Oil-In-Water Microemulsions for Thymol Solubilization

Autores
Fernández Peña, Laura; Gutiérrez Muro, Sonia; Guzmán, Eduardo; Lucia, Alejandro; Ortega, Francisco; Rubio, Ramón G.
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Essential oil compounds (EOCs) are molecules with well-known antimicrobial and antipest activity. However, such molecules possess limited solubility in water, making their handling difficult. This work aimed to enhance the distribution of a solid essential oil compound, thymol, using oil-in-water (o/w) microemulsions for its solubilization. The use of mixtures formed by an alkyl polyglucoside (APG) and soybean lecithin (SL) allowed for stabilization of the o/w microemulsions in a broad range of compositions, with the total concentration of the mixture of the two surfactants (APG+SL) and the APG:SL ratio both being essential for controlling the nature of the obtained dispersions. The microemulsions obtained using oleic acid as the oil phase and with compositions far from those corresponding to the onset of the emulsion region showed a good efficiency for thymol solubilization. This is an advantage from a stability point of view, as well as for ease of thymol preparation. The present work opens new alternatives for designing eco-sustainable formulations for EOC solubilization, with the possibility of preparing the formulations at the place of use, thereby saving transport costs and reducing the emission of pollutants.
Fil: Fernández Peña, Laura. Universidad Complutense de Madrid; España
Fil: Gutiérrez Muro, Sonia. Universidad Complutense de Madrid; España
Fil: Guzmán, Eduardo. Universidad Complutense de Madrid; España
Fil: Lucia, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable; Argentina. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Centro de Investigacion En Sanidad Vegetal.; Argentina
Fil: Ortega, Francisco. Universidad Complutense de Madrid; España
Fil: Rubio, Ramón G.. Universidad Complutense de Madrid; España
Materia
THYMOL
MICROEMULSIONS
SURFACTANTS
DINAMIC LIGHT SCATTERING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/124013
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Oil-In-Water Microemulsions for Thymol SolubilizationFernández Peña, LauraGutiérrez Muro, SoniaGuzmán, EduardoLucia, AlejandroOrtega, FranciscoRubio, Ramón G.THYMOLMICROEMULSIONSSURFACTANTSDINAMIC LIGHT SCATTERINGhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Essential oil compounds (EOCs) are molecules with well-known antimicrobial and antipest activity. However, such molecules possess limited solubility in water, making their handling difficult. This work aimed to enhance the distribution of a solid essential oil compound, thymol, using oil-in-water (o/w) microemulsions for its solubilization. The use of mixtures formed by an alkyl polyglucoside (APG) and soybean lecithin (SL) allowed for stabilization of the o/w microemulsions in a broad range of compositions, with the total concentration of the mixture of the two surfactants (APG+SL) and the APG:SL ratio both being essential for controlling the nature of the obtained dispersions. The microemulsions obtained using oleic acid as the oil phase and with compositions far from those corresponding to the onset of the emulsion region showed a good efficiency for thymol solubilization. This is an advantage from a stability point of view, as well as for ease of thymol preparation. The present work opens new alternatives for designing eco-sustainable formulations for EOC solubilization, with the possibility of preparing the formulations at the place of use, thereby saving transport costs and reducing the emission of pollutants.Fil: Fernández Peña, Laura. Universidad Complutense de Madrid; EspañaFil: Gutiérrez Muro, Sonia. Universidad Complutense de Madrid; EspañaFil: Guzmán, Eduardo. Universidad Complutense de Madrid; EspañaFil: Lucia, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable; Argentina. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Centro de Investigacion En Sanidad Vegetal.; ArgentinaFil: Ortega, Francisco. Universidad Complutense de Madrid; EspañaFil: Rubio, Ramón G.. Universidad Complutense de Madrid; EspañaMolecular Diversity Preservation International2019-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/124013Fernández Peña, Laura; Gutiérrez Muro, Sonia; Guzmán, Eduardo; Lucia, Alejandro; Ortega, Francisco; et al.; Oil-In-Water Microemulsions for Thymol Solubilization; Molecular Diversity Preservation International; Colloids and Interfaces; 3; 4; 12-2019; 1-132504-5377CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2504-5377/3/4/64info:eu-repo/semantics/altIdentifier/doi/10.3390/colloids3040064info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T10:06:08Zoai:ri.conicet.gov.ar:11336/124013instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 10:06:09.294CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Oil-In-Water Microemulsions for Thymol Solubilization
title Oil-In-Water Microemulsions for Thymol Solubilization
spellingShingle Oil-In-Water Microemulsions for Thymol Solubilization
Fernández Peña, Laura
THYMOL
MICROEMULSIONS
SURFACTANTS
DINAMIC LIGHT SCATTERING
title_short Oil-In-Water Microemulsions for Thymol Solubilization
title_full Oil-In-Water Microemulsions for Thymol Solubilization
title_fullStr Oil-In-Water Microemulsions for Thymol Solubilization
title_full_unstemmed Oil-In-Water Microemulsions for Thymol Solubilization
title_sort Oil-In-Water Microemulsions for Thymol Solubilization
dc.creator.none.fl_str_mv Fernández Peña, Laura
Gutiérrez Muro, Sonia
Guzmán, Eduardo
Lucia, Alejandro
Ortega, Francisco
Rubio, Ramón G.
