Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review

Autores
Verdes, Jose M.; Riet Correa, Franklin; Medeiros, Rosane M.T.; Moraña, Antonio; Battes, Daniel; Dehl, Virginia; Borteiro, Claudio; Gimeno, Eduardo Juan; Sant’Ana, Fabiano J.F.; Barros, Claudio S.L.; Barros, Servero S.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cattle that consume Solanum bonariense L (= Solanum fastigiatum Willd.) or Solanum paniculatum L. develop a typical cerebellar cortical degeneration characterized by periodic episodes of ataxia, hypermetria, hyperesthesia, head and thoracic limb extension, opisthotonus, nystagmus, and falling to the side or backward. Histological lesions include vacuolation, degeneration, and loss of Purkinje cells. Axonal spheroids, microcavitations, and other changes of Wallerian degeneration in cerebellar granular layer and white matter are also observed. Neurotoxic compounds in Solanum spp. causing neurologic dysfunction in ruminants were not definitively elucidated. The same Solanaceae species are extensively used with culinary purposes or for the treatment of liver and gastrointestinal disorders as hangovers in humans. In the present paper, we review the epidemiology, clinical signs, and pathological hallmarks of poisoning by Solanum —S. bonariense L. (=S. fastigiatum Willd.) and S. paniculatum—with emphasis in histopathology, ultrastructural, and lectin- and immuno-histochemical changes in spontaneous and experimentally poisoned cattle in South America. The current knowledge of the pathogenesis of these bovine cerebellar cortical degenerations is discussed, and some advances in botanical and toxicological aspects of these Solanaceae species are presented, taking into account the potential risk of human poisoning.
Fil: Verdes, Jose M.. Universidad de la República; Uruguay
Fil: Riet Correa, Franklin. Federal University of Campina Grande; Brasil
Fil: Medeiros, Rosane M.T.. Federal University of Campina Grande; Brasil
Fil: Moraña, Antonio. Universidad de la República; Uruguay
Fil: Battes, Daniel. Universidad de la República; Uruguay
Fil: Dehl, Virginia. Universidad de la República; Uruguay
Fil: Borteiro, Claudio. Universidad de la República; Uruguay
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sant’Ana, Fabiano J.F.. Universidade Federal de Goiás; Brasil
Fil: Barros, Claudio S.L.. Federal University of Santa Maria; Brasil
Fil: Barros, Servero S.. Federal University of Santa Maria; Brasil
Materia
cerebellar degeneration
diseases of cattle
poisonous plants
Solanacae
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23955
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/23955
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological ReviewVerdes, Jose M.Riet Correa, FranklinMedeiros, Rosane M.T.Moraña, AntonioBattes, DanielDehl, VirginiaBorteiro, ClaudioGimeno, Eduardo JuanSant’Ana, Fabiano J.F.Barros, Claudio S.L.Barros, Servero S.cerebellar degenerationdiseases of cattlepoisonous plantsSolanacaehttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Cattle that consume Solanum bonariense L (= Solanum fastigiatum Willd.) or Solanum paniculatum L. develop a typical cerebellar cortical degeneration characterized by periodic episodes of ataxia, hypermetria, hyperesthesia, head and thoracic limb extension, opisthotonus, nystagmus, and falling to the side or backward. Histological lesions include vacuolation, degeneration, and loss of Purkinje cells. Axonal spheroids, microcavitations, and other changes of Wallerian degeneration in cerebellar granular layer and white matter are also observed. Neurotoxic compounds in Solanum spp. causing neurologic dysfunction in ruminants were not definitively elucidated. The same Solanaceae species are extensively used with culinary purposes or for the treatment of liver and gastrointestinal disorders as hangovers in humans. In the present paper, we review the epidemiology, clinical signs, and pathological hallmarks of poisoning by Solanum —S. bonariense L. (=S. fastigiatum Willd.) and S. paniculatum—with emphasis in histopathology, ultrastructural, and lectin- and immuno-histochemical changes in spontaneous and experimentally poisoned cattle in South America. The current knowledge of the pathogenesis of these bovine cerebellar cortical degenerations is discussed, and some advances in botanical and toxicological aspects of these Solanaceae species are presented, taking into account the potential risk of human poisoning.Fil: Verdes, Jose M.. Universidad de la República; UruguayFil: Riet Correa, Franklin. Federal University of Campina Grande; BrasilFil: Medeiros, Rosane M.T.. Federal University of Campina Grande; BrasilFil: Moraña, Antonio. Universidad de la República; UruguayFil: Battes, Daniel. Universidad de la República; UruguayFil: Dehl, Virginia. Universidad de la República; UruguayFil: Borteiro, Claudio. Universidad de la República; UruguayFil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sant’Ana, Fabiano J.F.. Universidade Federal de Goiás; BrasilFil: Barros, Claudio S.L.. Federal University of Santa Maria; BrasilFil: Barros, Servero S.. Federal University of Santa Maria; BrasilUnited State Department of Agriculture2013-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23955Verdes, Jose M.; Riet Correa, Franklin; Medeiros, Rosane M.T.; Moraña, Antonio; Battes, Daniel; et al.; Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review; United State Department of Agriculture; International Journal of Poisonous Plants Research; 2; 1; 5-2013; 34-442154-3216CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ars.usda.gov/oc/np/poisonousplants/fall2012/index/info:eu-repo/semantics/altIdentifier/url/https://www.ars.usda.gov/ARSUserFiles/oc/np/PoisonousPlants/Fall2012/cortical.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:37:03Zoai:ri.conicet.gov.ar:11336/23955instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:37:03.368CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review
title Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review
spellingShingle Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review
Verdes, Jose M.
cerebellar degeneration
diseases of cattle
poisonous plants
Solanacae
title_short Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review
title_full Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review
title_fullStr Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review
title_full_unstemmed Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review
title_sort Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review
dc.creator.none.fl_str_mv Verdes, Jose M.
