Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep
- Autores
- Hathaway, Evan; Morgan, Kyle; Carson, Megan; Shusterman, Roma; Fernandez Corazza, Mariano; Luu, Phan; Tucker, Don M.
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Researchers have proposed that impaired sleep may be a causal link in the progression from Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD). Several recent findings suggest that enhancing deep sleep (N3) may improve neurological health in persons with MCI, and buffer the risk for AD. Specifically, Transcranial Electrical Stimulation (TES) of frontal brain areas, the inferred source of the Slow Oscillations (SOs) of N3 sleep, can extend N3 sleep duration and improve declarative memory for recently learned information. Recent work in our laboratory using dense array Electroencephalography (dEEG) localized the sources of SOs to anterior limbic sites – suggesting that targeting these sites with TES may be more effective for enhancing N3. Methods: For the present study, we recruited 13 healthy adults (M = 42 years) to participate in three all-night sleep EEG recordings where they received low level (0.5 mA) TES designed to target anterior limbic areas and a sham stimulation (placebo). We used a convolutional neural network, trained and tested on professionally scored EEG sleep staging, to predict sleep stages for each recording. Results: When compared to the sham session, limbic-targeted TES significantly increased the duration of N3 sleep. TES also significantly increased spectral power in the 0.5–1 Hz frequency band (relative to pre-TES epochs) in left temporoparietal and left occipital scalp regions compared to sham. Conclusion: These results suggest that even low-level TES, when specifically targeting anterior limbic sites, can increase deep (N3) sleep and thereby contribute to healthy sleep quality.
Fil: Hathaway, Evan. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Morgan, Kyle. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Carson, Megan. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Shusterman, Roma. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Fernandez Corazza, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina
Fil: Luu, Phan. University of Oregon; Estados Unidos
Fil: Tucker, Don M.. University of Oregon; Estados Unidos - Materia
-
EEG
Sleep
Memory
Slow oscillations
Deep Sleep
Slow wave sleep - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/173746
Ver los metadatos del registro completo
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Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleepHathaway, EvanMorgan, KyleCarson, MeganShusterman, RomaFernandez Corazza, MarianoLuu, PhanTucker, Don M.EEGSleepMemorySlow oscillationsDeep SleepSlow wave sleephttps://purl.org/becyt/ford/2.6https://purl.org/becyt/ford/2Background: Researchers have proposed that impaired sleep may be a causal link in the progression from Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD). Several recent findings suggest that enhancing deep sleep (N3) may improve neurological health in persons with MCI, and buffer the risk for AD. Specifically, Transcranial Electrical Stimulation (TES) of frontal brain areas, the inferred source of the Slow Oscillations (SOs) of N3 sleep, can extend N3 sleep duration and improve declarative memory for recently learned information. Recent work in our laboratory using dense array Electroencephalography (dEEG) localized the sources of SOs to anterior limbic sites – suggesting that targeting these sites with TES may be more effective for enhancing N3. Methods: For the present study, we recruited 13 healthy adults (M = 42 years) to participate in three all-night sleep EEG recordings where they received low level (0.5 mA) TES designed to target anterior limbic areas and a sham stimulation (placebo). We used a convolutional neural network, trained and tested on professionally scored EEG sleep staging, to predict sleep stages for each recording. Results: When compared to the sham session, limbic-targeted TES significantly increased the duration of N3 sleep. TES also significantly increased spectral power in the 0.5–1 Hz frequency band (relative to pre-TES epochs) in left temporoparietal and left occipital scalp regions compared to sham. Conclusion: These results suggest that even low-level TES, when specifically targeting anterior limbic sites, can increase deep (N3) sleep and thereby contribute to healthy sleep quality.Fil: Hathaway, Evan. Brain Electrophysiology Laboratory Company; Estados UnidosFil: Morgan, Kyle. Brain Electrophysiology Laboratory Company; Estados UnidosFil: Carson, Megan. Brain Electrophysiology Laboratory Company; Estados UnidosFil: Shusterman, Roma. Brain Electrophysiology Laboratory Company; Estados UnidosFil: Fernandez Corazza, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; ArgentinaFil: Luu, Phan. University of Oregon; Estados UnidosFil: Tucker, Don M.. University of Oregon; Estados UnidosElsevier Science2021-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/173746Hathaway, Evan; Morgan, Kyle; Carson, Megan; Shusterman, Roma; Fernandez Corazza, Mariano; et al.; Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep; Elsevier Science; Sleep Medicine; 81; 5-2021; 350-3571389-9457CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1389945721001623info:eu-repo/semantics/altIdentifier/doi/10.1016/j.sleep.2021.03.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:15Zoai:ri.conicet.gov.ar:11336/173746instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:16.206CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep |
title |
Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep |
spellingShingle |
Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep Hathaway, Evan EEG Sleep Memory Slow oscillations Deep Sleep Slow wave sleep |
