Oil-In-Water Microemulsions for Thymol Solubilization

Autores
Fernández Peña, Laura; Gutiérrez Muro, Sonia; Guzmán, Eduardo; Lucía, Alejandro; Ortega, Francisco; González Rubio, Ramón
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Essential oil compounds (EOCs) are molecules with well-known antimicrobial and antipest activity. However, such molecules possess limited solubility in water, making their handling difficult. This work aimed to enhance the distribution of a solid essential oil compound, thymol, using oil-in-water (o/w) microemulsions for its solubilization. The use of mixtures formed by an alkyl polyglucoside (APG) and soybean lecithin (SL) allowed for stabilization of the o/w microemulsions in a broad range of compositions, with the total concentration of the mixture of the two surfactants (APG+SL) and the APG:SL ratio both being essential for controlling the nature of the obtained dispersions. The microemulsions obtained using oleic acid as the oil phase and with compositions far from those corresponding to the onset of the emulsion region showed a good efficiency for thymol solubilization. This is an advantage from a stability point of view, as well as for ease of thymol preparation. The present work opens new alternatives for designing eco-sustainable formulations for EOC solubilization, with the possibility of preparing the formulations at the place of use, thereby saving transport costs and reducing the emission of pollutants.
Centro de Investigación en Sanidad Vegetal
Materia
Ciencias Agrarias
Microemulsions
Essential oil
Phase diagram
Dynamic light scattering
Solubilization
Fluorescence spectroscopy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/125396
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/125396
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Oil-In-Water Microemulsions for Thymol SolubilizationFernández Peña, LauraGutiérrez Muro, SoniaGuzmán, EduardoLucía, AlejandroOrtega, FranciscoGonzález Rubio, RamónCiencias AgrariasMicroemulsionsEssential oilPhase diagramDynamic light scatteringSolubilizationFluorescence spectroscopyEssential oil compounds (EOCs) are molecules with well-known antimicrobial and antipest activity. However, such molecules possess limited solubility in water, making their handling difficult. This work aimed to enhance the distribution of a solid essential oil compound, thymol, using oil-in-water (o/w) microemulsions for its solubilization. The use of mixtures formed by an alkyl polyglucoside (APG) and soybean lecithin (SL) allowed for stabilization of the o/w microemulsions in a broad range of compositions, with the total concentration of the mixture of the two surfactants (APG+SL) and the APG:SL ratio both being essential for controlling the nature of the obtained dispersions. The microemulsions obtained using oleic acid as the oil phase and with compositions far from those corresponding to the onset of the emulsion region showed a good efficiency for thymol solubilization. This is an advantage from a stability point of view, as well as for ease of thymol preparation. The present work opens new alternatives for designing eco-sustainable formulations for EOC solubilization, with the possibility of preparing the formulations at the place of use, thereby saving transport costs and reducing the emission of pollutants.Centro de Investigación en Sanidad Vegetal2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/125396enginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2504-5377/3/4/64info:eu-repo/semantics/altIdentifier/issn/2504-5377info:eu-repo/semantics/altIdentifier/doi/10.3390/colloids3040064info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T17:10:59Zoai:sedici.unlp.edu.ar:10915/125396Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 17:10:59.551SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Oil-In-Water Microemulsions for Thymol Solubilization
title Oil-In-Water Microemulsions for Thymol Solubilization
spellingShingle Oil-In-Water Microemulsions for Thymol Solubilization
Fernández Peña, Laura
Ciencias Agrarias
Microemulsions
Essential oil
Phase diagram
Dynamic light scattering
Solubilization
Fluorescence spectroscopy
title_short Oil-In-Water Microemulsions for Thymol Solubilization
title_full Oil-In-Water Microemulsions for Thymol Solubilization
title_fullStr Oil-In-Water Microemulsions for Thymol Solubilization
title_full_unstemmed Oil-In-Water Microemulsions for Thymol Solubilization
title_sort Oil-In-Water Microemulsions for Thymol Solubilization
dc.creator.none.fl_str_mv Fernández Peña, Laura
Gutiérrez Muro, Sonia
Guzmán, Eduardo
Lucía, Alejandro
Ortega, Francisco
González Rubio, Ramón
author Fernández Peña, Laura
author_facet Fernández Peña, Laura
Gutiérrez Muro, Sonia
Guzmán, Eduardo
Lucía, Alejandro
Ortega, Francisco
González Rubio, Ramón
author_role author
author2 Gutiérrez Muro, Sonia
Guzmán, Eduardo
Lucía, Alejandro
Ortega, Francisco
González Rubio, Ramón
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Agrarias
Microemulsions
Essential oil
Phase diagram
Dynamic light scattering
Solubilization
Fluorescence spectroscopy
topic Ciencias Agrarias
Microemulsions
Essential oil
Phase diagram
Dynamic light scattering
Solubilization
Fluorescence spectroscopy
dc.description.none.fl_txt_mv Essential oil compounds (EOCs) are molecules with well-known antimicrobial and antipest activity. However, such molecules possess limited solubility in water, making their handling difficult. This work aimed to enhance the distribution of a solid essential oil compound, thymol, using oil-in-water (o/w) microemulsions for its solubilization. The use of mixtures formed by an alkyl polyglucoside (APG) and soybean lecithin (SL) allowed for stabilization of the o/w microemulsions in a broad range of compositions, with the total concentration of the mixture of the two surfactants (APG+SL) and the APG:SL ratio both being essential for controlling the nature of the obtained dispersions. The microemulsions obtained using oleic acid as the oil phase and with compositions far from those corresponding to the onset of the emulsion region showed a good efficiency for thymol solubilization. This is an advantage from a stability point of view, as well as for ease of thymol preparation. The present work opens new alternatives for designing eco-sustainable formulations for EOC solubilization, with the possibility of preparing the formulations at the place of use, thereby saving transport costs and reducing the emission of pollutants.
Centro de Investigación en Sanidad Vegetal
description Essential oil compounds (EOCs) are molecules with well-known antimicrobial and antipest activity. However, such molecules possess limited solubility in water, making their handling difficult. This work aimed to enhance the distribution of a solid essential oil compound, thymol, using oil-in-water (o/w) microemulsions for its solubilization. The use of mixtures formed by an alkyl polyglucoside (APG) and soybean lecithin (SL) allowed for stabilization of the o/w microemulsions in a broad range of compositions, with the total concentration of the mixture of the two surfactants (APG+SL) and the APG:SL ratio both being essential for controlling the nature of the obtained dispersions. The microemulsions obtained using oleic acid as the oil phase and with compositions far from those corresponding to the onset of the emulsion region showed a good efficiency for thymol solubilization. This is an advantage from a stability point of view, as well as for ease of thymol preparation. The present work opens new alternatives for designing eco-sustainable formulations for EOC solubilization, with the possibility of preparing the formulations at the place of use, thereby saving transport costs and reducing the emission of pollutants.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/125396
url http://sedici.unlp.edu.ar/handle/10915/125396
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2504-5377/3/4/64
info:eu-repo/semantics/altIdentifier/issn/2504-5377
info:eu-repo/semantics/altIdentifier/doi/10.3390/colloids3040064
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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