Thermoresponsive hydrogels from alginate-based graft copolymers

Autores
Lencina, María Malvina Soledad; Iatridi, Zacharoula; Villar, Marcelo Armando; Tsitsilianis, Constantinos
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Three samples of sodium alginate grafted by amino-terminated PNIPAM (low and high molecular weight poly(N-isopropylacrylamide)) and a random P(NIPAM-co-NtBAM) (NtBAM: N-tertiary butyl acrylamide) copolymer, were synthesized via the carbodiimide chemistry and their temperature-induced hydrogelation capability was evaluated by rheology. All the samples showed thermothickening behaviour depending on concentration, ionic strength and hydrophobic comonomer content, incorporated to the PNIPAM thermo-sensitive pendant chains. The main result of this study was that a slight hydrophobic enrichment (just 15 mol% NtBAM) of PNIPAM was sufficient to shift the gelation temperature well below the physiological temperature at 32 ºC and at the lowest polymer concentration studied (i.e. 10 wt%). The consequence of that was that the ALG-g- P(NIPAM-co-NtBAM) graft copolymer hydrogel exhibited the best rheological thermo- responsive properties and might be used as injectable hydrogel for potential applications in biomedicine.
Fil: Lencina, María Malvina Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. University of Patras. Department of Chemical Engineering; Grecia
Fil: Iatridi, Zacharoula. University of Patras. Department of Chemical Engineering; Grecia
Fil: Villar, Marcelo Armando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Tsitsilianis, Constantinos. University of Patras. Department of Chemical Engineering; Grecia
Materia
Alginate
P(N-Isopropylacrylamide)
N-Tert-Butylacrylamide
Graft Copolymers
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25748
Acceder
id CONICETDig_428d62760e4dcf5b6eeeece1284de8da
oai_identifier_str oai:ri.conicet.gov.ar:11336/25748
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Thermoresponsive hydrogels from alginate-based graft copolymersLencina, María Malvina SoledadIatridi, ZacharoulaVillar, Marcelo ArmandoTsitsilianis, ConstantinosAlginateP(N-Isopropylacrylamide)N-Tert-ButylacrylamideGraft Copolymershttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Three samples of sodium alginate grafted by amino-terminated PNIPAM (low and high molecular weight poly(N-isopropylacrylamide)) and a random P(NIPAM-co-NtBAM) (NtBAM: N-tertiary butyl acrylamide) copolymer, were synthesized via the carbodiimide chemistry and their temperature-induced hydrogelation capability was evaluated by rheology. All the samples showed thermothickening behaviour depending on concentration, ionic strength and hydrophobic comonomer content, incorporated to the PNIPAM thermo-sensitive pendant chains. The main result of this study was that a slight hydrophobic enrichment (just 15 mol% NtBAM) of PNIPAM was sufficient to shift the gelation temperature well below the physiological temperature at 32 ºC and at the lowest polymer concentration studied (i.e. 10 wt%). The consequence of that was that the ALG-g- P(NIPAM-co-NtBAM) graft copolymer hydrogel exhibited the best rheological thermo- responsive properties and might be used as injectable hydrogel for potential applications in biomedicine.Fil: Lencina, María Malvina Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. University of Patras. Department of Chemical Engineering; GreciaFil: Iatridi, Zacharoula. University of Patras. Department of Chemical Engineering; GreciaFil: Villar, Marcelo Armando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Tsitsilianis, Constantinos. University of Patras. Department of Chemical Engineering; GreciaElsevier2014-10-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25748Lencina, María Malvina Soledad; Iatridi, Zacharoula; Villar, Marcelo Armando; Tsitsilianis, Constantinos; Thermoresponsive hydrogels from alginate-based graft copolymers; Elsevier; European Polymer Journal; 61; 2-10-2014; 33-440014-3057CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0014305714003292info:eu-repo/semantics/altIdentifier/doi/10.1016/j.eurpolymj.2014.09.011info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:07:41Zoai:ri.conicet.gov.ar:11336/25748instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:07:42.124CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Thermoresponsive hydrogels from alginate-based graft copolymers
title Thermoresponsive hydrogels from alginate-based graft copolymers
