Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet
- Autores
- Stefanolo, Juan Pablo; Segura, Verónica; Grizzuti, Martina; Heredia, Abel; Comino, Isabel; Costa, Ana Florencia; Puebla, Roberto; Temprano, María Paz; Niveloni, Sonia Isabel; de Diego, Gabriel Alejandro; Oregui, María E.; Smecuol, Edgardo Gustavo; de Marzi, Mauricio Cesar; Verdú, Elena F.; Sousa, Carolina; Bai, Julio César
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background/Aim: The gluten-free diet has limitations, and there is intense research in the development of adjuvant therapies. Our aim was to examine the effects of orally administered Aspergillus niger endopeptidase (AN-PEP) on inadvertent gluten exposure and symptom prevention in adult patients with celiac disease (CeD) following their usual gluten-free diet (GFD).Methods: This was an exploratory, double-blind, randomized, placebo-controlled trial that enrolled patients with CeD on a long-term GFD. After a four-week run-in period, patients were randomized to 4 weeks of 2 AN-PEP capsules (GliadinX. AVI Research LLC; USA) at each of 3 meals/day or placebo. Outcome endpoints were: 1- the average weekly stool gluten immunogenic peptides (GIP) between the run-in and end of treatments, and between AN-PEP and placebo; 2) the Celiac Symptom Index (CSI); 3- CeD-specific serology; and 4- the quality of life. Stool samples were collected for GIP by ELISA every Tuesday and Friday during run-ins and treatments.Results: 40 patients were randomized to the intention-to-treat analysis, and three were excluded from the per-protocol assessment. Overall, 628/640 (98.1%) stool samples were collected. GIP was undetectable (<0.08 µg/g) in 65.6% of samples, and no differences between arms were detected. Only 0.5% of samples had GIP concentrations sufficiently high (>0.32µg/g) to potentially cause mucosal damage. Median GIP concentration in the AN-PEP arm was 44.7% lower than in the run-in period. One-third of patients exhibiting GIP >0.08 µg/g during run-in had lower or undetectable GIP after AN-PEP treatment. Compared with the run-in period, the proportion of symptomatic patients (CSI >38) in the AN-PEP arm was significantly lower (p<0.03). AN-PEP did not result in changes in specific serologies.Conclusions: This exploratory study, conducted in a real-life setting, revealed high adherence to the GFD. The AN-PEP treatment did not significantly reduce overall GIP stool concentration. However, given the observation of a significantly lower prevalence of severe symptoms in the AN-PEP arm in patients following their usual GFD, further clinical research is warranted.
Fil: Stefanolo, Juan Pablo. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Segura, Verónica. Universidad de Sevilla. Facultad de Farmacia.; España
Fil: Grizzuti, Martina. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Heredia, Abel. Universidad de Sevilla. Facultad de Farmacia.; España
Fil: Comino, Isabel. Universidad de Sevilla. Facultad de Farmacia.; España
Fil: Costa, Ana Florencia. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Puebla, Roberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Temprano, María Paz. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Niveloni, Sonia Isabel. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: de Diego, Gabriel Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina
Fil: Oregui, María E.. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: Smecuol, Edgardo Gustavo. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Fil: de Marzi, Mauricio Cesar. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina
Fil: Verdú, Elena F.. Mc Master University; Canadá
Fil: Sousa, Carolina. Universidad de Sevilla. Facultad de Farmacia.; España
Fil: Bai, Julio César. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina - Materia
-
Celiac disease
Gluten immunogenic peptides
AN-PEP
Real-life trial - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/266979
Ver los metadatos del registro completo
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Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free dietStefanolo, Juan PabloSegura, VerónicaGrizzuti, MartinaHeredia, AbelComino, IsabelCosta, Ana FlorenciaPuebla, RobertoTemprano, María PazNiveloni, Sonia Isabelde Diego, Gabriel AlejandroOregui, María E.Smecuol, Edgardo Gustavode Marzi, Mauricio CesarVerdú, Elena F.Sousa, CarolinaBai, Julio CésarCeliac diseaseGluten immunogenic peptidesAN-PEPReal-life trialhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background/Aim: The gluten-free diet has limitations, and there is intense research in the development of adjuvant therapies. Our aim was to examine the effects of orally administered Aspergillus niger endopeptidase (AN-PEP) on inadvertent gluten exposure and symptom prevention in adult patients with celiac disease (CeD) following their usual gluten-free diet (GFD).Methods: This was an exploratory, double-blind, randomized, placebo-controlled trial that enrolled patients with CeD on a long-term GFD. After a four-week run-in period, patients were randomized to 4 weeks of 2 AN-PEP capsules (GliadinX. AVI Research LLC; USA) at each of 3 meals/day or placebo. Outcome endpoints were: 1- the average weekly stool gluten immunogenic peptides (GIP) between the run-in and end of treatments, and between AN-PEP and placebo; 2) the Celiac Symptom Index (CSI); 3- CeD-specific serology; and 4- the quality of life. Stool samples were collected for GIP by ELISA every Tuesday and Friday during run-ins and treatments.Results: 40 patients were randomized to the intention-to-treat analysis, and three were excluded from the per-protocol assessment. Overall, 628/640 (98.1%) stool samples