Anti-inflammatory properties of lactic acid bacteria: Current knowledge, applications and prospects

Autores
Leblanc, Jean Guy Joseph; de Moreno, Maria Alejandra; Perdigon, Gabriela del Valle; Miyoshi, Anderson; Rochat, Tatiana; Bermudez Humaran, Luis; Langella, Philippe; Sesma, Fernando Juan Manuel; Azevedo, Vasco
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods. Some selected strains are frequently added as probiotics in order to confer specific benefits to consumers. Many studies have shown that LAB possess therapeutic properties since they are able to prevent the development of some diseases, as shown mostly on animal models for cancer, infections and gastrointestinal disorders such as intestinal inflammation. They have been shown to regulate mucosal immune responses by modulating the production and liberation of regulatory agents such as cytokines by the host. Some of these cytokines, such as the anti-inflammatory interleukin-10 (IL-10), modulate the inflammatory immune response, thus immunomodulation is a mechanism by which LAB can prevent certain inflammatory bowel diseases (IBD). Since oxidative stress participates to the inflammatory processes and to the appearance of damages in pathologies of the gastrointestinal tract of humans such as IBD, LAB could also prevent inflammation by eliminating reactive oxygen species (ROS) through the activity of antioxidant enzymes. Engineering LAB to produce either antioxidant enzymes (such as catalases and superoxide dismutases) or anti-inflammatory cytokines (such as IL-10) is a strategy currently exploited by several groups. These novel strains have successfully been used to prevent inflammatory bowel diseases in animal models and could be evaluated in human clinical trials. Here, we present an overview of the current knowledge of the mechanisms by which LAB can be used to prevent undesired intestinal inflammatory responses.
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Miyoshi, Anderson. Universidade Federal de Minas Gerais; Brasil
Fil: Rochat, Tatiana. Institut National de la Recherche Agronomique; Francia
Fil: Bermudez Humaran, Luis. Institut National de la Recherche Agronomique; Francia
Fil: Langella, Philippe. Institut National de la Recherche Agronomique; Francia
Fil: Sesma, Fernando Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Azevedo, Vasco. Universidade Federal de Minas Gerais; Brasil
Materia
Anti-Inflammatory
Lactic Acid Bacteria
Inflammation
Colon Cancer
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/56425
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/56425
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Anti-inflammatory properties of lactic acid bacteria: Current knowledge, applications and prospectsLeblanc, Jean Guy Josephde Moreno, Maria AlejandraPerdigon, Gabriela del ValleMiyoshi, AndersonRochat, TatianaBermudez Humaran, LuisLangella, PhilippeSesma, Fernando Juan ManuelAzevedo, VascoAnti-InflammatoryLactic Acid BacteriaInflammationColon Cancerhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods. Some selected strains are frequently added as probiotics in order to confer specific benefits to consumers. Many studies have shown that LAB possess therapeutic properties since they are able to prevent the development of some diseases, as shown mostly on animal models for cancer, infections and gastrointestinal disorders such as intestinal inflammation. They have been shown to regulate mucosal immune responses by modulating the production and liberation of regulatory agents such as cytokines by the host. Some of these cytokines, such as the anti-inflammatory interleukin-10 (IL-10), modulate the inflammatory immune response, thus immunomodulation is a mechanism by which LAB can prevent certain inflammatory bowel diseases (IBD). Since oxidative stress participates to the inflammatory processes and to the appearance of damages in pathologies of the gastrointestinal tract of humans such as IBD, LAB could also prevent inflammation by eliminating reactive oxygen species (ROS) through the activity of antioxidant enzymes. Engineering LAB to produce either antioxidant enzymes (such as catalases and superoxide dismutases) or anti-inflammatory cytokines (such as IL-10) is a strategy currently exploited by several groups. These novel strains have successfully been used to prevent inflammatory bowel diseases in animal models and could be evaluated in human clinical trials. Here, we present an overview of the current knowledge of the mechanisms by which LAB can be used to prevent undesired intestinal inflammatory responses.Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Miyoshi, Anderson. Universidade Federal de Minas Gerais; BrasilFil: Rochat, Tatiana. Institut National de la Recherche Agronomique; FranciaFil: Bermudez Humaran, Luis. Institut National de la Recherche Agronomique; FranciaFil: Langella, Philippe. Institut National de la Recherche Agronomique; FranciaFil: Sesma, Fernando Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Azevedo, Vasco. Universidade Federal de Minas Gerais; BrasilBentham Science Publishers2008-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/56425Leblanc, Jean Guy Joseph; de Moreno, Maria Alejandra; Perdigon, Gabriela del Valle; Miyoshi, Anderson; Rochat, Tatiana; et al.; Anti-inflammatory properties of lactic acid bacteria: Current knowledge, applications and prospects; Bentham Science Publishers; Anti-Infective Agents in Medicinal Chemistry; 7; 3; 7-2008; 148-1541871-52141875-6018CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/67181/articleinfo:eu-repo/semantics/altIdentifier/doi/10.2174/187152108784911287info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:19Zoai:ri.conicet.gov.ar:11336/56425instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:19.335CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Anti-inflammatory properties of lactic acid bacteria: Current knowledge, applications and prospects
title Anti-inflammatory properties of lactic acid bacteria: Current knowledge, applications and prospects
spellingShingle Anti-inflammatory properties of lactic acid bacteria: Current knowledge, applications and prospects
Leblanc, Jean Guy Joseph
Anti-Inflammatory
Lactic Acid Bacteria
Inflammation
