Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating

Autores
Nooeaid, Patcharakamon; Li, Wei; Roether, Judith A.; Mouriño, Viviana Silvia Lourdes; Goudouri, Ourania Menti; Schubert, Dirk W.; Boccaccini, Aldo R.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Highly porous 45S5 Bioglass®-based scaffolds coated with two polymer layers were fabricated to serve as a multifunctional device with controlled drug release capability for bone regeneration applications. An interior poly(d,l-lactide)/poly(ethylene glycol)-(polypropylene glycol)-poly(ethylene glycol) triblock copolymer (Pluronic P123) coating improved the mechanical stability of Bioglass-based scaffolds, while an exterior natural polymer (alginate or gelatin) coating served as an antibiotic drug carrier. The results showed improved mechanical properties of Bioglass-based scaffolds by the bilayer polymer coating. In addition, hydrochloride tetracycline loaded in either alginate or gelatin coatings was released rapidly at the initial stage (∼1 h), while the released rate subsequently decreased and was sustained for 14 days in phosphate buffered saline. Therefore, these layered polymer coated scaffolds exhibit attractive characteristics in terms of improved mechanical properties and controlled drug release, simultaneously with the added advantage that the drug release rate is decoupled from the intrinsic scaffold Bioglass degradation mechanism. The layered polymer coated scaffolds are of interest for drug-delivery enhanced bone regeneration applications.
Fil: Nooeaid, Patcharakamon. Universitat Erlangen-Nuremberg; Alemania
Fil: Li, Wei. Universitat Erlangen-Nuremberg; Alemania
Fil: Roether, Judith A.. Universitat Erlangen-Nuremberg; Alemania
Fil: Mouriño, Viviana Silvia Lourdes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Goudouri, Ourania Menti. Universitat Erlangen-Nuremberg; Alemania
Fil: Schubert, Dirk W.. Universitat Erlangen-Nuremberg; Alemania
Fil: Boccaccini, Aldo R.. Universitat Erlangen-Nuremberg; Alemania
Materia
Bioactive Glass Based Scaffolds
Controlled Release
Bone Tissue Engineering
Polymer Layered Coatings
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16123
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/16123
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coatingNooeaid, PatcharakamonLi, WeiRoether, Judith A.Mouriño, Viviana Silvia LourdesGoudouri, Ourania MentiSchubert, Dirk W.Boccaccini, Aldo R.Bioactive Glass Based ScaffoldsControlled ReleaseBone Tissue EngineeringPolymer Layered Coatingshttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2https://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Highly porous 45S5 Bioglass®-based scaffolds coated with two polymer layers were fabricated to serve as a multifunctional device with controlled drug release capability for bone regeneration applications. An interior poly(d,l-lactide)/poly(ethylene glycol)-(polypropylene glycol)-poly(ethylene glycol) triblock copolymer (Pluronic P123) coating improved the mechanical stability of Bioglass-based scaffolds, while an exterior natural polymer (alginate or gelatin) coating served as an antibiotic drug carrier. The results showed improved mechanical properties of Bioglass-based scaffolds by the bilayer polymer coating. In addition, hydrochloride tetracycline loaded in either alginate or gelatin coatings was released rapidly at the initial stage (∼1 h), while the released rate subsequently decreased and was sustained for 14 days in phosphate buffered saline. Therefore, these layered polymer coated scaffolds exhibit attractive characteristics in terms of improved mechanical properties and controlled drug release, simultaneously with the added advantage that the drug release rate is decoupled from the intrinsic scaffold Bioglass degradation mechanism. The layered polymer coated scaffolds are of interest for drug-delivery enhanced bone regeneration applications.Fil: Nooeaid, Patcharakamon. Universitat Erlangen-Nuremberg; AlemaniaFil: Li, Wei. Universitat Erlangen-Nuremberg; AlemaniaFil: Roether, Judith A.. Universitat Erlangen-Nuremberg; AlemaniaFil: Mouriño, Viviana Silvia Lourdes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Goudouri, Ourania Menti. Universitat Erlangen-Nuremberg; AlemaniaFil: Schubert, Dirk W.. Universitat Erlangen-Nuremberg; AlemaniaFil: Boccaccini, Aldo R.. Universitat Erlangen-Nuremberg; AlemaniaAvs2014-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16123Nooeaid, Patcharakamon; Li, Wei; Roether, Judith A.; Mouriño, Viviana Silvia Lourdes; Goudouri, Ourania Menti; et al.; Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating; Avs; Biointerphases; 9; 4; 10-2014; 1-101934-86301559-4106enginfo:eu-repo/semantics/altIdentifier/doi/10.1116/1.4897217info:eu-repo/semantics/altIdentifier/url/http://avs.scitation.org/doi/10.1116/1.4897217info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:49:05Zoai:ri.conicet.gov.ar:11336/16123instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:49:05.783CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating
title Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating
spellingShingle Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating
Nooeaid, Patcharakamon
Bioactive Glass Based Scaffolds
Controlled Release
Bone Tissue Engineering
Polymer Layered Coatings
title_short Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating
title_full Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating
title_fullStr Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating
title_full_unstemmed Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating
title_sort Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating
dc.creator.none.fl_str_mv Nooeaid, Patcharakamon
Li, Wei
Roether, Judith A.
