Human periprostatic adipose tissue: Secretome from patients with prostate cancer or benign prostate hyperplasia

Autores
Sacca, Paula Alejandra; Mazza, Osvaldo Néstor; Scorticati, Carlos; Vitagliano, Gonzalo; Casas, Gabriel; Calvo, Juan Carlos
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Periprostatic adipose tissue (PPAT) directs tumour behaviour. Microenvironment secretome provides information related to its biology. This study was performed to identify secreted proteins by PPAT, from both prostate cancer and benign prostate hyperplasia (BPH) patients. Liquid chromatography-mass spectrometry-based proteomic analysis was performed in PPAT-conditioned media (CM) from patients with prostate cancer (CMs-T) (stage T3: CM-T3, stage T2: CM-T2) or benign disease (CM-BPH). The highest number and diversity of proteins was identified in CM-T3. Locomotion was the biological process mainly associated to CMs-T and reproduction to CM-T3. Immune responses were enriched in CMs-T. Extracellular matrix and structural proteins were associated to CMs-T. CM-T3 was enriched in proteins with catalytic activity and CM-T2 in proteins with defense/immunity activity. Metabolism and energy pathways were enriched in CM-T3 and those with immune system functions in CMs-T. Transport proteins were enriched in CM-T2 and CM-BPH. Proteins and pathways reported in this study could be useful to distinguish stages of disease and may become targets for novel therapies.
Fil: Sacca, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Mazza, Osvaldo Néstor. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Scorticati, Carlos. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Vitagliano, Gonzalo. Hospital Aleman; Argentina
Fil: Casas, Gabriel. Hospital Aleman; Argentina
Fil: Calvo, Juan Carlos. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Materia
PERIPROSTATIC ADIPOSE TISSUE
BENIGN PROSTATE HYPERPLASIA
FAT TISSUE
MICROENVIRONMENT
PROSTATE CANCER
PROTEOMIC
SECRETOME
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/129328
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/129328
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Human periprostatic adipose tissue: Secretome from patients with prostate cancer or benign prostate hyperplasiaSacca, Paula AlejandraMazza, Osvaldo NéstorScorticati, CarlosVitagliano, GonzaloCasas, GabrielCalvo, Juan CarlosPERIPROSTATIC ADIPOSE TISSUEBENIGN PROSTATE HYPERPLASIAFAT TISSUEMICROENVIRONMENTPROSTATE CANCERPROTEOMICSECRETOMEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Periprostatic adipose tissue (PPAT) directs tumour behaviour. Microenvironment secretome provides information related to its biology. This study was performed to identify secreted proteins by PPAT, from both prostate cancer and benign prostate hyperplasia (BPH) patients. Liquid chromatography-mass spectrometry-based proteomic analysis was performed in PPAT-conditioned media (CM) from patients with prostate cancer (CMs-T) (stage T3: CM-T3, stage T2: CM-T2) or benign disease (CM-BPH). The highest number and diversity of proteins was identified in CM-T3. Locomotion was the biological process mainly associated to CMs-T and reproduction to CM-T3. Immune responses were enriched in CMs-T. Extracellular matrix and structural proteins were associated to CMs-T. CM-T3 was enriched in proteins with catalytic activity and CM-T2 in proteins with defense/immunity activity. Metabolism and energy pathways were enriched in CM-T3 and those with immune system functions in CMs-T. Transport proteins were enriched in CM-T2 and CM-BPH. Proteins and pathways reported in this study could be useful to distinguish stages of disease and may become targets for novel therapies.Fil: Sacca, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Mazza, Osvaldo Néstor. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Scorticati, Carlos. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Vitagliano, Gonzalo. Hospital Aleman; ArgentinaFil: Casas, Gabriel. Hospital Aleman; ArgentinaFil: Calvo, Juan Carlos. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaInternational Institute of Anticancer Research2019-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/129328Sacca, Paula Alejandra; Mazza, Osvaldo Néstor; Scorticati, Carlos; Vitagliano, Gonzalo; Casas, Gabriel; et al.; Human periprostatic adipose tissue: Secretome from patients with prostate cancer or benign prostate hyperplasia; International Institute of Anticancer Research; Cancer Genomics & Proteomics; 16; 1; 1-2019; 29-581790-6245CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.21873/cgp.20110info:eu-repo/semantics/altIdentifier/url/https://cgp.iiarjournals.org/content/16/1/29.longinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:24:32Zoai:ri.conicet.gov.ar:11336/129328instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:24:32.53CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Human periprostatic adipose tissue: Secretome from patients with prostate cancer or benign prostate hyperplasia
title Human periprostatic adipose tissue: Secretome from patients with prostate cancer or benign prostate hyperplasia
spellingShingle Human periprostatic adipose tissue: Secretome from patients with prostate cancer or benign prostate hyperplasia
Sacca, Paula Alejandra
PERIPROSTATIC ADIPOSE TISSUE
BENIGN PROSTATE HYPERPLASIA
FAT TISSUE
MICROENVIRONMENT
PROSTATE CANCER
PROTEOMIC
SECRETOME
