FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticola

Autores
Fuentes Castillo, Danny; Power, Pablo; Cerdeira, Louise; Cardenas-Arias, Adriana; Moura, Quézia; Oliveira, Flavio A.; Levy, Carlos E.; Gutkind, Gabriel Osvaldo; Catão-Dias, José L.; Lincopan, Nilton
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Serratia fonticola is a human pathogen widely found in the environment, with birds being reported as possible natural hosts. During an epidemiological and genomic surveillance study conducted to monitor the occurrence of extended-spectrum b-lactamase (ESBL)-producing Enterobacterales in South American wild birds, we identified an ESBL-positive S. fonticola in a fecal sample collected from a Hudsonian Whimbrel, during its non-breeding range on the Pacific Coast of Chile. Whole genome sequencing analysis and in silico modeling revealed a novel variant of the class A ESBLs FONA family, designated FONA-7, which shows 96.28% amino acid identity with FONA-6; with amino acid substitutions occurring in the signal peptide sequence (Thr22/Ser), and in the mature protein (Ser39/Asn and Thr227/Ile). This finding denotes that migratory birds can be potential vectors for the transboundary spread of ESBL-producing bacteria, creating a further theoretical riskfor the origin of novel plasmid-encoded b-lactamases.
Fil: Fuentes Castillo, Danny. Universidade de Sao Paulo; Brasil
Fil: Power, Pablo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Cerdeira, Louise. Universidade de Sao Paulo; Brasil
Fil: Cardenas-Arias, Adriana. Universidade de Sao Paulo; Brasil
Fil: Moura, Quézia. Universidade de Sao Paulo; Brasil
Fil: Oliveira, Flavio A.. Universidade Estadual de Campinas; Brasil
Fil: Levy, Carlos E.. Universidade Estadual de Campinas; Brasil
Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Catão-Dias, José L.. Universidade de Sao Paulo; Brasil
Fil: Lincopan, Nilton. Universidade de Sao Paulo; Brasil
Materia
ESBL
BLAFONA-7
WILD BIRD
SOUTH AMERICA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/128888
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/128888
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticolaFuentes Castillo, DannyPower, PabloCerdeira, LouiseCardenas-Arias, AdrianaMoura, QuéziaOliveira, Flavio A.Levy, Carlos E.Gutkind, Gabriel OsvaldoCatão-Dias, José L.Lincopan, NiltonESBLBLAFONA-7WILD BIRDSOUTH AMERICAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Serratia fonticola is a human pathogen widely found in the environment, with birds being reported as possible natural hosts. During an epidemiological and genomic surveillance study conducted to monitor the occurrence of extended-spectrum b-lactamase (ESBL)-producing Enterobacterales in South American wild birds, we identified an ESBL-positive S. fonticola in a fecal sample collected from a Hudsonian Whimbrel, during its non-breeding range on the Pacific Coast of Chile. Whole genome sequencing analysis and in silico modeling revealed a novel variant of the class A ESBLs FONA family, designated FONA-7, which shows 96.28% amino acid identity with FONA-6; with amino acid substitutions occurring in the signal peptide sequence (Thr22/Ser), and in the mature protein (Ser39/Asn and Thr227/Ile). This finding denotes that migratory birds can be potential vectors for the transboundary spread of ESBL-producing bacteria, creating a further theoretical riskfor the origin of novel plasmid-encoded b-lactamases.Fil: Fuentes Castillo, Danny. Universidade de Sao Paulo; BrasilFil: Power, Pablo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Cerdeira, Louise. Universidade de Sao Paulo; BrasilFil: Cardenas-Arias, Adriana. Universidade de Sao Paulo; BrasilFil: Moura, Quézia. Universidade de Sao Paulo; BrasilFil: Oliveira, Flavio A.. Universidade Estadual de Campinas; BrasilFil: Levy, Carlos E.. Universidade Estadual de Campinas; BrasilFil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Catão-Dias, José L.. Universidade de Sao Paulo; BrasilFil: Lincopan, Nilton. Universidade de Sao Paulo; BrasilMary Ann Liebert2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/128888Fuentes Castillo, Danny; Power, Pablo; Cerdeira, Louise; Cardenas-Arias, Adriana; Moura, Quézia; et al.; FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticola; Mary Ann Liebert; Microbial Drug Resistance: Mechanisms Epidemiology and Disease; 9-2020; 1-51076-6294CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/10.1089/mdr.2020.0061info:eu-repo/semantics/altIdentifier/doi/10.1089/mdr.2020.0061info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:56Zoai:ri.conicet.gov.ar:11336/128888instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:56.693CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticola
title FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticola
spellingShingle FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticola
Fuentes Castillo, Danny
ESBL
BLAFONA-7
WILD BIRD
SOUTH AMERICA
title_short FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticola
title_full FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticola
title_fullStr FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticola
title_full_unstemmed FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticola
title_sort FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticola
dc.creator.none.fl_str_mv Fuentes Castillo, Danny
Power, Pablo
Cerdeira, Louise
Cardenas-Arias, Adriana
Moura, Quézia
Oliveira, Flavio A.
