Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts

Autores
Daray, Federico Manuel; Arena, Ángeles R.; Armesto, Arnaldo Raúl; Rodante, Demián E.; Puppo, Soledad; Vidjen, Patricia; Portela, Alicia; Grendas, Leandro; Errasti, Andrea Emilse
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: The serotonin-transporter-linked polymorphic region (5-HTTLPR) polymorphisms are associated with suicidal behavior; however, prospective studies are scarce. Herein we aim to determine if 5-HTTLPR polymorphisms predict risk of short-term suicide reattempt in a high-risk suicidal sample. We also explore possible mediators or moderators of this relationship. Methods: A multicenter prospective cohort study was designed to compare data obtained form 136 patients admitted to the emergency department for current suicidal ideation or a recent suicide attempt. Subjects were clinically evaluated, genotyped, and monitored for a new suicide attempt for 6 months. Results: At 6 months of follow up, 21% of the subjects had a new suicide attempt. The frequency of L-allele and L-carrier was higher in reattempters when compared with non-reattempters (55.8% vs. 35.4%, p = 0.01 and 76.9% vs. 54.2%, p = 0.04, respectively). Reattempters also differ from non-reattempters patients with respect to age, history of previous suicide attempts, and age of onset of suicidal behavior. The logistic regression model showed that L-carriers had an odds ratio of 2.8 (95% CI: 1.0–7.6) for reattempts when compared to SS genotype. The adjusted model indicates that this association is not mediated or moderated by impulsivity. Conclusion: The 5-HTTLPR polymorphisms predicted short-term risk of suicidal reattempt independently of age and sex. L-carriers have almost three times more risk of relapse when compared with SS carriers.
Fil: Daray, Federico Manuel. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Hospital Neuropsiquiátrico Braulio A. Moyano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Arena, Ángeles R.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Armesto, Arnaldo Raúl. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rodante, Demián E.. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Hospital Neuropsiquiátrico Braulio A. Moyano; Argentina
Fil: Puppo, Soledad. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Vidjen, Patricia. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina
Fil: Portela, Alicia. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina
Fil: Grendas, Leandro. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Errasti, Andrea Emilse. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
5-HTTLPR
IMPULSIVITY
POLYMORPHISM
PREDICTOR
SEROTONIN
SUICIDE BEHAVIOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/99038
Acceder
id CONICETDig_d60b3d730dddfca32b84f712ee70d933
oai_identifier_str oai:ri.conicet.gov.ar:11336/99038
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattemptsDaray, Federico ManuelArena, Ángeles R.Armesto, Arnaldo RaúlRodante, Demián E.Puppo, SoledadVidjen, PatriciaPortela, AliciaGrendas, LeandroErrasti, Andrea Emilse5-HTTLPRIMPULSIVITYPOLYMORPHISMPREDICTORSEROTONINSUICIDE BEHAVIORhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective: The serotonin-transporter-linked polymorphic region (5-HTTLPR) polymorphisms are associated with suicidal behavior; however, prospective studies are scarce. Herein we aim to determine if 5-HTTLPR polymorphisms predict risk of short-term suicide reattempt in a high-risk suicidal sample. We also explore possible mediators or moderators of this relationship. Methods: A multicenter prospective cohort study was designed to compare data obtained form 136 patients admitted to the emergency department for current suicidal ideation or a recent suicide attempt. Subjects were clinically evaluated, genotyped, and monitored for a new suicide attempt for 6 months. Results: At 6 months of follow up, 21% of the subjects had a new suicide attempt. The frequency of L-allele and L-carrier was higher in reattempters when compared with non-reattempters (55.8% vs. 35.4%, p = 0.01 and 76.9% vs. 54.2%, p = 0.04, respectively). Reattempters also differ from non-reattempters patients with respect to age, history of previous suicide attempts, and age of onset of suicidal behavior. The logistic regression model showed that L-carriers had an odds ratio of 2.8 (95% CI: 1.0–7.6) for reattempts when compared to SS genotype. The adjusted model indicates that this association is not mediated or moderated by impulsivity. Conclusion: The 5-HTTLPR polymorphisms predicted short-term risk of suicidal reattempt independently of age and sex. L-carriers have almost three times more risk of relapse when compared with SS carriers.Fil: Daray, Federico Manuel. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Hospital Neuropsiquiátrico Braulio A. Moyano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Arena, Ángeles R.. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Armesto, Arnaldo Raúl. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rodante, Demián E.. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Hospital Neuropsiquiátrico Braulio A. Moyano; ArgentinaFil: Puppo, Soledad. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Vidjen, Patricia. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; ArgentinaFil: Portela, Alicia. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; ArgentinaFil: Grendas, Leandro. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Errasti, Andrea Emilse. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier France-editions Scientifiques Medicales Elsevier2018-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99038Daray, Federico Manuel; Arena, Ángeles R.; Armesto, Arnaldo Raúl; Rodante, Demián E.; Puppo, Soledad; et al.; Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts; Elsevier France-editions Scientifiques Medicales Elsevier; European Psychiatry; 54; 10-2018; 19-260924-9338CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0924933818301366info:eu-repo/semantics/altIdentifier/doi/10.1016/j.eurpsy.2018.07.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:12Zoai:ri.conicet.gov.ar:11336/99038instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:12.719CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts
title Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts
spellingShingle Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts
Daray, Federico Manuel
5-HTTLPR
IMPULSIVITY
POLYMORPHISM
PREDICTOR
SEROTONIN
SUICIDE BEHAVIOR
title_short Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts
title_full Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts
title_fullStr Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts
title_full_unstemmed Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts
title_sort Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts
dc.creator.none.fl_str_mv Daray, Federico Manuel
Arena, Ángeles R.