title_short |
Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep |
title_full |
Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep |
title_fullStr |
Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep |
title_full_unstemmed |
Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep |
title_sort |
Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep |
dc.creator.none.fl_str_mv |
Hathaway, Evan Morgan, Kyle Carson, Megan Shusterman, Roma Fernandez Corazza, Mariano Luu, Phan Tucker, Don M. |
author |
Hathaway, Evan |
author_facet |
Hathaway, Evan Morgan, Kyle Carson, Megan Shusterman, Roma Fernandez Corazza, Mariano Luu, Phan Tucker, Don M. |
author_role |
author |
author2 |
Morgan, Kyle Carson, Megan Shusterman, Roma Fernandez Corazza, Mariano Luu, Phan Tucker, Don M. |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
EEG Sleep Memory Slow oscillations Deep Sleep Slow wave sleep |
topic |
EEG Sleep Memory Slow oscillations Deep Sleep Slow wave sleep |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.6 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
Background: Researchers have proposed that impaired sleep may be a causal link in the progression from Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD). Several recent findings suggest that enhancing deep sleep (N3) may improve neurological health in persons with MCI, and buffer the risk for AD. Specifically, Transcranial Electrical Stimulation (TES) of frontal brain areas, the inferred source of the Slow Oscillations (SOs) of N3 sleep, can extend N3 sleep duration and improve declarative memory for recently learned information. Recent work in our laboratory using dense array Electroencephalography (dEEG) localized the sources of SOs to anterior limbic sites – suggesting that targeting these sites with TES may be more effective for enhancing N3. Methods: For the present study, we recruited 13 healthy adults (M = 42 years) to participate in three all-night sleep EEG recordings where they received low level (0.5 mA) TES designed to target anterior limbic areas and a sham stimulation (placebo). We used a convolutional neural network, trained and tested on professionally scored EEG sleep staging, to predict sleep stages for each recording. Results: When compared to the sham session, limbic-targeted TES significantly increased the duration of N3 sleep. TES also significantly increased spectral power in the 0.5–1 Hz frequency band (relative to pre-TES epochs) in left temporoparietal and left occipital scalp regions compared to sham. Conclusion: These results suggest that even low-level TES, when specifically targeting anterior limbic sites, can increase deep (N3) sleep and thereby contribute to healthy sleep quality. Fil: Hathaway, Evan. Brain Electrophysiology Laboratory Company; Estados Unidos Fil: Morgan, Kyle. Brain Electrophysiology Laboratory Company; Estados Unidos Fil: Carson, Megan. Brain Electrophysiology Laboratory Company; Estados Unidos Fil: Shusterman, Roma. Brain Electrophysiology Laboratory Company; Estados Unidos Fil: Fernandez Corazza, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina Fil: Luu, Phan. University of Oregon; Estados Unidos Fil: Tucker, Don M.. University of Oregon; Estados Unidos |
description |
Background: Researchers have proposed that impaired sleep may be a causal link in the progression from Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD). Several recent findings suggest that enhancing deep sleep (N3) may improve neurological health in persons with MCI, and buffer the risk for AD. Specifically, Transcranial Electrical Stimulation (TES) of frontal brain areas, the inferred source of the Slow Oscillations (SOs) of N3 sleep, can extend N3 sleep duration and improve declarative memory for recently learned information. Recent work in our laboratory using dense array Electroencephalography (dEEG) localized the sources of SOs to anterior limbic sites – suggesting that targeting these sites with TES may be more effective for enhancing N3. Methods: For the present study, we recruited 13 healthy adults (M = 42 years) to participate in three all-night sleep EEG recordings where they received low level (0.5 mA) TES designed to target anterior limbic areas and a sham stimulation (placebo). We used a convolutional neural network, trained and tested on professionally scored EEG sleep staging, to predict sleep stages for each recording. Results: When compared to the sham session, limbic-targeted TES significantly increased the duration of N3 sleep. TES also significantly increased spectral power in the 0.5–1 Hz frequency band (relative to pre-TES epochs) in left temporoparietal and left occipital scalp regions compared to sham. Conclusion: These results suggest that even low-level TES, when specifically targeting anterior limbic sites, can increase deep (N3) sleep and thereby contribute to healthy sleep quality. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/173746 Hathaway, Evan; Morgan, Kyle; Carson, Megan; Shusterman, Roma; Fernandez Corazza, Mariano; et al.; Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep; Elsevier Science; Sleep Medicine; 81; 5-2021; 350-357 1389-9457 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/173746 |
identifier_str_mv |
Hathaway, Evan; Morgan, Kyle; Carson, Megan; Shusterman, Roma; Fernandez Corazza, Mariano; et al.; Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep; Elsevier Science; Sleep Medicine; 81; 5-2021; 350-357 1389-9457 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1389945721001623 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.sleep.2021.03.001 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269571151560704 |
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13.13397 |