were collected. GIP was undetectable (<0.08 µg/g) in 65.6% of samples, and no differences between arms were detected. Only 0.5% of samples had GIP concentrations sufficiently high (>0.32µg/g) to potentially cause mucosal damage. Median GIP concentration in the AN-PEP arm was 44.7% lower than in the run-in period. One-third of patients exhibiting GIP >0.08 µg/g during run-in had lower or undetectable GIP after AN-PEP treatment. Compared with the run-in period, the proportion of symptomatic patients (CSI >38) in the AN-PEP arm was significantly lower (p<0.03). AN-PEP did not result in changes in specific serologies.Conclusions: This exploratory study, conducted in a real-life setting, revealed high adherence to the GFD. The AN-PEP treatment did not significantly reduce overall GIP stool concentration. However, given the observation of a significantly lower prevalence of severe symptoms in the AN-PEP arm in patients following their usual GFD, further clinical research is warranted.Fil: Stefanolo, Juan Pablo. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Segura, Verónica. Universidad de Sevilla. Facultad de Farmacia.; EspañaFil: Grizzuti, Martina. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Heredia, Abel. Universidad de Sevilla. Facultad de Farmacia.; EspañaFil: Comino, Isabel. Universidad de Sevilla. Facultad de Farmacia.; EspañaFil: Costa, Ana Florencia. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Puebla, Roberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Temprano, María Paz. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Niveloni, Sonia Isabel. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: de Diego, Gabriel Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; ArgentinaFil: Oregui, María E.. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Smecuol, Edgardo Gustavo. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: de Marzi, Mauricio Cesar. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; ArgentinaFil: Verdú, Elena F.. Mc Master University; CanadáFil: Sousa, Carolina. Universidad de Sevilla. Facultad de Farmacia.; EspañaFil: Bai, Julio César. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaW J G Press2024-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/266979Stefanolo, Juan Pablo; Segura, Verónica; Grizzuti, Martina; Heredia, Abel; Comino, Isabel; et al.; Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet; W J G Press; World Journal of Gastroenterology; 30; 11; 3-2024; 1545-15551007-93272219-2840CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3748/wjg.v30.i11.1545info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/1007-9327/full/v30/i11/1545.htminfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:45:18Zoai:ri.conicet.gov.ar:11336/266979instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:45:18.623CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet |
title |
Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet |
spellingShingle |
Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet Stefanolo, Juan Pablo Celiac disease Gluten immunogenic peptides AN-PEP Real-life trial |
title_short |
Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet |
title_full |
Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet |
title_fullStr |
Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet |
title_full_unstemmed |
Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet |
title_sort |
Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet |
dc.creator.none.fl_str_mv |
Stefanolo, Juan Pablo Segura, Verónica Grizzuti, Martina Heredia, Abel Comino, Isabel Costa, Ana Florencia Puebla, Roberto Temprano, María Paz Niveloni, Sonia Isabel de Diego, Gabriel Alejandro Oregui, María E. Smecuol, Edgardo Gustavo de Marzi, Mauricio Cesar Verdú, Elena F. Sousa, Carolina Bai, Julio César |
author |
Stefanolo, Juan Pablo |
author_facet |
Stefanolo, Juan Pablo Segura, Verónica Grizzuti, Martina Heredia, Abel Comino, Isabel Costa, Ana Florencia Puebla, Roberto Temprano, María Paz Niveloni, Sonia Isabel de Diego, Gabriel Alejandro Oregui, María E. Smecuol, Edgardo Gustavo de Marzi, Mauricio Cesar Verdú, Elena F. Sousa, Carolina Bai, Julio César |
author_role |
author |
author2 |
Segura, Verónica Grizzuti, Martina Heredia, Abel Comino, Isabel Costa, Ana Florencia Puebla, Roberto Temprano, María Paz Niveloni, Sonia Isabel de Diego, Gabriel Alejandro Oregui, María E. Smecuol, Edgardo Gustavo de Marzi, Mauricio Cesar Verdú, Elena F. Sousa, Carolina Bai, Julio César |
author2_role |
author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Celiac disease Gluten immunogenic peptides AN-PEP Real-life trial |
topic |
Celiac disease Gluten immunogenic peptides AN-PEP Real-life trial |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background/Aim: The gluten-free diet has limitations, and there is intense research in the development of adjuvant therapies. Our aim was to examine the effects of orally administered Aspergillus niger endopeptidase (AN-PEP) on inadvertent gluten exposure and symptom prevention in adult patients with celiac disease (CeD) following their usual gluten-free diet (GFD).Methods: This was an exploratory, double-blind, randomized, placebo-controlled trial that enrolled patients with CeD on a long-term GFD. After a four-week run-in period, patients were randomized to 4 weeks of 2 AN-PEP capsules (GliadinX. AVI Research LLC; USA) at each of 3 meals/day or placebo. Outcome endpoints were: 1- the average weekly stool gluten immunogenic peptides (GIP) between the run-in and end of treatments, and between AN-PEP and placebo; 2) the Celiac Symptom Index (CSI); 3- CeD-specific serology; and 4- the quality of life. Stool