Actin cytoskeleton remodelling by sex steroids in neurones

Autores
Sanchez, Angel Matias; Flamini, Marina Ines; Polak, K.; Palla G.; Spina, S.; Mannella, P.; Genazzani, A. D.; Simoncini, T.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cell morphology and its interaction with the extracellular environment are integrated processes involving a number of intracellular controllers orchestrating cytoskeletal proteins and their interaction with the cell membrane and anchorage proteins. Sex steroids are effective regulators of cell morphology and tissue organisation, and recent evidence indicates that this is obtained through the regulation of the actin cytoskeleton. Intriguingly, many of these regulatory actions related to cell morphology are achieved through the rapid, nonclassical signalling of sex steroid receptors to kinase cascades, independently from nuclear alteration of gene expression or protein synthesis. The identification of the mechanistic basis for these rapid actions on cell cytoskeleton has special relevance for the characterisation of the effects of sex steroids under physiological conditions, such as for the development of neurone/neurone interconnections and dendritic spine density. This is considered to be critical for gender-specific differences in brain function and dysfunction. Recent advancements in the characterisation of the molecular basis of the extranuclear signalling of sex steroids help to clarify the role of oestrogen and progesterone in the brain, and may turn out to be of relevance for clinical purposes. This review highlights the regulatory effects of oestrogens and progesterone on actin cytoskeleton and neurone morphology, as well as recent progresses in the characterisation of these mechanisms, providing insights and working hypotheses on possible clinical applications for the modulation of these pathways in the central nervous system.
Fil: Sanchez, Angel Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Flamini, Marina Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Polak, K.. Università degli Studi di Pisa; Italia
Fil: Palla G.. Università degli Studi di Pisa; Italia
Fil: Spina, S.. Università degli Studi di Pisa; Italia
Fil: Mannella, P.. Università degli Studi di Pisa; Italia
Fil: Genazzani, A. D.. Università degli Studi di Pisa; Italia
Fil: Simoncini, T.. Università degli Studi di Pisa; Italia
Materia
Dendritic Spine Formation
Focal Adhesion Kinase
Moesin
Sex Steroids
Wasp
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79163
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/79163
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Actin cytoskeleton remodelling by sex steroids in neuronesSanchez, Angel MatiasFlamini, Marina InesPolak, K.Palla G.Spina, S.Mannella, P.Genazzani, A. D.Simoncini, T.Dendritic Spine FormationFocal Adhesion KinaseMoesinSex SteroidsWasphttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Cell morphology and its interaction with the extracellular environment are integrated processes involving a number of intracellular controllers orchestrating cytoskeletal proteins and their interaction with the cell membrane and anchorage proteins. Sex steroids are effective regulators of cell morphology and tissue organisation, and recent evidence indicates that this is obtained through the regulation of the actin cytoskeleton. Intriguingly, many of these regulatory actions related to cell morphology are achieved through the rapid, nonclassical signalling of sex steroid receptors to kinase cascades, independently from nuclear alteration of gene expression or protein synthesis. The identification of the mechanistic basis for these rapid actions on cell cytoskeleton has special relevance for the characterisation of the effects of sex steroids under physiological conditions, such as for the development of neurone/neurone interconnections and dendritic spine density. This is considered to be critical for gender-specific differences in brain function and dysfunction. Recent advancements in the characterisation of the molecular basis of the extranuclear signalling of sex steroids help to clarify the role of oestrogen and progesterone in the brain, and may turn out to be of relevance for clinical purposes. This review highlights the regulatory effects of oestrogens and progesterone on actin cytoskeleton and neurone morphology, as well as recent progresses in the characterisation of these mechanisms, providing insights and working hypotheses on possible clinical applications for the modulation of these pathways in the central nervous system.Fil: Sanchez, Angel Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Flamini, Marina Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Polak, K.. Università degli Studi di Pisa; ItaliaFil: Palla G.. Università degli Studi di Pisa; ItaliaFil: Spina, S.. Università degli Studi di Pisa; ItaliaFil: Mannella, P.. Università degli Studi di Pisa; ItaliaFil: Genazzani, A. D.. Università degli Studi di Pisa; ItaliaFil: Simoncini, T.. Università degli Studi di Pisa; ItaliaWiley Blackwell Publishing, Inc2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79163Sanchez, Angel Matias; Flamini, Marina Ines; Polak, K.; Palla G.; Spina, S.; et al.; Actin cytoskeleton remodelling by sex steroids in neurones; Wiley Blackwell Publishing, Inc; Journal of Neuroendocrinology; 24; 1; 1-2012; 195-2010953-8194CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2826.2011.02258.xinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2826.2011.02258.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:04Zoai:ri.conicet.gov.ar:11336/79163instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:04.746CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Actin cytoskeleton remodelling by sex steroids in neurones
title Actin cytoskeleton remodelling by sex steroids in neurones
spellingShingle Actin cytoskeleton remodelling by sex steroids in neurones
Sanchez, Angel Matias
Dendritic Spine Formation
Focal Adhesion Kinase
Moesin
Sex Steroids
Wasp
title_short Actin cytoskeleton remodelling by sex steroids in neurones
title_full Actin cytoskeleton remodelling by sex steroids in neurones
title_fullStr Actin cytoskeleton remodelling by sex steroids in neurones
title_full_unstemmed Actin cytoskeleton remodelling by sex steroids in neurones
title_sort Actin cytoskeleton remodelling by sex steroids in neurones
dc.creator.none.fl_str_mv Sanchez, Angel Matias
Flamini, Marina Ines
Polak, K.
