Correlation between DAS-28 and Neopterin as a Biochemical Marker of Immune System Activation in Early Rheumatoid Arthritis

Autores
D'agostino, Liliana Elena; Ventimiglia, Fernando; Verna, Juan Antonio; de la Colina, Amelia; Aguirre, Yanina; Arturi, Alfredo; Capparelli, Alberto Luis
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: The objective of this study was to evaluate neopterin plasma concentrations in patients with early Rheumatoid Arthritis (RA) and correlate them with disease activity. Methods: This is a 28-month prospective study carried out on 65 individuals. There were 27 patients with early RA and 38 healthy volunteers as control group. Enzyme immunoassay was used to measure concentrations of neopterin and anti-cyclic citrullinated peptide (CCP) antibodies. Rheumatoid factor (RF) and C-reactive protein (CRP) were measured turbidimetrically, and antinuclear antibodies (ANA) were detected by immunofluorescence. Patients with early RA disease activity were divided into 4 groups according to DAS-28 criteria. Neopterin concentrations in RA patients were compared to conventional RA diagnostic serological markers. Results: Healthy volunteers had a mean neopterin concentration of 5.63 ^ 0.38 [1.36?9.93] nmol. L21. A statistically significant elevation of neopterin mean concentration was found on early RA patients: mean value of 8.92 ^ 0.93 [3.94?28.3] nmol. L21 ( p , 0.001). Pearson product moment correlation suggests a correlation between neopterin concentrations and DAS-28 (r ¼ 0.208, p ¼ 0.065). The analysis of the mean values grouped according with the DAS-28 criteria showed a correspondence between these means, with a Pearson correlation coefficient r ¼ 0.979, p ¼ 0.021. CRP concentrations also showed a similar trend. Anti-CCP antibodies and RF revealed a positive relationship with RA activity. Such a correlation was not found with ANA results. Conclusions: The elevation of plasma neopterin concentrations in early RA patients may indicate stimulation of immune response. Good correlation between neopterin concentrations and DAS-28 may facilitate assessing disease activity.
Fil: D'agostino, Liliana Elena. Laboratorio de Análisis Clínicos e Inmunología, La Plata; Argentina
Fil: Ventimiglia, Fernando. Laboratorio de Análisis Clínicos e Inmunología, La Plata; Argentina
Fil: Verna, Juan Antonio. Laboratorio de Análisis Clínicos e Inmunología, La Plata; Argentina
Fil: de la Colina, Amelia. Laboratorio de Análisis Clínicos e Inmunología, La Plata; Argentina
Fil: Aguirre, Yanina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Fil: Arturi, Alfredo. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Fil: Capparelli, Alberto Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Materia
Rheumatoid Arthritis
Immune Activation
Neopterin
Das-28
Rheumatoid Factor
C-Reactive Protein
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/5329
Acceder
id CONICETDig_9373fd12a9f654b0dae1771b16304d4a
oai_identifier_str oai:ri.conicet.gov.ar:11336/5329
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Correlation between DAS-28 and Neopterin as a Biochemical Marker of Immune System Activation in Early Rheumatoid ArthritisD'agostino, Liliana ElenaVentimiglia, FernandoVerna, Juan Antoniode la Colina, AmeliaAguirre, YaninaArturi, AlfredoCapparelli, Alberto LuisRheumatoid ArthritisImmune ActivationNeopterinDas-28Rheumatoid FactorC-Reactive Proteinhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective: The objective of this study was to evaluate neopterin plasma concentrations in patients with early Rheumatoid Arthritis (RA) and correlate them with disease activity. Methods: This is a 28-month prospective study carried out on 65 individuals. There were 27 patients with early RA and 38 healthy volunteers as control group. Enzyme immunoassay was used to measure concentrations of neopterin and anti-cyclic citrullinated peptide (CCP) antibodies. Rheumatoid factor (RF) and C-reactive protein (CRP) were measured turbidimetrically, and antinuclear antibodies (ANA) were detected by immunofluorescence. Patients with early RA disease activity were divided into 4 groups according to DAS-28 criteria. Neopterin concentrations in RA patients were compared to conventional RA diagnostic serological markers. Results: Healthy volunteers had a mean neopterin concentration of 5.63 ^ 0.38 [1.36?9.93] nmol. L21. A statistically significant elevation of neopterin mean concentration was found on early RA patients: mean value of 8.92 ^ 0.93 [3.94?28.3] nmol. L21 ( p , 0.001). Pearson product moment correlation suggests a correlation between neopterin concentrations and DAS-28 (r ¼ 0.208, p ¼ 0.065). The analysis of the mean values grouped according with the DAS-28 criteria showed a correspondence between these means, with a Pearson correlation coefficient r ¼ 0.979, p ¼ 0.021. CRP concentrations also showed a similar trend. Anti-CCP antibodies and RF revealed a positive relationship with RA activity. Such a correlation was not found with ANA results. Conclusions: The elevation of plasma neopterin concentrations in early RA patients may indicate stimulation of immune response. Good correlation between neopterin concentrations and DAS-28 may facilitate assessing disease activity.Fil: D'agostino, Liliana Elena. Laboratorio de Análisis Clínicos e Inmunología, La Plata; ArgentinaFil: Ventimiglia, Fernando. Laboratorio de Análisis Clínicos e Inmunología, La Plata; ArgentinaFil: Verna, Juan Antonio. Laboratorio de Análisis Clínicos e Inmunología, La Plata; ArgentinaFil: de la Colina, Amelia. Laboratorio de Análisis Clínicos e Inmunología, La Plata; ArgentinaFil: Aguirre, Yanina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Arturi, Alfredo. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaFil: Capparelli, Alberto Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; ArgentinaTaylor & Francis2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/5329D'agostino, Liliana Elena; Ventimiglia, Fernando; Verna, Juan Antonio; de la Colina, Amelia; Aguirre, Yanina; et al.; Correlation between DAS-28 and Neopterin as a Biochemical Marker of Immune System Activation in Early Rheumatoid Arthritis; Taylor & Francis; Autoimmunity; 46; 1; 2-2013; 44-490891-6934enginfo:eu-repo/semantics/altIdentifier/pmid/22978451info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.3109/08916934.2012.722143info:eu-repo/semantics/altIdentifier/doi/10.3109/08916934.2012.722143info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:14:34Zoai:ri.conicet.gov.ar:11336/5329instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:14:34.783CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Correlation between DAS-28 and Neopterin as a Biochemical Marker of Immune System Activation in Early Rheumatoid Arthritis
title Correlation between DAS-28 and Neopterin as a Biochemical Marker of Immune System Activation in Early Rheumatoid Arthritis
spellingShingle Correlation between DAS-28 and Neopterin as a Biochemical Marker of Immune System Activation in Early Rheumatoid Arthritis
D'agostino, Liliana Elena
Rheumatoid Arthritis
Immune Activation
Neopterin
Das-28
Rheumatoid Factor
C-Reactive Protein
title_short Correlation between DAS-28 and Neopterin as a Biochemical Marker of Immune System Activation in Early Rheumatoid Arthritis
title_full Correlation between DAS-28 and Neopterin as a Biochemical Marker of Immune System Activation in Early Rheumatoid Arthritis
title_fullStr Correlation between DAS-28 and Neopterin as a Biochemical Marker of Immune System Activation in Early Rheumatoid Arthritis
title_full_unstemmed Correlation between DAS-28 and Neopterin as a Biochemical Marker of Immune System Activation in Early Rheumatoid Arthritis
title_sort Correlation between DAS-28 and Neopterin as a Biochemical Marker of Immune System Activation in Early Rheumatoid Arthritis
dc.creator.none.fl_str_mv D'agostino, Liliana Elena
Ventimiglia, Fernando
Verna, Juan Antonio
de la Colina, Amelia
Aguirre, Yanina
Arturi, Alfredo
Capparelli, Alberto Luis
author D'agostino, Liliana Elena
author_facet D'agostino, Liliana Elena
Ventimiglia, Fernando
Verna, Juan Antonio
de la Colina, Amelia
Aguirre, Yanina
Arturi, Alfredo
Capparelli, Alberto Luis
author_role author
author2 Ventimiglia, Fernando
Verna, Juan Antonio
de la Colina, Amelia
Aguirre, Yanina
Arturi, Alfredo
Capparelli, Alberto Luis
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Rheumatoid Arthritis
Immune Activation
Neopterin
Das-28
Rheumatoid Factor
C-Reactive Protein
topic Rheumatoid Arthritis
Immune Activation
Neopterin
Das-28
Rheumatoid Factor
C-Reactive Protein
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: The objective of this study was to evaluate neopterin plasma concentrations in patients with early Rheumatoid Arthritis (RA) and correlate them with disease activity. Methods: This is a 28-month prospective study carried out on 65 individuals. There were 27 patients with early RA and 38 healthy volunteers as control group. Enzyme immunoassay was used to measure concentrations of neopterin and anti-cyclic citrullinated peptide (CCP) antibodies. Rheumatoid factor (RF) and C-reactive protein (CRP) were measured turbidimetrically, and antinuclear antibodies (ANA) were detected by immunofluorescence. Patients with early RA disease activity were divided into 4 groups according to DAS-28 criteria. Neopterin concentrations in RA patients were compared to conventional RA diagnostic serological markers. Results: Healthy volunteers had a mean neopterin concentration of 5.63 ^ 0.38 [1.36?9.93] nmol. L21. A statistically significant elevation of neopterin mean concentration was found on early RA patients: mean value of 8.92 ^ 0.93 [3.94?28.3] nmol. L21 ( p , 0.001). Pearson product moment correlation suggests a correlation between neopterin concentrations and DAS-28 (r ¼ 0.208, p ¼ 0.065). The analysis of the mean values grouped according with the DAS-28 criteria showed a correspondence between these means, with a Pearson correlation coefficient r ¼ 0.979, p ¼ 0.021. CRP concentrations also showed a similar trend. Anti-CCP antibodies and RF revealed a positive relationship with RA activity. Such a correlation was not found with ANA results. Conclusions: The elevation of plasma neopterin concentrations in early RA patients may indicate stimulation of immune response. Good correlation between neopterin concentrations and DAS-28 may facilitate assessing disease activity.
