Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
- Autores
- Smulski, Cristian Roberto; Zhang, Luyao; Burek, Malte; Teixidó Rubio, Ariadna; Briem, Jana Susann; Sica, Mauricio Pablo; Sevdali, Eirini; Vigolo, Michele; Willen, Laure; Odermatt, Patricia; Istanbullu, Duygu; Herr, Stephanie; Cavallari, Marco; Hess, Henry; Rizzi, Marta; Eibel, Hermann; Schneider, Pascal
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- In mature B cells, TACI controls class-switch recombination and differentiation into plasma cells during T cell-independent antibody responses. TACI binds the ligands BAFF and APRIL. Approximately 10% of patients with common variable immunodeficiency (CVID) carry TACI mutations, of which A181E and C172Y are in the transmembrane domain. Residues A181 and C172 are located on distinct sides of the transmembrane helix, which is predicted by molecular modeling to spontaneously assemble into trimers and dimers. In human B cells, these mutations impair ligand-dependent (C172Y) and -independent (A181E) TACI multimerization and signaling, as well as TACI-enhanced proliferation and/or IgA production. Genetic inactivation of TACI in primary human B cells impaired survival of CpG-activated cells in the absence of ligand. These results identify the transmembrane region of TACI as an active interface for TACI multimerization in signal transduction, in particular for ligand-independent signals. These functions are perturbed by CVID-associated mutations.
Fil: Smulski, Cristian Roberto. Universite de Lausanne; Suiza. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro | Universidad Nacional de Cuyo. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina
Fil: Zhang, Luyao. Albert Ludwigs University of Freiburg; Alemania
Fil: Burek, Malte. Albert Ludwigs University of Freiburg; Alemania
Fil: Teixidó Rubio, Ariadna. Albert Ludwigs University of Freiburg; Alemania
Fil: Briem, Jana Susann. Albert Ludwigs University of Freiburg; Alemania
Fil: Sica, Mauricio Pablo. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro | Universidad Nacional de Cuyo. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina
Fil: Sevdali, Eirini. Albert Ludwigs University of Freiburg; Alemania
Fil: Vigolo, Michele. Universite de Lausanne; Suiza
Fil: Willen, Laure. Universite de Lausanne; Suiza
Fil: Odermatt, Patricia. Albert Ludwigs University of Freiburg; Alemania
Fil: Istanbullu, Duygu. Albert Ludwigs University of Freiburg; Alemania
Fil: Herr, Stephanie. Albert Ludwigs University of Freiburg; Alemania
Fil: Cavallari, Marco. Albert Ludwigs University of Freiburg; Alemania
Fil: Hess, Henry. No especifíca;
Fil: Rizzi, Marta. Albert Ludwigs University of Freiburg; Alemania
Fil: Eibel, Hermann. Albert Ludwigs University of Freiburg; Alemania
Fil: Schneider, Pascal. Universite de Lausanne; Suiza - Materia
-
CP: IMMUNOLOGY
CP: MOLECULAR BIOLOGY
IMMUNODEFICIENCY
OLIGOMERIZATION
PLAD
SIGNALING
TACI
TNFRSF
TRANSMEMBRANE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/216314
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/216314 |
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repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cellsSmulski, Cristian RobertoZhang, LuyaoBurek, MalteTeixidó Rubio, AriadnaBriem, Jana SusannSica, Mauricio PabloSevdali, EiriniVigolo, MicheleWillen, LaureOdermatt, PatriciaIstanbullu, DuyguHerr, StephanieCavallari, MarcoHess, HenryRizzi, MartaEibel, HermannSchneider, PascalCP: IMMUNOLOGYCP: MOLECULAR BIOLOGYIMMUNODEFICIENCYOLIGOMERIZATIONPLADSIGNALINGTACITNFRSFTRANSMEMBRANEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In mature B cells, TACI controls class-switch recombination and differentiation into plasma cells during T cell-independent antibody responses. TACI binds the ligands BAFF and APRIL. Approximately 10% of patients with common variable immunodeficiency (CVID) carry TACI mutations, of which A181E and C172Y are in the transmembrane domain. Residues A181 and C172 are located on distinct sides of the transmembrane helix, which is predicted by molecular modeling to spontaneously assemble into trimers and dimers. In human B cells, these mutations impair ligand-dependent (C172Y) and -independent (A181E) TACI multimerization and signaling, as well as TACI-enhanced proliferation and/or IgA production. Genetic inactivation of TACI in primary human B cells impaired survival of CpG-activated cells in the absence of ligand. These results identify the transmembrane region of TACI as an active interface for TACI multimerization in signal transduction, in particular for ligand-independent signals. These functions are perturbed by CVID-associated mutations.Fil: Smulski, Cristian Roberto. Universite de Lausanne; Suiza. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro | Universidad Nacional de Cuyo. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Zhang, Luyao. Albert Ludwigs University of Freiburg; AlemaniaFil: Burek, Malte. Albert Ludwigs University of Freiburg; AlemaniaFil: Teixidó Rubio, Ariadna. Albert Ludwigs University of Freiburg; AlemaniaFil: Briem, Jana Susann. Albert Ludwigs University of Freiburg; AlemaniaFil: Sica, Mauricio Pablo. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro | Universidad Nacional de Cuyo. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Sevdali, Eirini. Albert Ludwigs University of Freiburg; AlemaniaFil: Vigolo, Michele. Universite de Lausanne; SuizaFil: Willen, Laure. Universite de Lausanne; SuizaFil: Odermatt, Patricia. Albert Ludwigs University of Freiburg; AlemaniaFil: Istanbullu, Duygu. Albert Ludwigs University of Freiburg; AlemaniaFil: Herr, Stephanie. Albert Ludwigs University of Freiburg; AlemaniaFil: Cavallari, Marco. Albert Ludwigs University of Freiburg; AlemaniaFil: Hess, Henry. No especifíca;Fil: Rizzi, Marta. Albert Ludwigs University of Freiburg; AlemaniaFil: Eibel, Hermann. Albert Ludwigs University of Freiburg; AlemaniaFil: Schneider, Pascal. Universite de Lausanne; SuizaElsevier2022-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216314Smulski, Cristian Roberto; Zhang, Luyao; Burek, Malte; Teixidó Rubio, Ariadna; Briem, Jana Susann; et al.; Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells; Elsevier; Cell Reports; 38; 13; 3-2022; 1-342211-1247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2022.110583info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:39:57Zoai:ri.conicet.gov.ar:11336/216314instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:39:57.919CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells |
title |
Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells |
spellingShingle |
Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells Smulski, Cristian Roberto CP: IMMUNOLOGY CP: MOLECULAR BIOLOGY IMMUNODEFICIENCY OLIGOMERIZATION PLAD SIGNALING TACI TNFRSF TRANSMEMBRANE |
title_short |
Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells |
title_full |
Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells |
title_fullStr |
Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells |
title_full_unstemmed |
Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells |
title_sort |
Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells |
dc.creator.none.fl_str_mv |
Smulski, Cristian Roberto Zhang, Luyao Burek, Malte Teixidó Rubio, Ariadna Briem, Jana Susann Sica, Mauricio Pablo Sevdali, Eirini Vigolo, Michele Willen, Laure Odermatt, Patricia Istanbullu, Duygu Herr, Stephanie Cavallari, Marco Hess, Henry Rizzi, Marta Eibel, Hermann Schneider, Pascal |
author |
Smulski, Cristian Roberto |
author_facet |
Smulski, Cristian Roberto Zhang, Luyao Burek, Malte Teixidó Rubio, Ariadna Briem, Jana Susann Sica, Mauricio Pablo Sevdali, Eirini Vigolo, Michele Willen, Laure Odermatt, Patricia Istanbullu, Duygu Herr, Stephanie Cavallari, Marco Hess, Henry Rizzi, Marta Eibel, Hermann Schneider, Pascal |
author_role |
author |
author2 |
Zhang, Luyao Burek, Malte Teixidó Rubio, Ariadna Briem, Jana Susann Sica, Mauricio Pablo Sevdali, Eirini Vigolo, Michele Willen, Laure Odermatt, Patricia Istanbullu, Duygu Herr, Stephanie Cavallari, Marco Hess, Henry Rizzi, Marta Eibel, Hermann Schneider, Pascal |
author2_role |
author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
CP: IMMUNOLOGY CP: MOLECULAR BIOLOGY IMMUNODEFICIENCY OLIGOMERIZATION PLAD SIGNALING TACI TNFRSF TRANSMEMBRANE |
topic |
CP: IMMUNOLOGY CP: MOLECULAR BIOLOGY IMMUNODEFICIENCY OLIGOMERIZATION PLAD SIGNALING TACI TNFRSF TRANSMEMBRANE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
