Periprostatic adipose tissue microenvironment: metabolic and hormonal pathways during prostate cancer progression

Autores
Sacca, Paula Alejandra; Calvo, Juan Carlos
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The periprostatic adipose tissue (PPAT) is a site of invasion of prostate cancer (PCa) and is part of the microenvironment. It was shown that PPAT secretes factors and fatty acids (FAs) that alter the microenvironment of the PCa. The PPAT secretome of patients with PCa-T3 stage (PPAT-T3) has a metabolic profile enriched in several pathways related to energy production, indicating a greater energy requirement by the tumor, when compared to that of patients in the PCa-T2 stage (PPAT-T2). PPAT-T3 also shows enrichment in pathways related to hormone response, polyamine synthesis, and control of protein synthesis, through amino acid, RNA, and nucleotide metabolism. PPAT-T2 and PPAT-BPH secretomes have less complex metabolic profile, both related with energy balance, while PPAT-BPH has hormone response through insulin pathway. Undoubtedly, a deeper characterization of the human PPAT will lead to a better understanding of the disease and possibly allow new stratification factors and the design of a specific therapy that targets crucial components of the tumor microenvironment as another way to treat or control the disease.
Fil: Sacca, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Calvo, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Materia
ADIPOSE TISSUE
BENIGN PROSTATIC HYPERPLASIA
METABOLISM
MICROENVIRONMENT
PERIPROSTATIC ADIPOSE TISSUE
PROSTATE CANCER
PROTEOMICS
SECRETOME
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/163190
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Periprostatic adipose tissue microenvironment: metabolic and hormonal pathways during prostate cancer progressionSacca, Paula AlejandraCalvo, Juan CarlosADIPOSE TISSUEBENIGN PROSTATIC HYPERPLASIAMETABOLISMMICROENVIRONMENTPERIPROSTATIC ADIPOSE TISSUEPROSTATE CANCERPROTEOMICSSECRETOMEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The periprostatic adipose tissue (PPAT) is a site of invasion of prostate cancer (PCa) and is part of the microenvironment. It was shown that PPAT secretes factors and fatty acids (FAs) that alter the microenvironment of the PCa. The PPAT secretome of patients with PCa-T3 stage (PPAT-T3) has a metabolic profile enriched in several pathways related to energy production, indicating a greater energy requirement by the tumor, when compared to that of patients in the PCa-T2 stage (PPAT-T2). PPAT-T3 also shows enrichment in pathways related to hormone response, polyamine synthesis, and control of protein synthesis, through amino acid, RNA, and nucleotide metabolism. PPAT-T2 and PPAT-BPH secretomes have less complex metabolic profile, both related with energy balance, while PPAT-BPH has hormone response through insulin pathway. Undoubtedly, a deeper characterization of the human PPAT will lead to a better understanding of the disease and possibly allow new stratification factors and the design of a specific therapy that targets crucial components of the tumor microenvironment as another way to treat or control the disease.Fil: Sacca, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Calvo, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFrontiers Media2022-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/163190Sacca, Paula Alejandra; Calvo, Juan Carlos; Periprostatic adipose tissue microenvironment: metabolic and hormonal pathways during prostate cancer progression; Frontiers Media; Frontiers in Endocrinology; 13; 13; 4-2022; 1-61664-2392CONICET DigitalCONICETenghttps://ri.conicet.gov.ar/handle/11336/129328info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fendo.2022.863027/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fendo.2022.863027info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:26Zoai:ri.conicet.gov.ar:11336/163190instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:26.525CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Periprostatic adipose tissue microenvironment: metabolic and hormonal pathways during prostate cancer progression
title Periprostatic adipose tissue microenvironment: metabolic and hormonal pathways during prostate cancer progression
spellingShingle Periprostatic adipose tissue microenvironment: metabolic and hormonal pathways during prostate cancer progression
Sacca, Paula Alejandra
ADIPOSE TISSUE
BENIGN PROSTATIC HYPERPLASIA
METABOLISM
MICROENVIRONMENT
PERIPROSTATIC ADIPOSE TISSUE
PROSTATE CANCER
PROTEOMICS
SECRETOME
