Evidence of association between epstein barr virus serum antibodies with HAs and RI as biomarkers of active rheumatoid arthritis

Autores
Perez, Germán; Svetaz, María José; Urli, Leda Diana; Volpintesta, Ricardo; Taborda, Miguel Angel; Gardiol, Daniela Nora; Giri, Adriana Angelica; Luquita, Alejandra Nora
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Epstein Barr Virus (EBV) infection has been associated with the Rheumatoid Arthritis (RA) etiopathology, thus, considering it a relevant etiological agent in the disease development. We have previously observed the Hyaluronic Acid (HA) serum increase in active RA patients (DAS 28-4 > 2.6) which might be responsible for the erythrocyte deformability, estimated by the erythrocyte Rigidity Index (RI). Objective: In the present study, we analyzed in one hundred RA patients if anti-EBV serum antibodies (TsEBV) and HA and RI levels are related with the disease activity. Results: [HA] s [[controls]]: 20.0 ± 9; [HA] s [[AR]]: 155.8 ± 44 (p< 0.00001 vs. controls (n:40). Antibodies anti-EBV (1/ TsEBV) [[controls]]: 2.55 ± 0.49; [[RA]]: 1.85 ± 0.35 (p< 0.00001 vs. controls). There were significant correlations between DAS 28-4 vs. log2 1/TsEBV (r: 0.70, p < 0.00001) and DAS 28-4 vs. RI (r: 0.75, p < 0.00001) in active RA patients. However, we observed a strong positive correlation between [HA] s in active RA patients vs. log2 1/TsEBV (r: 0.83, p < 0.00001) and [HA] s vs. RI (r: 0.91, p < 0.00001). Conclusion: The correlation obtained points out that the TsEBV may be related with the degree of RA activity determined by DAS28-4 and [HA]s in these patients. There was also a decrease in erythrocyte deformability estimated as RI, which is correlated with the DAS 28-4 activity index. Therefore, RI can be used as a reliable marker of RA activity. These findings might suggest a role of EBV infection regarding an autoimmune mechanism present in RA.
Fil: Perez, Germán. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Svetaz, María José. Universidad Nacional de Rosario; Argentina
Fil: Leda Urli. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Volpintesta, Ricardo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Taborda, Miguel Ángel. Universidad Nacional de Rosario; Argentina
Fil: Gardiol, Daniela Nora. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Gir, Adriana. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Luquita, Alejandra Nora. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Universidad Nacional de Rosario; Argentina
Materia
DISEASE ACTIVITY SCORE 28-4
EPSTEIN-BARR VIRUS
ERYTHROCYTE DEFORMABILITY
ERYTHROCYTE RIGIDITY INDEX
HYALURONIC ACID
RHEUMATOID ARTHRITIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/92611
Acceder
id CONICETDig_5cf0decc23ac3ccaea6015b7a5751a1d
oai_identifier_str oai:ri.conicet.gov.ar:11336/92611
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evidence of association between epstein barr virus serum antibodies with HAs and RI as biomarkers of active rheumatoid arthritisPerez, GermánSvetaz, María JoséUrli, Leda DianaVolpintesta, RicardoTaborda, Miguel AngelGardiol, Daniela NoraGiri, Adriana AngelicaLuquita, Alejandra NoraDISEASE ACTIVITY SCORE 28-4EPSTEIN-BARR VIRUSERYTHROCYTE DEFORMABILITYERYTHROCYTE RIGIDITY INDEXHYALURONIC ACIDRHEUMATOID ARTHRITIShttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Background: Epstein Barr Virus (EBV) infection has been associated with the Rheumatoid Arthritis (RA) etiopathology, thus, considering it a relevant etiological agent in the disease development. We have previously observed the Hyaluronic Acid (HA) serum increase in active RA patients (DAS 28-4 > 2.6) which might be responsible for the erythrocyte deformability, estimated by the erythrocyte Rigidity Index (RI). Objective: In the present study, we analyzed in one hundred RA patients if anti-EBV serum antibodies (TsEBV) and HA and RI levels are related with the disease activity. Results: [HA] s [[controls]]: 20.0 ± 9; [HA] s [[AR]]: 155.8 ± 44 (p< 0.00001 vs. controls (n:40). Antibodies anti-EBV (1/ TsEBV) [[controls]]: 2.55 ± 0.49; [[RA]]: 1.85 ± 0.35 (p< 0.00001 vs. controls). There were significant correlations between DAS 28-4 vs. log2 1/TsEBV (r: 0.70, p < 0.00001) and DAS 28-4 vs. RI (r: 0.75, p < 0.00001) in active RA patients. However, we observed a strong positive correlation between [HA] s in active RA patients vs. log2 1/TsEBV (r: 0.83, p < 0.00001) and [HA] s vs. RI (r: 0.91, p < 0.00001). Conclusion: The correlation obtained points out that the TsEBV may be related with the degree of RA activity determined by DAS28-4 and [HA]s in these patients. There was also a decrease in erythrocyte deformability estimated as RI, which is correlated with the DAS 28-4 activity index. Therefore, RI can be used as a reliable marker of RA activity. These findings might suggest a role of EBV infection regarding an autoimmune mechanism present in RA.Fil: Perez, Germán. