Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria
- Autores
- Leblanc, Jean Guy Joseph; del Carmen, Silvina Andrea; Zurita Turk, Meritxell; Alvarenga Lima, Fernanda; Santos Ponce, Daniela; Miyoshi, Aanderson; Azevedo, Vasco; de Moreno, Maria Alejandra
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that have been shown to possess therapeutic properties since they are able to prevent the development of some diseases, as shown mostly on animal models for cancer, infections and gastrointestinal disorders such as intestinal inflammation. LAB have been shown to regulate mucosal immune responses by modulating the production and liberation of regulatory agents such as cytokines by the host. Some of these cytokines, such as the anti-inflammatory interleukin-10 (IL-10), modulate the inflammatory immune response, thus immunomodulation is a mechanism by which LAB can prevent certain inflammatory bowel diseases (IBD). Since oxidative stress participates to the inflammatory processes and to the appearance of damages in pathologies of the gastrointestinal tract of humans such as IBD, LAB could also prevent inflammation by eliminating reactive oxygen species (ROS) through the activity of antioxidant enzymes.In order to obtain novel strains or enhance beneficial effects of LAB, genetic engineering has been used to produce either antioxidant enzymes (such as catalases and superoxide dismutases) or anti-inflammatory cytokines (such as IL-10) producing LAB. These novel strains have successfully been used to prevent inflammatory bowel diseases in animal models and could be evaluated in human clinical trials. Here, we present an overview of the current knowledge of the mechanisms by which LAB can be used to prevent undesired intestinal inflammatory responses and could be used as a therapeutic tool for IBD.
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
Fil: del Carmen, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
Fil: Zurita Turk, Meritxell. Universidade Federal Do Minas Gerais; Brasil;
Fil: Alvarenga Lima, Fernanda. Universidade Federal Do Minas Gerais; Brasil;
Fil: Santos Ponce, Daniela. Universidade Federal Do Minas Gerais; Brasil;
Fil: Miyoshi, Aanderson. Universidade Federal Do Minas Gerais; Brasil;
Fil: Azevedo, Vasco. Universidade Federal Do Minas Gerais; Brasil;
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina - Materia
-
Lactic Acid Bacteria
Anti-Inflammatory
Antioxidant
Interleukin-10
Catalase
Immune Regulation
Superoxide Dismutase - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/2566
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Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteriaLeblanc, Jean Guy Josephdel Carmen, Silvina AndreaZurita Turk, MeritxellAlvarenga Lima, FernandaSantos Ponce, DanielaMiyoshi, AandersonAzevedo, Vascode Moreno, Maria AlejandraLactic Acid BacteriaAnti-InflammatoryAntioxidantInterleukin-10CatalaseImmune RegulationSuperoxide Dismutasehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that have been shown to possess therapeutic properties since they are able to prevent the development of some diseases, as shown mostly on animal models for cancer, infections and gastrointestinal disorders such as intestinal inflammation. LAB have been shown to regulate mucosal immune responses by modulating the production and liberation of regulatory agents such as cytokines by the host. Some of these cytokines, such as the anti-inflammatory interleukin-10 (IL-10), modulate the inflammatory immune response, thus immunomodulation is a mechanism by which LAB can prevent certain inflammatory bowel diseases (IBD). Since oxidative stress participates to the inflammatory processes and to the appearance of damages in pathologies of the gastrointestinal tract of humans such as IBD, LAB could also prevent inflammation by eliminating reactive oxygen species (ROS) through the activity of antioxidant enzymes.In order to obtain novel strains or enhance beneficial effects of LAB, genetic engineering has been used to produce either antioxidant enzymes (such as catalases and superoxide dismutases) or anti-inflammatory cytokines (such as IL-10) producing LAB. These novel strains have successfully been used to prevent inflammatory bowel diseases in animal models and could be evaluated in human clinical trials. Here, we present an overview of the current knowledge of the mechanisms by which LAB can be used to prevent undesired intestinal inflammatory responses and could be used as a therapeutic tool for IBD.Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); ArgentinaFil: del Carmen, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); ArgentinaFil: Zurita Turk, Meritxell. Universidade Federal Do Minas Gerais; Brasil;Fil: Alvarenga Lima, Fernanda. Universidade Federal Do Minas Gerais; Brasil;Fil: Santos Ponce, Daniela. Universidade Federal Do Minas Gerais; Brasil;Fil: Miyoshi, Aanderson. Universidade Federal Do Minas Gerais; Brasil;Fil: Azevedo, Vasco. Universidade Federal Do Minas Gerais; Brasil;Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); ArgentinaBentham Science Publishers2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/2566Leblanc, Jean Guy Joseph; del Carmen, Silvina Andrea; Zurita Turk, Meritxell; Alvarenga Lima, Fernanda; Santos Ponce, Daniela; et al.; Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria; Bentham Science Publishers; Anti-Infective Agents; 11; 1; 1-2013; 59-692211-35252211-3533enginfo:eu-repo/semantics/altIdentifier/url/http://benthamscience.com/journals/anti-infective-agents/volume/11/info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/104672info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/ben/aia/2013/00000011/00000001/art00007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:41:31Zoai:ri.conicet.gov.ar:11336/2566instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:41:31.624CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria |
title |
Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria |
spellingShingle |
Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria Leblanc, Jean Guy Joseph Lactic Acid Bacteria Anti-Inflammatory Antioxidant Interleukin-10 Catalase Immune Regulation Superoxide Dismutase |
title_short |
Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria |
title_full |
Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria |
title_fullStr |
Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria |
title_full_unstemmed |
Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria |
title_sort |
Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria |
dc.creator.none.fl_str_mv |
Leblanc, Jean Guy Joseph del Carmen, Silvina Andrea Zurita Turk, Meritxell Alvarenga Lima, Fernanda Santos Ponce, Daniela Miyoshi, Aanderson Azevedo, Vasco de Moreno, Maria Alejandra |
author |
Leblanc, Jean Guy Joseph |
author_facet |
Leblanc, Jean Guy Joseph del Carmen, Silvina Andrea Zurita Turk, Meritxell Alvarenga Lima, Fernanda Santos Ponce, Daniela Miyoshi, Aanderson Azevedo, Vasco de Moreno, Maria Alejandra |
author_role |
author |
author2 |
del Carmen, Silvina Andrea Zurita Turk, Meritxell Alvarenga Lima, Fernanda Santos Ponce, Daniela Miyoshi, Aanderson Azevedo, Vasco de Moreno, Maria Alejandra |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
Lactic Acid Bacteria Anti-Inflammatory Antioxidant Interleukin-10 Catalase Immune Regulation Superoxide Dismutase |
topic |
Lactic Acid Bacteria Anti-Inflammatory Antioxidant Interleukin-10 Catalase Immune Regulation Superoxide Dismutase |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that have been shown to possess therapeutic properties since they are able to prevent the development of some diseases, as shown mostly on animal models for cancer, infections and gastrointestinal disorders such as intestinal inflammation. LAB have been shown to regulate mucosal immune responses by modulating the production and liberation of regulatory agents such as cytokines by the host. Some of these cytokines, such as the anti-inflammatory interleukin-10 (IL-10), modulate the inflammatory immune response, thus immunomodulation is a mechanism by which LAB can prevent certain inflammatory bowel diseases (IBD). Since oxidative stress participates to the inflammatory processes and to the appearance of damages in pathologies of the gastrointestinal tract of humans such as IBD, LAB could also prevent inflammation by eliminating reactive oxygen species (ROS) through the activity of antioxidant enzymes.In order to obtain novel strains or enhance beneficial effects of LAB, genetic engineering has been used to produce either antioxidant enzymes (such as catalases and superoxide dismutases) or anti-inflammatory cytokines (such as IL-10) producing LAB. These novel strains have successfully been used to prevent inflammatory bowel diseases in animal models and could be evaluated in human clinical trials. Here, we present an overview of the current knowledge of the mechanisms by which LAB can be used to prevent undesired intestinal inflammatory responses and could be used as a therapeutic tool for IBD. Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina Fil: del Carmen, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina Fil: Zurita Turk, Meritxell. Universidade Federal Do Minas Gerais; Brasil; Fil: Alvarenga Lima, Fernanda. Universidade Federal Do Minas Gerais; Brasil; Fil: Santos Ponce, Daniela. Universidade Federal Do Minas Gerais; Brasil; Fil: Miyoshi, Aanderson. Universidade Federal Do Minas Gerais; Brasil; Fil: Azevedo, Vasco. Universidade Federal Do Minas Gerais; Brasil; Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina |
description |
Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that have been shown to possess therapeutic properties since they are able to prevent the development of some diseases, as shown mostly on animal models for cancer, infections and gastrointestinal disorders such as intestinal inflammation. LAB have been shown to regulate mucosal immune responses by modulating the production and liberation of regulatory agents such as cytokines by the host. Some of these cytokines, such as the anti-inflammatory interleukin-10 (IL-10), modulate the inflammatory immune response, thus immunomodulation is a mechanism by which LAB can prevent certain inflammatory bowel diseases (IBD). Since oxidative stress participates to the inflammatory processes and to the appearance of damages in pathologies of the gastrointestinal tract of humans such as IBD, LAB could also prevent inflammation by eliminating reactive oxygen species (ROS) through the activity of antioxidant enzymes.In order to obtain novel strains or enhance beneficial effects of LAB, genetic engineering has been used to produce either antioxidant enzymes (such as catalases and superoxide dismutases) or anti-inflammatory cytokines (such as IL-10) producing LAB. These novel strains have successfully been used to prevent inflammatory bowel diseases in animal models and could be evaluated in human clinical trials. Here, we present an overview of the current knowledge of the mechanisms by which LAB can be used to prevent undesired intestinal inflammatory responses and could be used as a therapeutic tool for IBD. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/2566 Leblanc, Jean Guy Joseph; del Carmen, Silvina Andrea; Zurita Turk, Meritxell; Alvarenga Lima, Fernanda; Santos Ponce, Daniela; et al.; Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria; Bentham Science Publishers; Anti-Infective Agents; 11; 1; 1-2013; 59-69 2211-3525 2211-3533 |
url |
http://hdl.handle.net/11336/2566 |
identifier_str_mv |
Leblanc, Jean Guy Joseph; del Carmen, Silvina Andrea; Zurita Turk, Meritxell; Alvarenga Lima, Fernanda; Santos Ponce, Daniela; et al.; Mechanisms involved in the anti-inflammatory properties of native and genetically engineered lactic acid bacteria; Bentham Science Publishers; Anti-Infective Agents; 11; 1; 1-2013; 59-69 2211-3525 2211-3533 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://benthamscience.com/journals/anti-infective-agents/volume/11/ info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/104672 info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/ben/aia/2013/00000011/00000001/art00007 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Bentham Science Publishers |
publisher.none.fl_str_mv |
Bentham Science Publishers |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1846782094904131584 |
score |
12.982451 |