Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep

Autores
Hathaway, Evan; Morgan, Kyle; Carson, Megan; Shusterman, Roma; Fernandez Corazza, Mariano; Luu, Phan; Tucker, Don M.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Researchers have proposed that impaired sleep may be a causal link in the progression from Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD). Several recent findings suggest that enhancing deep sleep (N3) may improve neurological health in persons with MCI, and buffer the risk for AD. Specifically, Transcranial Electrical Stimulation (TES) of frontal brain areas, the inferred source of the Slow Oscillations (SOs) of N3 sleep, can extend N3 sleep duration and improve declarative memory for recently learned information. Recent work in our laboratory using dense array Electroencephalography (dEEG) localized the sources of SOs to anterior limbic sites – suggesting that targeting these sites with TES may be more effective for enhancing N3. Methods: For the present study, we recruited 13 healthy adults (M = 42 years) to participate in three all-night sleep EEG recordings where they received low level (0.5 mA) TES designed to target anterior limbic areas and a sham stimulation (placebo). We used a convolutional neural network, trained and tested on professionally scored EEG sleep staging, to predict sleep stages for each recording. Results: When compared to the sham session, limbic-targeted TES significantly increased the duration of N3 sleep. TES also significantly increased spectral power in the 0.5–1 Hz frequency band (relative to pre-TES epochs) in left temporoparietal and left occipital scalp regions compared to sham. Conclusion: These results suggest that even low-level TES, when specifically targeting anterior limbic sites, can increase deep (N3) sleep and thereby contribute to healthy sleep quality.
Fil: Hathaway, Evan. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Morgan, Kyle. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Carson, Megan. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Shusterman, Roma. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Fernandez Corazza, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina
Fil: Luu, Phan. University of Oregon; Estados Unidos
Fil: Tucker, Don M.. University of Oregon; Estados Unidos
Materia
EEG
Sleep
Memory
Slow oscillations
Deep Sleep
Slow wave sleep
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/173746

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network_name_str CONICET Digital (CONICET)
spelling Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleepHathaway, EvanMorgan, KyleCarson, MeganShusterman, RomaFernandez Corazza, MarianoLuu, PhanTucker, Don M.EEGSleepMemorySlow oscillationsDeep SleepSlow wave sleephttps://purl.org/becyt/ford/2.6https://purl.org/becyt/ford/2Background: Researchers have proposed that impaired sleep may be a causal link in the progression from Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD). Several recent findings suggest that enhancing deep sleep (N3) may improve neurological health in persons with MCI, and buffer the risk for AD. Specifically, Transcranial Electrical Stimulation (TES) of frontal brain areas, the inferred source of the Slow Oscillations (SOs) of N3 sleep, can extend N3 sleep duration and improve declarative memory for recently learned information. Recent work in our laboratory using dense array Electroencephalography (dEEG) localized the sources of SOs to anterior limbic sites – suggesting that targeting these sites with TES may be more effective for enhancing N3. Methods: For the present study, we recruited 13 healthy adults (M = 42 years) to participate in three all-night sleep EEG recordings where they received low level (0.5 mA) TES designed to target anterior limbic areas and a sham stimulation (placebo). We used a convolutional neural network, trained and tested on professionally scored EEG sleep staging, to predict sleep stages for each recording. Results: When compared to the sham session, limbic-targeted TES significantly increased the duration of N3 sleep. TES also significantly increased spectral power in the 0.5–1 Hz frequency band (relative to pre-TES epochs) in left temporoparietal and left occipital scalp regions compared to sham. Conclusion: These results suggest that even low-level TES, when specifically targeting anterior limbic sites, can increase deep (N3) sleep and thereby contribute to healthy sleep quality.Fil: Hathaway, Evan. Brain Electrophysiology Laboratory Company; Estados UnidosFil: Morgan, Kyle. Brain Electrophysiology Laboratory Company; Estados UnidosFil: Carson, Megan. Brain Electrophysiology Laboratory Company; Estados UnidosFil: Shusterman, Roma. Brain Electrophysiology Laboratory Company; Estados UnidosFil: Fernandez Corazza, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; ArgentinaFil: Luu, Phan. University of Oregon; Estados UnidosFil: Tucker, Don M.. University of Oregon; Estados UnidosElsevier Science2021-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/173746Hathaway, Evan; Morgan, Kyle; Carson, Megan; Shusterman, Roma; Fernandez Corazza, Mariano; et al.; Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep; Elsevier Science; Sleep Medicine; 81; 5-2021; 350-3571389-9457CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1389945721001623info:eu-repo/semantics/altIdentifier/doi/10.1016/j.sleep.2021.03.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:15Zoai:ri.conicet.gov.ar:11336/173746instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:16.206CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep
title Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep
spellingShingle Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep
Hathaway, Evan
EEG
Sleep
Memory
Slow oscillations
Deep Sleep
Slow wave sleep
title_short Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep
title_full Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep
title_fullStr Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep
title_full_unstemmed Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep
title_sort Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep
dc.creator.none.fl_str_mv Hathaway, Evan
Morgan, Kyle
Carson, Megan
Shusterman, Roma
Fernandez Corazza, Mariano
Luu, Phan
Tucker, Don M.