title_short Periprostatic adipose tissue microenvironment: metabolic and hormonal pathways during prostate cancer progression
title_full Periprostatic adipose tissue microenvironment: metabolic and hormonal pathways during prostate cancer progression
title_fullStr Periprostatic adipose tissue microenvironment: metabolic and hormonal pathways during prostate cancer progression
title_full_unstemmed Periprostatic adipose tissue microenvironment: metabolic and hormonal pathways during prostate cancer progression
title_sort Periprostatic adipose tissue microenvironment: metabolic and hormonal pathways during prostate cancer progression
dc.creator.none.fl_str_mv Sacca, Paula Alejandra
Calvo, Juan Carlos
author Sacca, Paula Alejandra
author_facet Sacca, Paula Alejandra
Calvo, Juan Carlos
author_role author
author2 Calvo, Juan Carlos
author2_role author
dc.subject.none.fl_str_mv ADIPOSE TISSUE
BENIGN PROSTATIC HYPERPLASIA
METABOLISM
MICROENVIRONMENT
PERIPROSTATIC ADIPOSE TISSUE
PROSTATE CANCER
PROTEOMICS
SECRETOME
topic ADIPOSE TISSUE
BENIGN PROSTATIC HYPERPLASIA
METABOLISM
MICROENVIRONMENT
PERIPROSTATIC ADIPOSE TISSUE
PROSTATE CANCER
PROTEOMICS
SECRETOME
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The periprostatic adipose tissue (PPAT) is a site of invasion of prostate cancer (PCa) and is part of the microenvironment. It was shown that PPAT secretes factors and fatty acids (FAs) that alter the microenvironment of the PCa. The PPAT secretome of patients with PCa-T3 stage (PPAT-T3) has a metabolic profile enriched in several pathways related to energy production, indicating a greater energy requirement by the tumor, when compared to that of patients in the PCa-T2 stage (PPAT-T2). PPAT-T3 also shows enrichment in pathways related to hormone response, polyamine synthesis, and control of protein synthesis, through amino acid, RNA, and nucleotide metabolism. PPAT-T2 and PPAT-BPH secretomes have less complex metabolic profile, both related with energy balance, while PPAT-BPH has hormone response through insulin pathway. Undoubtedly, a deeper characterization of the human PPAT will lead to a better understanding of the disease and possibly allow new stratification factors and the design of a specific therapy that targets crucial components of the tumor microenvironment as another way to treat or control the disease.
Fil: Sacca, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Calvo, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
description The periprostatic adipose tissue (PPAT) is a site of invasion of prostate cancer (PCa) and is part of the microenvironment. It was shown that PPAT secretes factors and fatty acids (FAs) that alter the microenvironment of the PCa. The PPAT secretome of patients with PCa-T3 stage (PPAT-T3) has a metabolic profile enriched in several pathways related to energy production, indicating a greater energy requirement by the tumor, when compared to that of patients in the PCa-T2 stage (PPAT-T2). PPAT-T3 also shows enrichment in pathways related to hormone response, polyamine synthesis, and control of protein synthesis, through amino acid, RNA, and nucleotide metabolism. PPAT-T2 and PPAT-BPH secretomes have less complex metabolic profile, both related with energy balance, while PPAT-BPH has hormone response through insulin pathway. Undoubtedly, a deeper characterization of the human PPAT will lead to a better understanding of the disease and possibly allow new stratification factors and the design of a specific therapy that targets crucial components of the tumor microenvironment as another way to treat or control the disease.
publishDate 2022
dc.date.none.fl_str_mv 2022-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/163190
Sacca, Paula Alejandra; Calvo, Juan Carlos; Periprostatic adipose tissue microenvironment: metabolic and hormonal pathways during prostate cancer progression; Frontiers Media; Frontiers in Endocrinology; 13; 13; 4-2022; 1-6
1664-2392
CONICET Digital
CONICET
url http://hdl.handle.net/11336/163190
identifier_str_mv Sacca, Paula Alejandra; Calvo, Juan Carlos; Periprostatic adipose tissue microenvironment: metabolic and hormonal pathways during prostate cancer progression; Frontiers Media; Frontiers in Endocrinology; 13; 13; 4-2022; 1-6
1664-2392
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ri.conicet.gov.ar/handle/11336/129328
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fendo.2022.863027/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fendo.2022.863027
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269224978874368
score 13.13397

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