Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity

Autores
Cadet, Jean Lud; Bisagno, Veronica
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Drug addiction is manifested by a compulsive drive to take licit or illicit substances despite repeated severe adverse consequences (Volkow et al., 2012). Addiction is also accompanied by a vicious cycle of binges, abstinence, and relapses. Almost all drugs of abuse trigger euphoric feelings consequent to a rapid increase of dopamine levels in the mesolimbic system. Even after long periods of abstinence, addicts remain vulnerable to drug craving and/or relapses that can be triggered by stimuli previously associated with drugs (Koob and Volkow, 2010). These features of addiction suggest that drugs might cause a form of persistent neuroplasticity that is acutely responsive to environmental stimuli, with consequent compulsive drug-seeking and taking behaviors.
Fil: Cadet, Jean Lud. National Institute on Drug Abuse; Estados Unidos
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Universidad de Buenos Aires; Argentina
Materia
synaptic plasticity
drug abuse
microglia
astroglia
oligodendroglia
inflammation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13589
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticityCadet, Jean LudBisagno, Veronicasynaptic plasticitydrug abusemicrogliaastrogliaoligodendrogliainflammationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Drug addiction is manifested by a compulsive drive to take licit or illicit substances despite repeated severe adverse consequences (Volkow et al., 2012). Addiction is also accompanied by a vicious cycle of binges, abstinence, and relapses. Almost all drugs of abuse trigger euphoric feelings consequent to a rapid increase of dopamine levels in the mesolimbic system. Even after long periods of abstinence, addicts remain vulnerable to drug craving and/or relapses that can be triggered by stimuli previously associated with drugs (Koob and Volkow, 2010). These features of addiction suggest that drugs might cause a form of persistent neuroplasticity that is acutely responsive to environmental stimuli, with consequent compulsive drug-seeking and taking behaviors.Fil: Cadet, Jean Lud. National Institute on Drug Abuse; Estados UnidosFil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Universidad de Buenos Aires; ArgentinaFrontiers2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13589Cadet, Jean Lud; Bisagno, Veronica; Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity; Frontiers; Frontiers in Pharmacology; 5; 204; 9-2014; 1-51663-9812enginfo:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00204/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fphar.2014.00204info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:12:04Zoai:ri.conicet.gov.ar:11336/13589instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:12:05.207CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity
title Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity
spellingShingle Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity
Cadet, Jean Lud
synaptic plasticity
drug abuse
microglia
astroglia
oligodendroglia
inflammation
title_short Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity
title_full Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity
title_fullStr Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity
title_full_unstemmed Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity
title_sort Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity
dc.creator.none.fl_str_mv Cadet, Jean Lud
Bisagno, Veronica
author Cadet, Jean Lud
author_facet Cadet, Jean Lud
Bisagno, Veronica
author_role author
author2 Bisagno, Veronica
author2_role author
dc.subject.none.fl_str_mv synaptic plasticity
drug abuse
microglia
astroglia
oligodendroglia
inflammation
topic synaptic plasticity
drug abuse
microglia
astroglia
oligodendroglia
inflammation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Drug addiction is manifested by a compulsive drive to take licit or illicit substances despite repeated severe adverse consequences (Volkow et al., 2012). Addiction is also accompanied by a vicious cycle of binges, abstinence, and relapses. Almost all drugs of abuse trigger euphoric feelings consequent to a rapid increase of dopamine levels in the mesolimbic system. Even after long periods of abstinence, addicts remain vulnerable to drug craving and/or relapses that can be triggered by stimuli previously associated with drugs (Koob and Volkow, 2010). These features of addiction suggest that drugs might cause a form of persistent neuroplasticity that is acutely responsive to environmental stimuli, with consequent compulsive drug-seeking and taking behaviors.
Fil: Cadet, Jean Lud. National Institute on Drug Abuse; Estados Unidos
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Universidad de Buenos Aires; Argentina
description Drug addiction is manifested by a compulsive drive to take licit or illicit substances despite repeated severe adverse consequences (Volkow et al., 2012). Addiction is also accompanied by a vicious cycle of binges, abstinence, and relapses. Almost all drugs of abuse trigger euphoric feelings consequent to a rapid increase of dopamine levels in the mesolimbic system. Even after long periods of abstinence, addicts remain vulnerable to drug craving and/or relapses that can be triggered by stimuli previously associated with drugs (Koob and Volkow, 2010). These features of addiction suggest that drugs might cause a form of persistent neuroplasticity that is acutely responsive to environmental stimuli, with consequent compulsive drug-seeking and taking behaviors.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13589
Cadet, Jean Lud; Bisagno, Veronica; Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity; Frontiers; Frontiers in Pharmacology; 5; 204; 9-2014; 1-5
1663-9812
url http://hdl.handle.net/11336/13589
identifier_str_mv Cadet, Jean Lud; Bisagno, Veronica; Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity; Frontiers; Frontiers in Pharmacology; 5; 204; 9-2014; 1-5
1663-9812
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00204/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fphar.2014.00204
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270184356708352
score 13.13397

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