author Hathaway, Evan
author_facet Hathaway, Evan
Morgan, Kyle
Carson, Megan
Shusterman, Roma
Fernandez Corazza, Mariano
Luu, Phan
Tucker, Don M.
author_role author
author2 Morgan, Kyle
Carson, Megan
Shusterman, Roma
Fernandez Corazza, Mariano
Luu, Phan
Tucker, Don M.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv EEG
Sleep
Memory
Slow oscillations
Deep Sleep
Slow wave sleep
topic EEG
Sleep
Memory
Slow oscillations
Deep Sleep
Slow wave sleep
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.6
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Background: Researchers have proposed that impaired sleep may be a causal link in the progression from Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD). Several recent findings suggest that enhancing deep sleep (N3) may improve neurological health in persons with MCI, and buffer the risk for AD. Specifically, Transcranial Electrical Stimulation (TES) of frontal brain areas, the inferred source of the Slow Oscillations (SOs) of N3 sleep, can extend N3 sleep duration and improve declarative memory for recently learned information. Recent work in our laboratory using dense array Electroencephalography (dEEG) localized the sources of SOs to anterior limbic sites – suggesting that targeting these sites with TES may be more effective for enhancing N3. Methods: For the present study, we recruited 13 healthy adults (M = 42 years) to participate in three all-night sleep EEG recordings where they received low level (0.5 mA) TES designed to target anterior limbic areas and a sham stimulation (placebo). We used a convolutional neural network, trained and tested on professionally scored EEG sleep staging, to predict sleep stages for each recording. Results: When compared to the sham session, limbic-targeted TES significantly increased the duration of N3 sleep. TES also significantly increased spectral power in the 0.5–1 Hz frequency band (relative to pre-TES epochs) in left temporoparietal and left occipital scalp regions compared to sham. Conclusion: These results suggest that even low-level TES, when specifically targeting anterior limbic sites, can increase deep (N3) sleep and thereby contribute to healthy sleep quality.
Fil: Hathaway, Evan. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Morgan, Kyle. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Carson, Megan. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Shusterman, Roma. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Fernandez Corazza, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina
Fil: Luu, Phan. University of Oregon; Estados Unidos
Fil: Tucker, Don M.. University of Oregon; Estados Unidos
description Background: Researchers have proposed that impaired sleep may be a causal link in the progression from Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD). Several recent findings suggest that enhancing deep sleep (N3) may improve neurological health in persons with MCI, and buffer the risk for AD. Specifically, Transcranial Electrical Stimulation (TES) of frontal brain areas, the inferred source of the Slow Oscillations (SOs) of N3 sleep, can extend N3 sleep duration and improve declarative memory for recently learned information. Recent work in our laboratory using dense array Electroencephalography (dEEG) localized the sources of SOs to anterior limbic sites – suggesting that targeting these sites with TES may be more effective for enhancing N3. Methods: For the present study, we recruited 13 healthy adults (M = 42 years) to participate in three all-night sleep EEG recordings where they received low level (0.5 mA) TES designed to target anterior limbic areas and a sham stimulation (placebo). We used a convolutional neural network, trained and tested on professionally scored EEG sleep staging, to predict sleep stages for each recording. Results: When compared to the sham session, limbic-targeted TES significantly increased the duration of N3 sleep. TES also significantly increased spectral power in the 0.5–1 Hz frequency band (relative to pre-TES epochs) in left temporoparietal and left occipital scalp regions compared to sham. Conclusion: These results suggest that even low-level TES, when specifically targeting anterior limbic sites, can increase deep (N3) sleep and thereby contribute to healthy sleep quality.
publishDate 2021
dc.date.none.fl_str_mv 2021-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/173746
Hathaway, Evan; Morgan, Kyle; Carson, Megan; Shusterman, Roma; Fernandez Corazza, Mariano; et al.; Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep; Elsevier Science; Sleep Medicine; 81; 5-2021; 350-357
1389-9457
CONICET Digital
CONICET
url http://hdl.handle.net/11336/173746
identifier_str_mv Hathaway, Evan; Morgan, Kyle; Carson, Megan; Shusterman, Roma; Fernandez Corazza, Mariano; et al.; Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep; Elsevier Science; Sleep Medicine; 81; 5-2021; 350-357
1389-9457
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1389945721001623
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.sleep.2021.03.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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