Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria

Autores
Leblanc, Jean Guy Joseph; del Carmen, Silvina Andrea; Zurita Turk, Meritxell; Alvarenga Lima, Fernanda; Santos Ponce, Daniela; Miyoshi, Aanderson; Azevedo, Vasco; de Moreno, Maria Alejandra
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that have been shown to possess therapeutic properties since they are able to prevent the development of some diseases, as shown mostly on animal models for cancer, infections and gastrointestinal disorders such as intestinal inflammation. LAB have been shown to regulate mucosal immune responses by modulating the production and liberation of regulatory agents such as cytokines by the host. Some of these cytokines, such as the anti-inflammatory interleukin-10 (IL-10), modulate the inflammatory immune response, thus immunomodulation is a mechanism by which LAB can prevent certain inflammatory bowel diseases (IBD). Since oxidative stress participates to the inflammatory processes and to the appearance of damages in pathologies of the gastrointestinal tract of humans such as IBD, LAB could also prevent inflammation by eliminating reactive oxygen species (ROS) through the activity of antioxidant enzymes.In order to obtain novel strains or enhance beneficial effects of LAB, genetic engineering has been used to produce either antioxidant enzymes (such as catalases and superoxide dismutases) or anti-inflammatory cytokines (such as IL-10) producing LAB. These novel strains have successfully been used to prevent inflammatory bowel diseases in animal models and could be evaluated in human clinical trials. Here, we present an overview of the current knowledge of the mechanisms by which LAB can be used to prevent undesired intestinal inflammatory responses and could be used as a therapeutic tool for IBD.
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
Fil: del Carmen, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
Fil: Zurita Turk, Meritxell. Universidade Federal Do Minas Gerais; Brasil;
Fil: Alvarenga Lima, Fernanda. Universidade Federal Do Minas Gerais; Brasil;
Fil: Santos Ponce, Daniela. Universidade Federal Do Minas Gerais; Brasil;
Fil: Miyoshi, Aanderson. Universidade Federal Do Minas Gerais; Brasil;
Fil: Azevedo, Vasco. Universidade Federal Do Minas Gerais; Brasil;
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
Materia
Lactic Acid Bacteria
Anti-Inflammatory
Antioxidant
Interleukin-10
Catalase
Immune Regulation
Superoxide Dismutase
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/2566
Acceder
id CONICETDig_56fe10f5c643dc9803f61785c2046d58
oai_identifier_str oai:ri.conicet.gov.ar:11336/2566
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteriaLeblanc, Jean Guy Josephdel Carmen, Silvina AndreaZurita Turk, MeritxellAlvarenga Lima, FernandaSantos Ponce, DanielaMiyoshi, AandersonAzevedo, Vascode Moreno, Maria AlejandraLactic Acid BacteriaAnti-InflammatoryAntioxidantInterleukin-10CatalaseImmune RegulationSuperoxide Dismutasehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that have been shown to possess therapeutic properties since they are able to prevent the development of some diseases, as shown mostly on animal models for cancer, infections and gastrointestinal disorders such as intestinal inflammation. LAB have been shown to regulate mucosal immune responses by modulating the production and liberation of regulatory agents such as cytokines by the host. Some of these cytokines, such as the anti-inflammatory interleukin-10 (IL-10), modulate the inflammatory immune response, thus immunomodulation is a mechanism by which LAB can prevent certain inflammatory bowel diseases (IBD). Since oxidative stress participates to the inflammatory processes and to the appearance of damages in pathologies of the gastrointestinal tract of humans such as IBD, LAB could also prevent inflammation by eliminating reactive oxygen species (ROS) through the activity of antioxidant enzymes.In order to obtain novel strains or enhance beneficial effects of LAB, genetic engineering has been used to produce either antioxidant enzymes (such as catalases and superoxide dismutases) or anti-inflammatory cytokines (such as IL-10) producing LAB. These novel strains have successfully been used to prevent inflammatory bowel diseases in animal models and could be evaluated in human clinical trials. Here, we present an overview of the current knowledge of the mechanisms by which LAB can be used to prevent undesired intestinal inflammatory responses and could be used as a therapeutic tool for IBD.Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); ArgentinaFil: del Carmen, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); ArgentinaFil: Zurita Turk, Meritxell. Universidade Federal Do Minas Gerais; Brasil;Fil: Alvarenga Lima, Fernanda. Universidade Federal Do Minas Gerais; Brasil;Fil: Santos Ponce, Daniela. Universidade Federal Do Minas Gerais; Brasil;Fil: Miyoshi, Aanderson. Universidade Federal Do Minas Gerais; Brasil;Fil: Azevedo, Vasco. Universidade Federal Do Minas Gerais; Brasil;Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); ArgentinaBentham Science Publishers2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/2566Leblanc, Jean Guy Joseph; del Carmen, Silvina Andrea; Zurita Turk, Meritxell; Alvarenga Lima, Fernanda; Santos Ponce, Daniela; et al.; Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria; Bentham Science Publishers; Anti-Infective Agents; 11; 1; 1-2013; 59-692211-35252211-3533enginfo:eu-repo/semantics/altIdentifier/url/http://benthamscience.com/journals/anti-infective-agents/volume/11/info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/104672info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/ben/aia/2013/00000011/00000001/art00007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:41:31Zoai:ri.conicet.gov.ar:11336/2566instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:41:31.624CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria
title Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria
spellingShingle Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria
Leblanc, Jean Guy Joseph
Lactic Acid Bacteria
