BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
- Autores
- Sevdali, Eirini; Block, Violeta; Lataretu, Marie; Li, Huiying; Smulski, Cristian Roberto; Briem, Jana Susann; Heitz, Yannic; Fischer, Beate; Ramirez, Neftali Jose; Grimbacher, Bodo; Jäck, Hans-Martin; Voll, Reinhard E.; Hölzer, Martin; Schneider, Pascal; Eibel, Hermann
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Binding of BAFF to BAFFR activates in mature B cells PI3K/AKT signaling regulating protein synthesis, metabolic fitness, and survival. In humans, naive and memory B cells express the same levels of BAFFR, but only memory B cells seem to survive without BAFF. Here, we show that BAFF activates PI3K/AKT only in naive B cells and changes the expression of genes regulating migration, proliferation, growth, and survival. BAFF-induced PI3K/AKT activation requires direct interactions between BAFFR and the B cell antigen receptor (BCR) components CD79A and CD79B and is enhanced by the AKT coactivator TCL1A. Compared to memory B cells, naive B cells express more surface BCRs, which interact better with BAFFR than IgG or IgA, thus allowing stronger responses to BAFF. As ablation of BAFFR in naive and memory B cells causes cell death independent of BAFF-induced signaling, BAFFR seems to act also as an intrinsic factor for B cell survival.
Fil: Sevdali, Eirini. Albert Ludwigs University of Freiburg; Alemania
Fil: Block, Violeta. Albert Ludwigs University of Freiburg; Alemania
Fil: Lataretu, Marie. Universitat Jena; Alemania
Fil: Li, Huiying. Albert Ludwigs University of Freiburg; Alemania
Fil: Smulski, Cristian Roberto. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina
Fil: Briem, Jana Susann. Albert Ludwigs University of Freiburg; Alemania
Fil: Heitz, Yannic. Albert Ludwigs University of Freiburg; Alemania
Fil: Fischer, Beate. Albert Ludwigs University of Freiburg; Alemania
Fil: Ramirez, Neftali Jose. Albert Ludwigs University of Freiburg; Alemania
Fil: Grimbacher, Bodo. Albert Ludwigs University of Freiburg; Alemania
Fil: Jäck, Hans-Martin. Universitat Erlangen-Nuremberg; Alemania
Fil: Voll, Reinhard E.. Albert Ludwigs University of Freiburg; Alemania
Fil: Hölzer, Martin. Robert Koch Institut; Alemania
Fil: Schneider, Pascal. Universite de Lausanne; Suiza
Fil: Eibel, Hermann. Albert Ludwigs University of Freiburg; Alemania - Materia
-
BAFF
BAFFR
BCR
CP: IMMUNOLOGY
HUMAN MEMORY B CELLS
PI3K SIGNALING - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/216824
Ver los metadatos del registro completo
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BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptorsSevdali, EiriniBlock, VioletaLataretu, MarieLi, HuiyingSmulski, Cristian RobertoBriem, Jana SusannHeitz, YannicFischer, BeateRamirez, Neftali JoseGrimbacher, BodoJäck, Hans-MartinVoll, Reinhard E.Hölzer, MartinSchneider, PascalEibel, HermannBAFFBAFFRBCRCP: IMMUNOLOGYHUMAN MEMORY B CELLSPI3K SIGNALINGhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Binding of BAFF to BAFFR activates in mature B cells PI3K/AKT signaling regulating protein synthesis, metabolic fitness, and survival. In humans, naive and memory B cells express the same levels of BAFFR, but only memory B cells seem to survive without BAFF. Here, we show that BAFF activates PI3K/AKT only in naive B cells and changes the expression of genes regulating migration, proliferation, growth, and survival. BAFF-induced PI3K/AKT activation requires direct interactions between BAFFR and the B cell antigen receptor (BCR) components CD79A and CD79B and is enhanced by the AKT coactivator TCL1A. Compared to memory B cells, naive B cells express more surface BCRs, which interact better with BAFFR than IgG or IgA, thus allowing stronger responses to BAFF. As ablation of BAFFR in naive and memory B cells causes cell death independent of BAFF-induced signaling, BAFFR seems to act also as an intrinsic factor for B cell survival.Fil: Sevdali, Eirini. Albert Ludwigs University of Freiburg; AlemaniaFil: Block, Violeta. Albert Ludwigs University of Freiburg; AlemaniaFil: Lataretu, Marie. Universitat Jena; AlemaniaFil: Li, Huiying. Albert Ludwigs University of Freiburg; AlemaniaFil: Smulski, Cristian Roberto. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Briem, Jana Susann. Albert Ludwigs University of Freiburg; AlemaniaFil: Heitz, Yannic. Albert Ludwigs University of Freiburg; AlemaniaFil: Fischer, Beate. Albert Ludwigs University of Freiburg; AlemaniaFil: Ramirez, Neftali Jose. Albert Ludwigs University of Freiburg; AlemaniaFil: Grimbacher, Bodo. Albert Ludwigs University of Freiburg; AlemaniaFil: Jäck, Hans-Martin. Universitat Erlangen-Nuremberg; AlemaniaFil: Voll, Reinhard E.. Albert Ludwigs University of Freiburg; AlemaniaFil: Hölzer, Martin. Robert Koch Institut; AlemaniaFil: Schneider, Pascal. Universite de Lausanne; SuizaFil: Eibel, Hermann. Albert Ludwigs University of Freiburg; AlemaniaElsevier2022-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216824Sevdali, Eirini; Block, Violeta; Lataretu, Marie; Li, Huiying; Smulski, Cristian Roberto; et al.; BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors; Elsevier; Cell Reports; 39; 13; 6-2022; 1-502211-1247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2022.111019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:04:37Zoai:ri.conicet.gov.ar:11336/216824instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:04:37.501CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors |
| title |
BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors |
| spellingShingle |
BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors Sevdali, Eirini BAFF BAFFR BCR CP: IMMUNOLOGY HUMAN MEMORY B CELLS PI3K SIGNALING |
| title_short |
BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors |
| title_full |
BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors |
| title_fullStr |
BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors |
| title_full_unstemmed |
BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors |
| title_sort |
BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors |
| dc.creator.none.fl_str_mv |
Sevdali, Eirini Block, Violeta Lataretu, Marie Li, Huiying Smulski, Cristian Roberto Briem, Jana Susann Heitz, Yannic Fischer, Beate Ramirez, Neftali Jose Grimbacher, Bodo Jäck, Hans-Martin Voll, Reinhard E. Hölzer, Martin Schneider, Pascal Eibel, Hermann |
| author |
Sevdali, Eirini |
| author_facet |
Sevdali, Eirini Block, Violeta Lataretu, Marie Li, Huiying Smulski, Cristian Roberto Briem, Jana Susann Heitz, Yannic Fischer, Beate Ramirez, Neftali Jose Grimbacher, Bodo Jäck, Hans-Martin Voll, Reinhard E. Hölzer, Martin Schneider, Pascal Eibel, Hermann |
| author_role |
author |
| author2 |
Block, Violeta Lataretu, Marie Li, Huiying Smulski, Cristian Roberto Briem, Jana Susann Heitz, Yannic Fischer, Beate Ramirez, Neftali Jose Grimbacher, Bodo Jäck, Hans-Martin Voll, Reinhard E. Hölzer, Martin Schneider, Pascal Eibel, Hermann |
| author2_role |
author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
BAFF BAFFR BCR CP: IMMUNOLOGY HUMAN MEMORY B CELLS PI3K SIGNALING |
| topic |
BAFF BAFFR BCR CP: IMMUNOLOGY HUMAN MEMORY B CELLS PI3K SIGNALING |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Binding of BAFF to BAFFR activates in mature B cells PI3K/AKT signaling regulating protein synthesis, metabolic fitness, and survival. In humans, naive and memory B cells express the same levels of BAFFR, but only memory B cells seem to survive without BAFF. Here, we show that BAFF activates PI3K/AKT only in naive B cells and changes the expression of genes regulating migration, proliferation, growth, and survival. BAFF-induced PI3K/AKT activation requires direct interactions between BAFFR and the B cell antigen receptor (BCR) components CD79A and CD79B and is enhanced by the AKT coactivator TCL1A. Compared to memory B cells, naive B cells express more surface BCRs, which interact better with BAFFR than IgG or IgA, thus allowing stronger responses to BAFF. As ablation of BAFFR in naive and memory B cells causes cell death independent of BAFF-induced signaling, BAFFR seems to act also as an intrinsic factor for B cell survival. Fil: Sevdali, Eirini. Albert Ludwigs University of Freiburg; Alemania Fil: Block, Violeta. Albert Ludwigs University of Freiburg; Alemania Fil: Lataretu, Marie. Universitat Jena; Alemania Fil: Li, Huiying. Albert Ludwigs University of Freiburg; Alemania Fil: Smulski, Cristian Roberto. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina Fil: Briem, Jana Susann. Albert Ludwigs University of Freiburg; Alemania Fil: Heitz, Yannic. Albert Ludwigs University of Freiburg; Alemania Fil: Fischer, Beate. Albert Ludwigs University of Freiburg; Alemania Fil: Ramirez, Neftali Jose. Albert Ludwigs University of Freiburg; Alemania Fil: Grimbacher, Bodo. Albert Ludwigs University of Freiburg; Alemania Fil: Jäck, Hans-Martin. Universitat Erlangen-Nuremberg; Alemania Fil: Voll, Reinhard E.. Albert Ludwigs University of Freiburg; Alemania Fil: Hölzer, Martin. Robert Koch Institut; Alemania Fil: Schneider, Pascal. Universite de Lausanne; Suiza Fil: Eibel, Hermann. Albert Ludwigs University of Freiburg; Alemania |
| description |
Binding of BAFF to BAFFR activates in mature B cells PI3K/AKT signaling regulating protein synthesis, metabolic fitness, and survival. In humans, naive and memory B cells express the same levels of BAFFR, but only memory B cells seem to survive without BAFF. Here, we show that BAFF activates PI3K/AKT only in naive B cells and changes the expression of genes regulating migration, proliferation, growth, and survival. BAFF-induced PI3K/AKT activation requires direct interactions between BAFFR and the B cell antigen receptor (BCR) components CD79A and CD79B and is enhanced by the AKT coactivator TCL1A. Compared to memory B cells, naive B cells express more surface BCRs, which interact better with BAFFR than IgG or IgA, thus allowing stronger responses to BAFF. As ablation of BAFFR in naive and memory B cells causes cell death independent of BAFF-induced signaling, BAFFR seems to act also as an intrinsic factor for B cell survival. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-06 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/216824 Sevdali, Eirini; Block, Violeta; Lataretu, Marie; Li, Huiying; Smulski, Cristian Roberto; et al.; BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors; Elsevier; Cell Reports; 39; 13; 6-2022; 1-50 2211-1247 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/216824 |
| identifier_str_mv |
Sevdali, Eirini; Block, Violeta; Lataretu, Marie; Li, Huiying; Smulski, Cristian Roberto; et al.; BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors; Elsevier; Cell Reports; 39; 13; 6-2022; 1-50 2211-1247 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2022.111019 |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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