Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells

Autores
Smulski, Cristian Roberto; Zhang, Luyao; Burek, Malte; Teixidó Rubio, Ariadna; Briem, Jana Susann; Sica, Mauricio Pablo; Sevdali, Eirini; Vigolo, Michele; Willen, Laure; Odermatt, Patricia; Istanbullu, Duygu; Herr, Stephanie; Cavallari, Marco; Hess, Henry; Rizzi, Marta; Eibel, Hermann; Schneider, Pascal
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In mature B cells, TACI controls class-switch recombination and differentiation into plasma cells during T cell-independent antibody responses. TACI binds the ligands BAFF and APRIL. Approximately 10% of patients with common variable immunodeficiency (CVID) carry TACI mutations, of which A181E and C172Y are in the transmembrane domain. Residues A181 and C172 are located on distinct sides of the transmembrane helix, which is predicted by molecular modeling to spontaneously assemble into trimers and dimers. In human B cells, these mutations impair ligand-dependent (C172Y) and -independent (A181E) TACI multimerization and signaling, as well as TACI-enhanced proliferation and/or IgA production. Genetic inactivation of TACI in primary human B cells impaired survival of CpG-activated cells in the absence of ligand. These results identify the transmembrane region of TACI as an active interface for TACI multimerization in signal transduction, in particular for ligand-independent signals. These functions are perturbed by CVID-associated mutations.
Fil: Smulski, Cristian Roberto. Universite de Lausanne; Suiza. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro | Universidad Nacional de Cuyo. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina
Fil: Zhang, Luyao. Albert Ludwigs University of Freiburg; Alemania
Fil: Burek, Malte. Albert Ludwigs University of Freiburg; Alemania
Fil: Teixidó Rubio, Ariadna. Albert Ludwigs University of Freiburg; Alemania
Fil: Briem, Jana Susann. Albert Ludwigs University of Freiburg; Alemania
Fil: Sica, Mauricio Pablo. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro | Universidad Nacional de Cuyo. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina
Fil: Sevdali, Eirini. Albert Ludwigs University of Freiburg; Alemania
Fil: Vigolo, Michele. Universite de Lausanne; Suiza
Fil: Willen, Laure. Universite de Lausanne; Suiza
Fil: Odermatt, Patricia. Albert Ludwigs University of Freiburg; Alemania
Fil: Istanbullu, Duygu. Albert Ludwigs University of Freiburg; Alemania
Fil: Herr, Stephanie. Albert Ludwigs University of Freiburg; Alemania
Fil: Cavallari, Marco. Albert Ludwigs University of Freiburg; Alemania
Fil: Hess, Henry. No especifíca;
Fil: Rizzi, Marta. Albert Ludwigs University of Freiburg; Alemania
Fil: Eibel, Hermann. Albert Ludwigs University of Freiburg; Alemania
Fil: Schneider, Pascal. Universite de Lausanne; Suiza
Materia
CP: IMMUNOLOGY
CP: MOLECULAR BIOLOGY
IMMUNODEFICIENCY
OLIGOMERIZATION
PLAD
SIGNALING
TACI
TNFRSF
TRANSMEMBRANE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/216314

id CONICETDig_4f4ec06f5395f93b6d51862f788d2bd0
oai_identifier_str oai:ri.conicet.gov.ar:11336/216314
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cellsSmulski, Cristian RobertoZhang, LuyaoBurek, MalteTeixidó Rubio, AriadnaBriem, Jana SusannSica, Mauricio PabloSevdali, EiriniVigolo, MicheleWillen, LaureOdermatt, PatriciaIstanbullu, DuyguHerr, StephanieCavallari, MarcoHess, HenryRizzi, MartaEibel, HermannSchneider, PascalCP: IMMUNOLOGYCP: MOLECULAR BIOLOGYIMMUNODEFICIENCYOLIGOMERIZATIONPLADSIGNALINGTACITNFRSFTRANSMEMBRANEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In mature B cells, TACI controls class-switch recombination and differentiation into plasma cells during T cell-independent antibody responses. TACI binds the ligands BAFF and APRIL. Approximately 10% of patients with common variable immunodeficiency (CVID) carry TACI mutations, of which A181E and C172Y are in the transmembrane domain. Residues A181 and C172 are located on distinct sides of the transmembrane helix, which is predicted by molecular modeling to spontaneously assemble into trimers and dimers. In human B cells, these mutations impair ligand-dependent (C172Y) and -independent (A181E) TACI multimerization and signaling, as well as TACI-enhanced proliferation and/or IgA production. Genetic inactivation of TACI in primary human B cells impaired survival of CpG-activated cells in the absence of ligand. These results identify the transmembrane region of TACI as an active interface for TACI multimerization in signal transduction, in particular for ligand-independent signals. These functions are perturbed by CVID-associated mutations.Fil: Smulski, Cristian Roberto. Universite de Lausanne; Suiza. