Congenital Cerebellar Cortical Degeneration in Holstein Cattle in Southern Brazil

Autores
Schild, Ana Lucia; Riet-Correa, Franklin; Portiansky, Enrique Leo; Méndez, M. C.; Graça, D. L.
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A congenital progressive cerebellar disorder is described in Holstein calves. The clinical signs were progressive and were characterized by ataxia, hypermetria, a wide stance and fine head tremors. When the affected cattle were forced to run, the signs were exacerbated, leading to epileptiform attacks. Histological lesions consisted of a very selective cerebellar cortical degeneration, almost exclusively affecting the Purkinje cells. The disease affected 6 out of 200 Holstein calves from the same bull. However, results of mating tests of the bull with his daughters and granddaughters suggested that it was not hereditary (p = 0.0062) although an environmental–genetic interaction could not be ruled out.
Facultad de Ciencias Veterinarias
Materia
Veterinaria
cattle
cerebellar degeneration
cerebellum
Genetics
histopathology
neurology
Purkinje cells
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/132543
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/132543
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Congenital Cerebellar Cortical Degeneration in Holstein Cattle in Southern BrazilSchild, Ana LuciaRiet-Correa, FranklinPortiansky, Enrique LeoMéndez, M. C.Graça, D. L.Veterinariacattlecerebellar degenerationcerebellumGeneticshistopathologyneurologyPurkinje cellsA congenital progressive cerebellar disorder is described in Holstein calves. The clinical signs were progressive and were characterized by ataxia, hypermetria, a wide stance and fine head tremors. When the affected cattle were forced to run, the signs were exacerbated, leading to epileptiform attacks. Histological lesions consisted of a very selective cerebellar cortical degeneration, almost exclusively affecting the Purkinje cells. The disease affected 6 out of 200 Holstein calves from the same bull. However, results of mating tests of the bull with his daughters and granddaughters suggested that it was not hereditary (p = 0.0062) although an environmental–genetic interaction could not be ruled out.Facultad de Ciencias Veterinarias2001-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf189-195http://sedici.unlp.edu.ar/handle/10915/132543enginfo:eu-repo/semantics/altIdentifier/issn/0165-7380info:eu-repo/semantics/altIdentifier/doi/10.1023/a:1006477508776info:eu-repo/semantics/altIdentifier/pmid/11334148info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:04:34Zoai:sedici.unlp.edu.ar:10915/132543Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:04:34.401SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Congenital Cerebellar Cortical Degeneration in Holstein Cattle in Southern Brazil
title Congenital Cerebellar Cortical Degeneration in Holstein Cattle in Southern Brazil
spellingShingle Congenital Cerebellar Cortical Degeneration in Holstein Cattle in Southern Brazil
Schild, Ana Lucia
Veterinaria
cattle
cerebellar degeneration
cerebellum
Genetics
histopathology
neurology
Purkinje cells
title_short Congenital Cerebellar Cortical Degeneration in Holstein Cattle in Southern Brazil
title_full Congenital Cerebellar Cortical Degeneration in Holstein Cattle in Southern Brazil
title_fullStr Congenital Cerebellar Cortical Degeneration in Holstein Cattle in Southern Brazil
title_full_unstemmed Congenital Cerebellar Cortical Degeneration in Holstein Cattle in Southern Brazil
title_sort Congenital Cerebellar Cortical Degeneration in Holstein Cattle in Southern Brazil
dc.creator.none.fl_str_mv Schild, Ana Lucia
Riet-Correa, Franklin
Portiansky, Enrique Leo
Méndez, M. C.
Graça, D. L.
author Schild, Ana Lucia
author_facet Schild, Ana Lucia
Riet-Correa, Franklin
Portiansky, Enrique Leo
Méndez, M. C.
Graça, D. L.
author_role author
author2 Riet-Correa, Franklin
Portiansky, Enrique Leo
Méndez, M. C.
Graça, D. L.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Veterinaria
cattle
cerebellar degeneration
cerebellum
Genetics
histopathology
neurology
Purkinje cells
topic Veterinaria
cattle
cerebellar degeneration
cerebellum
Genetics
histopathology
neurology
Purkinje cells
dc.description.none.fl_txt_mv A congenital progressive cerebellar disorder is described in Holstein calves. The clinical signs were progressive and were characterized by ataxia, hypermetria, a wide stance and fine head tremors. When the affected cattle were forced to run, the signs were exacerbated, leading to epileptiform attacks. Histological lesions consisted of a very selective cerebellar cortical degeneration, almost exclusively affecting the Purkinje cells. The disease affected 6 out of 200 Holstein calves from the same bull. However, results of mating tests of the bull with his daughters and granddaughters suggested that it was not hereditary (p = 0.0062) although an environmental–genetic interaction could not be ruled out.
Facultad de Ciencias Veterinarias
description A congenital progressive cerebellar disorder is described in Holstein calves. The clinical signs were progressive and were characterized by ataxia, hypermetria, a wide stance and fine head tremors. When the affected cattle were forced to run, the signs were exacerbated, leading to epileptiform attacks. Histological lesions consisted of a very selective cerebellar cortical degeneration, almost exclusively affecting the Purkinje cells. The disease affected 6 out of 200 Holstein calves from the same bull. However, results of mating tests of the bull with his daughters and granddaughters suggested that it was not hereditary (p = 0.0062) although an environmental–genetic interaction could not be ruled out.
publishDate 2001
dc.date.none.fl_str_mv 2001-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/132543
url http://sedici.unlp.edu.ar/handle/10915/132543
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0165-7380
info:eu-repo/semantics/altIdentifier/doi/10.1023/a:1006477508776
info:eu-repo/semantics/altIdentifier/pmid/11334148
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
189-195
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.13397

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