Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions

Autores
Pandya, Shivani R.; Singh, Harjeet; Desimone, Martín Federico; Singh, Jagpreet; George, Noble; Jasani, Srushti
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cancer is a highly complex disease that affects lives and causes millions of deaths worldwide. Several approaches are currently employed as cancer treatment options. Among them, mitochondrial targeting offers a highly promising approach to precise cancer treatment. Indeed, various engineered nanomaterials loaded with chemotherapeutic drugs were developed to precisely target mitochondria. This review investigates the challenges of cancer treatment, particularly in photodynamic, photothermal, and chemotherapies. Drawing on insights from mitochondrial biology and targeting materials, it unravels the complex connection between cancer, mitochondria, and nanoplatform-based targeted therapy. The attention is specifically on nanoparticles and their emerging role in precisely targeting mitochondria, offering solutions for effective treatment of cancer.
Fil: Pandya, Shivani R.. Parul University; India
Fil: Singh, Harjeet. Parul University; India
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Singh, Jagpreet. Chandigarh University; India
Fil: George, Noble. Parul University; India
Fil: Jasani, Srushti. Parul University; India
Materia
Mitochondrial targeting
Targeting materials
Mitochondrial biology
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/265114
Acceder
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spelling Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutionsPandya, Shivani R.Singh, HarjeetDesimone, Martín FedericoSingh, JagpreetGeorge, NobleJasani, SrushtiMitochondrial targetingTargeting materialsMitochondrial biologyhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Cancer is a highly complex disease that affects lives and causes millions of deaths worldwide. Several approaches are currently employed as cancer treatment options. Among them, mitochondrial targeting offers a highly promising approach to precise cancer treatment. Indeed, various engineered nanomaterials loaded with chemotherapeutic drugs were developed to precisely target mitochondria. This review investigates the challenges of cancer treatment, particularly in photodynamic, photothermal, and chemotherapies. Drawing on insights from mitochondrial biology and targeting materials, it unravels the complex connection between cancer, mitochondria, and nanoplatform-based targeted therapy. The attention is specifically on nanoparticles and their emerging role in precisely targeting mitochondria, offering solutions for effective treatment of cancer.Fil: Pandya, Shivani R.. Parul University; IndiaFil: Singh, Harjeet. Parul University; IndiaFil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Singh, Jagpreet. Chandigarh University; IndiaFil: George, Noble. Parul University; IndiaFil: Jasani, Srushti. Parul University; IndiaRoyal Society of Chemistry2024-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/265114Pandya, Shivani R.; Singh, Harjeet; Desimone, Martín Federico; Singh, Jagpreet; George, Noble; et al.; Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions; Royal Society of Chemistry; Materials Advances; 5; 2; 1-2024; 409-4312633-5409CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2024/ma/d3ma00629hinfo:eu-repo/semantics/altIdentifier/doi/10.1039/D3MA00629Hinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:51:29Zoai:ri.conicet.gov.ar:11336/265114instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:51:30.265CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions
title Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions
spellingShingle Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions
Pandya, Shivani R.
Mitochondrial targeting
Targeting materials
Mitochondrial biology
title_short Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions
title_full Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions
title_fullStr Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions
title_full_unstemmed Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions
title_sort Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions
dc.creator.none.fl_str_mv Pandya, Shivani R.
Singh, Harjeet
Desimone, Martín Federico
Singh, Jagpreet
George, Noble
Jasani, Srushti
author Pandya, Shivani R.
author_facet Pandya, Shivani R.
Singh, Harjeet
Desimone, Martín Federico
Singh, Jagpreet
George, Noble
Jasani, Srushti
author_role author
author2 Singh, Harjeet
Desimone, Martín Federico
Singh, Jagpreet
George, Noble
Jasani, Srushti
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Mitochondrial targeting
Targeting materials
Mitochondrial biology
topic Mitochondrial targeting
Targeting materials
Mitochondrial biology
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Cancer is a highly complex disease that affects lives and causes millions of deaths worldwide. Several approaches are currently employed as cancer treatment options. Among them, mitochondrial targeting offers a highly promising approach to precise cancer treatment. Indeed, various engineered nanomaterials loaded with chemotherapeutic drugs were developed to precisely target mitochondria. This review investigates the challenges of cancer treatment, particularly in photodynamic, photothermal, and chemotherapies. Drawing on insights from mitochondrial biology and targeting materials, it unravels the complex connection between cancer, mitochondria, and nanoplatform-based targeted therapy. The attention is specifically on nanoparticles and their emerging role in precisely targeting mitochondria, offering solutions for effective treatment of cancer.
Fil: Pandya, Shivani R.. Parul University; India
Fil: Singh, Harjeet. Parul University; India
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Singh, Jagpreet. Chandigarh University; India
Fil: George, Noble. Parul University; India
Fil: Jasani, Srushti. Parul University; India
description Cancer is a highly complex disease that affects lives and causes millions of deaths worldwide. Several approaches are currently employed as cancer treatment options. Among them, mitochondrial targeting offers a highly promising approach to precise cancer treatment. Indeed, various engineered nanomaterials loaded with chemotherapeutic drugs were developed to precisely target mitochondria. This review investigates the challenges of cancer treatment, particularly in photodynamic, photothermal, and chemotherapies. Drawing on insights from mitochondrial biology and targeting materials, it unravels the complex connection between cancer, mitochondria, and nanoplatform-based targeted therapy. The attention is specifically on nanoparticles and their emerging role in precisely targeting mitochondria, offering solutions for effective treatment of cancer.
publishDate 2024
dc.date.none.fl_str_mv 2024-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/265114
Pandya, Shivani R.; Singh, Harjeet; Desimone, Martín Federico; Singh, Jagpreet; George, Noble; et al.; Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions; Royal Society of Chemistry; Materials Advances; 5; 2; 1-2024; 409-431
2633-5409
CONICET Digital
CONICET
url http://hdl.handle.net/11336/265114
identifier_str_mv Pandya, Shivani R.; Singh, Harjeet; Desimone, Martín Federico; Singh, Jagpreet; George, Noble; et al.; Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions; Royal Society of Chemistry; Materials Advances; 5; 2; 1-2024; 409-431
2633-5409
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2024/ma/d3ma00629h
info:eu-repo/semantics/altIdentifier/doi/10.1039/D3MA00629H
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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