In mature B cells, TACI controls class-switch recombination and differentiation into plasma cells during T cell-independent antibody responses. TACI binds the ligands BAFF and APRIL. Approximately 10% of patients with common variable immunodeficiency (CVID) carry TACI mutations, of which A181E and C172Y are in the transmembrane domain. Residues A181 and C172 are located on distinct sides of the transmembrane helix, which is predicted by molecular modeling to spontaneously assemble into trimers and dimers. In human B cells, these mutations impair ligand-dependent (C172Y) and -independent (A181E) TACI multimerization and signaling, as well as TACI-enhanced proliferation and/or IgA production. Genetic inactivation of TACI in primary human B cells impaired survival of CpG-activated cells in the absence of ligand. These results identify the transmembrane region of TACI as an active interface for TACI multimerization in signal transduction, in particular for ligand-independent signals. These functions are perturbed by CVID-associated mutations. Fil: Smulski, Cristian Roberto. Universite de Lausanne; Suiza. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro | Universidad Nacional de Cuyo. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina Fil: Zhang, Luyao. Albert Ludwigs University of Freiburg; Alemania Fil: Burek, Malte. Albert Ludwigs University of Freiburg; Alemania Fil: Teixidó Rubio, Ariadna. Albert Ludwigs University of Freiburg; Alemania Fil: Briem, Jana Susann. Albert Ludwigs University of Freiburg; Alemania Fil: Sica, Mauricio Pablo. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro | Universidad Nacional de Cuyo. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina Fil: Sevdali, Eirini. Albert Ludwigs University of Freiburg; Alemania Fil: Vigolo, Michele. Universite de Lausanne; Suiza Fil: Willen, Laure. Universite de Lausanne; Suiza Fil: Odermatt, Patricia. Albert Ludwigs University of Freiburg; Alemania Fil: Istanbullu, Duygu. Albert Ludwigs University of Freiburg; Alemania Fil: Herr, Stephanie. Albert Ludwigs University of Freiburg; Alemania Fil: Cavallari, Marco. Albert Ludwigs University of Freiburg; Alemania Fil: Hess, Henry. No especifíca; Fil: Rizzi, Marta. Albert Ludwigs University of Freiburg; Alemania Fil: Eibel, Hermann. Albert Ludwigs University of Freiburg; Alemania Fil: Schneider, Pascal. Universite de Lausanne; Suiza |
description |
In mature B cells, TACI controls class-switch recombination and differentiation into plasma cells during T cell-independent antibody responses. TACI binds the ligands BAFF and APRIL. Approximately 10% of patients with common variable immunodeficiency (CVID) carry TACI mutations, of which A181E and C172Y are in the transmembrane domain. Residues A181 and C172 are located on distinct sides of the transmembrane helix, which is predicted by molecular modeling to spontaneously assemble into trimers and dimers. In human B cells, these mutations impair ligand-dependent (C172Y) and -independent (A181E) TACI multimerization and signaling, as well as TACI-enhanced proliferation and/or IgA production. Genetic inactivation of TACI in primary human B cells impaired survival of CpG-activated cells in the absence of ligand. These results identify the transmembrane region of TACI as an active interface for TACI multimerization in signal transduction, in particular for ligand-independent signals. These functions are perturbed by CVID-associated mutations. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/216314 Smulski, Cristian Roberto; Zhang, Luyao; Burek, Malte; Teixidó Rubio, Ariadna; Briem, Jana Susann; et al.; Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells; Elsevier; Cell Reports; 38; 13; 3-2022; 1-34 2211-1247 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/216314 |
identifier_str_mv |
Smulski, Cristian Roberto; Zhang, Luyao; Burek, Malte; Teixidó Rubio, Ariadna; Briem, Jana Susann; et al.; Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells; Elsevier; Cell Reports; 38; 13; 3-2022; 1-34 2211-1247 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2022.110583 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614426508918784 |
score |
13.070432 |