Riet Correa, Franklin
Medeiros, Rosane M.T.
Moraña, Antonio
Battes, Daniel
Dehl, Virginia
Borteiro, Claudio
Gimeno, Eduardo Juan
Sant’Ana, Fabiano J.F.
Barros, Claudio S.L.
Barros, Servero S.
author Verdes, Jose M.
author_facet Verdes, Jose M.
Riet Correa, Franklin
Medeiros, Rosane M.T.
Moraña, Antonio
Battes, Daniel
Dehl, Virginia
Borteiro, Claudio
Gimeno, Eduardo Juan
Sant’Ana, Fabiano J.F.
Barros, Claudio S.L.
Barros, Servero S.
author_role author
author2 Riet Correa, Franklin
Medeiros, Rosane M.T.
Moraña, Antonio
Battes, Daniel
Dehl, Virginia
Borteiro, Claudio
Gimeno, Eduardo Juan
Sant’Ana, Fabiano J.F.
Barros, Claudio S.L.
Barros, Servero S.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv cerebellar degeneration
diseases of cattle
poisonous plants
Solanacae
topic cerebellar degeneration
diseases of cattle
poisonous plants
Solanacae
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Cattle that consume Solanum bonariense L (= Solanum fastigiatum Willd.) or Solanum paniculatum L. develop a typical cerebellar cortical degeneration characterized by periodic episodes of ataxia, hypermetria, hyperesthesia, head and thoracic limb extension, opisthotonus, nystagmus, and falling to the side or backward. Histological lesions include vacuolation, degeneration, and loss of Purkinje cells. Axonal spheroids, microcavitations, and other changes of Wallerian degeneration in cerebellar granular layer and white matter are also observed. Neurotoxic compounds in Solanum spp. causing neurologic dysfunction in ruminants were not definitively elucidated. The same Solanaceae species are extensively used with culinary purposes or for the treatment of liver and gastrointestinal disorders as hangovers in humans. In the present paper, we review the epidemiology, clinical signs, and pathological hallmarks of poisoning by Solanum —S. bonariense L. (=S. fastigiatum Willd.) and S. paniculatum—with emphasis in histopathology, ultrastructural, and lectin- and immuno-histochemical changes in spontaneous and experimentally poisoned cattle in South America. The current knowledge of the pathogenesis of these bovine cerebellar cortical degenerations is discussed, and some advances in botanical and toxicological aspects of these Solanaceae species are presented, taking into account the potential risk of human poisoning.
Fil: Verdes, Jose M.. Universidad de la República; Uruguay
Fil: Riet Correa, Franklin. Federal University of Campina Grande; Brasil
Fil: Medeiros, Rosane M.T.. Federal University of Campina Grande; Brasil
Fil: Moraña, Antonio. Universidad de la República; Uruguay
Fil: Battes, Daniel. Universidad de la República; Uruguay
Fil: Dehl, Virginia. Universidad de la República; Uruguay
Fil: Borteiro, Claudio. Universidad de la República; Uruguay
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sant’Ana, Fabiano J.F.. Universidade Federal de Goiás; Brasil
Fil: Barros, Claudio S.L.. Federal University of Santa Maria; Brasil
Fil: Barros, Servero S.. Federal University of Santa Maria; Brasil
description Cattle that consume Solanum bonariense L (= Solanum fastigiatum Willd.) or Solanum paniculatum L. develop a typical cerebellar cortical degeneration characterized by periodic episodes of ataxia, hypermetria, hyperesthesia, head and thoracic limb extension, opisthotonus, nystagmus, and falling to the side or backward. Histological lesions include vacuolation, degeneration, and loss of Purkinje cells. Axonal spheroids, microcavitations, and other changes of Wallerian degeneration in cerebellar granular layer and white matter are also observed. Neurotoxic compounds in Solanum spp. causing neurologic dysfunction in ruminants were not definitively elucidated. The same Solanaceae species are extensively used with culinary purposes or for the treatment of liver and gastrointestinal disorders as hangovers in humans. In the present paper, we review the epidemiology, clinical signs, and pathological hallmarks of poisoning by Solanum —S. bonariense L. (=S. fastigiatum Willd.) and S. paniculatum—with emphasis in histopathology, ultrastructural, and lectin- and immuno-histochemical changes in spontaneous and experimentally poisoned cattle in South America. The current knowledge of the pathogenesis of these bovine cerebellar cortical degenerations is discussed, and some advances in botanical and toxicological aspects of these Solanaceae species are presented, taking into account the potential risk of human poisoning.
publishDate 2013
dc.date.none.fl_str_mv 2013-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23955
Verdes, Jose M.; Riet Correa, Franklin; Medeiros, Rosane M.T.; Moraña, Antonio; Battes, Daniel; et al.; Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review; United State Department of Agriculture; International Journal of Poisonous Plants Research; 2; 1; 5-2013; 34-44
2154-3216
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23955
identifier_str_mv Verdes, Jose M.; Riet Correa, Franklin; Medeiros, Rosane M.T.; Moraña, Antonio; Battes, Daniel; et al.; Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review; United State Department of Agriculture; International Journal of Poisonous Plants Research; 2; 1; 5-2013; 34-44
2154-3216
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ars.usda.gov/oc/np/poisonousplants/fall2012/index/
info:eu-repo/semantics/altIdentifier/url/https://www.ars.usda.gov/ARSUserFiles/oc/np/PoisonousPlants/Fall2012/cortical.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv United State Department of Agriculture
publisher.none.fl_str_mv United State Department of Agriculture
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782015789072384
score 13.167486

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