Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review
- Autores
- Verdes, Jose M.; Riet Correa, Franklin; Medeiros, Rosane M.T.; Moraña, Antonio; Battes, Daniel; Dehl, Virginia; Borteiro, Claudio; Gimeno, Eduardo Juan; Sant’Ana, Fabiano J.F.; Barros, Claudio S.L.; Barros, Servero S.
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Cattle that consume Solanum bonariense L (= Solanum fastigiatum Willd.) or Solanum paniculatum L. develop a typical cerebellar cortical degeneration characterized by periodic episodes of ataxia, hypermetria, hyperesthesia, head and thoracic limb extension, opisthotonus, nystagmus, and falling to the side or backward. Histological lesions include vacuolation, degeneration, and loss of Purkinje cells. Axonal spheroids, microcavitations, and other changes of Wallerian degeneration in cerebellar granular layer and white matter are also observed. Neurotoxic compounds in Solanum spp. causing neurologic dysfunction in ruminants were not definitively elucidated. The same Solanaceae species are extensively used with culinary purposes or for the treatment of liver and gastrointestinal disorders as hangovers in humans. In the present paper, we review the epidemiology, clinical signs, and pathological hallmarks of poisoning by Solanum —S. bonariense L. (=S. fastigiatum Willd.) and S. paniculatum—with emphasis in histopathology, ultrastructural, and lectin- and immuno-histochemical changes in spontaneous and experimentally poisoned cattle in South America. The current knowledge of the pathogenesis of these bovine cerebellar cortical degenerations is discussed, and some advances in botanical and toxicological aspects of these Solanaceae species are presented, taking into account the potential risk of human poisoning.
Fil: Verdes, Jose M.. Universidad de la República; Uruguay
Fil: Riet Correa, Franklin. Federal University of Campina Grande; Brasil
Fil: Medeiros, Rosane M.T.. Federal University of Campina Grande; Brasil
Fil: Moraña, Antonio. Universidad de la República; Uruguay
Fil: Battes, Daniel. Universidad de la República; Uruguay
Fil: Dehl, Virginia. Universidad de la República; Uruguay
Fil: Borteiro, Claudio. Universidad de la República; Uruguay
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sant’Ana, Fabiano J.F.. Universidade Federal de Goiás; Brasil
Fil: Barros, Claudio S.L.. Federal University of Santa Maria; Brasil
Fil: Barros, Servero S.. Federal University of Santa Maria; Brasil - Materia
-
cerebellar degeneration
diseases of cattle
poisonous plants
Solanacae - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/23955
Ver los metadatos del registro completo
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Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological ReviewVerdes, Jose M.Riet Correa, FranklinMedeiros, Rosane M.T.Moraña, AntonioBattes, DanielDehl, VirginiaBorteiro, ClaudioGimeno, Eduardo JuanSant’Ana, Fabiano J.F.Barros, Claudio S.L.Barros, Servero S.cerebellar degenerationdiseases of cattlepoisonous plantsSolanacaehttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Cattle that consume Solanum bonariense L (= Solanum fastigiatum Willd.) or Solanum paniculatum L. develop a typical cerebellar cortical degeneration characterized by periodic episodes of ataxia, hypermetria, hyperesthesia, head and thoracic limb extension, opisthotonus, nystagmus, and falling to the side or backward. Histological lesions include vacuolation, degeneration, and loss of Purkinje cells. Axonal spheroids, microcavitations, and other changes of Wallerian degeneration in cerebellar granular layer and white matter are also observed. Neurotoxic compounds in Solanum spp. causing neurologic dysfunction in ruminants were not definitively elucidated. The same Solanaceae species are extensively used with culinary purposes or for the treatment of liver and gastrointestinal disorders as hangovers in humans. In the present paper, we review the epidemiology, clinical signs, and pathological hallmarks of poisoning by Solanum —S. bonariense L. (=S. fastigiatum Willd.) and S. paniculatum—with emphasis in histopathology, ultrastructural, and lectin- and immuno-histochemical changes in spontaneous