title_short Human periprostatic adipose tissue: Secretome from patients with prostate cancer or benign prostate hyperplasia
title_full Human periprostatic adipose tissue: Secretome from patients with prostate cancer or benign prostate hyperplasia
title_fullStr Human periprostatic adipose tissue: Secretome from patients with prostate cancer or benign prostate hyperplasia
title_full_unstemmed Human periprostatic adipose tissue: Secretome from patients with prostate cancer or benign prostate hyperplasia
title_sort Human periprostatic adipose tissue: Secretome from patients with prostate cancer or benign prostate hyperplasia
dc.creator.none.fl_str_mv Sacca, Paula Alejandra
Mazza, Osvaldo Néstor
Scorticati, Carlos
Vitagliano, Gonzalo
Casas, Gabriel
Calvo, Juan Carlos
author Sacca, Paula Alejandra
author_facet Sacca, Paula Alejandra
Mazza, Osvaldo Néstor
Scorticati, Carlos
Vitagliano, Gonzalo
Casas, Gabriel
Calvo, Juan Carlos
author_role author
author2 Mazza, Osvaldo Néstor
Scorticati, Carlos
Vitagliano, Gonzalo
Casas, Gabriel
Calvo, Juan Carlos
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv PERIPROSTATIC ADIPOSE TISSUE
BENIGN PROSTATE HYPERPLASIA
FAT TISSUE
MICROENVIRONMENT
PROSTATE CANCER
PROTEOMIC
SECRETOME
topic PERIPROSTATIC ADIPOSE TISSUE
BENIGN PROSTATE HYPERPLASIA
FAT TISSUE
MICROENVIRONMENT
PROSTATE CANCER
PROTEOMIC
SECRETOME
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Periprostatic adipose tissue (PPAT) directs tumour behaviour. Microenvironment secretome provides information related to its biology. This study was performed to identify secreted proteins by PPAT, from both prostate cancer and benign prostate hyperplasia (BPH) patients. Liquid chromatography-mass spectrometry-based proteomic analysis was performed in PPAT-conditioned media (CM) from patients with prostate cancer (CMs-T) (stage T3: CM-T3, stage T2: CM-T2) or benign disease (CM-BPH). The highest number and diversity of proteins was identified in CM-T3. Locomotion was the biological process mainly associated to CMs-T and reproduction to CM-T3. Immune responses were enriched in CMs-T. Extracellular matrix and structural proteins were associated to CMs-T. CM-T3 was enriched in proteins with catalytic activity and CM-T2 in proteins with defense/immunity activity. Metabolism and energy pathways were enriched in CM-T3 and those with immune system functions in CMs-T. Transport proteins were enriched in CM-T2 and CM-BPH. Proteins and pathways reported in this study could be useful to distinguish stages of disease and may become targets for novel therapies.
Fil: Sacca, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Mazza, Osvaldo Néstor. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Scorticati, Carlos. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Vitagliano, Gonzalo. Hospital Aleman; Argentina
Fil: Casas, Gabriel. Hospital Aleman; Argentina
Fil: Calvo, Juan Carlos. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
description Periprostatic adipose tissue (PPAT) directs tumour behaviour. Microenvironment secretome provides information related to its biology. This study was performed to identify secreted proteins by PPAT, from both prostate cancer and benign prostate hyperplasia (BPH) patients. Liquid chromatography-mass spectrometry-based proteomic analysis was performed in PPAT-conditioned media (CM) from patients with prostate cancer (CMs-T) (stage T3: CM-T3, stage T2: CM-T2) or benign disease (CM-BPH). The highest number and diversity of proteins was identified in CM-T3. Locomotion was the biological process mainly associated to CMs-T and reproduction to CM-T3. Immune responses were enriched in CMs-T. Extracellular matrix and structural proteins were associated to CMs-T. CM-T3 was enriched in proteins with catalytic activity and CM-T2 in proteins with defense/immunity activity. Metabolism and energy pathways were enriched in CM-T3 and those with immune system functions in CMs-T. Transport proteins were enriched in CM-T2 and CM-BPH. Proteins and pathways reported in this study could be useful to distinguish stages of disease and may become targets for novel therapies.
publishDate 2019
dc.date.none.fl_str_mv 2019-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/129328
Sacca, Paula Alejandra; Mazza, Osvaldo Néstor; Scorticati, Carlos; Vitagliano, Gonzalo; Casas, Gabriel; et al.; Human periprostatic adipose tissue: Secretome from patients with prostate cancer or benign prostate hyperplasia; International Institute of Anticancer Research; Cancer Genomics & Proteomics; 16; 1; 1-2019; 29-58
1790-6245
CONICET Digital
CONICET
url http://hdl.handle.net/11336/129328
identifier_str_mv Sacca, Paula Alejandra; Mazza, Osvaldo Néstor; Scorticati, Carlos; Vitagliano, Gonzalo; Casas, Gabriel; et al.; Human periprostatic adipose tissue: Secretome from patients with prostate cancer or benign prostate hyperplasia; International Institute of Anticancer Research; Cancer Genomics & Proteomics; 16; 1; 1-2019; 29-58
1790-6245
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.21873/cgp.20110
info:eu-repo/semantics/altIdentifier/url/https://cgp.iiarjournals.org/content/16/1/29.long
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv International Institute of Anticancer Research
publisher.none.fl_str_mv International Institute of Anticancer Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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