Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs

Autores
Abraham, Gustavo Abel; Gallardo, Alberto; San Roman, Julio; Fernández Mayoralas, Alfonso; Zurita, Mercedes; Vaquero, Jesús
Año de publicación
2003
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Graft copolymers of poly(ϵ‐caprolactone) (PCL) on poly(dimethylacrylamide) (PDMAm), poly(methylmethacrylate) (PMMA), or on copolymers of poly(DMAm‐co‐MMA) have been synthesized and characterized by 1H NMR spectroscopy, differential scanning calorimetry (DSC), and size exclusion chromatography (SEC). These partially biodegradable copolymer matrices have been proposed as drug delivery systems for the release of low‐molecular‐weight glycosides. Octyl‐N‐acetyl‐6‐O‐[2,2‐bis(hydroxymethyl)‐3‐hydroxypropyl]‐α‐D‐glucosamide, a synthetic carbohydrate able to inhibit the proliferation of human malignant glioma cells in culture and transplanted glioma in rats was selected as drug model. The in vitro aqueous behavior of four drug‐loaded and unloaded graft copolymers of different MMA: DMAm and PCL ratios has been analyzed performing swelling, degradation, and drug release experiments. An intimate dependence of the aqueous behavior with the composition has been found. The higher was the DMAm content, the higher was the hydrophilicity of the synthesized systems as well as the swelling, degradation, and drug release rate. In vivo experiments in pigs demonstrated the very good tolerance of drug‐loaded implanted polymeric discs, and that >95% of the charged drug is released after 2 months' implantation.
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Gallardo, Alberto. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: San Roman, Julio. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Fernández Mayoralas, Alfonso. Consejo Superior de Investigaciones Científicas; España. Instituto de Química Orgánica General; España
Fil: Zurita, Mercedes. Clínica Puerta de Hierro; España
Fil: Vaquero, Jesús. Clínica Puerta de Hierro; España
Materia
Partially Biodegradable Matrices
Graft Copolymers
Antitumoral Drugs
Drug Release
In Vivo Experiments
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/77591
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/77591
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugsAbraham, Gustavo AbelGallardo, AlbertoSan Roman, JulioFernández Mayoralas, AlfonsoZurita, MercedesVaquero, JesúsPartially Biodegradable MatricesGraft CopolymersAntitumoral DrugsDrug ReleaseIn Vivo Experimentshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Graft copolymers of poly(ϵ‐caprolactone) (PCL) on poly(dimethylacrylamide) (PDMAm), poly(methylmethacrylate) (PMMA), or on copolymers of poly(DMAm‐co‐MMA) have been synthesized and characterized by 1H NMR spectroscopy, differential scanning calorimetry (DSC), and size exclusion chromatography (SEC). These partially biodegradable copolymer matrices have been proposed as drug delivery systems for the release of low‐molecular‐weight glycosides. Octyl‐N‐acetyl‐6‐O‐[2,2‐bis(hydroxymethyl)‐3‐hydroxypropyl]‐α‐D‐glucosamide, a synthetic carbohydrate able to inhibit the proliferation of human malignant glioma cells in culture and transplanted glioma in rats was selected as drug model. The in vitro aqueous behavior of four drug‐loaded and unloaded graft copolymers of different MMA: DMAm and PCL ratios has been analyzed performing swelling, degradation, and drug release experiments. An intimate dependence of the aqueous behavior with the composition has been found. The higher was the DMAm content, the higher was the hydrophilicity of the synthesized systems as well as the swelling, degradation, and drug release rate. In vivo experiments in pigs demonstrated the very good tolerance of drug‐loaded implanted polymeric discs, and that >95% of the charged drug is released after 2 months' implantation.Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: Gallardo, Alberto. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: San Roman, Julio. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: Fernández Mayoralas, Alfonso. Consejo Superior de Investigaciones Científicas; España. Instituto de Química Orgánica General; EspañaFil: Zurita, Mercedes. Clínica Puerta de Hierro; EspañaFil: Vaquero, Jesús. Clínica Puerta de Hierro; EspañaWiley-liss, Div John Wiley & Sons Inc2003-03-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/77591Abraham, Gustavo Abel; Gallardo, Alberto; San Roman, Julio; Fernández Mayoralas, Alfonso; Zurita, Mercedes; et al.; Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part A; 64A; 4; 7-3-2003; 638-6471549-32961552-4965CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.10297info:eu-repo/semantics/altIdentifier/doi/10.1002/jbm.a.10297info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:58Zoai:ri.conicet.gov.ar:11336/77591instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:58.388CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs
title Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs
spellingShingle Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs
Abraham, Gustavo Abel
