Self-curing acrylic formulations containing PMMA/PCL composites: Properties and antibiotic release behavior

Autores
Méndez, José A.; Abraham, Gustavo Abel; Fernández, María Del Mar; Vázquez, Blanca; Román, Julio San
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Partially biodegradable acrylic composites containing poly(methyl methacrylate)-poly(ε-caprolactone) (PMMA/PCL) systems were prepared by mixing the corresponding PMMA/PCL beads (89:11, 86:14, 83:17, and 77:23 weight ratio) used as solid phase with methyl methacrylate (MMA) (liquid phase) in a solid/liquid ratio of 1.5:1. The physical and chemical microheterogeneity of these beads influenced significantly the curing parameters, because several aspects involved in the polymerization reaction are closely related to both morphology and size distribution of the particles. In vitro behavior was studied by immersion in simulated body fluid at pH = 7.4 and 37°C for more than 8 weeks and the composition was followed by 1H-nuclear magnetic resonance spectroscopy. Approximately 2% wt/wt weight loss was observed after a period of 8 weeks for the composites richest in PCL. Mechanical properties of the dry and wet specimens were evaluated by compressive and tensile tests. In all cases, the presence of PCL in the composites provided a significant decrease in both compressive strength and elastic modulus compared with plain PMMA. Tensile and compressive strength also decreased significantly after 2 weeks of immersion in simulated body fluid compared with dry specimens. The self-curing composites based on PMMA/PCL beads and loaded with 3% wt/wt vancomycin were evaluated as carriers for local release of antibiotics. The composite prepared with beads of PMMA/PCL ratio 86:14 was the most effective. It eluted 64% of the initial drug within the first 5 h, allowing progressive release of nearly the total amount of the initial drug (90%) in approximately 2 months. The results obtained suggest that the described composites can be suitable for antibiotic release in non-load bearing graft applications. © 2002 Wiley Periodicals, Inc.
Fil: Méndez, José A.. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Fernández, María Del Mar. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Vázquez, Blanca. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Román, Julio San. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
Materia
Bone Graft
Partially Biodegradable Composites
Poly(Ε-Caprolactone)
Self-Curing Formulations
Vancomycin Release
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/55130
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/55130
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Self-curing acrylic formulations containing PMMA/PCL composites: Properties and antibiotic release behaviorMéndez, José A.Abraham, Gustavo AbelFernández, María Del MarVázquez, BlancaRomán, Julio SanBone GraftPartially Biodegradable CompositesPoly(Ε-Caprolactone)Self-Curing FormulationsVancomycin Releasehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Partially biodegradable acrylic composites containing poly(methyl methacrylate)-poly(ε-caprolactone) (PMMA/PCL) systems were prepared by mixing the corresponding PMMA/PCL beads (89:11, 86:14, 83:17, and 77:23 weight ratio) used as solid phase with methyl methacrylate (MMA) (liquid phase) in a solid/liquid ratio of 1.5:1. The physical and chemical microheterogeneity of these beads influenced significantly the curing parameters, because several aspects involved in the polymerization reaction are closely related to both morphology and size distribution of the particles. In vitro behavior was studied by immersion in simulated body fluid at pH = 7.4 and 37°C for more than 8 weeks and the composition was followed by 1H-nuclear magnetic resonance spectroscopy. Approximately 2% wt/wt weight loss was observed after a period of 8 weeks for the composites richest in PCL. Mechanical properties of the dry and wet specimens were evaluated by compressive and tensile tests. In all cases, the presence of PCL in the composites provided a significant decrease in both compressive strength and elastic modulus compared with plain PMMA. Tensile and compressive strength also decreased significantly after 2 weeks of immersion in simulated body fluid compared with dry specimens. The self-curing composites based on PMMA/PCL beads and loaded with 3% wt/wt vancomycin were evaluated as carriers for local release of antibiotics. The composite prepared with beads of PMMA/PCL ratio 86:14 was the most effective. It eluted 64% of the initial drug within the first 5 h, allowing progressive release of nearly the total amount of the initial drug (90%) in approximately 2 months. The results obtained suggest that the described composites can be suitable for antibiotic release in non-load bearing graft applications. © 2002 Wiley Periodicals, Inc.Fil: Méndez, José A.. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: Fernández, María Del Mar. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: Vázquez, Blanca. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: Román, Julio San. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; EspañaWiley2002-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/55130Méndez, José A.; Abraham, Gustavo Abel; Fernández, María Del Mar; Vázquez, Blanca; Román, Julio San; Self-curing acrylic formulations containing PMMA/PCL composites: Properties and antibiotic release behavior; Wiley; Journal Of Biomedical Materials Research; 61; 1; 12-2002; 66-740021-9304CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/jbm.10142info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.10142info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:13Zoai:ri.conicet.gov.ar:11336/55130instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:13.352CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Self-curing acrylic formulations containing PMMA/PCL composites: Properties and antibiotic release behavior
title Self-curing acrylic formulations containing PMMA/PCL composites: Properties and antibiotic release behavior
spellingShingle Self-curing acrylic formulations containing PMMA/PCL composites: Properties and antibiotic release behavior
Méndez, José A.
Bone Graft
Partially Biodegradable Composites
Poly(Ε-Caprolactone)
Self-Curing Formulations
Vancomycin Release
title_short Self-curing acrylic formulations containing PMMA/PCL composites: Properties and antibiotic release behavior
title_full Self-curing acrylic formulations containing PMMA/PCL composites: Properties and antibiotic release behavior
title_fullStr Self-curing acrylic formulations containing PMMA/PCL composites: Properties and antibiotic release behavior
title_full_unstemmed Self-curing acrylic formulations containing PMMA/PCL composites: Properties and antibiotic release behavior
title_sort Self-curing acrylic formulations containing PMMA/PCL composites: Properties and antibiotic release behavior
dc.creator.none.fl_str_mv Méndez, José A.
