon Health and Science University; Estados Unidos Fil: Kishi, Toshiro. Harvard Medical School; Estados Unidos Fil: Tecott, Laurence H.. University of California; Estados Unidos Fil: Fan, Wei. Oregon Health and Science University; Estados Unidos Fil: Low, Malcolm J.. Oregon Health and Science University; Estados Unidos Fil: Smart, James L.. Oregon Health and Science University; Estados Unidos Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Tatro, Jeffrey B.. Tufts University School of Medicine; Estados Unidos Fil: Zigman, Jeffrey M.. Harvard Medical School; Estados Unidos Fil: Cone, Roger D.. Oregon Health and Science University; Estados Unidos Fil: Elmquist, Joel K.. Harvard Medical School; Estados Unidos |
description |
It is now established that the hypothalamus is essential in coordinating endocrine, autonomic, and behavioral responses to changes in energy availability. However, the interaction of key peptides, neuropeptides, and neurotransmitters systems within the hypothalamus has yet to be delineated. Recently, we investigated the mechanisms through which central serotonergic (5-hydroxytryptamine, 5-HT) systems recruit leptin-responsive hypothalamic pathways, such as the melanocortin systems, to affect energy balance. Through a combination of functional neuroanatomy, feeding, and electrophysiology studies in rodents, we found that 5-HT drugs require functional melanocortin pathways to exert their effects on food intake. Specifically, we observed that anorectic 5-HT drugs activate pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (Arc). We provide evidence that the serotonin 2C receptor (5-HT2CR) is expressed on POMC neurons and contributes to this effect. Finally, we found that 5-HT drug-induced hypophagia is attenuated by pharmacological or genetic blockade of downstream melanocortin 3 and 4 receptors. We review candidate brain regions expressing melanocortin 3 and 4 receptors that play a role in energy balance. A model is presented in which activation of the melanocortin system is downstream of 5-HT and is necessary to produce the complete anorectic effect of 5-HT drugs. The data reviewed in this paper incorporate the central 5-HT system to the growing list of metabolic signals that converge on melanocortin neurons in the hypothalamus. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/79832 Heisler, Lora K.; Cowley, Michael A.; Kishi, Toshiro; Tecott, Laurence H.; Fan, Wei; et al.; Central serotonin and melanocortin pathways regulating energy homeostasis; The New York Academy of Sciences; Annals of the New York Academy of Sciences; 994; 6-2003; 169-174 0077-8923 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/79832 |
identifier_str_mv |
Heisler, Lora K.; Cowley, Michael A.; Kishi, Toshiro; Tecott, Laurence H.; Fan, Wei; et al.; Central serotonin and melanocortin pathways regulating energy homeostasis; The New York Academy of Sciences; Annals of the New York Academy of Sciences; 994; 6-2003; 169-174 0077-8923 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/12851313 info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1749-6632.2003.tb03177.x info:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.2003.tb03177.x |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
The New York Academy of Sciences |
publisher.none.fl_str_mv |
The New York Academy of Sciences |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1842269681637916672 |
score |
13.13397 |