Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering

Autores
Erol, M. M.; Mouriño, Viviana Silvia Lourdes; Newby, P.; Chatzistavrou, X.; Roether, Judith A.; Hupa, L.; Boccaccini, Aldo R.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this study was to synthesize and characterize new boron-containing bioactive glass-based scaffolds coated with alginate cross-linked with copper ions. A recently developed bioactive glass powder with nominal composition (wt.%) 65 SiO2, 15 CaO, 18.4 Na2O, 0.1 MgO and 1.5 B2O3 was fabricated as porous scaffolds by the foam replica method. Scaffolds were alginate coated by dipping them in alginate solution. Scanning electron microscopy investigations indicated that the alginate effectively attached on the surface of the three-dimensional scaffolds leading to a homogeneous coating. It was confirmed that the scaffold structure remained amorphous after the sintering process and that the alginate coating improved the scaffold bioactivity and mechanical properties. Copper release studies showed that the alginate-coated scaffolds allowed controlled release of copper ions. The novel copper-releasing composite scaffolds represent promising candidates for bone regeneration.
Fil: Erol, M. M.. İstanbul Teknik Üniversitesi; Turquía
Fil: Mouriño, Viviana Silvia Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Newby, P.. Imperial College London; Reino Unido
Fil: Chatzistavrou, X.. Universitat Erlangen-Nuremberg; Alemania
Fil: Roether, Judith A.. Universitat Erlangen-Nuremberg; Alemania
Fil: Hupa, L.. Abo Akademi University; Finlandia
Fil: Boccaccini, Aldo R.. Imperial College London; Reino Unido. Universitat Erlangen-Nuremberg; Alemania
Materia
ALGINATE
ANTIBACTERIAL
BIOACTIVE GLASS
CU ION RELEASE
SCAFFOLDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/211821
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/211821
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineeringErol, M. M.Mouriño, Viviana Silvia LourdesNewby, P.Chatzistavrou, X.Roether, Judith A.Hupa, L.Boccaccini, Aldo R.ALGINATEANTIBACTERIALBIOACTIVE GLASSCU ION RELEASESCAFFOLDShttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2The aim of this study was to synthesize and characterize new boron-containing bioactive glass-based scaffolds coated with alginate cross-linked with copper ions. A recently developed bioactive glass powder with nominal composition (wt.%) 65 SiO2, 15 CaO, 18.4 Na2O, 0.1 MgO and 1.5 B2O3 was fabricated as porous scaffolds by the foam replica method. Scaffolds were alginate coated by dipping them in alginate solution. Scanning electron microscopy investigations indicated that the alginate effectively attached on the surface of the three-dimensional scaffolds leading to a homogeneous coating. It was confirmed that the scaffold structure remained amorphous after the sintering process and that the alginate coating improved the scaffold bioactivity and mechanical properties. Copper release studies showed that the alginate-coated scaffolds allowed controlled release of copper ions. The novel copper-releasing composite scaffolds represent promising candidates for bone regeneration.Fil: Erol, M. M.. İstanbul Teknik Üniversitesi; TurquíaFil: Mouriño, Viviana Silvia Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Newby, P.. Imperial College London; Reino UnidoFil: Chatzistavrou, X.. Universitat Erlangen-Nuremberg; AlemaniaFil: Roether, Judith A.. Universitat Erlangen-Nuremberg; AlemaniaFil: Hupa, L.. Abo Akademi University; FinlandiaFil: Boccaccini, Aldo R.. Imperial College London; Reino Unido. Universitat Erlangen-Nuremberg; AlemaniaElsevier2012-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/octet-streamapplication/pdfhttp://hdl.handle.net/11336/211821Erol, M. M.; Mouriño, Viviana Silvia Lourdes; Newby, P.; Chatzistavrou, X.; Roether, Judith A.; et al.; Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering; Elsevier; Acta Biomaterialia; 8; 2; 2-2012; 792-8011742-7061CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1742706111004442info:eu-repo/semantics/altIdentifier/doi/10.1016/j.actbio.2011.10.013info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:41:01Zoai:ri.conicet.gov.ar:11336/211821instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:41:01.686CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering
title Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering
spellingShingle Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering
Erol, M. M.