and experimentally poisoned cattle in South America. The current knowledge of the pathogenesis of these bovine cerebellar cortical degenerations is discussed, and some advances in botanical and toxicological aspects of these Solanaceae species are presented, taking into account the potential risk of human poisoning.Fil: Verdes, Jose M.. Universidad de la República; UruguayFil: Riet Correa, Franklin. Federal University of Campina Grande; BrasilFil: Medeiros, Rosane M.T.. Federal University of Campina Grande; BrasilFil: Moraña, Antonio. Universidad de la República; UruguayFil: Battes, Daniel. Universidad de la República; UruguayFil: Dehl, Virginia. Universidad de la República; UruguayFil: Borteiro, Claudio. Universidad de la República; UruguayFil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sant’Ana, Fabiano J.F.. Universidade Federal de Goiás; BrasilFil: Barros, Claudio S.L.. Federal University of Santa Maria; BrasilFil: Barros, Servero S.. Federal University of Santa Maria; BrasilUnited State Department of Agriculture2013-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23955Verdes, Jose M.; Riet Correa, Franklin; Medeiros, Rosane M.T.; Moraña, Antonio; Battes, Daniel; et al.; Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review; United State Department of Agriculture; International Journal of Poisonous Plants Research; 2; 1; 5-2013; 34-442154-3216CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ars.usda.gov/oc/np/poisonousplants/fall2012/index/info:eu-repo/semantics/altIdentifier/url/https://www.ars.usda.gov/ARSUserFiles/oc/np/PoisonousPlants/Fall2012/cortical.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:07:07Zoai:ri.conicet.gov.ar:11336/23955instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:07:07.515CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review |
title |
Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review |
spellingShingle |
Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review Verdes, Jose M. cerebellar degeneration diseases of cattle poisonous plants Solanacae |
title_short |
Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review |
title_full |
Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review |
title_fullStr |
Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review |
title_full_unstemmed |
Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review |
title_sort |
Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review |
dc.creator.none.fl_str_mv |
Verdes, Jose M. Riet Correa, Franklin Medeiros, Rosane M.T. Moraña, Antonio Battes, Daniel Dehl, Virginia Borteiro, Claudio Gimeno, Eduardo Juan Sant’Ana, Fabiano J.F. Barros, Claudio S.L. Barros, Servero S. |
author |
Verdes, Jose M. |
author_facet |
Verdes, Jose M. Riet Correa, Franklin Medeiros, Rosane M.T. Moraña, Antonio Battes, Daniel Dehl, Virginia Borteiro, Claudio Gimeno, Eduardo Juan Sant’Ana, Fabiano J.F. Barros, Claudio S.L. Barros, Servero S. |
author_role |
author |
author2 |
Riet Correa, Franklin Medeiros, Rosane M.T. Moraña, Antonio Battes, Daniel Dehl, Virginia Borteiro, Claudio Gimeno, Eduardo Juan Sant’Ana, Fabiano J.F. Barros, Claudio S.L. Barros, Servero S. |
author2_role |
author author author author author author author author author author |
dc.subject.none.fl_str_mv |
cerebellar degeneration diseases of cattle poisonous plants Solanacae |
topic |
cerebellar degeneration diseases of cattle poisonous plants Solanacae |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
dc.description.none.fl_txt_mv |
Cattle that consume Solanum bonariense L (= Solanum fastigiatum Willd.) or Solanum paniculatum L. develop a typical cerebellar cortical degeneration characterized by periodic episodes of ataxia, hypermetria, hyperesthesia, head and thoracic limb extension, opisthotonus, nystagmus, and falling to the side or backward. Histological lesions include vacuolation, degeneration, and loss of Purkinje cells. Axonal spheroids, microcavitations, and other changes of Wallerian degeneration in cerebellar granular layer and white matter are also observed. Neurotoxic compounds in Solanum spp. causing neurologic dysfunction in ruminants were not definitively elucidated. The