spellingShingle Thermoresponsive hydrogels from alginate-based graft copolymers
Lencina, María Malvina Soledad
Alginate
P(N-Isopropylacrylamide)
N-Tert-Butylacrylamide
Graft Copolymers
title_short Thermoresponsive hydrogels from alginate-based graft copolymers
title_full Thermoresponsive hydrogels from alginate-based graft copolymers
title_fullStr Thermoresponsive hydrogels from alginate-based graft copolymers
title_full_unstemmed Thermoresponsive hydrogels from alginate-based graft copolymers
title_sort Thermoresponsive hydrogels from alginate-based graft copolymers
dc.creator.none.fl_str_mv Lencina, María Malvina Soledad
Iatridi, Zacharoula
Villar, Marcelo Armando
Tsitsilianis, Constantinos
author Lencina, María Malvina Soledad
author_facet Lencina, María Malvina Soledad
Iatridi, Zacharoula
Villar, Marcelo Armando
Tsitsilianis, Constantinos
author_role author
author2 Iatridi, Zacharoula
Villar, Marcelo Armando
Tsitsilianis, Constantinos
author2_role author
author
author
dc.subject.none.fl_str_mv Alginate
P(N-Isopropylacrylamide)
N-Tert-Butylacrylamide
Graft Copolymers
topic Alginate
P(N-Isopropylacrylamide)
N-Tert-Butylacrylamide
Graft Copolymers
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Three samples of sodium alginate grafted by amino-terminated PNIPAM (low and high molecular weight poly(N-isopropylacrylamide)) and a random P(NIPAM-co-NtBAM) (NtBAM: N-tertiary butyl acrylamide) copolymer, were synthesized via the carbodiimide chemistry and their temperature-induced hydrogelation capability was evaluated by rheology. All the samples showed thermothickening behaviour depending on concentration, ionic strength and hydrophobic comonomer content, incorporated to the PNIPAM thermo-sensitive pendant chains. The main result of this study was that a slight hydrophobic enrichment (just 15 mol% NtBAM) of PNIPAM was sufficient to shift the gelation temperature well below the physiological temperature at 32 ºC and at the lowest polymer concentration studied (i.e. 10 wt%). The consequence of that was that the ALG-g- P(NIPAM-co-NtBAM) graft copolymer hydrogel exhibited the best rheological thermo- responsive properties and might be used as injectable hydrogel for potential applications in biomedicine.
Fil: Lencina, María Malvina Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. University of Patras. Department of Chemical Engineering; Grecia
Fil: Iatridi, Zacharoula. University of Patras. Department of Chemical Engineering; Grecia
Fil: Villar, Marcelo Armando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Tsitsilianis, Constantinos. University of Patras. Department of Chemical Engineering; Grecia
description Three samples of sodium alginate grafted by amino-terminated PNIPAM (low and high molecular weight poly(N-isopropylacrylamide)) and a random P(NIPAM-co-NtBAM) (NtBAM: N-tertiary butyl acrylamide) copolymer, were synthesized via the carbodiimide chemistry and their temperature-induced hydrogelation capability was evaluated by rheology. All the samples showed thermothickening behaviour depending on concentration, ionic strength and hydrophobic comonomer content, incorporated to the PNIPAM thermo-sensitive pendant chains. The main result of this study was that a slight hydrophobic enrichment (just 15 mol% NtBAM) of PNIPAM was sufficient to shift the gelation temperature well below the physiological temperature at 32 ºC and at the lowest polymer concentration studied (i.e. 10 wt%). The consequence of that was that the ALG-g- P(NIPAM-co-NtBAM) graft copolymer hydrogel exhibited the best rheological thermo- responsive properties and might be used as injectable hydrogel for potential applications in biomedicine.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25748
Lencina, María Malvina Soledad; Iatridi, Zacharoula; Villar, Marcelo Armando; Tsitsilianis, Constantinos; Thermoresponsive hydrogels from alginate-based graft copolymers; Elsevier; European Polymer Journal; 61; 2-10-2014; 33-44
0014-3057
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25748
identifier_str_mv Lencina, María Malvina Soledad; Iatridi, Zacharoula; Villar, Marcelo Armando; Tsitsilianis, Constantinos; Thermoresponsive hydrogels from alginate-based graft copolymers; Elsevier; European Polymer Journal; 61; 2-10-2014; 33-44
0014-3057
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0014305714003292
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.eurpolymj.2014.09.011
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980349646209024
score 12.993085

Publicaciones similares