Ocular surface degenerative diseases studies in an isolated region of Argentine Patagonia

Autores
Suarez, Maria Fernanda; Crim, Nicolás; Correa, Leandro; Maccio, Juan Pablo; Knoll, Erna G.; Piqueras, Carmen; Bhattacharya, S. K.; Serra, Horacio Marcelo
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this study was to investigate the prevalence of Environmental proteinaceous corneal degeneration (EPCD), pinguecula andpterygium and any association among them, and to perform lipidomic studies in some samples of EPCD and pterygium.Materials and methods: It was a transversal/observational and analytical study; the sample was consecutive non-probabilistic. All patients examine dresided all their lives in the department El Cuy (Río Negro). Corneal epithelium and conjunctiva tissue samples were taken to perform massspectrometric lipidomic studies.Results: One hundred and fifty-nine patients were studied (52.83% male and 47.17% female). The prevalence of ophthalmoheliosis was: pinguecula32.1%, EPCD 28.9%, and pterygium 13.2%. A statistically significant association was found between EPCD and male patients (21.4% vs 7.5%)(p <0.05). There was association between EPCD with pinguecula and with pterygium, both more frequent in males (p <0.05). Lipidomic studiesin EPCD showed a decrease in the concentration of phospholipids in affected areas (15 times less). In pterygium, there was an increase in theconcentration of phospholipids (6.67 times more).Conclusion: Our investigation shows important prevalence of EPCD, pinguecula and pterygium in individuals that live at El Cuy (ArgentinePatagonia). As far as we know, this is the first work in the world that shows coexistences between these three ophthalmoheliosis. The decreaseconcentration of phospholipids in EPCD affected areas could be due to lipid peroxidation, as a consequence of oxidative stress. On the other hand,higher levels of PC and PS in pterygium samples could be explained by the increase in proliferation and angiogenesis.
Fil: Suarez, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Crim, Nicolás. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola. Dto de Oftalmologia; Argentina
Fil: Correa, Leandro. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola. Dto de Oftalmologia; Argentina
Fil: Maccio, Juan Pablo. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola. Dto de Oftalmologia; Argentina
Fil: Knoll, Erna G.. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola. Dto de Oftalmologia; Argentina
Fil: Piqueras, Carmen. University of Miami; Estados Unidos
Fil: Bhattacharya, S. K.. University of Miami; Estados Unidos
Fil: Serra, Horacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Materia
ENVIRONMENTAL PROTEINACEOUS CORNEAL DEGENERATION
ARGENTINA
PTERYGIUM
PINGUECULA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/128716
Acceder
id CONICETDig_528cdf720841091c5ea0f8a8f9be989a
oai_identifier_str oai:ri.conicet.gov.ar:11336/128716
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Ocular surface degenerative diseases studies in an isolated region of Argentine PatagoniaSuarez, Maria FernandaCrim, NicolásCorrea, LeandroMaccio, Juan PabloKnoll, Erna G.Piqueras, CarmenBhattacharya, S. K.Serra, Horacio MarceloENVIRONMENTAL PROTEINACEOUS CORNEAL DEGENERATIONARGENTINAPTERYGIUMPINGUECULAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The aim of this study was to investigate the prevalence of Environmental proteinaceous corneal degeneration (EPCD), pinguecula andpterygium and any association among them, and to perform lipidomic studies in some samples of EPCD and pterygium.Materials and methods: It was a transversal/observational and analytical study; the sample was consecutive non-probabilistic. All patients examine dresided all their lives in the department El Cuy (Río Negro). Corneal epithelium and conjunctiva tissue samples were taken to perform massspectrometric lipidomic studies.Results: One hundred and fifty-nine