same Solanaceae species are extensively used with culinary purposes or for the treatment of liver and gastrointestinal disorders as hangovers in humans. In the present paper, we review the epidemiology, clinical signs, and pathological hallmarks of poisoning by Solanum —S. bonariense L. (=S. fastigiatum Willd.) and S. paniculatum—with emphasis in histopathology, ultrastructural, and lectin- and immuno-histochemical changes in spontaneous and experimentally poisoned cattle in South America. The current knowledge of the pathogenesis of these bovine cerebellar cortical degenerations is discussed, and some advances in botanical and toxicological aspects of these Solanaceae species are presented, taking into account the potential risk of human poisoning. Fil: Verdes, Jose M.. Universidad de la República; Uruguay Fil: Riet Correa, Franklin. Federal University of Campina Grande; Brasil Fil: Medeiros, Rosane M.T.. Federal University of Campina Grande; Brasil Fil: Moraña, Antonio. Universidad de la República; Uruguay Fil: Battes, Daniel. Universidad de la República; Uruguay Fil: Dehl, Virginia. Universidad de la República; Uruguay Fil: Borteiro, Claudio. Universidad de la República; Uruguay Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Sant’Ana, Fabiano J.F.. Universidade Federal de Goiás; Brasil Fil: Barros, Claudio S.L.. Federal University of Santa Maria; Brasil Fil: Barros, Servero S.. Federal University of Santa Maria; Brasil |
description |
Cattle that consume Solanum bonariense L (= Solanum fastigiatum Willd.) or Solanum paniculatum L. develop a typical cerebellar cortical degeneration characterized by periodic episodes of ataxia, hypermetria, hyperesthesia, head and thoracic limb extension, opisthotonus, nystagmus, and falling to the side or backward. Histological lesions include vacuolation, degeneration, and loss of Purkinje cells. Axonal spheroids, microcavitations, and other changes of Wallerian degeneration in cerebellar granular layer and white matter are also observed. Neurotoxic compounds in Solanum spp. causing neurologic dysfunction in ruminants were not definitively elucidated. The same Solanaceae species are extensively used with culinary purposes or for the treatment of liver and gastrointestinal disorders as hangovers in humans. In the present paper, we review the epidemiology, clinical signs, and pathological hallmarks of poisoning by Solanum —S. bonariense L. (=S. fastigiatum Willd.) and S. paniculatum—with emphasis in histopathology, ultrastructural, and lectin- and immuno-histochemical changes in spontaneous and experimentally poisoned cattle in South America. The current knowledge of the pathogenesis of these bovine cerebellar cortical degenerations is discussed, and some advances in botanical and toxicological aspects of these Solanaceae species are presented, taking into account the potential risk of human poisoning. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/23955 Verdes, Jose M.; Riet Correa, Franklin; Medeiros, Rosane M.T.; Moraña, Antonio; Battes, Daniel; et al.; Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review; United State Department of Agriculture; International Journal of Poisonous Plants Research; 2; 1; 5-2013; 34-44 2154-3216 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/23955 |
identifier_str_mv |
Verdes, Jose M.; Riet Correa, Franklin; Medeiros, Rosane M.T.; Moraña, Antonio; Battes, Daniel; et al.; Cerebellar Cortical Degeneration in Cattle Poisoned With Solanum spp. in South America: An Epidemiological, Clinicopathological, Pathological, and Toxicological Review; United State Department of Agriculture; International Journal of Poisonous Plants Research; 2; 1; 5-2013; 34-44 2154-3216 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.ars.usda.gov/oc/np/poisonousplants/fall2012/index/ info:eu-repo/semantics/altIdentifier/url/https://www.ars.usda.gov/ARSUserFiles/oc/np/PoisonousPlants/Fall2012/cortical.pdf |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
United State Department of Agriculture |
publisher.none.fl_str_mv |
United State Department of Agriculture |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613927468531712 |
score |
13.070432 |