Levy, Carlos E.
Gutkind, Gabriel Osvaldo
Catão-Dias, José L.
Lincopan, Nilton
author Fuentes Castillo, Danny
author_facet Fuentes Castillo, Danny
Power, Pablo
Cerdeira, Louise
Cardenas-Arias, Adriana
Moura, Quézia
Oliveira, Flavio A.
Levy, Carlos E.
Gutkind, Gabriel Osvaldo
Catão-Dias, José L.
Lincopan, Nilton
author_role author
author2 Power, Pablo
Cerdeira, Louise
Cardenas-Arias, Adriana
Moura, Quézia
Oliveira, Flavio A.
Levy, Carlos E.
Gutkind, Gabriel Osvaldo
Catão-Dias, José L.
Lincopan, Nilton
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ESBL
BLAFONA-7
WILD BIRD
SOUTH AMERICA
topic ESBL
BLAFONA-7
WILD BIRD
SOUTH AMERICA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Serratia fonticola is a human pathogen widely found in the environment, with birds being reported as possible natural hosts. During an epidemiological and genomic surveillance study conducted to monitor the occurrence of extended-spectrum b-lactamase (ESBL)-producing Enterobacterales in South American wild birds, we identified an ESBL-positive S. fonticola in a fecal sample collected from a Hudsonian Whimbrel, during its non-breeding range on the Pacific Coast of Chile. Whole genome sequencing analysis and in silico modeling revealed a novel variant of the class A ESBLs FONA family, designated FONA-7, which shows 96.28% amino acid identity with FONA-6; with amino acid substitutions occurring in the signal peptide sequence (Thr22/Ser), and in the mature protein (Ser39/Asn and Thr227/Ile). This finding denotes that migratory birds can be potential vectors for the transboundary spread of ESBL-producing bacteria, creating a further theoretical riskfor the origin of novel plasmid-encoded b-lactamases.
Fil: Fuentes Castillo, Danny. Universidade de Sao Paulo; Brasil
Fil: Power, Pablo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Cerdeira, Louise. Universidade de Sao Paulo; Brasil
Fil: Cardenas-Arias, Adriana. Universidade de Sao Paulo; Brasil
Fil: Moura, Quézia. Universidade de Sao Paulo; Brasil
Fil: Oliveira, Flavio A.. Universidade Estadual de Campinas; Brasil
Fil: Levy, Carlos E.. Universidade Estadual de Campinas; Brasil
Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Catão-Dias, José L.. Universidade de Sao Paulo; Brasil
Fil: Lincopan, Nilton. Universidade de Sao Paulo; Brasil
description Serratia fonticola is a human pathogen widely found in the environment, with birds being reported as possible natural hosts. During an epidemiological and genomic surveillance study conducted to monitor the occurrence of extended-spectrum b-lactamase (ESBL)-producing Enterobacterales in South American wild birds, we identified an ESBL-positive S. fonticola in a fecal sample collected from a Hudsonian Whimbrel, during its non-breeding range on the Pacific Coast of Chile. Whole genome sequencing analysis and in silico modeling revealed a novel variant of the class A ESBLs FONA family, designated FONA-7, which shows 96.28% amino acid identity with FONA-6; with amino acid substitutions occurring in the signal peptide sequence (Thr22/Ser), and in the mature protein (Ser39/Asn and Thr227/Ile). This finding denotes that migratory birds can be potential vectors for the transboundary spread of ESBL-producing bacteria, creating a further theoretical riskfor the origin of novel plasmid-encoded b-lactamases.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/128888
Fuentes Castillo, Danny; Power, Pablo; Cerdeira, Louise; Cardenas-Arias, Adriana; Moura, Quézia; et al.; FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticola; Mary Ann Liebert; Microbial Drug Resistance: Mechanisms Epidemiology and Disease; 9-2020; 1-5
1076-6294
CONICET Digital
CONICET
url http://hdl.handle.net/11336/128888
identifier_str_mv Fuentes Castillo, Danny; Power, Pablo; Cerdeira, Louise; Cardenas-Arias, Adriana; Moura, Quézia; et al.; FONA-7, a Novel Extended-Spectrum β-Lactamase Variant of the FONA Family Identified in Serratia fonticola; Mary Ann Liebert; Microbial Drug Resistance: Mechanisms Epidemiology and Disease; 9-2020; 1-5
1076-6294
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/10.1089/mdr.2020.0061
info:eu-repo/semantics/altIdentifier/doi/10.1089/mdr.2020.0061
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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