Fatty acid composition of human periprostatic adipose tissue from Argentine patients and its relationship to prostate cancer and benign prostatic hyperplasia

Autores
Careaga Quiroga, Valeria Pilar; Sacca, Paula Alejandra; Mazza, Osvaldo Néstor; Scorticati, Carlos; Vitagliano, Gonzalo; Fletcher, Sabrina Johanna; Maier, Marta Silvia; Calvo, Juan Carlos
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this study was to determine fatty acid composition in periprostatic adipose tissue (PPAT) of patients undergoing surgery for either prostatic cancer or benign prostatic hyperplasia (BPH). PPAT were obtained from 12 patients undergoing radical prostatectomy for clinically localized prostate tumors (TPPAT, age range 55-70 years) and 11 patients undergoing adenomectomy for BPH (BPPAT, age range 57-79 years). Fatty acid methyl esters of total lipids of PPAT were processed and then analyzed by gas chromatography-mass spectrometry. Quantitation was performed by comparing the percentage area of each FAME peak on the chromatogram with that of the internal standard of known weight, and expressed as percentage of total fatty acids. There were differences in fatty acid content of PPAT, with higher levels of palmitic acid (16:0; P = 0.036) and dihomo-gammalinolenic acid (20:3 n-6; P = 0.020) and lower levels of arachidonic acid (20:4 n-6; P = 0.030) in prostate cancer PPAT, along with a higher 20:4/20:3 (P = 0.001) and lower 20:3/18:2 (P = 0.027) fatty acid ratio in benign prostate hyperplasia PPAT. To the best of our knowledge, this study represents the first attempt at comparing periprostatic fat pad lipid composition in different prostate pathologies. Fatty acid analysis and lipidomics may be important tools to further understand events that occur in tumor microenvironment during prostate cancer disease.
Fil: Careaga Quiroga, Valeria Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
Fil: Sacca, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Mazza,Osvaldo N. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Hospital Aleman; Argentina
Fil: Scorticati, Carlos. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Vitagliano, Gonzalo. Hospital Aleman; Argentina
Fil: Fletcher, Sabrina Johanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Maier, Marta Silvia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina
Fil: Calvo, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Materia
Prostate Cancert
Benign Prostate Hyperplasia
Periprostatic Adipose Tissue
Fatty Acids
Lipid Composition
Lipidomics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/3062
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/3062
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Fatty acid composition of human periprostatic adipose tissue from Argentine patients and its relationship to prostate cancer and benign prostatic hyperplasiaCareaga Quiroga, Valeria PilarSacca, Paula AlejandraMazza, Osvaldo NéstorScorticati, CarlosVitagliano, GonzaloFletcher, Sabrina JohannaMaier, Marta SilviaCalvo, Juan CarlosProstate CancertBenign Prostate HyperplasiaPeriprostatic Adipose TissueFatty AcidsLipid CompositionLipidomicshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The aim of this study was to determine fatty acid composition in periprostatic adipose tissue (PPAT) of patients undergoing surgery for either prostatic cancer or benign prostatic hyperplasia (BPH). PPAT were obtained from 12 patients undergoing radical prostatectomy for clinically localized prostate tumors (TPPAT, age range 55-70 years) and 11 patients undergoing adenomectomy for BPH (BPPAT, age range 57-79 years). Fatty acid methyl esters of total lipids of PPAT were processed and then analyzed by gas chromatography-mass spectrometry. Quantitation was performed by comparing the percentage area of each FAME peak on the chromatogram with that of the internal standard of known weight, and expressed as percentage of total fatty acids. There were differences in fatty acid content of PPAT, with higher levels of palmitic acid (16:0; P = 0.036) and dihomo-gammalinolenic acid (20:3 n-6; P = 0.020) and lower levels of arachidonic acid (20:4 n-6; P = 0.030) in prostate cancer PPAT, along with a higher 20:4/20:3 (P = 0.001) and lower 20:3/18:2 (P = 0.027) fatty acid ratio in benign prostate hyperplasia PPAT. To the best of our knowledge, this study represents the first attempt at comparing periprostatic fat pad lipid composition in different prostate pathologies. Fatty acid analysis and lipidomics may be important tools to further understand events that occur in tumor microenvironment during prostate cancer disease.Fil: Careaga Quiroga, Valeria Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; ArgentinaFil: Sacca, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Mazza,Osvaldo N. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Hospital Aleman; ArgentinaFil: Scorticati, Carlos. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Vitagliano, Gonzalo. Hospital Aleman; ArgentinaFil: Fletcher, Sabrina Johanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Maier, Marta Silvia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; ArgentinaFil: Calvo, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaScientific and Academic Publishing2015-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/3062Careaga Quiroga, Valeria Pilar; Sacca, Paula Alejandra; Mazza, Osvaldo Néstor; Scorticati, Carlos; Vitagliano, Gonzalo; et al.; Fatty acid composition of human periprostatic adipose tissue from Argentine patients and its relationship to prostate cancer and benign prostatic hyperplasia; Scientific and Academic Publishing; Research in Cancer and Tumor; 4; 1; 4-2015; 1-62475-2150enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/url/http://www.sapub.org/global/showpaperpdf.aspx?doi=10.5923/j.rct.20150401.01info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)https://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:31Zoai:ri.conicet.gov.ar:11336/3062instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:31.947CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fatty acid composition of human periprostatic adipose tissue from Argentine patients and its relationship to prostate cancer and benign prostatic hyperplasia
title Fatty acid composition of human periprostatic adipose tissue from Argentine patients and its relationship to prostate cancer and benign prostatic hyperplasia
spellingShingle Fatty acid composition of human periprostatic adipose tissue from Argentine patients and its relationship to prostate cancer and benign prostatic hyperplasia
Careaga Quiroga, Valeria Pilar
Prostate Cancert
Benign Prostate Hyperplasia
Periprostatic Adipose Tissue
Fatty Acids
Lipid Composition
Lipidomics
title_short Fatty acid composition of human periprostatic adipose tissue from Argentine patients and its relationship to prostate cancer and benign prostatic hyperplasia
title_full Fatty acid composition of human periprostatic adipose tissue from Argentine patients and its relationship to prostate cancer and benign prostatic hyperplasia
title_fullStr Fatty acid composition of human periprostatic adipose tissue from Argentine patients and its relationship to prostate cancer and benign prostatic hyperplasia
title_full_unstemmed Fatty acid composition of human periprostatic adipose tissue from Argentine patients and its relationship to prostate cancer and benign prostatic hyperplasia
title_sort Fatty acid composition of human periprostatic adipose tissue from Argentine patients and its relationship to prostate cancer and benign prostatic hyperplasia
dc.creator.none.fl_str_mv Careaga Quiroga, Valeria Pilar
Sacca, Paula Alejandra
Mazza, Osvaldo Néstor
Scorticati, Carlos
Vitagliano, Gonzalo
Fletcher, Sabrina Johanna
Maier, Marta Silvia
Calvo, Juan Carlos
author Careaga Quiroga, Valeria Pilar
author_facet Careaga Quiroga, Valeria Pilar
Sacca, Paula Alejandra
Mazza, Osvaldo Néstor
Scorticati, Carlos
Vitagliano, Gonzalo
Fletcher, Sabrina Johanna
Maier, Marta Silvia
Calvo, Juan Carlos
author_role author
author2 Sacca, Paula Alejandra
Mazza, Osvaldo Néstor
Scorticati, Carlos
Vitagliano, Gonzalo
Fletcher, Sabrina Johanna
Maier, Marta Silvia
Calvo, Juan Carlos
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Prostate Cancert
Benign Prostate Hyperplasia
Periprostatic Adipose Tissue
Fatty Acids
Lipid Composition
Lipidomics
topic Prostate Cancert
Benign Prostate Hyperplasia
Periprostatic Adipose Tissue
Fatty Acids
Lipid Composition
Lipidomics
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of this study was to determine fatty acid composition in periprostatic adipose tissue (PPAT) of patients undergoing surgery for either prostatic cancer or benign prostatic hyperplasia (BPH). PPAT were obtained from 12 patients undergoing radical prostatectomy for clinically localized prostate tumors (TPPAT, age range 55-70 years) and 11 patients undergoing adenomectomy for BPH (BPPAT, age range 57-79 years). Fatty acid methyl esters of total lipids of PPAT were processed and then analyzed by gas chromatography-mass spectrometry. Quantitation was performed by comparing the percentage area of each FAME peak on the chromatogram with that of the internal standard of known weight, and expressed as percentage of total fatty acids. There were differences in fatty acid content of PPAT, with higher levels of palmitic acid (16:0; P = 0.036) and dihomo-gammalinolenic acid (20:3 n-6; P = 0.020) and lower levels of arachidonic acid (20:4 n-6; P = 0.030) in prostate cancer PPAT, along with a higher 20:4/20:3 (P = 0.001) and lower 20:3/18:2 (P = 0.027) fatty acid ratio in benign prostate hyperplasia PPAT. To the best of our knowledge, this study represents the first attempt at comparing periprostatic fat pad lipid composition in different prostate pathologies. Fatty acid analysis and lipidomics may be important tools to further understand events that occur in tumor microenvironment during prostate cancer disease.
