Development, Characterization, and In Vitro Evaluation of Tamoxifen Microemulsions

Autores
Monteagudo, Ezequiel; Gándola, Yamila Belén; Gonzalez, Lorena; Bregni, Carlos; Carlucci, Adriana Mónica
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Microemulsions (MEs) were designed by an innovative rational development, characterized and used to load up to 20 mM of Tamoxifen citrate (TMX). They were made with acceptable and well-characterized excipients for all the routes of administration. Some of their properties, such as nanometric mean size and long stability shelf-life, make them interesting drug delivery systems. The results obtained after the in vitro inhibition of estradiol-induced proliferation in MCF-7 breast cancer cells, demonstrated a significant effect in cell growth. A decreasing of at least 90% in viable cells was shown after the incubation with MEs containing 20 mM of TMX. Besides, two compositions which loaded 10 mM of drug showed a cytotoxic effect higher than 70%. These results encourage the evaluation of alternative protocols for this drug administration, not only for Estrogen Receptor (ER) positive tumors, but also for ER negative
Fil: Monteagudo, Ezequiel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Gándola, Yamila Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Gonzalez, Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Carlucci, Adriana Mónica. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Materia
Tamoxifen
Microemulsions
Breast cancer
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/268986
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/268986
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Development, Characterization, and In Vitro Evaluation of Tamoxifen MicroemulsionsMonteagudo, EzequielGándola, Yamila BelénGonzalez, LorenaBregni, CarlosCarlucci, Adriana MónicaTamoxifenMicroemulsionsBreast cancerhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Microemulsions (MEs) were designed by an innovative rational development, characterized and used to load up to 20 mM of Tamoxifen citrate (TMX). They were made with acceptable and well-characterized excipients for all the routes of administration. Some of their properties, such as nanometric mean size and long stability shelf-life, make them interesting drug delivery systems. The results obtained after the in vitro inhibition of estradiol-induced proliferation in MCF-7 breast cancer cells, demonstrated a significant effect in cell growth. A decreasing of at least 90% in viable cells was shown after the incubation with MEs containing 20 mM of TMX. Besides, two compositions which loaded 10 mM of drug showed a cytotoxic effect higher than 70%. These results encourage the evaluation of alternative protocols for this drug administration, not only for Estrogen Receptor (ER) positive tumors, but also for ER negativeFil: Monteagudo, Ezequiel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Gándola, Yamila Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Gonzalez, Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Carlucci, Adriana Mónica. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaWiley2012-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/268986Monteagudo, Ezequiel; Gándola, Yamila Belén; Gonzalez, Lorena; Bregni, Carlos; Carlucci, Adriana Mónica; Development, Characterization, and In Vitro Evaluation of Tamoxifen Microemulsions; Wiley; Journal of Drug Delivery; 2012; 2-2012; 1-112090-30142090-3022CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1155/2012/236713info:eu-repo/semantics/altIdentifier/doi/10.1155/2012/236713info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:23Zoai:ri.conicet.gov.ar:11336/268986instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:23.885CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Development, Characterization, and In Vitro Evaluation of Tamoxifen Microemulsions
title Development, Characterization, and In Vitro Evaluation of Tamoxifen Microemulsions
spellingShingle Development, Characterization, and In Vitro Evaluation of Tamoxifen Microemulsions
Monteagudo, Ezequiel
Tamoxifen
Microemulsions
Breast cancer
title_short Development, Characterization, and In Vitro Evaluation of Tamoxifen Microemulsions
title_full Development, Characterization, and In Vitro Evaluation of Tamoxifen Microemulsions
title_fullStr Development, Characterization, and In Vitro Evaluation of Tamoxifen Microemulsions
title_full_unstemmed Development, Characterization, and In Vitro Evaluation of Tamoxifen Microemulsions
title_sort Development, Characterization, and In Vitro Evaluation of Tamoxifen Microemulsions
dc.creator.none.fl_str_mv Monteagudo, Ezequiel
Gándola, Yamila Belén
Gonzalez, Lorena
Bregni, Carlos
Carlucci, Adriana Mónica
author Monteagudo, Ezequiel
author_facet Monteagudo, Ezequiel
Gándola, Yamila Belén
Gonzalez, Lorena
Bregni, Carlos
Carlucci, Adriana Mónica
author_role author
author2 Gándola, Yamila Belén
Gonzalez, Lorena
Bregni, Carlos
Carlucci, Adriana Mónica
author2_role author
author
author
author
dc.subject.none.fl_str_mv Tamoxifen
Microemulsions
Breast cancer
topic Tamoxifen
Microemulsions
Breast cancer
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Microemulsions (MEs) were designed by an innovative rational development, characterized and used to load up to 20 mM of Tamoxifen citrate (TMX). They were made with acceptable and well-characterized excipients for all the routes of administration. Some of their properties, such as nanometric mean size and long stability shelf-life, make them interesting drug delivery systems. The results obtained after the in vitro inhibition of estradiol-induced proliferation in MCF-7 breast cancer cells, demonstrated a significant effect in cell growth. A decreasing of at least 90% in viable cells was shown after the incubation with MEs containing 20 mM of TMX. Besides, two compositions which loaded 10 mM of drug showed a cytotoxic effect higher than 70%. These results encourage the evaluation of alternative protocols for this drug administration, not only for Estrogen Receptor (ER) positive tumors, but also for ER negative
Fil: Monteagudo, Ezequiel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Gándola, Yamila Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Gonzalez, Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Carlucci, Adriana Mónica. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
description Microemulsions (MEs) were designed by an innovative rational development, characterized and used to load up to 20 mM of Tamoxifen citrate (TMX). They were made with acceptable and well-characterized excipients for all the routes of administration. Some of their properties, such as nanometric mean size and long stability shelf-life, make them interesting drug delivery systems. The results obtained after the in vitro inhibition of estradiol-induced proliferation in MCF-7 breast cancer cells, demonstrated a significant effect in cell growth. A decreasing of at least 90% in viable cells was shown after the incubation with MEs containing 20 mM of TMX. Besides, two compositions which loaded 10 mM of drug showed a cytotoxic effect higher than 70%. These results encourage the evaluation of alternative protocols for this drug administration, not only for Estrogen Receptor (ER) positive tumors, but also for ER negative
publishDate 2012
dc.date.none.fl_str_mv 2012-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/268986
Monteagudo, Ezequiel; Gándola, Yamila Belén; Gonzalez, Lorena; Bregni, Carlos; Carlucci, Adriana Mónica; Development, Characterization, and In Vitro Evaluation of Tamoxifen Microemulsions; Wiley; Journal of Drug Delivery; 2012; 2-2012; 1-11
2090-3014
2090-3022
CONICET Digital
CONICET
url http://hdl.handle.net/11336/268986
identifier_str_mv Monteagudo, Ezequiel; Gándola, Yamila Belén; Gonzalez, Lorena; Bregni, Carlos; Carlucci, Adriana Mónica; Development, Characterization, and In Vitro Evaluation of Tamoxifen Microemulsions; Wiley; Journal of Drug Delivery; 2012; 2-2012; 1-11
2090-3014
2090-3022
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1155/2012/236713
info:eu-repo/semantics/altIdentifier/doi/10.1155/2012/236713
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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