Abraham, Gustavo Abel
Fernández, María Del Mar
Vázquez, Blanca
Román, Julio San
author Méndez, José A.
author_facet Méndez, José A.
Abraham, Gustavo Abel
Fernández, María Del Mar
Vázquez, Blanca
Román, Julio San
author_role author
author2 Abraham, Gustavo Abel
Fernández, María Del Mar
Vázquez, Blanca
Román, Julio San
author2_role author
author
author
author
dc.subject.none.fl_str_mv Bone Graft
Partially Biodegradable Composites
Poly(Ε-Caprolactone)
Self-Curing Formulations
Vancomycin Release
topic Bone Graft
Partially Biodegradable Composites
Poly(Ε-Caprolactone)
Self-Curing Formulations
Vancomycin Release
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Partially biodegradable acrylic composites containing poly(methyl methacrylate)-poly(ε-caprolactone) (PMMA/PCL) systems were prepared by mixing the corresponding PMMA/PCL beads (89:11, 86:14, 83:17, and 77:23 weight ratio) used as solid phase with methyl methacrylate (MMA) (liquid phase) in a solid/liquid ratio of 1.5:1. The physical and chemical microheterogeneity of these beads influenced significantly the curing parameters, because several aspects involved in the polymerization reaction are closely related to both morphology and size distribution of the particles. In vitro behavior was studied by immersion in simulated body fluid at pH = 7.4 and 37°C for more than 8 weeks and the composition was followed by 1H-nuclear magnetic resonance spectroscopy. Approximately 2% wt/wt weight loss was observed after a period of 8 weeks for the composites richest in PCL. Mechanical properties of the dry and wet specimens were evaluated by compressive and tensile tests. In all cases, the presence of PCL in the composites provided a significant decrease in both compressive strength and elastic modulus compared with plain PMMA. Tensile and compressive strength also decreased significantly after 2 weeks of immersion in simulated body fluid compared with dry specimens. The self-curing composites based on PMMA/PCL beads and loaded with 3% wt/wt vancomycin were evaluated as carriers for local release of antibiotics. The composite prepared with beads of PMMA/PCL ratio 86:14 was the most effective. It eluted 64% of the initial drug within the first 5 h, allowing progressive release of nearly the total amount of the initial drug (90%) in approximately 2 months. The results obtained suggest that the described composites can be suitable for antibiotic release in non-load bearing graft applications. © 2002 Wiley Periodicals, Inc.
Fil: Méndez, José A.. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Fernández, María Del Mar. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Vázquez, Blanca. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Román, Julio San. Consejo Superior de Investigaciones Científicas; España. Instituto en Ciencia y Tecnología de Polímeros; España
description Partially biodegradable acrylic composites containing poly(methyl methacrylate)-poly(ε-caprolactone) (PMMA/PCL) systems were prepared by mixing the corresponding PMMA/PCL beads (89:11, 86:14, 83:17, and 77:23 weight ratio) used as solid phase with methyl methacrylate (MMA) (liquid phase) in a solid/liquid ratio of 1.5:1. The physical and chemical microheterogeneity of these beads influenced significantly the curing parameters, because several aspects involved in the polymerization reaction are closely related to both morphology and size distribution of the particles. In vitro behavior was studied by immersion in simulated body fluid at pH = 7.4 and 37°C for more than 8 weeks and the composition was followed by 1H-nuclear magnetic resonance spectroscopy. Approximately 2% wt/wt weight loss was observed after a period of 8 weeks for the composites richest in PCL. Mechanical properties of the dry and wet specimens were evaluated by compressive and tensile tests. In all cases, the presence of PCL in the composites provided a significant decrease in both compressive strength and elastic modulus compared with plain PMMA. Tensile and compressive strength also decreased significantly after 2 weeks of immersion in simulated body fluid compared with dry specimens. The self-curing composites based on PMMA/PCL beads and loaded with 3% wt/wt vancomycin were evaluated as carriers for local release of antibiotics. The composite prepared with beads of PMMA/PCL ratio 86:14 was the most effective. It eluted 64% of the initial drug within the first 5 h, allowing progressive release of nearly the total amount of the initial drug (90%) in approximately 2 months. The results obtained suggest that the described composites can be suitable for antibiotic release in non-load bearing graft applications. © 2002 Wiley Periodicals, Inc.
publishDate 2002
dc.date.none.fl_str_mv 2002-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/55130
Méndez, José A.; Abraham, Gustavo Abel; Fernández, María Del Mar; Vázquez, Blanca; Román, Julio San; Self-curing acrylic formulations containing PMMA/PCL composites: Properties and antibiotic release behavior; Wiley; Journal Of Biomedical Materials Research; 61; 1; 12-2002; 66-74
0021-9304
CONICET Digital
CONICET
url http://hdl.handle.net/11336/55130
identifier_str_mv Méndez, José A.; Abraham, Gustavo Abel; Fernández, María Del Mar; Vázquez, Blanca; Román, Julio San; Self-curing acrylic formulations containing PMMA/PCL composites: Properties and antibiotic release behavior; Wiley; Journal Of Biomedical Materials Research; 61; 1; 12-2002; 66-74
0021-9304
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/jbm.10142
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.10142
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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