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro | Universidad Nacional de Cuyo. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Zhang, Luyao. Albert Ludwigs University of Freiburg; AlemaniaFil: Burek, Malte. Albert Ludwigs University of Freiburg; AlemaniaFil: Teixidó Rubio, Ariadna. Albert Ludwigs University of Freiburg; AlemaniaFil: Briem, Jana Susann. Albert Ludwigs University of Freiburg; AlemaniaFil: Sica, Mauricio Pablo. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro | Universidad Nacional de Cuyo. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Sevdali, Eirini. Albert Ludwigs University of Freiburg; AlemaniaFil: Vigolo, Michele. Universite de Lausanne; SuizaFil: Willen, Laure. Universite de Lausanne; SuizaFil: Odermatt, Patricia. Albert Ludwigs University of Freiburg; AlemaniaFil: Istanbullu, Duygu. Albert Ludwigs University of Freiburg; AlemaniaFil: Herr, Stephanie. Albert Ludwigs University of Freiburg; AlemaniaFil: Cavallari, Marco. Albert Ludwigs University of Freiburg; AlemaniaFil: Hess, Henry. No especifíca;Fil: Rizzi, Marta. Albert Ludwigs University of Freiburg; AlemaniaFil: Eibel, Hermann. Albert Ludwigs University of Freiburg; AlemaniaFil: Schneider, Pascal. Universite de Lausanne; SuizaElsevier2022-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216314Smulski, Cristian Roberto; Zhang, Luyao; Burek, Malte; Teixidó Rubio, Ariadna; Briem, Jana Susann; et al.; Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells; Elsevier; Cell Reports; 38; 13; 3-2022; 1-342211-1247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2022.110583info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:39:57Zoai:ri.conicet.gov.ar:11336/216314instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:39:57.919CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
title Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
spellingShingle Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
Smulski, Cristian Roberto
CP: IMMUNOLOGY
CP: MOLECULAR BIOLOGY
IMMUNODEFICIENCY
OLIGOMERIZATION
PLAD
SIGNALING
TACI
TNFRSF
TRANSMEMBRANE
title_short Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
title_full Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
title_fullStr Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
title_full_unstemmed Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
title_sort Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
dc.creator.none.fl_str_mv Smulski, Cristian Roberto
Zhang, Luyao
Burek, Malte
Teixidó Rubio, Ariadna
Briem, Jana Susann
Sica, Mauricio Pablo
Sevdali, Eirini
Vigolo, Michele
Willen, Laure
Odermatt, Patricia
Istanbullu, Duygu
Herr, Stephanie
Cavallari, Marco
Hess, Henry
Rizzi, Marta
Eibel, Hermann
Schneider, Pascal
author Smulski, Cristian Roberto
author_facet Smulski, Cristian Roberto
Zhang, Luyao
Burek, Malte
Teixidó Rubio, Ariadna
Briem, Jana Susann
Sica, Mauricio Pablo
Sevdali, Eirini
Vigolo, Michele
Willen, Laure
Odermatt, Patricia
Istanbullu, Duygu
Herr, Stephanie
Cavallari, Marco
Hess, Henry
Rizzi, Marta
Eibel, Hermann
Schneider, Pascal
author_role author
author2 Zhang, Luyao
Burek, Malte
Teixidó Rubio, Ariadna
Briem, Jana Susann
Sica, Mauricio Pablo
Sevdali, Eirini
Vigolo, Michele
Willen, Laure
Odermatt, Patricia
Istanbullu, Duygu
Herr, Stephanie
Cavallari, Marco
Hess, Henry
Rizzi, Marta
Eibel, Hermann
Schneider, Pascal
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CP: IMMUNOLOGY
CP: MOLECULAR BIOLOGY
IMMUNODEFICIENCY
OLIGOMERIZATION
PLAD
SIGNALING
TACI
TNFRSF
TRANSMEMBRANE
topic CP: IMMUNOLOGY
CP: MOLECULAR BIOLOGY
IMMUNODEFICIENCY
OLIGOMERIZATION
PLAD
SIGNALING
TACI
TNFRSF
TRANSMEMBRANE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In mature B cells, TACI controls class-switch recombination and differentiation into plasma cells during T cell-independent antibody responses. TACI binds the ligands BAFF and APRIL. Approximately 10% of patients with common variable immunodeficiency (CVID) carry TACI mutations, of which A181E and C172Y are in the transmembrane domain. Residues A181 and C172 are located on distinct sides of the transmembrane helix, which is predicted by molecular modeling to spontaneously assemble into trimers and dimers. In human B cells, these mutations impair ligand-dependent (C172Y) and -independent (A181E) TACI multimerization and signaling, as well as TACI-enhanced proliferation and/or IgA production. Genetic inactivation of TACI in primary human B cells impaired survival of CpG-activated cells in the absence of ligand. These results identify the transmembrane region of TACI as an active interface for TACI multimerization in signal transduction, in particular for ligand-independent signals. These functions are perturbed by CVID-associated mutations.