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; ArgentinaFil: Svetaz, María José. Universidad Nacional de Rosario; ArgentinaFil: Leda Urli. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Volpintesta, Ricardo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Taborda, Miguel Ángel. Universidad Nacional de Rosario; ArgentinaFil: Gardiol, Daniela Nora. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; ArgentinaFil: Gir, Adriana. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; ArgentinaFil: Luquita, Alejandra Nora. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Universidad Nacional de Rosario; ArgentinaBentham Science Publishers2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/92611Perez, Germán; Svetaz, María José; Urli, Leda Diana; Volpintesta, Ricardo; Taborda, Miguel Angel; et al.; Evidence of association between epstein barr virus serum antibodies with HAs and RI as biomarkers of active rheumatoid arthritis; Bentham Science Publishers; Current Biomarkers; 7; 1; 6-2018; 41-462468-4236CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2174/2468422808666180314120112info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/160472/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:02Zoai:ri.conicet.gov.ar:11336/92611instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:02.845CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evidence of association between epstein barr virus serum antibodies with HAs and RI as biomarkers of active rheumatoid arthritis
title Evidence of association between epstein barr virus serum antibodies with HAs and RI as biomarkers of active rheumatoid arthritis
spellingShingle Evidence of association between epstein barr virus serum antibodies with HAs and RI as biomarkers of active rheumatoid arthritis
Perez, Germán
DISEASE ACTIVITY SCORE 28-4
EPSTEIN-BARR VIRUS
ERYTHROCYTE DEFORMABILITY
ERYTHROCYTE RIGIDITY INDEX
HYALURONIC ACID
RHEUMATOID ARTHRITIS
title_short Evidence of association between epstein barr virus serum antibodies with HAs and RI as biomarkers of active rheumatoid arthritis
title_full Evidence of association between epstein barr virus serum antibodies with HAs and RI as biomarkers of active rheumatoid arthritis
title_fullStr Evidence of association between epstein barr virus serum antibodies with HAs and RI as biomarkers of active rheumatoid arthritis
title_full_unstemmed Evidence of association between epstein barr virus serum antibodies with HAs and RI as biomarkers of active rheumatoid arthritis
title_sort Evidence of association between epstein barr virus serum antibodies with HAs and RI as biomarkers of active rheumatoid arthritis
dc.creator.none.fl_str_mv Perez, Germán
Svetaz, María José
Urli, Leda Diana
Volpintesta, Ricardo
Taborda, Miguel Angel
Gardiol, Daniela Nora
Giri, Adriana Angelica
Luquita, Alejandra Nora
author Perez, Germán
author_facet Perez, Germán
Svetaz, María José
Urli, Leda Diana
Volpintesta, Ricardo
Taborda, Miguel Angel
Gardiol, Daniela Nora
Giri, Adriana Angelica
Luquita, Alejandra Nora
author_role author
author2 Svetaz, María José
Urli, Leda Diana
Volpintesta, Ricardo
Taborda, Miguel Angel
Gardiol, Daniela Nora
Giri, Adriana Angelica
Luquita, Alejandra Nora
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv DISEASE ACTIVITY SCORE 28-4
EPSTEIN-BARR VIRUS
ERYTHROCYTE DEFORMABILITY
ERYTHROCYTE RIGIDITY INDEX
HYALURONIC ACID
RHEUMATOID ARTHRITIS
topic DISEASE ACTIVITY SCORE 28-4
EPSTEIN-BARR VIRUS
ERYTHROCYTE DEFORMABILITY
ERYTHROCYTE RIGIDITY INDEX
HYALURONIC ACID