Mouriño, Viviana Silvia Lourdes
Goudouri, Ourania Menti
Schubert, Dirk W.
Boccaccini, Aldo R.
author Nooeaid, Patcharakamon
author_facet Nooeaid, Patcharakamon
Li, Wei
Roether, Judith A.
Mouriño, Viviana Silvia Lourdes
Goudouri, Ourania Menti
Schubert, Dirk W.
Boccaccini, Aldo R.
author_role author
author2 Li, Wei
Roether, Judith A.
Mouriño, Viviana Silvia Lourdes
Goudouri, Ourania Menti
Schubert, Dirk W.
Boccaccini, Aldo R.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Bioactive Glass Based Scaffolds
Controlled Release
Bone Tissue Engineering
Polymer Layered Coatings
topic Bioactive Glass Based Scaffolds
Controlled Release
Bone Tissue Engineering
Polymer Layered Coatings
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Highly porous 45S5 Bioglass®-based scaffolds coated with two polymer layers were fabricated to serve as a multifunctional device with controlled drug release capability for bone regeneration applications. An interior poly(d,l-lactide)/poly(ethylene glycol)-(polypropylene glycol)-poly(ethylene glycol) triblock copolymer (Pluronic P123) coating improved the mechanical stability of Bioglass-based scaffolds, while an exterior natural polymer (alginate or gelatin) coating served as an antibiotic drug carrier. The results showed improved mechanical properties of Bioglass-based scaffolds by the bilayer polymer coating. In addition, hydrochloride tetracycline loaded in either alginate or gelatin coatings was released rapidly at the initial stage (∼1 h), while the released rate subsequently decreased and was sustained for 14 days in phosphate buffered saline. Therefore, these layered polymer coated scaffolds exhibit attractive characteristics in terms of improved mechanical properties and controlled drug release, simultaneously with the added advantage that the drug release rate is decoupled from the intrinsic scaffold Bioglass degradation mechanism. The layered polymer coated scaffolds are of interest for drug-delivery enhanced bone regeneration applications.
Fil: Nooeaid, Patcharakamon. Universitat Erlangen-Nuremberg; Alemania
Fil: Li, Wei. Universitat Erlangen-Nuremberg; Alemania
Fil: Roether, Judith A.. Universitat Erlangen-Nuremberg; Alemania
Fil: Mouriño, Viviana Silvia Lourdes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Goudouri, Ourania Menti. Universitat Erlangen-Nuremberg; Alemania
Fil: Schubert, Dirk W.. Universitat Erlangen-Nuremberg; Alemania
Fil: Boccaccini, Aldo R.. Universitat Erlangen-Nuremberg; Alemania
description Highly porous 45S5 Bioglass®-based scaffolds coated with two polymer layers were fabricated to serve as a multifunctional device with controlled drug release capability for bone regeneration applications. An interior poly(d,l-lactide)/poly(ethylene glycol)-(polypropylene glycol)-poly(ethylene glycol) triblock copolymer (Pluronic P123) coating improved the mechanical stability of Bioglass-based scaffolds, while an exterior natural polymer (alginate or gelatin) coating served as an antibiotic drug carrier. The results showed improved mechanical properties of Bioglass-based scaffolds by the bilayer polymer coating. In addition, hydrochloride tetracycline loaded in either alginate or gelatin coatings was released rapidly at the initial stage (∼1 h), while the released rate subsequently decreased and was sustained for 14 days in phosphate buffered saline. Therefore, these layered polymer coated scaffolds exhibit attractive characteristics in terms of improved mechanical properties and controlled drug release, simultaneously with the added advantage that the drug release rate is decoupled from the intrinsic scaffold Bioglass degradation mechanism. The layered polymer coated scaffolds are of interest for drug-delivery enhanced bone regeneration applications.
publishDate 2014
dc.date.none.fl_str_mv 2014-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16123
Nooeaid, Patcharakamon; Li, Wei; Roether, Judith A.; Mouriño, Viviana Silvia Lourdes; Goudouri, Ourania Menti; et al.; Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating; Avs; Biointerphases; 9; 4; 10-2014; 1-10
1934-8630
1559-4106
url http://hdl.handle.net/11336/16123
identifier_str_mv Nooeaid, Patcharakamon; Li, Wei; Roether, Judith A.; Mouriño, Viviana Silvia Lourdes; Goudouri, Ourania Menti; et al.; Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating; Avs; Biointerphases; 9; 4; 10-2014; 1-10
1934-8630
1559-4106
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1116/1.4897217
info:eu-repo/semantics/altIdentifier/url/http://avs.scitation.org/doi/10.1116/1.4897217
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Avs
publisher.none.fl_str_mv Avs
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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