Palla G.
Spina, S.
Mannella, P.
Genazzani, A. D.
Simoncini, T.
author Sanchez, Angel Matias
author_facet Sanchez, Angel Matias
Flamini, Marina Ines
Polak, K.
Palla G.
Spina, S.
Mannella, P.
Genazzani, A. D.
Simoncini, T.
author_role author
author2 Flamini, Marina Ines
Polak, K.
Palla G.
Spina, S.
Mannella, P.
Genazzani, A. D.
Simoncini, T.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Dendritic Spine Formation
Focal Adhesion Kinase
Moesin
Sex Steroids
Wasp
topic Dendritic Spine Formation
Focal Adhesion Kinase
Moesin
Sex Steroids
Wasp
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cell morphology and its interaction with the extracellular environment are integrated processes involving a number of intracellular controllers orchestrating cytoskeletal proteins and their interaction with the cell membrane and anchorage proteins. Sex steroids are effective regulators of cell morphology and tissue organisation, and recent evidence indicates that this is obtained through the regulation of the actin cytoskeleton. Intriguingly, many of these regulatory actions related to cell morphology are achieved through the rapid, nonclassical signalling of sex steroid receptors to kinase cascades, independently from nuclear alteration of gene expression or protein synthesis. The identification of the mechanistic basis for these rapid actions on cell cytoskeleton has special relevance for the characterisation of the effects of sex steroids under physiological conditions, such as for the development of neurone/neurone interconnections and dendritic spine density. This is considered to be critical for gender-specific differences in brain function and dysfunction. Recent advancements in the characterisation of the molecular basis of the extranuclear signalling of sex steroids help to clarify the role of oestrogen and progesterone in the brain, and may turn out to be of relevance for clinical purposes. This review highlights the regulatory effects of oestrogens and progesterone on actin cytoskeleton and neurone morphology, as well as recent progresses in the characterisation of these mechanisms, providing insights and working hypotheses on possible clinical applications for the modulation of these pathways in the central nervous system.
Fil: Sanchez, Angel Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Flamini, Marina Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Polak, K.. Università degli Studi di Pisa; Italia
Fil: Palla G.. Università degli Studi di Pisa; Italia
Fil: Spina, S.. Università degli Studi di Pisa; Italia
Fil: Mannella, P.. Università degli Studi di Pisa; Italia
Fil: Genazzani, A. D.. Università degli Studi di Pisa; Italia
Fil: Simoncini, T.. Università degli Studi di Pisa; Italia
description Cell morphology and its interaction with the extracellular environment are integrated processes involving a number of intracellular controllers orchestrating cytoskeletal proteins and their interaction with the cell membrane and anchorage proteins. Sex steroids are effective regulators of cell morphology and tissue organisation, and recent evidence indicates that this is obtained through the regulation of the actin cytoskeleton. Intriguingly, many of these regulatory actions related to cell morphology are achieved through the rapid, nonclassical signalling of sex steroid receptors to kinase cascades, independently from nuclear alteration of gene expression or protein synthesis. The identification of the mechanistic basis for these rapid actions on cell cytoskeleton has special relevance for the characterisation of the effects of sex steroids under physiological conditions, such as for the development of neurone/neurone interconnections and dendritic spine density. This is considered to be critical for gender-specific differences in brain function and dysfunction. Recent advancements in the characterisation of the molecular basis of the extranuclear signalling of sex steroids help to clarify the role of oestrogen and progesterone in the brain, and may turn out to be of relevance for clinical purposes. This review highlights the regulatory effects of oestrogens and progesterone on actin cytoskeleton and neurone morphology, as well as recent progresses in the characterisation of these mechanisms, providing insights and working hypotheses on possible clinical applications for the modulation of these pathways in the central nervous system.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79163
Sanchez, Angel Matias; Flamini, Marina Ines; Polak, K.; Palla G.; Spina, S.; et al.; Actin cytoskeleton remodelling by sex steroids in neurones; Wiley Blackwell Publishing, Inc; Journal of Neuroendocrinology; 24; 1; 1-2012; 195-201
0953-8194
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79163
identifier_str_mv Sanchez, Angel Matias; Flamini, Marina Ines; Polak, K.; Palla G.; Spina, S.; et al.; Actin cytoskeleton remodelling by sex steroids in neurones; Wiley Blackwell Publishing, Inc; Journal of Neuroendocrinology; 24; 1; 1-2012; 195-201
0953-8194
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2826.2011.02258.x
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2826.2011.02258.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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