Fil: D'agostino, Liliana Elena. Laboratorio de Análisis Clínicos e Inmunología, La Plata; Argentina
Fil: Ventimiglia, Fernando. Laboratorio de Análisis Clínicos e Inmunología, La Plata; Argentina
Fil: Verna, Juan Antonio. Laboratorio de Análisis Clínicos e Inmunología, La Plata; Argentina
Fil: de la Colina, Amelia. Laboratorio de Análisis Clínicos e Inmunología, La Plata; Argentina
Fil: Aguirre, Yanina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Fil: Arturi, Alfredo. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Fil: Capparelli, Alberto Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
description Objective: The objective of this study was to evaluate neopterin plasma concentrations in patients with early Rheumatoid Arthritis (RA) and correlate them with disease activity. Methods: This is a 28-month prospective study carried out on 65 individuals. There were 27 patients with early RA and 38 healthy volunteers as control group. Enzyme immunoassay was used to measure concentrations of neopterin and anti-cyclic citrullinated peptide (CCP) antibodies. Rheumatoid factor (RF) and C-reactive protein (CRP) were measured turbidimetrically, and antinuclear antibodies (ANA) were detected by immunofluorescence. Patients with early RA disease activity were divided into 4 groups according to DAS-28 criteria. Neopterin concentrations in RA patients were compared to conventional RA diagnostic serological markers. Results: Healthy volunteers had a mean neopterin concentration of 5.63 ^ 0.38 [1.36?9.93] nmol. L21. A statistically significant elevation of neopterin mean concentration was found on early RA patients: mean value of 8.92 ^ 0.93 [3.94?28.3] nmol. L21 ( p , 0.001). Pearson product moment correlation suggests a correlation between neopterin concentrations and DAS-28 (r ¼ 0.208, p ¼ 0.065). The analysis of the mean values grouped according with the DAS-28 criteria showed a correspondence between these means, with a Pearson correlation coefficient r ¼ 0.979, p ¼ 0.021. CRP concentrations also showed a similar trend. Anti-CCP antibodies and RF revealed a positive relationship with RA activity. Such a correlation was not found with ANA results. Conclusions: The elevation of plasma neopterin concentrations in early RA patients may indicate stimulation of immune response. Good correlation between neopterin concentrations and DAS-28 may facilitate assessing disease activity.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/5329
D'agostino, Liliana Elena; Ventimiglia, Fernando; Verna, Juan Antonio; de la Colina, Amelia; Aguirre, Yanina; et al.; Correlation between DAS-28 and Neopterin as a Biochemical Marker of Immune System Activation in Early Rheumatoid Arthritis; Taylor & Francis; Autoimmunity; 46; 1; 2-2013; 44-49
0891-6934
url http://hdl.handle.net/11336/5329
identifier_str_mv D'agostino, Liliana Elena; Ventimiglia, Fernando; Verna, Juan Antonio; de la Colina, Amelia; Aguirre, Yanina; et al.; Correlation between DAS-28 and Neopterin as a Biochemical Marker of Immune System Activation in Early Rheumatoid Arthritis; Taylor & Francis; Autoimmunity; 46; 1; 2-2013; 44-49
0891-6934
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/pmid/22978451
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.3109/08916934.2012.722143
info:eu-repo/semantics/altIdentifier/doi/10.3109/08916934.2012.722143
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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