Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus

Autores
Frecha, Cecilia Ariana; Chevalier, Sébastien A.; van Uden, Patrick; Rubio, Ivonne; Siouda, Maha; Saidj, Djamel; Cohen, Camille; Lomonte, Patrick; Accardi, Rosita; Tommasino, Massimo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
EVER1 and EVER2 are mutated in epidermodysplasia verruciformis patients, who are susceptible to human betapapillomavirus (HPV) infection. It is unknown whether their products control the infection of other viruses. Here, we show that the expression of both genes in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed via activation of the NF-κB signaling pathway by latent membrane protein 1 (LMP1). Ectopic expression of EVER1 impairs the ability of EBV to infect B cells.
Fil: Frecha, Cecilia Ariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. International Agency For Research On Cancer; Francia
Fil: Chevalier, Sébastien A.. International Agency For Research On Cancer; Francia
Fil: van Uden, Patrick. International Agency For Research On Cancer; Francia
Fil: Rubio, Ivonne. International Agency For Research On Cancer; Francia
Fil: Siouda, Maha. International Agency For Research On Cancer; Francia
Fil: Saidj, Djamel. International Agency For Research On Cancer; Francia
Fil: Cohen, Camille. Université Claude Bernard Lyon 1; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Lomonte, Patrick. Centre National de la Recherche Scientifique; Francia. Université Claude Bernard Lyon 1; Francia
Fil: Accardi, Rosita. International Agency For Research On Cancer; Francia
Fil: Tommasino, Massimo. International Agency For Research On Cancer; Francia
Materia
EVER1
EVER2
EBV-LMP1
BCELLS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/99773
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/99773
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virusFrecha, Cecilia ArianaChevalier, Sébastien A.van Uden, PatrickRubio, IvonneSiouda, MahaSaidj, DjamelCohen, CamilleLomonte, PatrickAccardi, RositaTommasino, MassimoEVER1EVER2EBV-LMP1BCELLShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1EVER1 and EVER2 are mutated in epidermodysplasia verruciformis patients, who are susceptible to human betapapillomavirus (HPV) infection. It is unknown whether their products control the infection of other viruses. Here, we show that the expression of both genes in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed via activation of the NF-κB signaling pathway by latent membrane protein 1 (LMP1). Ectopic expression of EVER1 impairs the ability of EBV to infect B cells.Fil: Frecha, Cecilia Ariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. International Agency For Research On Cancer; FranciaFil: Chevalier, Sébastien A.. International Agency For Research On Cancer; FranciaFil: van Uden, Patrick. International Agency For Research On Cancer; FranciaFil: Rubio, Ivonne. International Agency For Research On Cancer; FranciaFil: Siouda, Maha. International Agency For Research On Cancer; FranciaFil: Saidj, Djamel. International Agency For Research On Cancer; FranciaFil: Cohen, Camille. Université Claude Bernard Lyon 1; Francia. Centre National de la Recherche Scientifique; FranciaFil: Lomonte, Patrick. Centre National de la Recherche Scientifique; Francia. Université Claude Bernard Lyon 1; FranciaFil: Accardi, Rosita. International Agency For Research On Cancer; FranciaFil: Tommasino, Massimo. International Agency For Research On Cancer; FranciaAmerican Society for Microbiology2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99773Frecha, Cecilia Ariana; Chevalier, Sébastien A.; van Uden, Patrick; Rubio, Ivonne; Siouda, Maha; et al.; Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus; American Society for Microbiology; Journal of Virology; 89; 2; 1-2015; 1461-14670022-538XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://jvi.asm.org/content/89/2/1461info:eu-repo/semantics/altIdentifier/doi/10.1128/JVI.02936-14info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:31Zoai:ri.conicet.gov.ar:11336/99773instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:31.322CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus
title Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus
spellingShingle Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus
Frecha, Cecilia Ariana
EVER1
EVER2
EBV-LMP1
BCELLS
title_short Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus
title_full Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus
title_fullStr Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus
title_full_unstemmed Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus
title_sort Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus
dc.creator.none.fl_str_mv Frecha, Cecilia Ariana
Chevalier, Sébastien A.
van Uden, Patrick
Rubio, Ivonne
Siouda, Maha
Saidj, Djamel
Cohen, Camille
Lomonte, Patrick
Accardi, Rosita
Tommasino, Massimo
author Frecha, Cecilia Ariana
author_facet Frecha, Cecilia Ariana
Chevalier, Sébastien A.
van Uden, Patrick
Rubio, Ivonne
Siouda, Maha
Saidj, Djamel
Cohen, Camille
Lomonte, Patrick
Accardi, Rosita
Tommasino, Massimo
author_role author
author2 Chevalier, Sébastien A.
van Uden, Patrick
Rubio, Ivonne
Siouda, Maha
Saidj, Djamel
Cohen, Camille
Lomonte, Patrick
Accardi, Rosita
Tommasino, Massimo
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv EVER1
EVER2
EBV-LMP1
BCELLS
topic EVER1
EVER2
EBV-LMP1
BCELLS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv EVER1 and EVER2 are mutated in epidermodysplasia verruciformis patients, who are susceptible to human betapapillomavirus (HPV) infection. It is unknown whether their products control the infection of other viruses. Here, we show that the expression of both genes in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed via activation of the NF-κB signaling pathway by latent membrane protein 1 (LMP1). Ectopic expression of EVER1 impairs the ability of EBV to infect B cells.
Fil: Frecha, Cecilia Ariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. International Agency For Research On Cancer; Francia
Fil: Chevalier, Sébastien A.. International Agency For Research On Cancer; Francia
Fil: van Uden, Patrick. International Agency For Research On Cancer; Francia
Fil: Rubio, Ivonne. International Agency For Research On Cancer; Francia
Fil: Siouda, Maha. International Agency For Research On Cancer; Francia
Fil: Saidj, Djamel. International Agency For Research On Cancer; Francia
Fil: Cohen, Camille. Université Claude Bernard Lyon 1; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Lomonte, Patrick. Centre National de la Recherche Scientifique; Francia. Université Claude Bernard Lyon 1; Francia
Fil: Accardi, Rosita. International Agency For Research On Cancer; Francia
Fil: Tommasino, Massimo. International Agency For Research On Cancer; Francia
description EVER1 and EVER2 are mutated in epidermodysplasia verruciformis patients, who are susceptible to human betapapillomavirus (HPV) infection. It is unknown whether their products control the infection of other viruses. Here, we show that the expression of both genes in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed via activation of the NF-κB signaling pathway by latent membrane protein 1 (LMP1). Ectopic expression of EVER1 impairs the ability of EBV to infect B cells.
publishDate 2015
dc.date.none.fl_str_mv 2015-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99773
Frecha, Cecilia Ariana; Chevalier, Sébastien A.; van Uden, Patrick; Rubio, Ivonne; Siouda, Maha; et al.; Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus; American Society for Microbiology; Journal of Virology; 89; 2; 1-2015; 1461-1467
0022-538X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99773
identifier_str_mv Frecha, Cecilia Ariana; Chevalier, Sébastien A.; van Uden, Patrick; Rubio, Ivonne; Siouda, Maha; et al.; Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus; American Society for Microbiology; Journal of Virology; 89; 2; 1-2015; 1461-1467
0022-538X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://jvi.asm.org/content/89/2/1461
info:eu-repo/semantics/altIdentifier/doi/10.1128/JVI.02936-14
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269642584752128
score 13.13397

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