Relation between selenium plasma levels and different prostatic pathologies

Autores
López Fontana, Constanza Matilde; Pérez Elizalde, R. F.; Vanrell, M. C. M.; Recalde, Gabriela María; Uvilla, A. L.; López Laur, J. D.
Año de publicación
2010
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Several studies have demonstrated an inverse relation between serum selenium levels (Se) and advanced prostate cancer (PCa). Objective: To determine and compare selenium plasma levels in patients with different prostatic pathologies. Material and methods: It is a transversal, descriptive and comparative study. A sample of 64 men between 50 and 80 years old were selected for the study between 2007 and 2009. All volunteers underwent a digital rectal examination, prostate specific antigen level, ultrasound and transrectal prostate biopsy (1214 chips). Prostate cancer was subclassified according to Gleason Score. Selenium was determined indirectly by serum Glutathione peroxidase (Kit Ransel, Randox SRL, Crumlin, UK). Statistical analysis was performed using ANOVA I (p<0.05). Results: Glutathione Peroxidase level was 33.75±2.36 mg/ml in control patients. A decrease of 31.6% was observed in patients with BPH (23.08±1.57 mg/ml) and of (63.6%) in subjects with prostate cancer (12.28±1.03 mg/ml) (p<0,0001). There was no correlation with the Gleason Score. Conclusion: Serum Seleniun is lower in patients with prostatic pathologies being even more important in cancer patients regardless the Gleason Score.
Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; Argentina
Fil: Pérez Elizalde, R. F.. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; Argentina
Fil: Vanrell, M. C. M.. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; Argentina
Fil: Recalde, Gabriela María. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; Argentina
Fil: Uvilla, A. L.. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; Argentina
Fil: López Laur, J. D.. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Materia
Benign Prostatic Hyperplasia
Chronic Prostatitis
Prostate Cancer
Selenium
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/82308
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/82308
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Relation between selenium plasma levels and different prostatic pathologiesRelación entre los niveles plasmáticos de selenio y las diferentes enfermedades prostáticasLópez Fontana, Constanza MatildePérez Elizalde, R. F.Vanrell, M. C. M.Recalde, Gabriela MaríaUvilla, A. L.López Laur, J. D.Benign Prostatic HyperplasiaChronic ProstatitisProstate CancerSeleniumhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Several studies have demonstrated an inverse relation between serum selenium levels (Se) and advanced prostate cancer (PCa). Objective: To determine and compare selenium plasma levels in patients with different prostatic pathologies. Material and methods: It is a transversal, descriptive and comparative study. A sample of 64 men between 50 and 80 years old were selected for the study between 2007 and 2009. All volunteers underwent a digital rectal examination, prostate specific antigen level, ultrasound and transrectal prostate biopsy (1214 chips). Prostate cancer was subclassified according to Gleason Score. Selenium was determined indirectly by serum Glutathione peroxidase (Kit Ransel, Randox SRL, Crumlin, UK). Statistical analysis was performed using ANOVA I (p<0.05). Results: Glutathione Peroxidase level was 33.75±2.36 mg/ml in control patients. A decrease of 31.6% was observed in patients with BPH (23.08±1.57 mg/ml) and of (63.6%) in subjects with prostate cancer (12.28±1.03 mg/ml) (p<0,0001). There was no correlation with the Gleason Score. Conclusion: Serum Seleniun is lower in patients with prostatic pathologies being even more important in cancer patients regardless the Gleason Score.Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; ArgentinaFil: Pérez Elizalde, R. F.. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; ArgentinaFil: Vanrell, M. C. M.. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; ArgentinaFil: Recalde, Gabriela María. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; ArgentinaFil: Uvilla, A. L.. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; ArgentinaFil: López Laur, J. D.. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaElsevier2010-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/82308López Fontana, Constanza Matilde; Pérez Elizalde, R. F.; Vanrell, M. C. M.; Recalde, Gabriela María; Uvilla, A. L.; et al.; Relation between selenium plasma levels and different prostatic pathologies; Elsevier; Actas Urologicas Españolas; 34; 7; 7-2010; 625-6290210-4806CONICET DigitalCONICETspainfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.acuro.2010.03.028info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S021048061000172info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:46:08Zoai:ri.conicet.gov.ar:11336/82308instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:46:08.438CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Relation between selenium plasma levels and different prostatic pathologies
Relación entre los niveles plasmáticos de selenio y las diferentes enfermedades prostáticas
title Relation between selenium plasma levels and different prostatic pathologies
spellingShingle Relation between selenium plasma levels and different prostatic pathologies
López Fontana, Constanza Matilde
Benign Prostatic Hyperplasia
Chronic Prostatitis
Prostate Cancer
Selenium
title_short Relation between selenium plasma levels and different prostatic pathologies
title_full Relation between selenium plasma levels and different prostatic pathologies
title_fullStr Relation between selenium plasma levels and different prostatic pathologies
title_full_unstemmed Relation between selenium plasma levels and different prostatic pathologies
title_sort Relation between selenium plasma levels and different prostatic pathologies
dc.creator.none.fl_str_mv López Fontana, Constanza Matilde
Pérez Elizalde, R. F.
