Effect of doxycycline on atherosclerosis: From bench to bedside

Autores
Rodriguez Granillo, Gaston Alfredo; Rodriguez Granillo, Agustina; Milei, Jose
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Matrix metalloproteinases (MMPs) have a pivotal role in the natural history of atherosclerosis and its cardiovascular consequences. Non-selective MMP inhibition with doxycycline appears as a potential strategy to reduce the residual risk observed in patients already at intensive lipid lowering strategies. However, specific MMPs have different and even contradicting roles in the natural history of atherosclerosis, rendering broad spectrum MMP inhibition an important yet somewhat simplistic approach towards residual risk reduction in coronary atherosclerosis. Overall, the balance of non-selective MMP inhibition might shift to the favorable side in particular settings such as in acute coronary syndromes, where in addition to its potential plaque stabilization properties, doxycycline shows promise in preventing ischemia-reperfusion injury and left ventricular remodeling. Nevertheless, to date, most animal models used do not represent advanced coronary atherosclerosis seen in humans, and large and well-designed clinical studies are lacking. We discuss the available evidence and recent patents supporting the role of doxycycline in atherosclerosis.
Fil: Rodriguez Granillo, Gaston Alfredo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rodriguez Granillo, Agustina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Materia
Apo e Deficient Mice
Atherothrombosis
Coronary
Inflammation
Metalloproteinase
Mmp Inhibitor
Remodeling
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67706
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Effect of doxycycline on atherosclerosis: From bench to bedsideRodriguez Granillo, Gaston AlfredoRodriguez Granillo, AgustinaMilei, JoseApo e Deficient MiceAtherothrombosisCoronaryInflammationMetalloproteinaseMmp InhibitorRemodelinghttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Matrix metalloproteinases (MMPs) have a pivotal role in the natural history of atherosclerosis and its cardiovascular consequences. Non-selective MMP inhibition with doxycycline appears as a potential strategy to reduce the residual risk observed in patients already at intensive lipid lowering strategies. However, specific MMPs have different and even contradicting roles in the natural history of atherosclerosis, rendering broad spectrum MMP inhibition an important yet somewhat simplistic approach towards residual risk reduction in coronary atherosclerosis. Overall, the balance of non-selective MMP inhibition might shift to the favorable side in particular settings such as in acute coronary syndromes, where in addition to its potential plaque stabilization properties, doxycycline shows promise in preventing ischemia-reperfusion injury and left ventricular remodeling. Nevertheless, to date, most animal models used do not represent advanced coronary atherosclerosis seen in humans, and large and well-designed clinical studies are lacking. We discuss the available evidence and recent patents supporting the role of doxycycline in atherosclerosis.Fil: Rodriguez Granillo, Gaston Alfredo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rodriguez Granillo, Agustina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaBentham Science Publishers2011-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/67706Rodriguez Granillo, Gaston Alfredo; Rodriguez Granillo, Agustina; Milei, Jose; Effect of doxycycline on atherosclerosis: From bench to bedside; Bentham Science Publishers; Recent Patents on Cardiovascular Drug Discovery; 6; 1; 6-2011; 42-541574-89012212-3962CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/87422/article/effect-doxycycline-atherosclerosis-bench-bedsideinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:50Zoai:ri.conicet.gov.ar:11336/67706instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:50.572CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of doxycycline on atherosclerosis: From bench to bedside
title Effect of doxycycline on atherosclerosis: From bench to bedside
spellingShingle Effect of doxycycline on atherosclerosis: From bench to bedside
Rodriguez Granillo, Gaston Alfredo
Apo e Deficient Mice
Atherothrombosis
Coronary
Inflammation
Metalloproteinase
Mmp Inhibitor
Remodeling
title_short Effect of doxycycline on atherosclerosis: From bench to bedside
title_full Effect of doxycycline on atherosclerosis: From bench to bedside
title_fullStr Effect of doxycycline on atherosclerosis: From bench to bedside
title_full_unstemmed Effect of doxycycline on atherosclerosis: From bench to bedside
title_sort Effect of doxycycline on atherosclerosis: From bench to bedside
dc.creator.none.fl_str_mv Rodriguez Granillo, Gaston Alfredo
Rodriguez Granillo, Agustina
Milei, Jose
author Rodriguez Granillo, Gaston Alfredo
author_facet Rodriguez Granillo, Gaston Alfredo
Rodriguez Granillo, Agustina
Milei, Jose
author_role author
author2 Rodriguez Granillo, Agustina
Milei, Jose
author2_role author
author
dc.subject.none.fl_str_mv Apo e Deficient Mice
Atherothrombosis
Coronary
Inflammation
Metalloproteinase
Mmp Inhibitor
Remodeling
topic Apo e Deficient Mice
Atherothrombosis
Coronary
Inflammation
Metalloproteinase
Mmp Inhibitor
Remodeling
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Matrix metalloproteinases (MMPs) have a pivotal role in the natural history of atherosclerosis and its cardiovascular consequences. Non-selective MMP inhibition with doxycycline appears as a potential strategy to reduce the residual risk observed in patients already at intensive lipid lowering strategies. However, specific MMPs have different and even contradicting roles in the natural history of atherosclerosis, rendering broad spectrum MMP inhibition an important yet somewhat simplistic approach towards residual risk reduction in coronary atherosclerosis. Overall, the balance of non-selective MMP inhibition might shift to the favorable side in particular settings such as in acute coronary syndromes, where in addition to its potential plaque stabilization properties, doxycycline shows promise in preventing ischemia-reperfusion injury and left ventricular remodeling. Nevertheless, to date, most animal models used do not represent advanced coronary atherosclerosis seen in humans, and large and well-designed clinical studies are lacking. We discuss the available evidence and recent patents supporting the role of doxycycline in atherosclerosis.
Fil: Rodriguez Granillo, Gaston Alfredo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rodriguez Granillo, Agustina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
description Matrix metalloproteinases (MMPs) have a pivotal role in the natural history of atherosclerosis and its cardiovascular consequences. Non-selective MMP inhibition with doxycycline appears as a potential strategy to reduce the residual risk observed in patients already at intensive lipid lowering strategies. However, specific MMPs have different and even contradicting roles in the natural history of atherosclerosis, rendering broad spectrum MMP inhibition an important yet somewhat simplistic approach towards residual risk reduction in coronary atherosclerosis. Overall, the balance of non-selective MMP inhibition might shift to the favorable side in particular settings such as in acute coronary syndromes, where in addition to its potential plaque stabilization properties, doxycycline shows promise in preventing ischemia-reperfusion injury and left ventricular remodeling. Nevertheless, to date, most animal models used do not represent advanced coronary atherosclerosis seen in humans, and large and well-designed clinical studies are lacking. We discuss the available evidence and recent patents supporting the role of doxycycline in atherosclerosis.
publishDate 2011
dc.date.none.fl_str_mv 2011-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67706
Rodriguez Granillo, Gaston Alfredo; Rodriguez Granillo, Agustina; Milei, Jose; Effect of doxycycline on atherosclerosis: From bench to bedside; Bentham Science Publishers; Recent Patents on Cardiovascular Drug Discovery; 6; 1; 6-2011; 42-54
1574-8901
2212-3962
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67706
identifier_str_mv Rodriguez Granillo, Gaston Alfredo; Rodriguez Granillo, Agustina; Milei, Jose; Effect of doxycycline on atherosclerosis: From bench to bedside; Bentham Science Publishers; Recent Patents on Cardiovascular Drug Discovery; 6; 1; 6-2011; 42-54
1574-8901
2212-3962
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/87422/article/effect-doxycycline-atherosclerosis-bench-bedside
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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