Partially Biodegradable Matrices
Graft Copolymers
Antitumoral Drugs
Drug Release
In Vivo Experiments
title_short Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs
title_full Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs
title_fullStr Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs
title_full_unstemmed Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs
title_sort Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs
dc.creator.none.fl_str_mv Abraham, Gustavo Abel
Gallardo, Alberto
San Roman, Julio
Fernández Mayoralas, Alfonso
Zurita, Mercedes
Vaquero, Jesús
author Abraham, Gustavo Abel
author_facet Abraham, Gustavo Abel
Gallardo, Alberto
San Roman, Julio
Fernández Mayoralas, Alfonso
Zurita, Mercedes
Vaquero, Jesús
author_role author
author2 Gallardo, Alberto
San Roman, Julio
Fernández Mayoralas, Alfonso
Zurita, Mercedes
Vaquero, Jesús
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Partially Biodegradable Matrices
Graft Copolymers
Antitumoral Drugs
Drug Release
In Vivo Experiments
topic Partially Biodegradable Matrices
Graft Copolymers
Antitumoral Drugs
Drug Release
In Vivo Experiments
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Graft copolymers of poly(ϵ‐caprolactone) (PCL) on poly(dimethylacrylamide) (PDMAm), poly(methylmethacrylate) (PMMA), or on copolymers of poly(DMAm‐co‐MMA) have been synthesized and characterized by 1H NMR spectroscopy, differential scanning calorimetry (DSC), and size exclusion chromatography (SEC). These partially biodegradable copolymer matrices have been proposed as drug delivery systems for the release of low‐molecular‐weight glycosides. Octyl‐N‐acetyl‐6‐O‐[2,2‐bis(hydroxymethyl)‐3‐hydroxypropyl]‐α‐D‐glucosamide, a synthetic carbohydrate able to inhibit the proliferation of human malignant glioma cells in culture and transplanted glioma in rats was selected as drug model. The in vitro aqueous behavior of four drug‐loaded and unloaded graft copolymers of different MMA: DMAm and PCL ratios has been analyzed performing swelling, degradation, and drug release experiments. An intimate dependence of the aqueous behavior with the composition has been found. The higher was the DMAm content, the higher was the hydrophilicity of the synthesized systems as well as the swelling, degradation, and drug release rate. In vivo experiments in pigs demonstrated the very good tolerance of drug‐loaded implanted polymeric discs, and that >95% of the charged drug is released after 2 months' implantation.
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Gallardo, Alberto. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: San Roman, Julio. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Fernández Mayoralas, Alfonso. Consejo Superior de Investigaciones Científicas; España. Instituto de Química Orgánica General; España
Fil: Zurita, Mercedes. Clínica Puerta de Hierro; España
Fil: Vaquero, Jesús. Clínica Puerta de Hierro; España
description Graft copolymers of poly(ϵ‐caprolactone) (PCL) on poly(dimethylacrylamide) (PDMAm), poly(methylmethacrylate) (PMMA), or on copolymers of poly(DMAm‐co‐MMA) have been synthesized and characterized by 1H NMR spectroscopy, differential scanning calorimetry (DSC), and size exclusion chromatography (SEC). These partially biodegradable copolymer matrices have been proposed as drug delivery systems for the release of low‐molecular‐weight glycosides. Octyl‐N‐acetyl‐6‐O‐[2,2‐bis(hydroxymethyl)‐3‐hydroxypropyl]‐α‐D‐glucosamide, a synthetic carbohydrate able to inhibit the proliferation of human malignant glioma cells in culture and transplanted glioma in rats was selected as drug model. The in vitro aqueous behavior of four drug‐loaded and unloaded graft copolymers of different MMA: DMAm and PCL ratios has been analyzed performing swelling, degradation, and drug release experiments. An intimate dependence of the aqueous behavior with the composition has been found. The higher was the DMAm content, the higher was the hydrophilicity of the synthesized systems as well as the swelling, degradation, and drug release rate. In vivo experiments in pigs demonstrated the very good tolerance of drug‐loaded implanted polymeric discs, and that >95% of the charged drug is released after 2 months' implantation.
publishDate 2003
dc.date.none.fl_str_mv 2003-03-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/77591
Abraham, Gustavo Abel; Gallardo, Alberto; San Roman, Julio; Fernández Mayoralas, Alfonso; Zurita, Mercedes; et al.; Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part A; 64A; 4; 7-3-2003; 638-647
1549-3296
1552-4965
CONICET Digital
CONICET
url http://hdl.handle.net/11336/77591
identifier_str_mv Abraham, Gustavo Abel; Gallardo, Alberto; San Roman, Julio; Fernández Mayoralas, Alfonso; Zurita, Mercedes; et al.; Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part A; 64A; 4; 7-3-2003; 638-647
1549-3296
1552-4965
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.10297
info:eu-repo/semantics/altIdentifier/doi/10.1002/jbm.a.10297
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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