patients were studied (52.83% male and 47.17% female). The prevalence of ophthalmoheliosis was: pinguecula32.1%, EPCD 28.9%, and pterygium 13.2%. A statistically significant association was found between EPCD and male patients (21.4% vs 7.5%)(p <0.05). There was association between EPCD with pinguecula and with pterygium, both more frequent in males (p <0.05). Lipidomic studiesin EPCD showed a decrease in the concentration of phospholipids in affected areas (15 times less). In pterygium, there was an increase in theconcentration of phospholipids (6.67 times more).Conclusion: Our investigation shows important prevalence of EPCD, pinguecula and pterygium in individuals that live at El Cuy (ArgentinePatagonia). As far as we know, this is the first work in the world that shows coexistences between these three ophthalmoheliosis. The decreaseconcentration of phospholipids in EPCD affected areas could be due to lipid peroxidation, as a consequence of oxidative stress. On the other hand,higher levels of PC and PS in pterygium samples could be explained by the increase in proliferation and angiogenesis.Fil: Suarez, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Crim, Nicolás. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola. Dto de Oftalmologia; ArgentinaFil: Correa, Leandro. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola. Dto de Oftalmologia; ArgentinaFil: Maccio, Juan Pablo. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola. Dto de Oftalmologia; ArgentinaFil: Knoll, Erna G.. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola. Dto de Oftalmologia; ArgentinaFil: Piqueras, Carmen. University of Miami; Estados UnidosFil: Bhattacharya, S. K.. University of Miami; Estados UnidosFil: Serra, Horacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaOAT2019-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/128716Suarez, Maria Fernanda; Crim, Nicolás; Correa, Leandro; Maccio, Juan Pablo; Knoll, Erna G.; et al.; Ocular surface degenerative diseases studies in an isolated region of Argentine Patagonia; OAT; New Frontiers in Ophthalmology; 5; 7-2019; 1-72397-2092CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.15761/NFO.1000224info:eu-repo/semantics/altIdentifier/url/https://www.oatext.com/ocular-surface-degenerative-diseases-studies-in-an-isolated-region-of-argentine-patagonia.phpinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:04:04Zoai:ri.conicet.gov.ar:11336/128716instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:04:04.978CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ocular surface degenerative diseases studies in an isolated region of Argentine Patagonia
title Ocular surface degenerative diseases studies in an isolated region of Argentine Patagonia
spellingShingle Ocular surface degenerative diseases studies in an isolated region of Argentine Patagonia
Suarez, Maria Fernanda
ENVIRONMENTAL PROTEINACEOUS CORNEAL DEGENERATION
ARGENTINA
PTERYGIUM
PINGUECULA
title_short Ocular surface degenerative diseases studies in an isolated region of Argentine Patagonia
title_full Ocular surface degenerative diseases studies in an isolated region of Argentine Patagonia
title_fullStr Ocular surface degenerative diseases studies in an isolated region of Argentine Patagonia
title_full_unstemmed Ocular surface degenerative diseases studies in an isolated region of Argentine Patagonia
title_sort Ocular surface degenerative diseases studies in an isolated region of Argentine Patagonia
dc.creator.none.fl_str_mv Suarez, Maria Fernanda
Crim, Nicolás
Correa, Leandro
Maccio, Juan Pablo
Knoll, Erna G.
Piqueras, Carmen
Bhattacharya, S. K.
Serra, Horacio Marcelo
author Suarez, Maria Fernanda
author_facet Suarez, Maria Fernanda
Crim, Nicolás
Correa, Leandro
Maccio, Juan Pablo
Knoll, Erna G.
Piqueras, Carmen
Bhattacharya, S. K.
Serra, Horacio Marcelo
author_role author
author2 Crim, Nicolás
Correa, Leandro
Maccio, Juan Pablo
Knoll, Erna G.
Piqueras, Carmen
Bhattacharya, S. K.