Fil: Careaga Quiroga, Valeria Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
Fil: Sacca, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Mazza,Osvaldo N. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Hospital Aleman; Argentina
Fil: Scorticati, Carlos. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Vitagliano, Gonzalo. Hospital Aleman; Argentina
Fil: Fletcher, Sabrina Johanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Maier, Marta Silvia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina
Fil: Calvo, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
description The aim of this study was to determine fatty acid composition in periprostatic adipose tissue (PPAT) of patients undergoing surgery for either prostatic cancer or benign prostatic hyperplasia (BPH). PPAT were obtained from 12 patients undergoing radical prostatectomy for clinically localized prostate tumors (TPPAT, age range 55-70 years) and 11 patients undergoing adenomectomy for BPH (BPPAT, age range 57-79 years). Fatty acid methyl esters of total lipids of PPAT were processed and then analyzed by gas chromatography-mass spectrometry. Quantitation was performed by comparing the percentage area of each FAME peak on the chromatogram with that of the internal standard of known weight, and expressed as percentage of total fatty acids. There were differences in fatty acid content of PPAT, with higher levels of palmitic acid (16:0; P = 0.036) and dihomo-gammalinolenic acid (20:3 n-6; P = 0.020) and lower levels of arachidonic acid (20:4 n-6; P = 0.030) in prostate cancer PPAT, along with a higher 20:4/20:3 (P = 0.001) and lower 20:3/18:2 (P = 0.027) fatty acid ratio in benign prostate hyperplasia PPAT. To the best of our knowledge, this study represents the first attempt at comparing periprostatic fat pad lipid composition in different prostate pathologies. Fatty acid analysis and lipidomics may be important tools to further understand events that occur in tumor microenvironment during prostate cancer disease.
publishDate 2015
dc.date.none.fl_str_mv 2015-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/3062
Careaga Quiroga, Valeria Pilar; Sacca, Paula Alejandra; Mazza, Osvaldo Néstor; Scorticati, Carlos; Vitagliano, Gonzalo; et al.; Fatty acid composition of human periprostatic adipose tissue from Argentine patients and its relationship to prostate cancer and benign prostatic hyperplasia; Scientific and Academic Publishing; Research in Cancer and Tumor; 4; 1; 4-2015; 1-6
2475-2150
url http://hdl.handle.net/11336/3062
identifier_str_mv Careaga Quiroga, Valeria Pilar; Sacca, Paula Alejandra; Mazza, Osvaldo Néstor; Scorticati, Carlos; Vitagliano, Gonzalo; et al.; Fatty acid composition of human periprostatic adipose tissue from Argentine patients and its relationship to prostate cancer and benign prostatic hyperplasia; Scientific and Academic Publishing; Research in Cancer and Tumor; 4; 1; 4-2015; 1-6
2475-2150
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/url/http://www.sapub.org/global/showpaperpdf.aspx?doi=10.5923/j.rct.20150401.01
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Scientific and Academic Publishing
publisher.none.fl_str_mv Scientific and Academic Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270084392812544
score 13.13397

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