IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation

Autores
Velez, Carolina; Clauzure, Mariangeles; Williamson, Delia Maria; Koncurat, Mirta Adriana; Barbeito, Claudio Gustavo
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Concentration of interferon-gamma and interleukin-10 in maternal serum and in maternal and fetal porcine placental extracts from different gestation periods was determined. Crossbred pigs’ placental samples of 17, 30, 60, 70, and 114 days gestation and non-pregnant uteri were used. Interferon-gamma concentration was increased at the placental interface at 17 days, in maternal and fetal placenta, and decreased significantly in the remaining gestation periods. Interferon-gamma showed a peak in serum at 60 days. Regarding interleukin-10, placental tissue concentrations were unaltered, there were no significant differences with non-gestating uteri samples. In serum interleukin-10 increased at 17, 60, and 114 days gestation. At 17 days there are uterus structural and molecular changes that allow the embryos implantation and placenta development. The presence of interferon-gamma found at this moment in the interface would favor that placental growth. Moreover, its significant increase in serum at 60 days, would generate a proinflammatory cytokine pattern that facility the placental remodeling characteristic of this moment of porcine gestation. On the other hand, a significant interleukin-10 increase in serum at 17, 60 and 114 days could indicate its immunoregulatory role at a systemic level during pig gestation.
Fil: Velez, Carolina. Universidad Nacional de La Pampa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Confluencia; Argentina
Fil: Clauzure, Mariangeles. Universidad Nacional de La Pampa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Confluencia; Argentina
Fil: Williamson, Delia Maria. Universidad Nacional de La Pampa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Confluencia; Argentina
Fil: Koncurat, Mirta Adriana. Universidad Nacional de La Pampa; Argentina
Fil: Barbeito, Claudio Gustavo. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CYTOKINES
IMMUNOLOGY
PIG PLACENTA
PIG REPRODUCTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/222900
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/222900
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestationVelez, CarolinaClauzure, MariangelesWilliamson, Delia MariaKoncurat, Mirta AdrianaBarbeito, Claudio GustavoCYTOKINESIMMUNOLOGYPIG PLACENTAPIG REPRODUCTIONhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Concentration of interferon-gamma and interleukin-10 in maternal serum and in maternal and fetal porcine placental extracts from different gestation periods was determined. Crossbred pigs’ placental samples of 17, 30, 60, 70, and 114 days gestation and non-pregnant uteri were used. Interferon-gamma concentration was increased at the placental interface at 17 days, in maternal and fetal placenta, and decreased significantly in the remaining gestation periods. Interferon-gamma showed a peak in serum at 60 days. Regarding interleukin-10, placental tissue concentrations were unaltered, there were no significant differences with non-gestating uteri samples. In serum interleukin-10 increased at 17, 60, and 114 days gestation. At 17 days there are uterus structural and molecular changes that allow the embryos implantation and placenta development. The presence of interferon-gamma found at this moment in the interface would favor that placental growth. Moreover, its significant increase in serum at 60 days, would generate a proinflammatory cytokine pattern that facility the placental remodeling characteristic of this moment of porcine gestation. On the other hand, a significant interleukin-10 increase in serum at 17, 60 and 114 days could indicate its immunoregulatory role at a systemic level during pig gestation.Fil: Velez, Carolina. Universidad Nacional de La Pampa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Confluencia; ArgentinaFil: Clauzure, Mariangeles. Universidad Nacional de La Pampa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Confluencia; ArgentinaFil: Williamson, Delia Maria. Universidad Nacional de La Pampa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Confluencia; ArgentinaFil: Koncurat, Mirta Adriana. Universidad Nacional de La Pampa; ArgentinaFil: Barbeito, Claudio Gustavo. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAcademia Brasileira de Ciencias2023-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/222900Velez, Carolina; Clauzure, Mariangeles; Williamson, Delia Maria; Koncurat, Mirta Adriana; Barbeito, Claudio Gustavo; IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation; Academia Brasileira de Ciencias; Anais da Academia Brasileira de Ciencias; 95; 1; 4-2023; 1-110001-37651678-2690CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1590/0001-3765202320201160info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:58Zoai:ri.conicet.gov.ar:11336/222900instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:58.841CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation
title IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation
spellingShingle IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation
Velez, Carolina
CYTOKINES
IMMUNOLOGY
PIG PLACENTA
PIG REPRODUCTION