author Fernández Peña, Laura
author_facet Fernández Peña, Laura
Gutiérrez Muro, Sonia
Guzmán, Eduardo
Lucia, Alejandro
Ortega, Francisco
Rubio, Ramón G.
author_role author
author2 Gutiérrez Muro, Sonia
Guzmán, Eduardo
Lucia, Alejandro
Ortega, Francisco
Rubio, Ramón G.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv THYMOL
MICROEMULSIONS
SURFACTANTS
DINAMIC LIGHT SCATTERING
topic THYMOL
MICROEMULSIONS
SURFACTANTS
DINAMIC LIGHT SCATTERING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Essential oil compounds (EOCs) are molecules with well-known antimicrobial and antipest activity. However, such molecules possess limited solubility in water, making their handling difficult. This work aimed to enhance the distribution of a solid essential oil compound, thymol, using oil-in-water (o/w) microemulsions for its solubilization. The use of mixtures formed by an alkyl polyglucoside (APG) and soybean lecithin (SL) allowed for stabilization of the o/w microemulsions in a broad range of compositions, with the total concentration of the mixture of the two surfactants (APG+SL) and the APG:SL ratio both being essential for controlling the nature of the obtained dispersions. The microemulsions obtained using oleic acid as the oil phase and with compositions far from those corresponding to the onset of the emulsion region showed a good efficiency for thymol solubilization. This is an advantage from a stability point of view, as well as for ease of thymol preparation. The present work opens new alternatives for designing eco-sustainable formulations for EOC solubilization, with the possibility of preparing the formulations at the place of use, thereby saving transport costs and reducing the emission of pollutants.
Fil: Fernández Peña, Laura. Universidad Complutense de Madrid; España
Fil: Gutiérrez Muro, Sonia. Universidad Complutense de Madrid; España
Fil: Guzmán, Eduardo. Universidad Complutense de Madrid; España
Fil: Lucia, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable; Argentina. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Centro de Investigacion En Sanidad Vegetal.; Argentina
Fil: Ortega, Francisco. Universidad Complutense de Madrid; España
Fil: Rubio, Ramón G.. Universidad Complutense de Madrid; España
description Essential oil compounds (EOCs) are molecules with well-known antimicrobial and antipest activity. However, such molecules possess limited solubility in water, making their handling difficult. This work aimed to enhance the distribution of a solid essential oil compound, thymol, using oil-in-water (o/w) microemulsions for its solubilization. The use of mixtures formed by an alkyl polyglucoside (APG) and soybean lecithin (SL) allowed for stabilization of the o/w microemulsions in a broad range of compositions, with the total concentration of the mixture of the two surfactants (APG+SL) and the APG:SL ratio both being essential for controlling the nature of the obtained dispersions. The microemulsions obtained using oleic acid as the oil phase and with compositions far from those corresponding to the onset of the emulsion region showed a good efficiency for thymol solubilization. This is an advantage from a stability point of view, as well as for ease of thymol preparation. The present work opens new alternatives for designing eco-sustainable formulations for EOC solubilization, with the possibility of preparing the formulations at the place of use, thereby saving transport costs and reducing the emission of pollutants.
publishDate 2019
dc.date.none.fl_str_mv 2019-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/124013
Fernández Peña, Laura; Gutiérrez Muro, Sonia; Guzmán, Eduardo; Lucia, Alejandro; Ortega, Francisco; et al.; Oil-In-Water Microemulsions for Thymol Solubilization; Molecular Diversity Preservation International; Colloids and Interfaces; 3; 4; 12-2019; 1-13
2504-5377
CONICET Digital
CONICET
url http://hdl.handle.net/11336/124013
identifier_str_mv Fernández Peña, Laura; Gutiérrez Muro, Sonia; Guzmán, Eduardo; Lucia, Alejandro; Ortega, Francisco; et al.; Oil-In-Water Microemulsions for Thymol Solubilization; Molecular Diversity Preservation International; Colloids and Interfaces; 3; 4; 12-2019; 1-13
2504-5377
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2504-5377/3/4/64
info:eu-repo/semantics/altIdentifier/doi/10.3390/colloids3040064
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.087074

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