Anti-Inflammatory
Antioxidant
Interleukin-10
Catalase
Immune Regulation
Superoxide Dismutase
title_short Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria
title_full Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria
title_fullStr Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria
title_full_unstemmed Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria
title_sort Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria
dc.creator.none.fl_str_mv Leblanc, Jean Guy Joseph
del Carmen, Silvina Andrea
Zurita Turk, Meritxell
Alvarenga Lima, Fernanda
Santos Ponce, Daniela
Miyoshi, Aanderson
Azevedo, Vasco
de Moreno, Maria Alejandra
author Leblanc, Jean Guy Joseph
author_facet Leblanc, Jean Guy Joseph
del Carmen, Silvina Andrea
Zurita Turk, Meritxell
Alvarenga Lima, Fernanda
Santos Ponce, Daniela
Miyoshi, Aanderson
Azevedo, Vasco
de Moreno, Maria Alejandra
author_role author
author2 del Carmen, Silvina Andrea
Zurita Turk, Meritxell
Alvarenga Lima, Fernanda
Santos Ponce, Daniela
Miyoshi, Aanderson
Azevedo, Vasco
de Moreno, Maria Alejandra
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Lactic Acid Bacteria
Anti-Inflammatory
Antioxidant
Interleukin-10
Catalase
Immune Regulation
Superoxide Dismutase
topic Lactic Acid Bacteria
Anti-Inflammatory
Antioxidant
Interleukin-10
Catalase
Immune Regulation
Superoxide Dismutase
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that have been shown to possess therapeutic properties since they are able to prevent the development of some diseases, as shown mostly on animal models for cancer, infections and gastrointestinal disorders such as intestinal inflammation. LAB have been shown to regulate mucosal immune responses by modulating the production and liberation of regulatory agents such as cytokines by the host. Some of these cytokines, such as the anti-inflammatory interleukin-10 (IL-10), modulate the inflammatory immune response, thus immunomodulation is a mechanism by which LAB can prevent certain inflammatory bowel diseases (IBD). Since oxidative stress participates to the inflammatory processes and to the appearance of damages in pathologies of the gastrointestinal tract of humans such as IBD, LAB could also prevent inflammation by eliminating reactive oxygen species (ROS) through the activity of antioxidant enzymes.In order to obtain novel strains or enhance beneficial effects of LAB, genetic engineering has been used to produce either antioxidant enzymes (such as catalases and superoxide dismutases) or anti-inflammatory cytokines (such as IL-10) producing LAB. These novel strains have successfully been used to prevent inflammatory bowel diseases in animal models and could be evaluated in human clinical trials. Here, we present an overview of the current knowledge of the mechanisms by which LAB can be used to prevent undesired intestinal inflammatory responses and could be used as a therapeutic tool for IBD.
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
Fil: del Carmen, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
Fil: Zurita Turk, Meritxell. Universidade Federal Do Minas Gerais; Brasil;
Fil: Alvarenga Lima, Fernanda. Universidade Federal Do Minas Gerais; Brasil;
Fil: Santos Ponce, Daniela. Universidade Federal Do Minas Gerais; Brasil;
Fil: Miyoshi, Aanderson. Universidade Federal Do Minas Gerais; Brasil;
Fil: Azevedo, Vasco. Universidade Federal Do Minas Gerais; Brasil;
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
description Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that have been shown to possess therapeutic properties since they are able to prevent the development of some diseases, as shown mostly on animal models for cancer, infections and gastrointestinal disorders such as intestinal inflammation. LAB have been shown to regulate mucosal immune responses by modulating the production and liberation of regulatory agents such as cytokines by the host. Some of these cytokines, such as the anti-inflammatory interleukin-10 (IL-10), modulate the inflammatory immune response, thus immunomodulation is a mechanism by which LAB can prevent certain inflammatory bowel diseases (IBD). Since oxidative stress participates to the inflammatory processes and to the appearance of damages in pathologies of the gastrointestinal tract of humans such as IBD, LAB could also prevent inflammation by eliminating reactive oxygen species (ROS) through the activity of antioxidant enzymes.In order to obtain novel strains or enhance beneficial effects of LAB, genetic engineering has been used to produce either antioxidant enzymes (such as catalases and superoxide dismutases) or anti-inflammatory cytokines (such as IL-10) producing LAB. These novel strains have successfully been used to prevent inflammatory bowel diseases in animal models and could be evaluated in human clinical trials. Here, we present an overview of the current knowledge of the mechanisms by which LAB can be used to prevent undesired intestinal inflammatory responses and could be used as a therapeutic tool for IBD.
publishDate 2013
dc.date.none.fl_str_mv 2013-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/2566
Leblanc, Jean Guy Joseph; del Carmen, Silvina Andrea; Zurita Turk, Meritxell; Alvarenga Lima, Fernanda; Santos Ponce, Daniela; et al.; Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria; Bentham Science Publishers; Anti-Infective Agents; 11; 1; 1-2013; 59-69
2211-3525
2211-3533
url http://hdl.handle.net/11336/2566
identifier_str_mv Leblanc, Jean Guy Joseph; del Carmen, Silvina Andrea; Zurita Turk, Meritxell; Alvarenga Lima, Fernanda; Santos Ponce, Daniela; et al.; Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria; Bentham Science Publishers; Anti-Infective Agents; 11; 1; 1-2013; 59-69
2211-3525
2211-3533
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://benthamscience.com/journals/anti-infective-agents/volume/11/
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/104672
info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/ben/aia/2013/00000011/00000001/art00007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782094904131584
score 13.148871

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