title_short IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation
title_full IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation
title_fullStr IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation
title_full_unstemmed IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation
title_sort IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation
dc.creator.none.fl_str_mv Velez, Carolina
Clauzure, Mariangeles
Williamson, Delia Maria
Koncurat, Mirta Adriana
Barbeito, Claudio Gustavo
author Velez, Carolina
author_facet Velez, Carolina
Clauzure, Mariangeles
Williamson, Delia Maria
Koncurat, Mirta Adriana
Barbeito, Claudio Gustavo
author_role author
author2 Clauzure, Mariangeles
Williamson, Delia Maria
Koncurat, Mirta Adriana
Barbeito, Claudio Gustavo
author2_role author
author
author
author
dc.subject.none.fl_str_mv CYTOKINES
IMMUNOLOGY
PIG PLACENTA
PIG REPRODUCTION
topic CYTOKINES
IMMUNOLOGY
PIG PLACENTA
PIG REPRODUCTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Concentration of interferon-gamma and interleukin-10 in maternal serum and in maternal and fetal porcine placental extracts from different gestation periods was determined. Crossbred pigs’ placental samples of 17, 30, 60, 70, and 114 days gestation and non-pregnant uteri were used. Interferon-gamma concentration was increased at the placental interface at 17 days, in maternal and fetal placenta, and decreased significantly in the remaining gestation periods. Interferon-gamma showed a peak in serum at 60 days. Regarding interleukin-10, placental tissue concentrations were unaltered, there were no significant differences with non-gestating uteri samples. In serum interleukin-10 increased at 17, 60, and 114 days gestation. At 17 days there are uterus structural and molecular changes that allow the embryos implantation and placenta development. The presence of interferon-gamma found at this moment in the interface would favor that placental growth. Moreover, its significant increase in serum at 60 days, would generate a proinflammatory cytokine pattern that facility the placental remodeling characteristic of this moment of porcine gestation. On the other hand, a significant interleukin-10 increase in serum at 17, 60 and 114 days could indicate its immunoregulatory role at a systemic level during pig gestation.
Fil: Velez, Carolina. Universidad Nacional de La Pampa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Confluencia; Argentina
Fil: Clauzure, Mariangeles. Universidad Nacional de La Pampa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Confluencia; Argentina
Fil: Williamson, Delia Maria. Universidad Nacional de La Pampa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Confluencia; Argentina
Fil: Koncurat, Mirta Adriana. Universidad Nacional de La Pampa; Argentina
Fil: Barbeito, Claudio Gustavo. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Concentration of interferon-gamma and interleukin-10 in maternal serum and in maternal and fetal porcine placental extracts from different gestation periods was determined. Crossbred pigs’ placental samples of 17, 30, 60, 70, and 114 days gestation and non-pregnant uteri were used. Interferon-gamma concentration was increased at the placental interface at 17 days, in maternal and fetal placenta, and decreased significantly in the remaining gestation periods. Interferon-gamma showed a peak in serum at 60 days. Regarding interleukin-10, placental tissue concentrations were unaltered, there were no significant differences with non-gestating uteri samples. In serum interleukin-10 increased at 17, 60, and 114 days gestation. At 17 days there are uterus structural and molecular changes that allow the embryos implantation and placenta development. The presence of interferon-gamma found at this moment in the interface would favor that placental growth. Moreover, its significant increase in serum at 60 days, would generate a proinflammatory cytokine pattern that facility the placental remodeling characteristic of this moment of porcine gestation. On the other hand, a significant interleukin-10 increase in serum at 17, 60 and 114 days could indicate its immunoregulatory role at a systemic level during pig gestation.
publishDate 2023
dc.date.none.fl_str_mv 2023-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/222900
Velez, Carolina; Clauzure, Mariangeles; Williamson, Delia Maria; Koncurat, Mirta Adriana; Barbeito, Claudio Gustavo; IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation; Academia Brasileira de Ciencias; Anais da Academia Brasileira de Ciencias; 95; 1; 4-2023; 1-11
0001-3765
1678-2690
CONICET Digital
CONICET
url http://hdl.handle.net/11336/222900
identifier_str_mv Velez, Carolina; Clauzure, Mariangeles; Williamson, Delia Maria; Koncurat, Mirta Adriana; Barbeito, Claudio Gustavo; IFN-γ and IL-10: seric and placental profile during pig gestation Seric and placental cytokines in pig gestation; Academia Brasileira de Ciencias; Anais da Academia Brasileira de Ciencias; 95; 1; 4-2023; 1-11
0001-3765
1678-2690
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1590/0001-3765202320201160
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academia Brasileira de Ciencias
publisher.none.fl_str_mv Academia Brasileira de Ciencias
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613009405640704
score 13.070432

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