samples were collected for GIP by ELISA every Tuesday and Friday during run-ins and treatments.Results: 40 patients were randomized to the intention-to-treat analysis, and three were excluded from the per-protocol assessment. Overall, 628/640 (98.1%) stool samples were collected. GIP was undetectable (<0.08 µg/g) in 65.6% of samples, and no differences between arms were detected. Only 0.5% of samples had GIP concentrations sufficiently high (>0.32µg/g) to potentially cause mucosal damage. Median GIP concentration in the AN-PEP arm was 44.7% lower than in the run-in period. One-third of patients exhibiting GIP >0.08 µg/g during run-in had lower or undetectable GIP after AN-PEP treatment. Compared with the run-in period, the proportion of symptomatic patients (CSI >38) in the AN-PEP arm was significantly lower (p<0.03). AN-PEP did not result in changes in specific serologies.Conclusions: This exploratory study, conducted in a real-life setting, revealed high adherence to the GFD. The AN-PEP treatment did not significantly reduce overall GIP stool concentration. However, given the observation of a significantly lower prevalence of severe symptoms in the AN-PEP arm in patients following their usual GFD, further clinical research is warranted. Fil: Stefanolo, Juan Pablo. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina Fil: Segura, Verónica. Universidad de Sevilla. Facultad de Farmacia.; España Fil: Grizzuti, Martina. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina Fil: Heredia, Abel. Universidad de Sevilla. Facultad de Farmacia.; España Fil: Comino, Isabel. Universidad de Sevilla. Facultad de Farmacia.; España Fil: Costa, Ana Florencia. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina Fil: Puebla, Roberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina Fil: Temprano, María Paz. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina Fil: Niveloni, Sonia Isabel. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina Fil: de Diego, Gabriel Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina Fil: Oregui, María E.. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina Fil: Smecuol, Edgardo Gustavo. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina Fil: de Marzi, Mauricio Cesar. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina Fil: Verdú, Elena F.. Mc Master University; Canadá Fil: Sousa, Carolina. Universidad de Sevilla. Facultad de Farmacia.; España Fil: Bai, Julio César. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina |
description |
Background/Aim: The gluten-free diet has limitations, and there is intense research in the development of adjuvant therapies. Our aim was to examine the effects of orally administered Aspergillus niger endopeptidase (AN-PEP) on inadvertent gluten exposure and symptom prevention in adult patients with celiac disease (CeD) following their usual gluten-free diet (GFD).Methods: This was an exploratory, double-blind, randomized, placebo-controlled trial that enrolled patients with CeD on a long-term GFD. After a four-week run-in period, patients were randomized to 4 weeks of 2 AN-PEP capsules (GliadinX. AVI Research LLC; USA) at each of 3 meals/day or placebo. Outcome endpoints were: 1- the average weekly stool gluten immunogenic peptides (GIP) between the run-in and end of treatments, and between AN-PEP and placebo; 2) the Celiac Symptom Index (CSI); 3- CeD-specific serology; and 4- the quality of life. Stool samples were collected for GIP by ELISA every Tuesday and Friday during run-ins and treatments.Results: 40 patients were randomized to the intention-to-treat analysis, and three were excluded from the per-protocol assessment. Overall, 628/640 (98.1%) stool samples were collected. GIP was undetectable (<0.08 µg/g) in 65.6% of samples, and no differences between arms were detected. Only 0.5% of samples had GIP concentrations sufficiently high (>0.32µg/g) to potentially cause mucosal damage. Median GIP concentration in the AN-PEP arm was 44.7% lower than in the run-in period. One-third of patients exhibiting GIP >0.08 µg/g during run-in had lower or undetectable GIP after AN-PEP treatment. Compared with the run-in period, the proportion of symptomatic patients (CSI >38) in the AN-PEP arm was significantly lower (p<0.03). AN-PEP did not result in changes in specific serologies.Conclusions: This exploratory study, conducted in a real-life setting, revealed high adherence to the GFD. The AN-PEP treatment did not significantly reduce overall GIP stool concentration. However, given the observation of a significantly lower prevalence of severe symptoms in the AN-PEP arm in patients following their usual GFD, further clinical research is warranted. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/266979 Stefanolo, Juan Pablo; Segura, Verónica; Grizzuti, Martina; Heredia, Abel; Comino, Isabel; et al.; Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet; W J G Press; World Journal of Gastroenterology; 30; 11; 3-2024; 1545-1555 1007-9327 2219-2840 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/266979 |
identifier_str_mv |
Stefanolo, Juan Pablo; Segura, Verónica; Grizzuti, Martina; Heredia, Abel; Comino, Isabel; et al.; Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet; W J G Press; World Journal of Gastroenterology; 30; 11; 3-2024; 1545-1555 1007-9327 2219-2840 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.3748/wjg.v30.i11.1545 info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/1007-9327/full/v30/i11/1545.htm |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
W J G Press |
publisher.none.fl_str_mv |
W J G Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613423046852608 |
score |
13.070432 |