Fil: Smulski, Cristian Roberto. Universite de Lausanne; Suiza. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro | Universidad Nacional de Cuyo. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina
Fil: Zhang, Luyao. Albert Ludwigs University of Freiburg; Alemania
Fil: Burek, Malte. Albert Ludwigs University of Freiburg; Alemania
Fil: Teixidó Rubio, Ariadna. Albert Ludwigs University of Freiburg; Alemania
Fil: Briem, Jana Susann. Albert Ludwigs University of Freiburg; Alemania
Fil: Sica, Mauricio Pablo. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro | Universidad Nacional de Cuyo. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina
Fil: Sevdali, Eirini. Albert Ludwigs University of Freiburg; Alemania
Fil: Vigolo, Michele. Universite de Lausanne; Suiza
Fil: Willen, Laure. Universite de Lausanne; Suiza
Fil: Odermatt, Patricia. Albert Ludwigs University of Freiburg; Alemania
Fil: Istanbullu, Duygu. Albert Ludwigs University of Freiburg; Alemania
Fil: Herr, Stephanie. Albert Ludwigs University of Freiburg; Alemania
Fil: Cavallari, Marco. Albert Ludwigs University of Freiburg; Alemania
Fil: Hess, Henry. No especifíca;
Fil: Rizzi, Marta. Albert Ludwigs University of Freiburg; Alemania
Fil: Eibel, Hermann. Albert Ludwigs University of Freiburg; Alemania
Fil: Schneider, Pascal. Universite de Lausanne; Suiza
description In mature B cells, TACI controls class-switch recombination and differentiation into plasma cells during T cell-independent antibody responses. TACI binds the ligands BAFF and APRIL. Approximately 10% of patients with common variable immunodeficiency (CVID) carry TACI mutations, of which A181E and C172Y are in the transmembrane domain. Residues A181 and C172 are located on distinct sides of the transmembrane helix, which is predicted by molecular modeling to spontaneously assemble into trimers and dimers. In human B cells, these mutations impair ligand-dependent (C172Y) and -independent (A181E) TACI multimerization and signaling, as well as TACI-enhanced proliferation and/or IgA production. Genetic inactivation of TACI in primary human B cells impaired survival of CpG-activated cells in the absence of ligand. These results identify the transmembrane region of TACI as an active interface for TACI multimerization in signal transduction, in particular for ligand-independent signals. These functions are perturbed by CVID-associated mutations.
publishDate 2022
dc.date.none.fl_str_mv 2022-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/216314
Smulski, Cristian Roberto; Zhang, Luyao; Burek, Malte; Teixidó Rubio, Ariadna; Briem, Jana Susann; et al.; Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells; Elsevier; Cell Reports; 38; 13; 3-2022; 1-34
2211-1247
CONICET Digital
CONICET
url http://hdl.handle.net/11336/216314
identifier_str_mv Smulski, Cristian Roberto; Zhang, Luyao; Burek, Malte; Teixidó Rubio, Ariadna; Briem, Jana Susann; et al.; Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells; Elsevier; Cell Reports; 38; 13; 3-2022; 1-34
2211-1247
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2022.110583
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432