ALGINATE
ANTIBACTERIAL
BIOACTIVE GLASS
CU ION RELEASE
SCAFFOLDS
title_short Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering
title_full Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering
title_fullStr Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering
title_full_unstemmed Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering
title_sort Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering
dc.creator.none.fl_str_mv Erol, M. M.
Mouriño, Viviana Silvia Lourdes
Newby, P.
Chatzistavrou, X.
Roether, Judith A.
Hupa, L.
Boccaccini, Aldo R.
author Erol, M. M.
author_facet Erol, M. M.
Mouriño, Viviana Silvia Lourdes
Newby, P.
Chatzistavrou, X.
Roether, Judith A.
Hupa, L.
Boccaccini, Aldo R.
author_role author
author2 Mouriño, Viviana Silvia Lourdes
Newby, P.
Chatzistavrou, X.
Roether, Judith A.
Hupa, L.
Boccaccini, Aldo R.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ALGINATE
ANTIBACTERIAL
BIOACTIVE GLASS
CU ION RELEASE
SCAFFOLDS
topic ALGINATE
ANTIBACTERIAL
BIOACTIVE GLASS
CU ION RELEASE
SCAFFOLDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The aim of this study was to synthesize and characterize new boron-containing bioactive glass-based scaffolds coated with alginate cross-linked with copper ions. A recently developed bioactive glass powder with nominal composition (wt.%) 65 SiO2, 15 CaO, 18.4 Na2O, 0.1 MgO and 1.5 B2O3 was fabricated as porous scaffolds by the foam replica method. Scaffolds were alginate coated by dipping them in alginate solution. Scanning electron microscopy investigations indicated that the alginate effectively attached on the surface of the three-dimensional scaffolds leading to a homogeneous coating. It was confirmed that the scaffold structure remained amorphous after the sintering process and that the alginate coating improved the scaffold bioactivity and mechanical properties. Copper release studies showed that the alginate-coated scaffolds allowed controlled release of copper ions. The novel copper-releasing composite scaffolds represent promising candidates for bone regeneration.
Fil: Erol, M. M.. İstanbul Teknik Üniversitesi; Turquía
Fil: Mouriño, Viviana Silvia Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Newby, P.. Imperial College London; Reino Unido
Fil: Chatzistavrou, X.. Universitat Erlangen-Nuremberg; Alemania
Fil: Roether, Judith A.. Universitat Erlangen-Nuremberg; Alemania
Fil: Hupa, L.. Abo Akademi University; Finlandia
Fil: Boccaccini, Aldo R.. Imperial College London; Reino Unido. Universitat Erlangen-Nuremberg; Alemania
description The aim of this study was to synthesize and characterize new boron-containing bioactive glass-based scaffolds coated with alginate cross-linked with copper ions. A recently developed bioactive glass powder with nominal composition (wt.%) 65 SiO2, 15 CaO, 18.4 Na2O, 0.1 MgO and 1.5 B2O3 was fabricated as porous scaffolds by the foam replica method. Scaffolds were alginate coated by dipping them in alginate solution. Scanning electron microscopy investigations indicated that the alginate effectively attached on the surface of the three-dimensional scaffolds leading to a homogeneous coating. It was confirmed that the scaffold structure remained amorphous after the sintering process and that the alginate coating improved the scaffold bioactivity and mechanical properties. Copper release studies showed that the alginate-coated scaffolds allowed controlled release of copper ions. The novel copper-releasing composite scaffolds represent promising candidates for bone regeneration.
publishDate 2012
dc.date.none.fl_str_mv 2012-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/211821
Erol, M. M.; Mouriño, Viviana Silvia Lourdes; Newby, P.; Chatzistavrou, X.; Roether, Judith A.; et al.; Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering; Elsevier; Acta Biomaterialia; 8; 2; 2-2012; 792-801
1742-7061
CONICET Digital
CONICET
url http://hdl.handle.net/11336/211821
identifier_str_mv Erol, M. M.; Mouriño, Viviana Silvia Lourdes; Newby, P.; Chatzistavrou, X.; Roether, Judith A.; et al.; Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering; Elsevier; Acta Biomaterialia; 8; 2; 2-2012; 792-801
1742-7061
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1742706111004442
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.actbio.2011.10.013
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/octet-stream
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083522181201920
score 13.22299

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