Vanrell, M. C. M.
Recalde, Gabriela María
Uvilla, A. L.
López Laur, J. D.
author López Fontana, Constanza Matilde
author_facet López Fontana, Constanza Matilde
Pérez Elizalde, R. F.
Vanrell, M. C. M.
Recalde, Gabriela María
Uvilla, A. L.
López Laur, J. D.
author_role author
author2 Pérez Elizalde, R. F.
Vanrell, M. C. M.
Recalde, Gabriela María
Uvilla, A. L.
López Laur, J. D.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Benign Prostatic Hyperplasia
Chronic Prostatitis
Prostate Cancer
Selenium
topic Benign Prostatic Hyperplasia
Chronic Prostatitis
Prostate Cancer
Selenium
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Several studies have demonstrated an inverse relation between serum selenium levels (Se) and advanced prostate cancer (PCa). Objective: To determine and compare selenium plasma levels in patients with different prostatic pathologies. Material and methods: It is a transversal, descriptive and comparative study. A sample of 64 men between 50 and 80 years old were selected for the study between 2007 and 2009. All volunteers underwent a digital rectal examination, prostate specific antigen level, ultrasound and transrectal prostate biopsy (1214 chips). Prostate cancer was subclassified according to Gleason Score. Selenium was determined indirectly by serum Glutathione peroxidase (Kit Ransel, Randox SRL, Crumlin, UK). Statistical analysis was performed using ANOVA I (p<0.05). Results: Glutathione Peroxidase level was 33.75±2.36 mg/ml in control patients. A decrease of 31.6% was observed in patients with BPH (23.08±1.57 mg/ml) and of (63.6%) in subjects with prostate cancer (12.28±1.03 mg/ml) (p<0,0001). There was no correlation with the Gleason Score. Conclusion: Serum Seleniun is lower in patients with prostatic pathologies being even more important in cancer patients regardless the Gleason Score.
Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; Argentina
Fil: Pérez Elizalde, R. F.. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; Argentina
Fil: Vanrell, M. C. M.. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; Argentina
Fil: Recalde, Gabriela María. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; Argentina
Fil: Uvilla, A. L.. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; Argentina
Fil: López Laur, J. D.. Universidad "Juan Agustín Maza". Facultad de Farmacia y Bioquímica; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
description Several studies have demonstrated an inverse relation between serum selenium levels (Se) and advanced prostate cancer (PCa). Objective: To determine and compare selenium plasma levels in patients with different prostatic pathologies. Material and methods: It is a transversal, descriptive and comparative study. A sample of 64 men between 50 and 80 years old were selected for the study between 2007 and 2009. All volunteers underwent a digital rectal examination, prostate specific antigen level, ultrasound and transrectal prostate biopsy (1214 chips). Prostate cancer was subclassified according to Gleason Score. Selenium was determined indirectly by serum Glutathione peroxidase (Kit Ransel, Randox SRL, Crumlin, UK). Statistical analysis was performed using ANOVA I (p<0.05). Results: Glutathione Peroxidase level was 33.75±2.36 mg/ml in control patients. A decrease of 31.6% was observed in patients with BPH (23.08±1.57 mg/ml) and of (63.6%) in subjects with prostate cancer (12.28±1.03 mg/ml) (p<0,0001). There was no correlation with the Gleason Score. Conclusion: Serum Seleniun is lower in patients with prostatic pathologies being even more important in cancer patients regardless the Gleason Score.
publishDate 2010
dc.date.none.fl_str_mv 2010-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/82308
López Fontana, Constanza Matilde; Pérez Elizalde, R. F.; Vanrell, M. C. M.; Recalde, Gabriela María; Uvilla, A. L.; et al.; Relation between selenium plasma levels and different prostatic pathologies; Elsevier; Actas Urologicas Españolas; 34; 7; 7-2010; 625-629
0210-4806
CONICET Digital
CONICET
url http://hdl.handle.net/11336/82308
identifier_str_mv López Fontana, Constanza Matilde; Pérez Elizalde, R. F.; Vanrell, M. C. M.; Recalde, Gabriela María; Uvilla, A. L.; et al.; Relation between selenium plasma levels and different prostatic pathologies; Elsevier; Actas Urologicas Españolas; 34; 7; 7-2010; 625-629
0210-4806
CONICET Digital
CONICET
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.acuro.2010.03.028
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S021048061000172
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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