Colon Cancer
title_short Anti-inflammatory properties of lactic acid bacteria: Current knowledge, applications and prospects
title_full Anti-inflammatory properties of lactic acid bacteria: Current knowledge, applications and prospects
title_fullStr Anti-inflammatory properties of lactic acid bacteria: Current knowledge, applications and prospects
title_full_unstemmed Anti-inflammatory properties of lactic acid bacteria: Current knowledge, applications and prospects
title_sort Anti-inflammatory properties of lactic acid bacteria: Current knowledge, applications and prospects
dc.creator.none.fl_str_mv Leblanc, Jean Guy Joseph
de Moreno, Maria Alejandra
Perdigon, Gabriela del Valle
Miyoshi, Anderson
Rochat, Tatiana
Bermudez Humaran, Luis
Langella, Philippe
Sesma, Fernando Juan Manuel
Azevedo, Vasco
author Leblanc, Jean Guy Joseph
author_facet Leblanc, Jean Guy Joseph
de Moreno, Maria Alejandra
Perdigon, Gabriela del Valle
Miyoshi, Anderson
Rochat, Tatiana
Bermudez Humaran, Luis
Langella, Philippe
Sesma, Fernando Juan Manuel
Azevedo, Vasco
author_role author
author2 de Moreno, Maria Alejandra
Perdigon, Gabriela del Valle
Miyoshi, Anderson
Rochat, Tatiana
Bermudez Humaran, Luis
Langella, Philippe
Sesma, Fernando Juan Manuel
Azevedo, Vasco
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anti-Inflammatory
Lactic Acid Bacteria
Inflammation
Colon Cancer
topic Anti-Inflammatory
Lactic Acid Bacteria
Inflammation
Colon Cancer
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods. Some selected strains are frequently added as probiotics in order to confer specific benefits to consumers. Many studies have shown that LAB possess therapeutic properties since they are able to prevent the development of some diseases, as shown mostly on animal models for cancer, infections and gastrointestinal disorders such as intestinal inflammation. They have been shown to regulate mucosal immune responses by modulating the production and liberation of regulatory agents such as cytokines by the host. Some of these cytokines, such as the anti-inflammatory interleukin-10 (IL-10), modulate the inflammatory immune response, thus immunomodulation is a mechanism by which LAB can prevent certain inflammatory bowel diseases (IBD). Since oxidative stress participates to the inflammatory processes and to the appearance of damages in pathologies of the gastrointestinal tract of humans such as IBD, LAB could also prevent inflammation by eliminating reactive oxygen species (ROS) through the activity of antioxidant enzymes. Engineering LAB to produce either antioxidant enzymes (such as catalases and superoxide dismutases) or anti-inflammatory cytokines (such as IL-10) is a strategy currently exploited by several groups. These novel strains have successfully been used to prevent inflammatory bowel diseases in animal models and could be evaluated in human clinical trials. Here, we present an overview of the current knowledge of the mechanisms by which LAB can be used to prevent undesired intestinal inflammatory responses.
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Miyoshi, Anderson. Universidade Federal de Minas Gerais; Brasil
Fil: Rochat, Tatiana. Institut National de la Recherche Agronomique; Francia
Fil: Bermudez Humaran, Luis. Institut National de la Recherche Agronomique; Francia
Fil: Langella, Philippe. Institut National de la Recherche Agronomique; Francia
Fil: Sesma, Fernando Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Azevedo, Vasco. Universidade Federal de Minas Gerais; Brasil
description Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods. Some selected strains are frequently added as probiotics in order to confer specific benefits to consumers. Many studies have shown that LAB possess therapeutic properties since they are able to prevent the development of some diseases, as shown mostly on animal models for cancer, infections and gastrointestinal disorders such as intestinal inflammation. They have been shown to regulate mucosal immune responses by modulating the production and liberation of regulatory agents such as cytokines by the host. Some of these cytokines, such as the anti-inflammatory interleukin-10 (IL-10), modulate the inflammatory immune response, thus immunomodulation is a mechanism by which LAB can prevent certain inflammatory bowel diseases (IBD). Since oxidative stress participates to the inflammatory processes and to the appearance of damages in pathologies of the gastrointestinal tract of humans such as IBD, LAB could also prevent inflammation by eliminating reactive oxygen species (ROS) through the activity of antioxidant enzymes. Engineering LAB to produce either antioxidant enzymes (such as catalases and superoxide dismutases) or anti-inflammatory cytokines (such as IL-10) is a strategy currently exploited by several groups. These novel strains have successfully been used to prevent inflammatory bowel diseases in animal models and could be evaluated in human clinical trials. Here, we present an overview of the current knowledge of the mechanisms by which LAB can be used to prevent undesired intestinal inflammatory responses.
publishDate 2008
dc.date.none.fl_str_mv 2008-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/56425
Leblanc, Jean Guy Joseph; de Moreno, Maria Alejandra; Perdigon, Gabriela del Valle; Miyoshi, Anderson; Rochat, Tatiana; et al.; Anti-inflammatory properties of lactic acid bacteria: Current knowledge, applications and prospects; Bentham Science Publishers; Anti-Infective Agents in Medicinal Chemistry; 7; 3; 7-2008; 148-154
1871-5214
1875-6018
CONICET Digital
CONICET
url http://hdl.handle.net/11336/56425
identifier_str_mv Leblanc, Jean Guy Joseph; de Moreno, Maria Alejandra; Perdigon, Gabriela del Valle; Miyoshi, Anderson; Rochat, Tatiana; et al.; Anti-inflammatory properties of lactic acid bacteria: Current knowledge, applications and prospects; Bentham Science Publishers; Anti-Infective Agents in Medicinal Chemistry; 7; 3; 7-2008; 148-154
1871-5214
1875-6018
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/67181/article
info:eu-repo/semantics/altIdentifier/doi/10.2174/187152108784911287
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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