Serra, Horacio Marcelo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ENVIRONMENTAL PROTEINACEOUS CORNEAL DEGENERATION
ARGENTINA
PTERYGIUM
PINGUECULA
topic ENVIRONMENTAL PROTEINACEOUS CORNEAL DEGENERATION
ARGENTINA
PTERYGIUM
PINGUECULA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of this study was to investigate the prevalence of Environmental proteinaceous corneal degeneration (EPCD), pinguecula andpterygium and any association among them, and to perform lipidomic studies in some samples of EPCD and pterygium.Materials and methods: It was a transversal/observational and analytical study; the sample was consecutive non-probabilistic. All patients examine dresided all their lives in the department El Cuy (Río Negro). Corneal epithelium and conjunctiva tissue samples were taken to perform massspectrometric lipidomic studies.Results: One hundred and fifty-nine patients were studied (52.83% male and 47.17% female). The prevalence of ophthalmoheliosis was: pinguecula32.1%, EPCD 28.9%, and pterygium 13.2%. A statistically significant association was found between EPCD and male patients (21.4% vs 7.5%)(p <0.05). There was association between EPCD with pinguecula and with pterygium, both more frequent in males (p <0.05). Lipidomic studiesin EPCD showed a decrease in the concentration of phospholipids in affected areas (15 times less). In pterygium, there was an increase in theconcentration of phospholipids (6.67 times more).Conclusion: Our investigation shows important prevalence of EPCD, pinguecula and pterygium in individuals that live at El Cuy (ArgentinePatagonia). As far as we know, this is the first work in the world that shows coexistences between these three ophthalmoheliosis. The decreaseconcentration of phospholipids in EPCD affected areas could be due to lipid peroxidation, as a consequence of oxidative stress. On the other hand,higher levels of PC and PS in pterygium samples could be explained by the increase in proliferation and angiogenesis.
Fil: Suarez, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Crim, Nicolás. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola. Dto de Oftalmologia; Argentina
Fil: Correa, Leandro. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola. Dto de Oftalmologia; Argentina
Fil: Maccio, Juan Pablo. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola. Dto de Oftalmologia; Argentina
Fil: Knoll, Erna G.. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola. Dto de Oftalmologia; Argentina
Fil: Piqueras, Carmen. University of Miami; Estados Unidos
Fil: Bhattacharya, S. K.. University of Miami; Estados Unidos
Fil: Serra, Horacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
description The aim of this study was to investigate the prevalence of Environmental proteinaceous corneal degeneration (EPCD), pinguecula andpterygium and any association among them, and to perform lipidomic studies in some samples of EPCD and pterygium.Materials and methods: It was a transversal/observational and analytical study; the sample was consecutive non-probabilistic. All patients examine dresided all their lives in the department El Cuy (Río Negro). Corneal epithelium and conjunctiva tissue samples were taken to perform massspectrometric lipidomic studies.Results: One hundred and fifty-nine patients were studied (52.83% male and 47.17% female). The prevalence of ophthalmoheliosis was: pinguecula32.1%, EPCD 28.9%, and pterygium 13.2%. A statistically significant association was found between EPCD and male patients (21.4% vs 7.5%)(p <0.05). There was association between EPCD with pinguecula and with pterygium, both more frequent in males (p <0.05). Lipidomic studiesin EPCD showed a decrease in the concentration of phospholipids in affected areas (15 times less). In pterygium, there was an increase in theconcentration of phospholipids (6.67 times more).Conclusion: Our investigation shows important prevalence of EPCD, pinguecula and pterygium in individuals that live at El Cuy (ArgentinePatagonia). As far as we know, this is the first work in the world that shows coexistences between these three ophthalmoheliosis. The decreaseconcentration of phospholipids in EPCD affected areas could be due to lipid peroxidation, as a consequence of oxidative stress. On the other hand,higher levels of PC and PS in pterygium samples could be explained by the increase in proliferation and angiogenesis.
publishDate 2019
dc.date.none.fl_str_mv 2019-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/128716
Suarez, Maria Fernanda; Crim, Nicolás; Correa, Leandro; Maccio, Juan Pablo; Knoll, Erna G.; et al.; Ocular surface degenerative diseases studies in an isolated region of Argentine Patagonia; OAT; New Frontiers in Ophthalmology; 5; 7-2019; 1-7
2397-2092
CONICET Digital
CONICET
url http://hdl.handle.net/11336/128716
identifier_str_mv Suarez, Maria Fernanda; Crim, Nicolás; Correa, Leandro; Maccio, Juan Pablo; Knoll, Erna G.; et al.; Ocular surface degenerative diseases studies in an isolated region of Argentine Patagonia; OAT; New Frontiers in Ophthalmology; 5; 7-2019; 1-7
2397-2092
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.15761/NFO.1000224
info:eu-repo/semantics/altIdentifier/url/https://www.oatext.com/ocular-surface-degenerative-diseases-studies-in-an-isolated-region-of-argentine-patagonia.php
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv OAT
publisher.none.fl_str_mv OAT
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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