RHEUMATOID ARTHRITIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Epstein Barr Virus (EBV) infection has been associated with the Rheumatoid Arthritis (RA) etiopathology, thus, considering it a relevant etiological agent in the disease development. We have previously observed the Hyaluronic Acid (HA) serum increase in active RA patients (DAS 28-4 > 2.6) which might be responsible for the erythrocyte deformability, estimated by the erythrocyte Rigidity Index (RI). Objective: In the present study, we analyzed in one hundred RA patients if anti-EBV serum antibodies (TsEBV) and HA and RI levels are related with the disease activity. Results: [HA] s [[controls]]: 20.0 ± 9; [HA] s [[AR]]: 155.8 ± 44 (p< 0.00001 vs. controls (n:40). Antibodies anti-EBV (1/ TsEBV) [[controls]]: 2.55 ± 0.49; [[RA]]: 1.85 ± 0.35 (p< 0.00001 vs. controls). There were significant correlations between DAS 28-4 vs. log2 1/TsEBV (r: 0.70, p < 0.00001) and DAS 28-4 vs. RI (r: 0.75, p < 0.00001) in active RA patients. However, we observed a strong positive correlation between [HA] s in active RA patients vs. log2 1/TsEBV (r: 0.83, p < 0.00001) and [HA] s vs. RI (r: 0.91, p < 0.00001). Conclusion: The correlation obtained points out that the TsEBV may be related with the degree of RA activity determined by DAS28-4 and [HA]s in these patients. There was also a decrease in erythrocyte deformability estimated as RI, which is correlated with the DAS 28-4 activity index. Therefore, RI can be used as a reliable marker of RA activity. These findings might suggest a role of EBV infection regarding an autoimmune mechanism present in RA.
Fil: Perez, Germán. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Svetaz, María José. Universidad Nacional de Rosario; Argentina
Fil: Leda Urli. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Volpintesta, Ricardo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Taborda, Miguel Ángel. Universidad Nacional de Rosario; Argentina
Fil: Gardiol, Daniela Nora. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Gir, Adriana. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Luquita, Alejandra Nora. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Universidad Nacional de Rosario; Argentina
description Background: Epstein Barr Virus (EBV) infection has been associated with the Rheumatoid Arthritis (RA) etiopathology, thus, considering it a relevant etiological agent in the disease development. We have previously observed the Hyaluronic Acid (HA) serum increase in active RA patients (DAS 28-4 > 2.6) which might be responsible for the erythrocyte deformability, estimated by the erythrocyte Rigidity Index (RI). Objective: In the present study, we analyzed in one hundred RA patients if anti-EBV serum antibodies (TsEBV) and HA and RI levels are related with the disease activity. Results: [HA] s [[controls]]: 20.0 ± 9; [HA] s [[AR]]: 155.8 ± 44 (p< 0.00001 vs. controls (n:40). Antibodies anti-EBV (1/ TsEBV) [[controls]]: 2.55 ± 0.49; [[RA]]: 1.85 ± 0.35 (p< 0.00001 vs. controls). There were significant correlations between DAS 28-4 vs. log2 1/TsEBV (r: 0.70, p < 0.00001) and DAS 28-4 vs. RI (r: 0.75, p < 0.00001) in active RA patients. However, we observed a strong positive correlation between [HA] s in active RA patients vs. log2 1/TsEBV (r: 0.83, p < 0.00001) and [HA] s vs. RI (r: 0.91, p < 0.00001). Conclusion: The correlation obtained points out that the TsEBV may be related with the degree of RA activity determined by DAS28-4 and [HA]s in these patients. There was also a decrease in erythrocyte deformability estimated as RI, which is correlated with the DAS 28-4 activity index. Therefore, RI can be used as a reliable marker of RA activity. These findings might suggest a role of EBV infection regarding an autoimmune mechanism present in RA.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/92611
Perez, Germán; Svetaz, María José; Urli, Leda Diana; Volpintesta, Ricardo; Taborda, Miguel Angel; et al.; Evidence of association between epstein barr virus serum antibodies with HAs and RI as biomarkers of active rheumatoid arthritis; Bentham Science Publishers; Current Biomarkers; 7; 1; 6-2018; 41-46
2468-4236
CONICET Digital
CONICET
url http://hdl.handle.net/11336/92611
identifier_str_mv Perez, Germán; Svetaz, María José; Urli, Leda Diana; Volpintesta, Ricardo; Taborda, Miguel Angel; et al.; Evidence of association between epstein barr virus serum antibodies with HAs and RI as biomarkers of active rheumatoid arthritis; Bentham Science Publishers; Current Biomarkers; 7; 1; 6-2018; 41-46
2468-4236
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2174/2468422808666180314120112
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/160472/article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613012148715520
score 13.070432

Publicaciones similares