Armesto, Arnaldo Raúl
Rodante, Demián E.
Puppo, Soledad
Vidjen, Patricia
Portela, Alicia
Grendas, Leandro
Errasti, Andrea Emilse
author Daray, Federico Manuel
author_facet Daray, Federico Manuel
Arena, Ángeles R.
Armesto, Arnaldo Raúl
Rodante, Demián E.
Puppo, Soledad
Vidjen, Patricia
Portela, Alicia
Grendas, Leandro
Errasti, Andrea Emilse
author_role author
author2 Arena, Ángeles R.
Armesto, Arnaldo Raúl
Rodante, Demián E.
Puppo, Soledad
Vidjen, Patricia
Portela, Alicia
Grendas, Leandro
Errasti, Andrea Emilse
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv 5-HTTLPR
IMPULSIVITY
POLYMORPHISM
PREDICTOR
SEROTONIN
SUICIDE BEHAVIOR
topic 5-HTTLPR
IMPULSIVITY
POLYMORPHISM
PREDICTOR
SEROTONIN
SUICIDE BEHAVIOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: The serotonin-transporter-linked polymorphic region (5-HTTLPR) polymorphisms are associated with suicidal behavior; however, prospective studies are scarce. Herein we aim to determine if 5-HTTLPR polymorphisms predict risk of short-term suicide reattempt in a high-risk suicidal sample. We also explore possible mediators or moderators of this relationship. Methods: A multicenter prospective cohort study was designed to compare data obtained form 136 patients admitted to the emergency department for current suicidal ideation or a recent suicide attempt. Subjects were clinically evaluated, genotyped, and monitored for a new suicide attempt for 6 months. Results: At 6 months of follow up, 21% of the subjects had a new suicide attempt. The frequency of L-allele and L-carrier was higher in reattempters when compared with non-reattempters (55.8% vs. 35.4%, p = 0.01 and 76.9% vs. 54.2%, p = 0.04, respectively). Reattempters also differ from non-reattempters patients with respect to age, history of previous suicide attempts, and age of onset of suicidal behavior. The logistic regression model showed that L-carriers had an odds ratio of 2.8 (95% CI: 1.0–7.6) for reattempts when compared to SS genotype. The adjusted model indicates that this association is not mediated or moderated by impulsivity. Conclusion: The 5-HTTLPR polymorphisms predicted short-term risk of suicidal reattempt independently of age and sex. L-carriers have almost three times more risk of relapse when compared with SS carriers.
Fil: Daray, Federico Manuel. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Hospital Neuropsiquiátrico Braulio A. Moyano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Arena, Ángeles R.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Armesto, Arnaldo Raúl. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rodante, Demián E.. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Hospital Neuropsiquiátrico Braulio A. Moyano; Argentina
Fil: Puppo, Soledad. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Vidjen, Patricia. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina
Fil: Portela, Alicia. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina
Fil: Grendas, Leandro. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Errasti, Andrea Emilse. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Objective: The serotonin-transporter-linked polymorphic region (5-HTTLPR) polymorphisms are associated with suicidal behavior; however, prospective studies are scarce. Herein we aim to determine if 5-HTTLPR polymorphisms predict risk of short-term suicide reattempt in a high-risk suicidal sample. We also explore possible mediators or moderators of this relationship. Methods: A multicenter prospective cohort study was designed to compare data obtained form 136 patients admitted to the emergency department for current suicidal ideation or a recent suicide attempt. Subjects were clinically evaluated, genotyped, and monitored for a new suicide attempt for 6 months. Results: At 6 months of follow up, 21% of the subjects had a new suicide attempt. The frequency of L-allele and L-carrier was higher in reattempters when compared with non-reattempters (55.8% vs. 35.4%, p = 0.01 and 76.9% vs. 54.2%, p = 0.04, respectively). Reattempters also differ from non-reattempters patients with respect to age, history of previous suicide attempts, and age of onset of suicidal behavior. The logistic regression model showed that L-carriers had an odds ratio of 2.8 (95% CI: 1.0–7.6) for reattempts when compared to SS genotype. The adjusted model indicates that this association is not mediated or moderated by impulsivity. Conclusion: The 5-HTTLPR polymorphisms predicted short-term risk of suicidal reattempt independently of age and sex. L-carriers have almost three times more risk of relapse when compared with SS carriers.
publishDate 2018
dc.date.none.fl_str_mv 2018-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99038
Daray, Federico Manuel; Arena, Ángeles R.; Armesto, Arnaldo Raúl; Rodante, Demián E.; Puppo, Soledad; et al.; Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts; Elsevier France-editions Scientifiques Medicales Elsevier; European Psychiatry; 54; 10-2018; 19-26
0924-9338
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99038
identifier_str_mv Daray, Federico Manuel; Arena, Ángeles R.; Armesto, Arnaldo Raúl; Rodante, Demián E.; Puppo, Soledad; et al.; Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts; Elsevier France-editions Scientifiques Medicales Elsevier; European Psychiatry; 54; 10-2018; 19-26
0924-9338
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0924933818301366
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.eurpsy.2018.07.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier France-editions Scientifiques Medicales Elsevier
publisher.none.fl_str_mv Elsevier France-editions Scientifiques Medicales Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613498830585856
score 13.070432

Publicaciones similares